專利名稱：Hcv調(diào)節(jié)的蛋白表達(dá)的制作方法
技術(shù)領(lǐng)域：
本發(fā)明涉及通過對(duì)丙型肝炎病毒(HCV)復(fù)制子調(diào)節(jié)的多肽表達(dá)進(jìn)行分析鑒定的抗HCV藥物的新的宿主細(xì)胞靶標(biāo)，涉及預(yù)測病毒感染后果的預(yù)后標(biāo)記，涉及預(yù)測個(gè)體中HCV感染后果的體外方法，還涉及用于鑒定與該新的宿主細(xì)胞靶標(biāo)相互作用和/或調(diào)節(jié)該宿主細(xì)胞靶標(biāo)活性或者調(diào)節(jié)所述新的宿主細(xì)胞靶標(biāo)表達(dá)的化合物的篩選方法。
背景技術(shù)：
丙型肝炎病毒(HCV)感染是一種快速增長的公共健康問題，估計(jì)世界上有2億慢性感染的病人?，F(xiàn)在還沒有HCV疫苗(Hagedom，C.H.和Rice，C.M.eds.(1999)微生物學(xué)與免疫學(xué)當(dāng)今主題(Springer，Berlin))，現(xiàn)今的治療只對(duì)一部分病人有效。病毒感染、持續(xù)性和清除的機(jī)理還不很清楚，主要是因?yàn)槿狈ψ銐虻膭?dòng)物模型和細(xì)胞培養(yǎng)系統(tǒng)。
由于病毒在細(xì)胞培養(yǎng)物中的繁殖沒有成功(Tan.S.-L.等(2002)，丙型肝炎治療現(xiàn)狀與策略，Nature Reviews，Vol.1，867-881)，產(chǎn)生了一種HCV-復(fù)制子系統(tǒng)，其中HCV非結(jié)構(gòu)蛋白的表達(dá)驅(qū)動(dòng)了亞基因組HCV RNA的復(fù)制(Bartenschl_ger，R.(2002)，丙型肝炎病毒復(fù)制子藥物開發(fā)中的潛在角色，Nature Reviews，Vol.1，911-916)。有了該系統(tǒng)就可以更詳細(xì)地研究HCV復(fù)制和宿主-所有應(yīng)答。雖然大多數(shù)現(xiàn)今的抗病毒工作都針對(duì)HCV復(fù)制必需的關(guān)鍵病毒酶，但是在定向控制病毒的復(fù)制方面，例如當(dāng)用小分子定向控制病毒復(fù)制時(shí)，HCV復(fù)制所需的細(xì)胞基因代表一類引人注目的基因。
mRNA病毒完全依賴宿主細(xì)胞進(jìn)行蛋白合成。它們必須很大程度上顛覆宿主細(xì)胞的蛋白合成機(jī)器以便表達(dá)它們的病毒蛋白。并不奇怪，該過程的一些部分已經(jīng)在本領(lǐng)域中描述。從而，Krüger等(Krüger，M等，用功能基因組方法鑒定eIF2Bγ和eIF2γ為HCV IRES介導(dǎo)的翻譯的輔因子，PNAS，2000，vol.97，8566-8571)使用功能基因組方法鑒定了參與HCVIRES功能的eIF2Bγ和eIF2γ細(xì)胞輔因子。
在病毒裝配中，哺乳動(dòng)物病毒依賴于宿主細(xì)胞糖基化機(jī)器進(jìn)行形態(tài)發(fā)生和分泌。N-連接的糖基化途徑的第一步伴隨著位于內(nèi)質(zhì)網(wǎng)的葡糖苷酶，其可以在低水平被靶定以治療病毒感染而不危及宿主的安全。Su A.J.(SuAI，Pezacki JP等，PNAS，2002，99(24)，15669-15674)表明在HCV感染誘導(dǎo)的宿主基因中有一些參與免疫應(yīng)答并且被IFN-γ誘導(dǎo)，如CD8、MHC II類組分、趨化因子，如RANTES和MIG。其他鑒定的在早期HCV感染中被差異誘導(dǎo)或者抑制的基因與脂質(zhì)代謝有關(guān)(后果的預(yù)后標(biāo)記)。
然而，公知轉(zhuǎn)錄水平上的調(diào)節(jié)不一定指示相應(yīng)基因在翻譯水平上表達(dá)的類似調(diào)節(jié)。一些研究表明mRNA表達(dá)水平和實(shí)際的蛋白表達(dá)只有很弱的相關(guān)性(Gygi SP，Rochon Y，F(xiàn)ranza BR，Aebersold R.，Mol Cell Biol.，1999，19(3)，1720-30)。從而，只有闡明表1和表2中所列的多肽由于衍生自HCV復(fù)制子的RNA的存在而被下調(diào)或上調(diào)，才可能用它們作為病毒藥物的新靶標(biāo)和預(yù)測疾病后果的預(yù)后標(biāo)記。
所以，本領(lǐng)域中需要新的宿主細(xì)胞靶標(biāo)以治療HCV感染，并需要可用于研究和預(yù)測HCV感染的后果的標(biāo)記物。

發(fā)明內(nèi)容
本發(fā)明涉及通過對(duì)HCV復(fù)制子調(diào)節(jié)的多肽表達(dá)進(jìn)行分析鑒定的用于抗病毒化合物，優(yōu)選抗HCV化合物的新宿主細(xì)胞靶標(biāo)，涉及預(yù)測病毒感染后果的預(yù)后標(biāo)記，涉及預(yù)測個(gè)體中HCV感染后果的體外方法，還涉及用于鑒定與該新的宿主細(xì)胞靶標(biāo)相互作用和/或調(diào)節(jié)該宿主細(xì)胞靶標(biāo)活性或者調(diào)節(jié)所述新的宿主細(xì)胞靶標(biāo)表達(dá)的化合物的篩選方法。
本發(fā)明提供了抗病毒化合物的靶標(biāo)，其包括至少一種選自表1和表2中所列多肽的多肽。優(yōu)選地，提供了包括至少一種選自表3所列多肽的多肽的抗病毒化合物靶標(biāo)。表3中所列多肽包括上調(diào)或下調(diào)的mRNA伴侶蛋白、mRNA結(jié)合蛋白，例如PTB。還優(yōu)選地，提供了包括至少一種選自表4所列多肽的多肽的抗病毒化合物靶標(biāo)。表4中所列多肽包括上調(diào)或下調(diào)的翻譯起始蛋白，例如eIF2γ和eIF2Bγ。在其它優(yōu)選的實(shí)施方案中，提供了包括至少一種選自表5中所列多肽的多肽的抗病毒化合物靶標(biāo)。表5中所列多肽包括參與脂代謝的被上調(diào)或下調(diào)的多肽，例如，參與膽固醇合成和β-氧化的多肽。在另一個(gè)優(yōu)選的實(shí)施方案中，提供了包括至少一種選自表6中所列多肽的多肽的抗病毒化合物靶標(biāo)。表6中所列多肽包括參與信號(hào)轉(zhuǎn)導(dǎo)途徑的被上調(diào)或下調(diào)的多肽，例如，MAP激酶如MK01或癌基因如SRC8。上述靶標(biāo)優(yōu)選為抗HCV靶標(biāo)?？共《净衔铮瑑?yōu)選抗HCV化合物的靶標(biāo)可以包括表1、表2，優(yōu)選表3、表4、表5和表6中列出的兩種、三種、四種、五種、六種或甚至更多種多肽。特別優(yōu)選的抗HCV化合物的靶標(biāo)為SEQ ID NO70(PTB_HUMAN)，101(NR54_HUMAN)，72(ACDB_HUMAN)，193(CHR1-O14805)或166(SCR8_HUMAN)的多肽。此處所用抗病毒化合物可以包括抗任何病毒如DNA和RNA病毒的化合物，優(yōu)選包括抗RNA病毒，如HIV，脊髓灰質(zhì)炎病毒的化合物。最優(yōu)選地，抗病毒化合物為抗HCV的化合物。
此處所用術(shù)語“多肽”指氨基酸聚合物，而不指特定長度。從而，肽、寡肽和蛋白包括在多肽的定義內(nèi)。
本發(fā)明還提供了預(yù)測病毒感染后果的預(yù)后標(biāo)記，其包括至少一種選自表1和表2中所列多肽的多肽。優(yōu)選地，提供了包括至少一種選自表3至表6所列多肽的多肽的預(yù)測病毒感染后果的預(yù)后標(biāo)記。該標(biāo)記可以包括選自表1和表2或者表3到表6所列多肽的兩種、三種、四種、五種、六種、七種、八種、九種、十種或更多種多肽。優(yōu)選地，本發(fā)明提供了預(yù)測HCV感染后果的預(yù)后標(biāo)記。HCV感染的后果可以包括肝衰竭、肝細(xì)胞癌和肝硬化(Hofnagle，J.H.，丙型肝炎-疾病的臨床譜，肝臟病學(xué)(Hepatology)26，1997，15-20)。
本發(fā)明還提供了預(yù)測個(gè)體HCV感染后果的體外方法，其包括從HCV感染的個(gè)體得到生物學(xué)樣品；確定表1到表6所列的多肽中的至少一種多肽的表達(dá)水平。此處所用的術(shù)語“確定表達(dá)水平”指定量確定從HCV感染的個(gè)體得到的生物學(xué)樣品中多肽的表達(dá)。此外，體外方法還涉及將所述表1到表6中所列的多肽中的至少一種多肽的表達(dá)水平與其在HCV感染過程中不同時(shí)間點(diǎn)的表達(dá)水平和/或與來自未感染個(gè)體的生物學(xué)樣品中的差異表達(dá)進(jìn)行比較。確定生物學(xué)樣品中多肽表達(dá)的水平的方法是本領(lǐng)域熟知的，包括但不限于，Western雜交、ELISA或RIA。識(shí)別表1至表6中所列多肽的抗體可以或者通過如用純化蛋白免疫兔子來產(chǎn)生以檢測所述多肽，或者可以使用識(shí)別所述多肽的已知抗體。例如，能夠結(jié)合變性蛋白的抗體，如多克隆抗體可被用于Western印跡中檢測本發(fā)明多肽。檢測預(yù)后標(biāo)記的表達(dá)水平的方法的一個(gè)例子是ELISA。這種蛋白定量基于一種抗體能夠捕獲特定抗原而第二抗體能夠檢測所捕獲的抗原。用于確定預(yù)測HCV感染后果的標(biāo)記的表達(dá)的另一種方法包括分析活檢組織樣本是否存在本發(fā)明的標(biāo)記。檢測這些標(biāo)記的方法是本領(lǐng)域熟知的并且包括，但不限于，免疫組織化學(xué)或免疫熒光檢測是否存在本發(fā)明的多肽。抗體的制備和使用方法以及前面所提到的測定方法描述于Harlow，E.和Lane，D.抗體實(shí)驗(yàn)室指南(AntibodiesA Laboratory Manual)，(1988)，冷泉港實(shí)驗(yàn)室出版社。
對(duì)于本發(fā)明的預(yù)測HCV感染后果的方法，需要分析合適的生物學(xué)樣品中標(biāo)記的表達(dá)。所述生物學(xué)樣品可以是血清、血漿或肝臟組織。來自肝臟組織的細(xì)胞可以通過例如大孔徑針刺活組織檢查得到。
在本發(fā)明中，術(shù)語“個(gè)體”包括任何哺乳動(dòng)物，其可感染HCV。優(yōu)選地，該個(gè)體是人。
本發(fā)明還提供了用于鑒定和/或得到如下化合物的篩選方法，該化合物與選自表1到表6所列多肽的多肽相互作用，而該多肽的表達(dá)在HCV感染的組織中被上調(diào)或下調(diào)，所述篩選方法包括將所述多肽與一種化合物或多種化合物在允許所述化合物與所述多肽相互作用的條件下接觸；和檢測所述化合物或多種化合物與所述多肽之間的相互作用。
此處所公開的篩選方法中的“相互作用”可以通過常規(guī)方法測量。檢驗(yàn)化合物與可溶性多肽(與膜結(jié)合多肽相對(duì))相互作用的常規(guī)方法的類型可以是使用純化的重組多肽或者從內(nèi)源性表達(dá)該多肽的細(xì)胞中純化的天然多肽的體外方法。作為一個(gè)非限定性實(shí)例，本發(fā)明的多肽可以被結(jié)合到珠子上或者被固定到塑料或者其他表面上，并且化合物與多肽的相互作用可以通過使用標(biāo)記化合物并測量結(jié)合到多肽的標(biāo)記，或者通過從所述多肽上置換出標(biāo)記的已知配體來測量。
對(duì)于在細(xì)胞表面上與細(xì)胞膜結(jié)合的多肽，或者表達(dá)為跨膜或者膜整合多肽的多肽，化合物與所述多肽的相互作用可以用不同方法檢測，這些方法包括，但不限于，使用正常表達(dá)多肽或者過表達(dá)多肽的細(xì)胞的方法，例如，檢測待篩選的化合物對(duì)標(biāo)記的已知配體的置換。備選地，可以使用膜制品檢驗(yàn)化合物與所述多肽的相互作用。
在此處公開的方法中所用的相互作用測定法可以包括FRET-測定法(熒光共振能量轉(zhuǎn)移；如在Ng，Science283(1999)，2085-2089或Ubarretxena-Belandia，Biochem.38(1999)，7398-7405中公開的)、TR-FRET和此處公開的生化測定法。此外，可以使用商業(yè)測定法，像“Amplified Luminescent Proximity Homogenous AssayTM”(BioSignalPackard)。其他方法是本領(lǐng)域中熟知的，描述于例如Fernandez，Curr.Opin.Chem.Biol.2(1998)，597-603。
用于鑒定和/或得到相互作用化合物的方法也可以通過本領(lǐng)域熟知的特定免疫學(xué)和/或生物化學(xué)測定法進(jìn)行，這些測定法包括例如本文下面描述的均相(homogeneous)和非均相(heterogeneous)測定法。使用讀出系統(tǒng)的所述相互作用測定法是本領(lǐng)域中熟知的，包括例如，雙雜交篩選(如EP-0 963376，WO 98/25947，WO 00/02911中描述)；GST-pull-down柱，細(xì)胞提取物的共沉淀測定法(如Kasus-Jacobi，Oncogene 19(2000)，2052-2059中描述)、“相互作用捕獲”系統(tǒng)(“interaction-trap”system)(如US 6,004,746中描述)表達(dá)克隆(例如λgt11)、噬菌體展示(如US 5,541,109中描述)、體外結(jié)合測定法等等。其他相互作用測定方法和相應(yīng)的讀出系統(tǒng)描述于例如，US 5,525,490、WO 99/51741、WO 00/17221、WO 00/14271或WO 00/05410。Vidal和Legrain(Nudeic Acids Research 27(1999)，919-929)描述、評(píng)論并概括了本領(lǐng)域中已知的其它相互作用測定法，可以根據(jù)本發(fā)明使用這些測定法。
均相(相互作用)測定法包括結(jié)合對(duì)象保留在溶液中的測定法并包括例如凝集測定法等測定法。非均相測定法包括像免疫測定法，例如酶聯(lián)免疫吸附測定法(ELISA)、放射活性免疫測定法(RIA)、免疫放射分析(IRMA)、流動(dòng)注射分析(FIA)、流式激活細(xì)胞分揀(FACS)、化學(xué)發(fā)光免疫測定法(CLIA)或電化學(xué)發(fā)光(ECL)報(bào)告(Electrogenerated chemiluminescentreporting)。
本發(fā)明還提供了鑒定和/或得到如下化合物的篩選方法，該化合物是表2到6所列多肽的抑制劑或拮抗劑，該多肽的表達(dá)在HCV感染的組織中被上調(diào)，所述篩選方法包括下面步驟a)將所述多肽與一種或多種化合物在允許所述化合物與所述多肽相互作用的條件下接觸；b)測定所述多肽的活性；c)將存在該化合物或多種化合物時(shí)所述多肽的活性與沒有該化合物或多種化合物時(shí)測定的活性相比較；和鑒定和/或得到抑制劑或拮抗劑，其中(c)中測定的降低的活性說明存在抑制劑或拮抗劑。此處所用術(shù)語“抑制劑”和“拮抗劑”可以互換使用。篩選方法可以作為體外分析或者基于宿主的分析進(jìn)行?？梢栽诒景l(fā)明的篩選方法中使用并且含有和/或表達(dá)表2到表6中所列多肽的宿主可以包括原核和真核細(xì)胞。所述細(xì)胞可以包括細(xì)菌細(xì)胞、酵母細(xì)胞以及來自如哺乳動(dòng)物的培養(yǎng)(組織)細(xì)胞系。此外，動(dòng)物也可以用作宿主，例如非人轉(zhuǎn)基因動(dòng)物。因此，所述宿主(細(xì)胞)可以用含有編碼此處公開的在HCV-感染的組織中差異表達(dá)的多肽的核酸分子的載體轉(zhuǎn)染或轉(zhuǎn)化。所以，所述宿主細(xì)胞或宿主可以用編碼所述多肽的核酸分子或含有所述核酸分子的載體進(jìn)行遺傳修飾。
本發(fā)明還提供了鑒定和/或得到如下化合物的篩選方法，該化合物是表1，3到6中所列多肽的激活劑或興奮劑，所述多肽在HCV感染的組織中表達(dá)被下調(diào)，所述篩選方法包括下面步驟a)將所述多肽與一種或多種化合物在允許所述化合物與所述多肽相互作用的條件下接觸；b)測定所述多肽的活性；c)將存在該化合物或多種化合物時(shí)所述多肽的活性與沒有該化合物或多種化合物時(shí)測定的活性相比較；和鑒定和/或得到激活劑或興奮劑，其中(c)中測定的升高的活性說明存在激活劑或興奮劑。此處所用“激活劑”和“興奮劑”可以互換使用。篩選方法可以作為體外分析或者基于宿主的分析進(jìn)行。可在本發(fā)明的篩選方法中使用并且含有和/或表達(dá)表1，3到6中所列多肽的宿主可以包括原核和真核細(xì)胞。所述細(xì)胞可以包括細(xì)菌細(xì)胞、酵母細(xì)胞以及來自如哺乳動(dòng)物的培養(yǎng)(組織)細(xì)胞系。此外，動(dòng)物也可以用作宿主，例如非人轉(zhuǎn)基因動(dòng)物。因此，所述宿主(細(xì)胞)可以用含有編碼此處公開的在HCV-感染的組織中差異表達(dá)的多肽的核酸分子的載體轉(zhuǎn)染或轉(zhuǎn)化。所以，所述宿主細(xì)胞或宿主可以用編碼所述多肽的核酸分子或含有所述核酸分子的載體進(jìn)行遺傳修飾。
術(shù)語“遺傳修飾”指宿主細(xì)胞或宿主除了含有其天然基因組外還含有編碼表2到表6中所列多肽或者至少其片段的核酸分子或載體。所述額外的遺傳物質(zhì)可以導(dǎo)入宿主(細(xì)胞)中或者導(dǎo)入其祖先/親本之一。核酸分子或者載體可以存在于遺傳修飾的宿主細(xì)胞或宿主中作為基因組外的獨(dú)立分子，優(yōu)選作為能夠復(fù)制的分子，或者其可以穩(wěn)定整合進(jìn)宿主細(xì)胞或宿主的基因組中。
如上面所提到的，本發(fā)明的宿主細(xì)胞可以是任何原核或真核細(xì)胞。合適的原核細(xì)胞是那些通常用于克隆的細(xì)胞，像大腸桿菌(E.Coli)或枯草芽孢桿菌(Bacillus subtilis)。然而，可以想到這些原核宿主細(xì)胞也可用于此處公開的篩選方法中。此外，真核細(xì)胞包括例如真菌或動(dòng)物細(xì)胞。合適的真菌細(xì)胞的實(shí)例為酵母細(xì)胞，優(yōu)選酵母屬細(xì)胞，最優(yōu)選釀酒酵母(Saccharomycescerevisiae)種的細(xì)胞。合適的動(dòng)物細(xì)胞為例如昆蟲細(xì)胞、脊椎動(dòng)物細(xì)胞，優(yōu)選哺乳動(dòng)物細(xì)胞，如CHO、HeLa、NIH3T3或MOLT-4。本領(lǐng)域公知的其他合適的細(xì)胞系可從細(xì)胞系保藏單位得到，像美國典型培養(yǎng)物保藏中心(ATCC)。
宿主也可以選自非人哺乳動(dòng)物，最優(yōu)選小鼠、大鼠、羊、牛、狗、猴或猿。如上面所描述的，所述動(dòng)物/哺乳動(dòng)物也包括非人轉(zhuǎn)基因動(dòng)物，其優(yōu)選表達(dá)至少一種如此處公開的在HCV感染的細(xì)胞或組織中差異表達(dá)的多肽。優(yōu)選地，所述多肽是在來自HCV感染的個(gè)體的組織中被上調(diào)的多肽。然而，也可設(shè)想到產(chǎn)生非人轉(zhuǎn)基因動(dòng)物，其不表達(dá)此處公開的多肽或者只表達(dá)有限量的所述多肽。所述動(dòng)物優(yōu)選與在HCV感染的組織中被下調(diào)的多肽相關(guān)。包含和/或表達(dá)本發(fā)明的上調(diào)多肽或者，備選地，包含沉默或者較低效版本的下調(diào)多肽的轉(zhuǎn)基因非人動(dòng)物是研究HCV感染的過程和/或后果的有用模型，并為檢驗(yàn)治療HCV感染的藥物和療法提供了有用模型。
抑制或拮抗或者激活或興奮表1到6中所列的多肽的化合物可以通過測定存在所述化合物時(shí)所述多肽的活性來鑒定。
此處所用術(shù)語“活性”涉及特定多肽的一種或多種功能性質(zhì)。對(duì)于表1到6中所列稱作酶的多肽，術(shù)語“活性”涉及特定多肽的酶學(xué)活性。針對(duì)表1到6中所列酶的活性分析法是本領(lǐng)域中熟知的。
對(duì)于表1到6中所列稱作粘附分子的多肽，術(shù)語“活性”涉及多肽的粘附性質(zhì)并且可以用測定法如，但不限于，粘附測定法、細(xì)胞鋪展測定法或者粘附分子與已知配體的體外相互作用測定法來確定。這些測定法是本領(lǐng)域中熟知的。
對(duì)于表1到6中所列稱作細(xì)胞骨架蛋白的多肽，術(shù)語“活性”涉及這些多肽對(duì)細(xì)胞骨架的調(diào)節(jié)，或者涉及它們向細(xì)胞骨架中的摻入。作為一個(gè)非限定性實(shí)例，凝溶膠蛋白調(diào)節(jié)肌動(dòng)蛋白的聚合的能力，或者細(xì)絲蛋白A促進(jìn)肌動(dòng)蛋白絲正交分枝的能力可以使用體外肌動(dòng)蛋白聚合測定法確定。與調(diào)節(jié)細(xì)胞骨架結(jié)構(gòu)相關(guān)的活性還可以通過，作為非限定性實(shí)例，細(xì)胞鋪展測定法、細(xì)胞遷移測定法、細(xì)胞增殖測定法或免疫熒光測定法，或者通過用熒光標(biāo)記的鬼筆環(huán)肽對(duì)肌動(dòng)蛋白絲染色來確定。所有這些測定法是本領(lǐng)域技術(shù)人員熟知的。
對(duì)于表1到表6中列出的稱作離子通道的多肽，術(shù)語“活性”涉及跨膜離子流。確定跨膜離子流的方法是本領(lǐng)域技術(shù)人員熟知的。
對(duì)于表1到表6中列出的稱作轉(zhuǎn)錄因子的多肽，術(shù)語“活性”涉及它們調(diào)節(jié)基因轉(zhuǎn)錄的能力?？梢杂帽绢I(lǐng)域公知的測定法，如報(bào)道基因測定法確定多肽的轉(zhuǎn)錄活性。
對(duì)于表1到6中所列稱作生長因子和激素或它們的受體的多肽，術(shù)語“活性”涉及它們分別與它們的受體或配體結(jié)合并且誘導(dǎo)受體活化和隨后信號(hào)級(jí)聯(lián)的能力，和/或涉及該因子或受體介導(dǎo)一種或多種細(xì)胞功能的能力，所述細(xì)胞功能最終由生長因子或激素介導(dǎo)的受體活化引起?？梢酝ㄟ^通常已知的配體結(jié)合測定法確定結(jié)合受體的生長因子或激素?？梢酝ㄟ^檢測受體的自磷酸化或者通過分析受體的下游信號(hào)介質(zhì)的修飾或募集(通過信號(hào)復(fù)合物的免疫沉淀和Western印跡)來確定受體的活化。受生長因子或激素和它們的受體調(diào)節(jié)的細(xì)胞功能可以是細(xì)胞增殖(例如通過用胸苷摻入或細(xì)胞計(jì)數(shù)確定)、細(xì)胞遷移測定法(例如通過用改良的Boyden室確定)、細(xì)胞存活或凋亡測定法(例如通過用DAPI染色確定)、血管生成測定法(例如商業(yè)途徑可得到的測量內(nèi)皮管形成的體外測定法)。除了這些測定法，也可以使用其他測定法確定這些和其他細(xì)胞功能。
表2到6中所列多肽的抑制劑或拮抗劑可以通過上述篩選方法鑒定，此時(shí)篩選方法中存在該化合物比不存在該化合物時(shí)檢測到降低的活力。
表1，3到6中所列的多肽的激活劑或興奮劑可以通過本發(fā)明中描述的篩選方法鑒定，此時(shí)篩選方法中存在該化合物比不存在該化合物時(shí)檢測到增加的活力。
除了上面公開的篩選方法，本發(fā)明還提供了鑒定和/或得到作為多肽表達(dá)抑制劑的化合物的篩選方法，其中，該多肽選自表2到6所列的多肽，其在HCV感染的組織中的表達(dá)被上調(diào)，該篩選方法包括下面步驟a)將表達(dá)所述多肽的宿主與一種或多種化合物接觸；b)測定所述多肽的表達(dá)水平；c)比較存在和不存在該化合物或多種化合物時(shí)測定到的所述多肽的表達(dá)水平；和d)鑒定和/或得到多肽表達(dá)的抑制劑，其中(c)中測定到的降低的表達(dá)水平指示所述多肽表達(dá)的抑制劑。
除了上面公開的篩選方法，本發(fā)明還提供了鑒定和/或得到作為多肽表達(dá)激活劑的化合物的篩選方法，其中該多肽選自表1，3到6所列的多肽，其在HCV感染的組織中的表達(dá)被下調(diào)，該篩選方法包括下面步驟a)將表達(dá)所述多肽的宿主與一種或多種化合物接觸；b)測定所述多肽的表達(dá)水平；c)比較存在和不存在該化合物或多種化合物時(shí)測定到的所述多肽的表達(dá)水平；和d)鑒定和/或得到多肽表達(dá)的激活劑，其中(c)中測定到的增加的表達(dá)水平指示所述多肽表達(dá)的激活劑。
表2到6中所列的多肽的表達(dá)抑制劑可以通過上述篩選方法鑒定，當(dāng)篩選方法中存在化合物比不存在該化合物時(shí)測定到蛋白表達(dá)水平降低，說明化合物為該多肽的表達(dá)抑制劑。
此處所用術(shù)語“表達(dá)”涉及測定到的表2到6中所列在HCV感染的組織或HCV感染的細(xì)胞中被上調(diào)或下調(diào)的多肽的量，與未感染組織或未感染細(xì)胞中相同多肽的量相比，該多肽量上升或降低。優(yōu)選地，表達(dá)水平比未感染組織或細(xì)胞中的水平高或低至少2倍，優(yōu)選至少3倍，更優(yōu)選至少4倍，最選至少5倍。
此外，本發(fā)明提供了用上述篩選方法中的一種鑒定和/或得到的化合物。通過用本發(fā)明篩選方法中的一種鑒定和/或得到的化合物包括小分子、多肽、激素、多核苷酸(包括反義核苷酸)和抗體。本發(fā)明還提供了含有所述化合物和藥學(xué)上可接受的載體或稀釋劑的藥物組合物。還要求了制備所述藥物組合物的方法，該方法包括將所述化合物在藥學(xué)上可接受的載體或稀釋劑中配制?？梢允褂萌魏纬Ｒ?guī)載體材料。載體材料可以是適于經(jīng)腸、經(jīng)皮或胃腸外施用的有機(jī)或無機(jī)載體。合適的載體包括水、明膠、阿拉伯膠、乳糖、淀粉、硬脂酸鎂、滑石粉、植物油、聚亞烷基二醇、凡士林等等。此外，藥物組合物可含有其他藥學(xué)活性劑。其他添加劑如調(diào)味劑、穩(wěn)定劑、乳化劑、緩沖劑等等可以根據(jù)藥物配合中接受的慣例加入。
所述化合物可以用于制備治療或預(yù)防HCV感染的藥物。優(yōu)選地，所述化合物選自抗體、抗體衍生物、抗體片段、肽或反義構(gòu)建體。
在本發(fā)明范圍內(nèi)，提供了抗表1到6所列多肽的抗體或者其抗原結(jié)合片段，用于預(yù)測個(gè)體HCV感染后果的體外方法中。
為了有效進(jìn)行預(yù)后方法，本發(fā)明提供了預(yù)測個(gè)體HCV感染后果的試劑盒，其含有一種或多種上述抗體或其抗原結(jié)合片段。本發(fā)明提供的另一種試劑盒是篩選激活或抑制表1和2中所列多肽的任一種的活性，或激活或抑制表1和2中所列多肽的任何一種的表達(dá)的化合物的試劑盒。
現(xiàn)在已經(jīng)一般性的描述了本發(fā)明，通過參照此處的特定實(shí)例可以更好理解本發(fā)明，除非另外說明，這些實(shí)施例僅僅用于舉例闡明而不是想要進(jìn)行限制。
表1


表2




表3

表4

表5

表6

實(shí)施例除非另外說明，實(shí)施例中提及的商業(yè)上可以得到的試劑根據(jù)廠家說明使用。
實(shí)施例1Huh8.1細(xì)胞系在標(biāo)準(zhǔn)條件下生長(對(duì)照)并與Huh9.13(復(fù)制子)比較。根據(jù)Lohmann，V等(Science 1999，285，110-113)制備Huh 9.13細(xì)胞系。生長實(shí)驗(yàn)重復(fù)3次，每次使用不同細(xì)胞裂解條件(Lohmann，V，等(1999)，Science285，110-113；Bartenschl_ger，R.(2002)，Nature Reviews，丙型肝炎病毒復(fù)制子藥物開發(fā)中的潛在角色，Vol.1，911-916)。
使用差速離心(800g，12000g，60000g)得到幾種標(biāo)準(zhǔn)細(xì)胞級(jí)分。此外，通過差速離心/密度梯度離心分離了富含復(fù)制子蛋白(復(fù)制子顆粒)的顆粒級(jí)分。對(duì)于所有級(jí)分，在相同條件進(jìn)行樣品/對(duì)照的2D PAGE，使用的IPG范圍為3-10和4-7/6-10，并用MALDI MS肽指紋鑒定所有易得到的蛋白點(diǎn)。
為了比較，將所有實(shí)驗(yàn)結(jié)果合并并且產(chǎn)生了蛋白鑒定數(shù)。如果在至少兩個(gè)樣品中發(fā)現(xiàn)一種蛋白并且如果該蛋白在對(duì)照(相應(yīng)復(fù)制子樣品)中完全不存在或者樣品和對(duì)照中鑒定為蛋白的質(zhì)譜計(jì)數(shù)間的商大于2(小于0.5)，那么將該蛋白指定為“上調(diào)”(“下調(diào)”)。
因HCV復(fù)制子衍生的RNA的存在被下調(diào)的多肽描述于表1，被HCV復(fù)制子衍生的RNA的存在上調(diào)的多肽描述于表2，包括多種有意義的mRNA結(jié)合蛋白和蛋白合成機(jī)器的被異常調(diào)節(jié)的組分。
序列表<110>弗·哈夫曼-拉羅切有限公司<120>HCV調(diào)節(jié)的蛋白表達(dá)<130>21762<160>199<170>PatentIn version 3.1<210>1<211>414<212>PRT<213>人(Homo sapiens)<220>
<221>MISC_FEATURE<222>(307)..(307)<223>x<300>
<308>hsugp006101-3-0<309>2003-02-16<400>1Leu Pro Leu Leu Ala Arg Pro Ala Ala Leu Thr Ala Leu Leu Leu Leu1 5 10 15Leu Leu Ala Met Ala Ala Ala Asp Gly Pro Pro Ala Ala Asp Gly Glu20 25 30Asp Gly Gln Asp Pro His Ser Lys His Leu Tyr Thr Ala Asp Met Phe35 40 45Thr His Gly Ile Gln Ser Ala Ala His Phe Val Met Phe Phe Ala Pro50 55 60Glu Met Gly Ser Cys Ser Val Thr Gln Pro Glu Thr Ser Gly Thr Gln65 70 75 80Pro Gln Leu Thr Val Ala Ser Asn Ser Trp Ala Gln Val Ile Leu Leu85 90 95Pro Gln Pro Leu Lys Tyr Cys Asp Tyr Arg Arg Arg Cys Gly His Cys100 105 110Gln Arg Leu Gln Pro Thr Trp Asn Asp Leu Gly Asp Lys Tyr Asn Ser115 120 125
Met Glu Asp Ala Lys Val Tyr Val Ala Lys Val Asp Cys Thr Ala His130 135 140Ser Asp Val Cys Ser Ala Gln Gly Val Arg Gly Tyr Pro Thr Leu Lys145 150 155 160Leu Phe Lys Pro Gly Gln Glu Ala Val Lys Tyr Gln Gly Pro Arg Asp165 170 175Phe Gln Thr Leu Glu Asn Trp Met Leu Gln Thr Leu Asn Glu Glu Pro180 185 190Val Thr Pro Glu Pro Glu Val Glu Pro Pro Ser Ala Pro Glu Leu Lys195 200 205Gln Gly Leu Tyr Glu Leu Ser Ala Ser Asn Phe Glu Leu His Val Ala210 215 220Gln Gly Asp His Phe Ile Lys Phe Phe Ala Pro Trp Cys Gly His Cys225 230 235 240Lys Ala Leu Ala Pro Thr Trp Glu Gln Leu Ala Leu Gly Leu Glu His245 250 255Ser Glu Thr Val Lys Ile Gly Lys Val Asp Cys Thr Gln His Tyr Glu260 265 270Leu Cys Ser Gly Asn Gln Val Arg Gly Tyr Pro Thr Leu Leu Trp Phe275 280 285Arg Asp Gly Lys Lys Val Asp Gln Tyr Lys Gly Lys Arg Asp Leu Glu290 295 300Ser Gln Xaa Glu Pro Glu Ala Asp Lys Gly Thr Val Leu Ala Leu Thr305 310 315 320Glu Asn Asn Phe Asp Asp Thr Ile Ala Glu Gly Ile Thr Phe Ile Lys325 330 335Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Thr Leu Ala Pro Thr Trp340 345 350Glu Glu Leu Ser Lys Lys Glu Phe Pro Gly Leu Ala Gly Val Lys Ile355 360 365Ala Glu Val Asp Cys Thr Leu Asn Gly Ile Ser Ala Ala Ser Ile Arg370 375 380
Tyr Glu Ala Thr Pro Arg Tyr Cys Phe Ser Glu Glu Gly Arg Lys Ser385 390 395 400Val Ser Thr Val Glu Ala Glu Thr Leu Thr Arg Tyr Thr Ala405 410<210>2<211>503<212>PRT<213>人<300>
<308>humangpchr11-q9ums4<309>2003-04-22<400>2Ser Leu Phe Ser Thr Val Ser Asn Glu Val Pro Glu His Pro Cys Val1 5 10 15Ser Pro Val Ser Asn His Val Tyr Glu Arg Arg Leu Ile Glu Lys Tyr20 25 30Ile Ala Glu Asn Gly Thr Asp Pro Ile Asn Asn Gln Pro Leu Ser Glu35 40 45Glu Gln Leu Ile Asp Ile Lys Val Ala His Pro Ile Arg pro Lys Pro50 55 60Pro Ser Ala Thr Ser Ile Pro Ala Ile Leu Lys Ala Leu Gln Asp Glu65 70 75 80Trp Asp Ala Val Met Leu His Ser Phe Thr Leu Arg Gln Gln Leu Gln85 90 95Thr Thr Arg Gln Glu Leu Ser His Ala Leu Tyr Gln His Asp Ala Ala100 105 110Cys Arg Val Ile Ala Arg Leu Thr Lys Glu Val Thr Ala Ala Arg Glu115 120 125Ala Leu Ala Thr Leu Lys Pro Gln Ala Gly Leu Ile Val Pro Gln Ala130 135 140Val Pro Ser Ser Gln Pro Ser Val Val Gly Ala Gly Glu Pro Met Asp145 150 155 160Leu Gly Glu Leu Val Gly Met Thr Pro Glu Ile Ile Gln Lys Leu Gln
165 170 175Asp Lys Ala Thr Val Leu Thr Thr Glu Arg Lys Lys Arg Gly Lys Thr180 185 190Val Pro Glu Glu Leu Val Lys Pro Glu Glu Leu Ser Lys Tyr Arg Gln195 200 205Val Ala Ser His Val Gly Leu His Ser Ala Ser Ile Pro Gly Ile Leu210 215 220Ala Leu Asp Leu Cys Pro Ser Asp Thr Asn Lys Ile Leu Thr Gly Gly225 230 235 240Ala Asp Lys Asn Val Val Val Phe Asp Lys Ser Ser Glu Gln Ile Leu245 250 255Ala Thr Leu Lys Gly His Thr Lys Lys Val Thr Ser Val Val Phe His260 265 270Pro Ser Gln Asp Leu Val Phe Ser Ala Ser Pro Asp Ala Thr Ile Arg275 280 285Ile Trp Ser Val Pro Asn Ala Ser Cys Val Gln Val Val Arg Ala His290 295 300Glu Ser Ala Val Thr Gly Leu Ser Leu His Ala Thr Gly Asp Tyr Leu305 310 315 320Leu Ser Ser Ser Asp Asp Gln Tyr Trp Ala Phe Ser Asp Ile Gln Thr325 330 335Gly Arg Val Leu Thr Lys Val Thr Asp Glu Thr Ser Gly Cys Ser Leu340 345 350Thr Cys Ala Gln Phe His Pro Asp Gly Leu Ile Phe Gly Thr Gly Thr355 360 365Met Asp Ser Gln Ile Lys Ile Trp Asp Leu Lys Glu Arg Thr Asn Val370 375 380Ala Asn Phe Pro Gly His Ser Gly Pro Ile Thr Ser Ile Ala Phe Ser385 390 395 400Glu Asn Gly Tyr Tyr Leu Ala Thr Ala Ala Asp Asp Ser Ser Val Lys405 410 415
Leu Trp Asp Leu Arg Lys Leu Lys Asn Phe Lys Thr Leu Gln Leu Asp420 425 430Asn Asn Phe Glu Val Lys Ser Leu Ile Phe Asp Gln Ser Gly Thr Tyr435 440 445Leu Ala Leu Gly Gly Thr Asp Val Gln Ile Tyr Ile Cys Lys Gln Trp450 455 460Thr Glu Ile Leu His Phe Thr Glu His Ser Gly Leu Thr Thr Gly Val465 470 475 480Ala Phe Gly His His Ala Lys Phe Ile Ala Ser Thr Gly Met Asp Arg485 490 495Ser Leu Lys Phe Tyr Ser Leu500<210>3<211>201<212>PRT<213>人<300>
<308>humangp/chr17-q8tcd5<309>2003-04-22<400>3Met Ala Arg Ser Val Arg Val Leu Val Asp Met Asp Gly Val Leu Ala1 5 10 15Asp Phe Glu Ala Gly Leu Leu Arg Gly Phe Arg Arg Arg Phe Pro Glu20 25 30Glu Pro His Val Pro Leu Glu Gln Arg Arg Gly Phe Leu Ala Arg Glu35 40 45Gln Tyr Arg Ala Leu Arg Pro Asp Leu Ala Asp Lys Val Ala Ser Val50 55 60Tyr Glu Ala Pro Gly Phe Phe Leu Asp Leu Glu Pro Ile Pro Gly Ala65 70 75 80Leu Asp Ala Val Arg Glu Met Asn Asp Leu Pro Asp Thr Gln Val Phe85 90 95Ile Cys Thr Ser Pro Leu Leu Lys Tyr His His Cys Val Gly Glu Lys100 105 110
Tyr Arg Trp Val Glu Gln His Leu Gly Pro Gln Phe Val Glu Arg Ile115 120 125Ile Leu Thr Arg Asp Lys Thr Val Val Leu Gly Asp Leu Leu Ile Asp130 135 140Asp Lys Asp Thr Val Arg Gly Gln Glu Glu Thr Pro Ser Trp Glu His145 150 155 160Ile Leu Phe Thr Cys Cys His Asn Arg His Leu Val Leu Pro Pro Thr165 170 175Arg Arg Arg Leu Leu Ser Trp Ser Asp Asn Trp Arg Glu Ile Leu Asp180 185 190Ser Lys Arg Gly Ala Ala Gln Arg Glu195 200<210>4<211>277<212>PRT<213>人<300>
<308>humangp/chr19-q9bvl0<309>2003-04-22<400>4Met Ala Asn Pro Lys Leu Leu Gly Met Gly Leu Ser Glu Ala Glu Ala1 5 10 15Ile Gly Ala Asp Ser Ala Arg Phe Glu Glu Leu Leu Leu Gln Ala Ser20 25 30Lys Glu Leu Gln Gln Ala Gln Thr Thr Arg Pro Glu Ser Thr Gln Ile35 40 45Gln Pro Gln Pro Gly Phe Cys Ile Lys Thr Asn Ser Ser Glu Gly Lys50 55 60Val Phe Ile Asn Ile Cys His Ser Pro Ser Ile Pro Pro Pro Ala Asp65 70 75 80Val Thr Glu Glu Glu Leu Leu Gln Met Leu Glu Glu Asp Gln Ala Gly85 90 95Phe Arg Ile Pro Met Ser Leu Gly Glu Pro His Ala Glu Leu Asp Ala
100 105 110Lys Gly Gln Gly Cys Thr Ala Tyr Asp Val Ala Val Asn Ser Asp Phe115 120 125Tyr Arg Arg Met Gln Asn Ser Asp Phe Leu Arg Glu Leu Val Ile Thr130 135 140Ile Ala Arg Glu Gly Leu Glu Asp Lys Tyr Asn Leu Gln Leu Asn Pro145 150 155 160Glu Trp Arg Met Met Lys Asn Arg Pro Phe Met Gly Ser Ile Ser Gln165 170 175Gln Asn Ile Arg Ser Glu Gln Arg Pro Arg Ile Gln Glu Leu Gly Asp180 185 190Leu Tyr Thr Pro Ala Pro Gly Arg Ala Glu Ser Gly Pro Glu Lys Pro195 200 205His Leu Asn Leu Trp Leu Glu Ala Pro Asp Leu Leu Leu Ala Glu Val210 215 220Asp Leu Pro Lys Leu Asp Gly Ala Leu Gly Leu Ser Leu Glu Ile Gly225 230 235 240Glu Asn Arg Leu Val Met Gly Gly Pro Gln Gln Leu Tyr His Leu Asp245 250 255Ala Tyr Ile Pro Leu Gln Ile Asn Ser His Glu Ser Lys Ala Ala Phe260 265 270His Arg Lys Arg Lys275<210>5<211>224<212>PRT<213>人<300>
<308>humangp/chr1cac22475<309>2003-04-22<400>5Gln Leu Gln Lys Asp Leu Glu Glu Val Lys Val Leu Leu Glu Lys Ala1 5 10 15
Thr Arg Lys Arg Val Arg Asp Ala Leu Thr Ala Glu Lys Ser Lys Ile20 25 30Glu Thr Glu Ile Lys Asn Lys Met Gln Gln Lys Ser Gln Lys Lys Ala35 40 45Glu Leu Leu Asp Asn Glu Lys Pro Ala Ala Val Val Ala Pro Ile Thr50 55 60Thr Gly Tyr Thr Val Lys Ile Ser Asn Tyr Gly Trp Asp Gln Ser Asp65 70 75 80Lys Phe Val Lys Ile Tyr Ile Thr Leu Thr Gly Val His Gln Val Pro85 90 95Thr Glu Asn Val Gln Val His Phe Thr Glu Arg Ser Phe Asp Leu Leu100 105 110Val Lys Asn Leu Asn Gly Lys Ser Tyr Ser Met Ile Val Asn Asn Leu115 120 125Leu Lys Pro Ile Ser Val Glu Gly Ser Ser Lys Lys Val Lys Thr Asp130 135 140Thr Val Leu Ile Leu Cys Arg Lys Lys Val Glu Asn Thr Arg Trp Asp145 150 155 160Tyr Leu Thr Gln Val Glu Lys Glu Cys Lys Glu Lys Glu Lys Pro Ser165 170 175Tyr Asp Thr Glu Thr Asp Pro Ser Glu Gly Leu Met Asn Val Leu Lys180 185 190Lys Ile Tyr Glu Asp Gly Asp Asp Asp Met Lys Arg Thr Ile Asn Lys195 200 205Ala Trp Val Glu Ser Arg Glu Lys Gln Ala Lys Gly Asp Thr Glu Phe210 215 220<210>6<211>198<212>PRT<213>人<300>
<308>humangp/chr1q9hb71<309>2003-04-22<400>6
Gln Leu Gln Lys Asp Leu Glu Glu Val Lys Val Leu Leu Glu Lys Ala1 5 10 15Thr Arg Lys Arg Val Arg Asp Ala Leu Thr Ala Glu Lys Ser Lys Ile20 25 30Glu Thr Glu Ile Lys Asn Lys Met Gln Gln Lys Ser Gln Lys Lys Ala35 40 45Glu Leu Leu Asp Asn Glu Lys Pro Ala Ala Val Val Ala Pro Ile Thr50 55 60Thr Gly Tyr Thr Val Lys Ile Ser Asn Tyr Gly Trp Asp Gln Ser Asp65 70 75 80Lys Phe Val Lys Ile Tyr Ile Thr Leu Thr Gly Val His Gln Val Pro85 90 95Thr Glu Asn Val Gln Val His Phe Thr Glu Arg Ser Phe Asp Leu Leu100 105 110Val Lys Asn Leu Asn Gly Lys Ser Tyr Ser Met Ile Val Asn Asn Leu115 120 125Leu Lys Pro Ile Ser Val Glu Gly Ser Ser Lys Lys Val Lys Thr Asp130 135 140Thr Val Leu Ile Leu Cys Arg Lys Lys Val Glu Asn Thr Arg Trp Asp145 150 155 160Tyr Leu Thr Gln Val Glu Lys Glu Cys Lys Glu Lys Glu Lys Pro Ser165 170 175Tyr Asp Thr Glu Thr Asp Pro Ser Glu Gly Leu Met Asn Val Leu Lys180 185 190Lys Ile Tyr Glu Asp Gly195<210>7<211>244<212>PRT<213>人<300>
<308>humangp/chr4-q96s43<309>2003-04-22
<400>7Met Glu Asp Met Asn Glu Tyr Ser Asn Ile Glu Glu Phe Ala Glu Gly1 5 10 15Ser Lys Ile Asn Ala Ser Lys Asn Gln Gln Asp Asp Gly Lys Met Phe20 25 30Ile Gly Gly Leu Ser Trp Asp Thr Ser Lys Lys Asp Leu Thr Glu Tyr35 40 45Leu Ser Arg Phe Gly Glu Val Val Asp Cys Thr Ile Lys Thr Asp Pro50 55 60Val Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu Phe Lys Asp Ala65 70 75 80Ala Ser Val Asp Lys Val Leu Glu Leu Lys Glu His Lys Leu Asp Gly85 90 95Lys Leu Ile Asp Pro Lys Arg Ala Lys Ala Leu Lys Gly Lys Glu Pro100 105 110Pro Lys Lys Val Phe Val Gly Gly Leu Ser Pro Asp Thr Ser Glu Glu115 120 125Gln Ile Lys Glu Tyr Phe Gly Ala Phe Gly Glu Ile Glu Asn Ile Glu130 135 140Leu Pro Met Asp Thr Lys Thr Asn Glu Arg Arg Gly Phe Cys Phe Ile145 150 155 160Thr Tyr Thr Asp Glu Glu Pro Val Lys Lys Leu Leu Glu Ser Arg Tyr165 170 175His Gln Ile Gly Ser Gly Lys Cys Glu Ile Lys Val Ala Gln Pro Lys180 185 190Glu Val Tyr Arg Gln Gln Gln Gln Gln Gln Lys Gly Gly Arg Gly Ala195 200 205Ala Ala Gly Gly Arg Gly Gly Thr Arg Gly Arg Gly Arg Gly Gln Gln210 215 220Ser Thr Tyr Gly Lys Ala Ser Arg Gly Gly Gly Asn His Gln Asn Asn225 230 235 240
Tyr Gln Pro Tyr<210>8<211>301<212>PRT<213>人<300>
<308>humangp/chr4-q9z130<309>2003-04-22<400>8Met Glu Asp Met Asn Glu Tyr Ser Asn Ile Glu Glu Phe Ala Glu Gly1 5 10 15Ser Lys Ile Asn Ala Ser Lys Asn Gln Gln Asp Asp Gly Lys Met Phe20 25 30Ile Gly Gly Leu Ser Trp Asp Thr Ser Lys Lys Asp Leu Thr Glu Tyr35 40 45Leu Ser Arg Phe Gly Glu Val Val Asp Cys Thr Ile Lys Thr Asp Pro50 55 60Val Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu Phe Lys Asp Ala65 70 75 80Ala Ser Val Asp Lys Val Leu Glu Leu Lys Glu His Lys Leu Asp Gly85 90 95Lys Leu Ile Asp Pro Lys Arg Ala Lys Ala Leu Lys Gly Lys Glu Pro100 105 110Pro Lys Lys Val Phe Val Gly Gly Leu Ser Pro Asp Thr Ser Glu Glu115 120 125Gln Ile Lys Glu Tyr Phe Gly Ala Phe Gly Glu Ile Glu Asn Ile Glu130 135 140Leu Pro Met Asp Thr Lys Thr Asn Glu Arg Arg Gly Phe Cys Phe Ile145 150 155 160Thr Tyr Thr Asp Glu Glu Pro Val Lys Lys Leu Leu Glu Ser Arg Tyr165 170 175His Gln Ile Gly Ser Gly Lys Cys Glu Ile Lys Val Ala Gln Pro Lys180 185 190
Glu Val Tyr Arg Gln Gln Gln Gln Gln Gln Lys Gly Gly Arg Gly Ala195 200 205Ala Ala Gly Gly Arg Gly Gly Thr Arg Gly Arg Gly Arg Gly Gln Gly210 215 220Gln Asn Trp Asn Gln Gly Phe Asn Asn Tyr Tyr Asp Gln Gly Tyr Gly225 230 235 240Asn Tyr Asn Ser Ala Tyr Gly Gly Asp Gln Asn Tyr Ser Gly Tyr Gly245 250 255Gly Tyr Asp Tyr Thr Gly Tyr Asn Tyr Gly Asn Tyr Gly Tyr Gly Gln260 265 270Gly Tyr Ala Asp Tyr Ser Gly Gln Gln Ser Thr Tyr Gly Lys Ala Ser275 280 285Arg Gly Gly Gly Asn His Gln Asn Asn Tyr Gln Pro Tyr290 295 300<210>9<211>884<212>PRT<213>人<300>
<308>chr7-q13122<309>2003-04-22<400>9Val Leu Ser Gly Cys Ala Ile Ile Val Arg Gly Gln Pro Arg Gly Gly1 5 10 15Pro Pro Pro Glu Arg Gln Ile Asn Leu Ser Asn Ile Arg Ala Gly Asn20 25 30Leu Ala Arg Arg Ala Ala Ala Thr Gln Pro Asp Ala Lys Asp Thr Pro35 40 45Asp Glu Pro Trp Ala Phe Pro Ala Arg Glu Phe Leu Ar9 Lys Lys Leu50 55 60Ile Gly Lys Glu Val Cys Phe Thr Ile Glu Asn Lys Thr Pro Gln Gly65 70 75 80Arg Glu Tyr Gly Met Ile Tyr Leu Gly Lys Asp Thr Asn Gly Glu Asn85 90 95
Ile Ala Glu Ser Leu Val Ala Glu Gly Leu Ala Thr Arg Arg Glu Gly100 105 110Met Arg Ala Asn Asn Pro Glu Gln Asn Arg Leu Ser Glu Cys Glu Glu115 120 125Gln Ala Lys Ala Ala Lys Lys Gly Met Trp Ser Glu Gly Asn Gly Ser130 135 140His Thr Ile Arg Asp Leu Lys Tyr Thr Ile Glu Asn Pro Arg His Phe145 150 155 160Val Asp Ser His His Gln Lys Pro Val Asn Ala Ile Ile Glu His Val165 170 175Arg Asp Gly Ser Val Val Arg Ala Leu Leu Leu Pro Asp Tyr Tyr Leu180 185 190Val Thr Val Met Leu Ser Gly Ile Lys Cys Pro Thr Phe Arg Arg Glu195 200 205Ala Asp Gly Ser Glu Thr Pro Glu Pro Phe Ala Ala Glu Ala Lys Phe210 215 220Phe Thr Glu Ser Arg Leu Leu Gln Arg Asp Val Gln Ile Ile Leu Glu225 230 235 240Ser Cys His Asn Gln Asn Ile Leu Gly Thr Ile Leu His Pro Asn Gly245 250 255Asn Ile Thr Glu Leu Leu Leu Lys Glu Gly Phe Ala Arg Cys Val Asp260 265 270Trp Ser Ile Ala Val Tyr Thr Arg Gly Ala Glu Lys Leu Arg Ala Ala275 280 285Glu Arg Phe Ala Lys Glu Arg Arg Leu Arg Ile Trp Arg Asp Tyr Val290 295 300Ala Pro Thr Ala Asn Leu Asp Gln Lys Asp Lys Gln Phe Val Ala Lys305 310 315 320Val Met Gln Val Leu Asn Ala Asp Ala Ile Val Val Lys Leu Asn Ser325 330 335
Gly Asp Tyr Lys Thr Ile His Leu Ser Ser Ile Arg Pro Pro Arg Leu340 345 350Glu Gly Glu Asn Thr Gln Asp Lys Asn Lys Lys Leu Arg Pro Leu Tyr355 360 365Asp Ile Pro Tyr Met Phe Glu Ala Arg Glu Phe Leu Arg Lys Lys Leu370 375 380Ile Gly Lys Lys Val Asn Val Thr Val Asp Tyr Ile Arg Pro Ala Ser385 390 395 400Pro Ala Thr Glu Thr Val Pro Ala Phe Ser Glu Arg Thr Cys Ala Thr405 410 415Val Thr Ile Gly Gly Ile Asn Ile Ala Glu Ala Leu Val Ser Lys Gly420 425 430Leu Ala Thr Val Ile Arg Tyr Arg Gln Asp Asp Asp Gln Arg Ser Ser435 440 445His Tyr Asp Glu Leu Leu Ala Ala Glu Ala Arg Ala Ile Lys Asn Gly450 455 460Lys Gly Leu His Ser Lys Lys Glu Val Pro Ile His Arg Val Ala Asp465 470 475 480Ile Ser Gly Asp Thr Gln Lys Ala Lys Gln Phe Leu Pro Phe Leu Gln485 490 495Arg Ala Gly Arg Ser Glu Ala Val Val Glu Tyr Val Phe Ser Gly Ser500 505 510Arg Leu Lys Leu Tyr Leu Pro Lys Glu Thr Cys Leu Ile Thr Phe Leu515 520 525Leu Ala Gly Ile Glu Cys Pro Arg Gly Ala Arg Asn Leu Pro Gly Leu530 535 540Val Gln Glu Gly Glu Pro Phe Ser Glu Glu Ala Thr Leu Phe Thr Lys545 550 555 560Glu Leu Val Leu Gln Arg Glu Val Glu Val Glu Val Glu Ser Met Asp565 570 575Lys Ala Gly Asn Phe Ile Gly Trp Leu His Ile Asp Gly Ala Asn Leu580 585 590
Ser Val Leu Leu Val Glu His Ala Leu Ser Lys Val His Phe Thr Ala595 600 605Glu Arg Ser Ser Tyr Tyr Lys Ser Leu Leu Ser Ala Glu Glu Ala Ala610 615 620Lys Gln Lys Lys Glu Lys Val Trp Ala His Tyr Glu Glu Gln Pro Val625 630 635 640Glu Glu Val Met Pro Val Leu Glu Glu Lys Glu Arg Ser Ala Ser Tyr645 650 655Lys Pro Val Phe Val Thr Glu Ile Thr Asp Asp Leu His Phe Tyr Val660 665 670Gln Asp Val Glu Thr Gly Thr Gln Leu Glu Lys Leu Met Glu Asn Met675 680 685Arg Asn Asp Ile Ala Ser His Pro Pro Val Glu Gly Ser Tyr Ala Pro690 695 700Arg Arg Gly Glu Phe Cys Ile Ala Lys Phe Val Asp Gly Glu Trp Tyr705 710 715 720Arg Ala Arg Val Glu Lys Val Glu Ser Pro Ala Lys Ile His Val Phe725 730 735Tyr Ile Asp Tyr Gly Asn Arg Glu Val Leu Pro Ser Thr Arg Leu Gly740 745 750Thr Leu Ser Pro Ala Phe Ser Thr Arg Val Leu Pro Ala Gln Ala Thr755 760 765Glu Tyr Ala Phe Ala Phe Ile Gln Val Pro Gln Asp Asp Asp Ala Arg770 775 780Thr Asp Ala Val Asp Ser Val Val Arg Asp Ile Gln Asn Thr Gln Cys785 790 795 800Leu Leu Asn Val Glu His Leu Ser Ala Gly Cys Pro His Val Thr Leu805 810 815Gln Phe Ala Asp Ser Lys Gly Asp Val Gly Leu Gly Leu Val Lys Glu820 825 830
Gly Leu Val Met Val Glu Val Arg Lys Glu Lys Gln Phe Gln Lys Val835 840 845Ile Thr Glu Tyr Leu Asn Ala Gln Glu Ser Ala Lys Ser Ala Arg Leu850 855 860Asn Leu Trp Arg Tyr Gly Asp Phe Arg Ala Asp Asp Ala Asp Glu Phe865 870 875 880Gly Tyr Ser Arg<210>10<211>355<212>PRT<213>人<300>
<308>humangp/chr9-060376<309>2003-04-22<400>10Leu Gln Gly Ser Leu Leu Ala Ser Gly Arg Ala Pro Arg Arg Ala Ser1 5 10 15Ser Gly Leu Pro Arg Asn Thr Val Val Leu Phe Val Pro Gln Gln Glu20 25 30Ala Trp Val Val Glu Arg Met Gly Arg Phe His Arg Ile Leu Glu Pro35 40 45Gly Leu Asn Ile Leu Ile Pro Val Leu Asp Arg Ile Arg Tyr Val Gln50 55 60Ser Leu Lys Glu Ile Val Ile Asn Val Pro Glu Gln Ser Ala Val Thr65 70 75 80Leu Asp Asn Val Thr Leu Gln Ile Asp Gly Val Leu Tyr Leu Arg Ile85 90 95Met Asp Pro Tyr Lys Ala Ser Tyr Gly Val Glu Asp Pro Glu Tyr Ala100 105 110Val Thr Gln Leu Ala Gln Thr Thr Met Arg Ser Glu Leu Gly Lys Leu115 120 125Ser Leu Asp Lys Val Phe Arg Glu Arg Glu Ser Leu Asn Ala Ser Ile130 135 140
Val Asp Ala Ile Asn Gln Ala Ala Asp Cys Trp Gly Ile Arg Cys Leu145 150 155 160Arg Tyr Glu Ile Lys Asp Ile His Val Pro Pro Arg Val Lys Glu Ser165 170 175Met Gln Met Gln Val Gly Ala Lys Glu Gly Trp Glu Lys Gly Leu Arg180 185 190Val Glu Ala Glu Arg Arg Lys Arg Ala Thr Val Leu Glu Ser Glu Gly195 200 205Thr Arg Glu Ser Ala Ile Asn Val Ala Glu Gly Lys Lys Gln Ala Gln210 215 220Ile Leu Ala Ser Glu Ala Glu Lys Ala Glu Gln Ile Asn Gln Ala Ala225 230 235 240Gly Glu Ala Ser Ala Val Leu Ala Lys Ala Lys Ala Lys Ala Glu Ala245 250 255Ile Arg Ile Leu Ala Ala Ala Leu Thr Gln His Asn Gly Asp Ala Ala260 265 270Ala Ser Leu Thr Val Ala Glu Gln Tyr Val Ser Ala Phe Ser Lys Leu275 280 285Ala Lys Asp Ser Asn Thr Ile Leu Leu Pro Ser Asn Pro Gly Asp Val290 295 300Thr Ser Met Val Ala Gln Ala Met Gly Val Tyr Gly Ala Leu Thr Lys305 310 315 320Ala Pro Val Pro Gly Thr Pro Asp Ser Leu Ser Ser Gly Ser Ser Arg325 330 335Asp Val Gln Gly Thr Asp Ala Ser Leu Asp Glu Glu Leu Asp Arg Val340 345 350Lys Met Ser355<210>11<211>406<212>PRT<213>人
<300>
<308>humangp/chr9-q9bs26<309>2003-04-22<400>11Met His Pro Ala Val Phe Leu Ser Leu Pro Asp Leu Arg Cys Ser Leu1 5 10 15Leu Leu Leu Val Thr Trp Val Phe Thr Pro Val Thr Thr Glu Ile Thr20 25 30Ser Leu Asp Thr Glu Asn Ile Asp Glu Ile Leu Asn Asn Ala Asp Val35 40 45Ala Leu Val Asn Phe Tyr Ala Asp Trp Cys Arg Phe Ser Gln Met Leu50 55 60His Pro Ile Phe Glu Glu Ala Ser Asp Val Ile Lys Glu Glu Phe Pro65 70 75 80Asn Glu Asn Gln Val Val Phe Ala Arg Val Asp Cys Asp Gln His Ser85 90 95Asp Ile Ala Gln Arg Tyr Arg Ile Ser Lys Tyr Pro Thr Leu Lys Leu100 105 110Phe Arg Asn Gly Met Met Met Lys Arg Glu Tyr Arg Gly Gln Arg Ser115 120 125Val Lys Ala Leu Ala Asp Tyr Ile Arg Gln Gln Lys Ser Asp Pro Ile130 135 140Gln Glu Ile Arg Asp Leu Ala Glu Ile Thr Thr Leu Asp Arg Ser Lys145 150 155 160Arg Asn Ile Ile Gly Tyr Phe Glu Gln Lys Asp Ser Asp Asn Tyr Arg165 170 175Val Phe Glu Arg Val Ala Asn Ile Leu His Asp Asp Cys Ala Phe Leu180 185 190Ser Ala Phe Gly Asp Val Ser Lys Pro Glu Arg Tyr Ser Gly Asp Asn195 200 205Ile Ile Tyr Lys Pro Pro Gly His Ser Ala Pro Asp Met Val Tyr Leu210 215 220
Gly Ala Met Thr Asn Phe Asp Val Thr Tyr Asn Trp Ile Gln Asp Lys225 230 235 240Cys Val Pro Leu Val Arg Glu Ile Thr Phe Glu Asn Gly Glu Glu Leu245 250 255Thr Glu Glu Gly Leu Pro Phe Leu Ile Leu Phe His Met Lys Glu Asp260 265 270Thr Glu Ser Leu Glu Ile Phe Gln Asn Glu Val Ala Arg Gln Leu Ile275 280 285Ser Glu Lys Gly Thr Ile Asn Phe Leu His Ala Asp Cys Asp Lys Phe290 295 300Arg His Pro Leu Leu His Ile Gln Lys Thr Pro Ala Asp Cys Pro Val305 310 315 320Ile Ala Ile Asp Ser Phe Arg His Met Tyr Val Phe Gly Asp Phe Lys325 330 335Asp Val Leu Ile Pro Gly Lys Leu Lys Gln Phe Val Phe Asp Leu His340 345 350Ser Gly Lys Leu His Arg Glu Phe His His Gly Pro Asp Pro Thr Asp355 360 365Thr Ala Pro Gly Glu Gln Ala Gln Asp Val Ala Ser Ser Pro Pro Glu370 375 380Ser Ser Phe Gln Lys Leu Ala Pro Ser Glu Tyr Arg Tyr Thr Leu Leu385 390 395 400Arg Asp Arg Asp Glu Leu405<210>12<211>323<212>PRT<213>人<300>
<308>sw_hum/akc1_human<309>1993-10-01<400>12Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met1 5 10 15
Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Ala Glu Val Pro Lys Ser20 25 30Lys Ala Leu Glu Ala Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His35 40 45Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala50 55 60Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe65 70 75 80Tyr Thr Ser Lys Leu Trp Cys Asn Ser His Arg Pro Glu Leu Val Arg85 90 95Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp100 105 110Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu Glu Val115 120 125Ile Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Thr Val Asp Leu130 135 140Cys Ala Thr Trp Glu Ala Val Glu Lys Cys Lys Asp Ala Gly Leu Ala145 150 155 160Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile165 170 175Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu180 185 190Cys His Pro Tyr Phe Asn Gln Arg Lys Leu Leu Asp Phe Cys Lys Ser195 200 205Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser His Arg Glu210 215 220Glu Pro Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val225 230 235 240Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala245 250 255Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr
260 265 270Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu275 280 285Thr Ser Glu Glu Met Lys Ala Ile Asp Gly Leu Asn Arg Asn Val Arg290 295 300Tyr Leu Thr Leu Asp Ile Phe Ala Gly Pro Pro Asn Tyr Pro Phe Ser305 310 315 320Asp Glu Tyr<210>13<211>323<212>PRT<213>人<300>
<308>sw_hum/ack2_human<309>1996-10-01<400>13Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met1 5 10 15Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Ala Glu Val Pro Lys Ser20 25 30Lys Ala Leu Glu Ala Val Lys Leu Ala Ile Glu Ala Gly Phe His His35 40 45Ile Asp Ser Ala His Val Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala50 55 60Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe65 70 75 80Tyr Thr Ser Lys Leu Trp Ser Asn Ser His Arg Pro Glu Leu Val Arg85 90 95Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp100 105 110Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu Glu Val115 120 125
Ile Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Thr Val Asp Leu130 135 140Cys Ala Thr Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala145 150 155 160Lys Ser Ile Gly Val Ser Asn Phe Asn His Arg Leu Leu Glu Met Ile165 170 175Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu180 185 190Cys His Pro Tyr Phe Asn Gln Arg Lys Leu Leu Asp Phe Cys Lys Ser195 200 205Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser His Arg Glu210 215 220Glu Pro Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val225 230 235 240Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala245 250 255Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr260 265 270Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu275 280 285Thr Ser Glu Glu Met Lys Ala Ile Asp Gly Leu Asn Arg Asn Val Arg290 295 300Tyr Leu Thr Leu Asp Ile Phe Ala Gly Pro Pro Asn Tyr Pro Phe Ser305 310 315 320Asp Glu Tyr<210>14<211>363<212>PRT<213>人<300>
<308>sw_hum/alfc_human<309>1989-03-01<400>14
Pro His Ser Tyr Pro Ala Leu Ser Ala Glu Gln Lys Lys Glu Leu Ser1 5 10 15Asp Ile Ala Leu Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala Ala20 25 30Asp Glu Ser Val Gly Ser Met Ala Lys Arg Leu Ser Gln Ile Gly Val35 40 45Glu Asn Thr Glu Glu Asn Arg Arg Leu Tyr Arg Gln Val Leu Phe Ser50 55 60Ala Asp Asp Arg Val Lys Lys Cys Ile Gly Gly Val Ile Phe Phe His65 70 75 80Glu Thr Leu Tyr Gln Lys Asp Asp Asn Gly Val Pro Phe Val Arg Thr85 90 95Ile Gln Asp Lys Gly Ile Val Val Gly Ile Lys Val Asp Lys Gly Val100 105 110Val Pro Leu Ala Gly Thr Asp Gly Glu Thr Thr Thr Gln Gly Leu Asp115 120 125Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp Phe130 135 140Ala Lys Trp Arg Cys Val Leu Lys Ile Ser Glu Arg Thr Pro Ser Ala145 150 155 160Leu Ala Ile Leu Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser Ile165 170 175Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu Pro180 185 190Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys Val195 200 205Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Val Tyr Leu Glu210 215 220Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys Pro225 230 235 240Ile Lys Tyr Thr Pro Glu Glu Ile Ala Met Ala Thr Val Thr Ala Leu
245 250 255Arg Arg Thr Val Pro Pro Ala Val Pro Gly Val Thr Phe Leu Ser Gly260 265 270Gly Gln Ser Glu Glu Glu Ala Ser Phe Asn Leu Asn Ala Ile Asn Arg275 280 285Cys Pro Leu Pro Arg Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg Ala290 295 300Leu Gln Ala Ser Ala Leu Asn Ala Trp Arg Gly Gln Arg Asp Asn Ala305 3l0 315 320Gly Ala Ala Thr Glu Glu Phe Ile Lys Arg Ala Glu Val Asn Gly Leu325 330 335Ala Ala Gln Gly Lys Tyr Glu Gly Ser Gly Glu Asp Gly Gly Ala Ala340 345 350Ala Gln Ser Leu Tyr Ile Ala Asn His Ala Tyr355 360<210>15<211>179<212>PRT<213>人<300>
<308>sw_hum/apt_human<309>1988-08-01<400>15Ala Asp Ser Glu Leu Gln Leu Val Glu Gln Arg Ile Arg Ser Phe Pro1 5 10 15Asp Phe Pro Thr Pro Gly Val Val Phe Arg Asp Ile Ser Pro Val Leu20 25 30Lys Asp Pro Ala Ser Phe Arg Ala Ala Ile Gly Leu Leu Ala Arg His35 40 45Leu Lys Ala Thr His Gly Gly Arg Ile Asp Tyr Ile Ala Gly Leu Asp50 55 60Ser Arg Gly Phe Leu Phe Gly Pro Ser Leu Ala Gln Glu Leu Gly Leu65 70 75 80
Gly Cys Val Leu Ile Arg Lys Arg Gly Lys Leu Pro Gly Pro Thr Leu85 90 95Trp Ala Ser Tyr Ser Leu Glu Tyr Gly Lys Ala Glu Leu Glu Ile Gln100 105 110Lys Asp Ala Leu Glu Pro Gly Gln Arg Val Val Val Val Asp Asp Leu115 120 125Leu Ala Thr Gly Gly Thr Met Asn Ala Ala Cys Glu Leu Leu Gly Arg130 135 140Leu Gln Ala Glu Val Leu Glu Cys Val Ser Leu Val Glu Leu Thr Ser145 150 155 160Leu Lys Gly Arg Glu Lys Leu Ala Pro Val Pro Phe Phe Ser Leu Leu165 170 175Gln Tyr Glu<210>16<211>322<212>PRT<213>人<300>
<308>sw_hum/argi_human<309>1987-08-13<400>16Met Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser1 5 10 15Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg20 25 30Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys35 40 45Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe50 55 60Gln Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu65 70 75 80Ala Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val85 90 95
Leu Gly Gly Asp His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala100 105 110Arg Val His Pro Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp115 120 125Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro130 135 140Val Ser Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro145 150 155 160Gly Phe Ser Trp Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr165 170 175Ile Gly Leu Arg Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr180 185 190Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile195 200 205Gly Lys Val Met Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys210 215 220Arg Pro Ile His Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe225 230 235 240Thr Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu245 250 255Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly260 265 270Leu Asp Ile Met Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu275 280 285Val Thr Arg Thr Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe290 295 300Gly Leu Ala Arg Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro305 310 315 320Pro Lys<210>17
<211>429<212>PRT<213>人<300>
<308>sw_hum/b53a_human<309>2003-02-28<400>17Met Ser Gly Gly Val Tyr Gly Gly Asp Glu Val Gly Ala Leu Val Phe1 5 10 15Asp Ile Gly Ser Tyr Thr Val Arg Ala Gly Tyr Ala Gly Glu Asp Cys20 25 30Pro Lys Val Asp Phe Pro Thr Ala Ile Gly Met Val Val Glu Arg Asp35 40 45Asp Gly Ser Thr Leu Met Glu Ile Asp Gly Asp Lys Gly Lys Gln Gly50 55 60Gly Pro Thr Tyr Tyr Ile Asp Thr Asn Ala Leu Arg Val Pro Arg Glu65 70 75 80Asn Met Glu Ala Ile Ser Pro Leu Lys Asn Gly Met Val Glu Asp Trp85 90 95Asp Ser Phe Gln Ala Ile Leu Asp His Thr Tyr Lys Met His Val Lys100 105 110Ser Glu Ala Ser Leu His Pro Val Leu Met Ser Glu Ala Pro Trp Asn115 120 125Thr Arg Ala Lys Arg Glu Lys Leu Thr Glu Leu Met Phe Glu His Tyr130 135 140Asn Ile Pro Ala Phe Phe Leu Cys Lys Thr Ala Val Leu Thr Ala Phe145 150 155 160Ala Asn Gly Arg Ser Thr Gly Leu Ile Leu Asp Ser Gly Ala Thr His165 170 175Thr Thr Ala Ile Pro Val His Asp Gly Tyr Val Leu Gln Gln Gly Ile180 185 190Val Lys Ser Pro Leu Ala Gly Asp Phe Ile Thr Met Gln Cys Arg Glu195 200 205
Leu Phe Gln Glu Met Asn Ile Glu Leu Val Pro Pro Tyr Met Ile Ala210 215 220Ser Lys Glu Ala Val Arg Glu Gly Ser Pro Ala Asn Trp Lys Arg Lys225 230 235 240Glu Lys Leu Pro Gln Val Thr Arg Ser Trp His Asn Tyr Met Cys Asn245 250 255Cys Val Ile Gln Asp Phe Gln Ala Ser Val Leu Gln Val Ser Asp Ser260 265 270Thr Tyr Asp Glu Gln Val Ala Ala Gln Met Pro Thr Val His Tyr Glu275 280 285Phe Pro Asn Gly Tyr Asn Cys Asp Phe Gly Ala Glu Arg Leu Lys Ile290 295 300Pro Glu Gly Leu Phe Asp Pro Ser Asn Val Lys Gly Leu Ser Gly Asn305 310 315 320Thr Met Leu Gly Val Ser His Val Val Thr Thr Ser Val Gly Met Cys325 330 335Asp Ile Asp Ile Arg Pro Gly Leu Tyr Gly Ser Val Ile Val Ala Gly340 345 350Gly Asn Thr Leu Ile Gln Ser Phe Thr Asp Arg Leu Asn Arg Glu Leu355 360 365Ser Gln Lys Thr Pro Pro Ser Met Arg Leu Lys Leu Ile Ala Asn Asn370 375 380Thr Thr Val Glu Arg Arg Phe Ser Ser Trp Ile Gly Gly Ser Ile Leu385 390 395 400Ala Ser Leu Gly Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr405 410 415Glu Glu Gly Gly Lys Gln Cys Val Glu Arg Lys Cys Pro420 425<210>18<21l>339<212>PRT<213>人<300>
<308>sw_human/catb_human<309>1988-08-01<400>18Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu A1a Asn1 5 10 15Ala Arg Ser Arg Pro Ser Phe His Pro Val Ser Asp Glu Leu Val Asn20 25 30Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr35 40 45Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly50 55 60Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu65 70 75 80Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile85 90 95Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly100 105 110Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His115 120 125Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser130 135 140Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn145 150 155 160Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His165 170 175Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn180 185 190Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser195 200 205Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His210 215 220Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met
225 230 235 240Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr245 250 255Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly260 265 270Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu275 280 285Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp290 295 300Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly305 310 315 320Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp325 330 335Glu Lys Ile<210>19<211>338<212>PRT<213>人<300>
<308>sw_hum/cn03_human<309>2001-10-16<400>19Met Ala Lys Trp Gly Glu Gly Asp Pro Arg Trp Ile Val Glu Glu Arg1 5 10 15Ala Asp Ala Thr Asn Val Asn Asn Trp His Trp Thr Glu Arg Asp Ala20 25 30Ser Asn Trp Ser Thr Asp Lys Leu Lys Thr Leu Phe Leu Ala Val Gln35 40 45Val Gln Asn Glu Glu Gly Lys Cys Glu Val Thr Glu Val Ser Lys Leu50 55 60Asp Gly Glu Ala Ser Ile Asn Asn Arg Lys Gly Lys Leu Ile Phe Phe65 70 75 80
Tyr Glu Trp Ser Val Lys Leu Asn Trp Thr Gly Thr Ser Lys Ser Gly85 90 95Val Gln Tyr Lys Gly His Val Glu Ile Pro Asn Leu Ser Asp Glu Asn100 105 110Ser Val Asp Glu Val Glu Ile Ser Val Ser Leu Ala Lys Asp Glu Pro115 120 125Asp Thr Asn Leu Val Ala Leu Met Lys Glu Glu Gly Val Lys Leu Leu130 135 140Arg Glu Ala Met Gly Ile Tyr Ile Ser Thr Leu Lys Thr Glu Phe Thr145 150 155 160Gln Gly Met Ile Leu Pro Thr Met Asn Gly Glu Ser Val Asp Pro Val165 170 175Gly Gln Pro Ala Leu Lys Thr Glu Glu Arg Lys Ala Lys Pro Ala Pro180 185 190Ser Lys Thr Gln Ala Arg Pro Val Gly Val Lys Ile Pro Thr Cys Lys195 200 205Ile Thr Leu Lys Glu Thr Phe Leu Thr Ser Pro Glu Glu Leu Tyr Arg210 215 220Val Phe Thr Thr Gln Glu Leu Val Gln Ala Phe Thr His Ala Pro Ala225 230 235 240Thr Leu Glu Ala Asp Arg Gly Gly Lys Phe His Met Val Asp Gly Asn245 250 255Val Ser Gly Glu Phe Thr Asp Leu Val Pro Glu Lys His Ile Val Met260 265 270Lys Trp Arg Phe Lys Ser Trp Pro Glu Gly His Phe Ala Thr Ile Thr275 280 285Leu Thr Phe Ile Asp Lys Asn Gly Glu Thr Glu Leu Cys Met Glu Gly290 295 300Arg Gly Ile Pro Ala Pro Glu Glu Glu Arg Thr Arg Gln Gly Trp Gln305 310 315 320Arg Tyr Tyr Phe Glu Gly Ile Lys Gln Thr Phe Gly Tyr Gly Ala Arg325 330 335
Leu Phe<210>20<211>166<212>PRT<213>人<300>
<308>sw_hum/cof1_human<309>1991-11-01<400>20Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn1 5 10 15Asp Met Lys Val Arg Lys Ser Ser Thr Pro Glu Glu Val Lys Lys Arg20 25 30Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile35 40 45Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Thr Val50 55 60Asp Asp Pro Tyr Ala Thr Phe Val Lys Met Leu Pro Asp Lys Asp Cys65 70 75 80Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys85 90 95Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys100 105 110Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu115 120 125Thr Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys130 135 140Asp Arg Cys Thr Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser145 150 155 160Leu Glu Gly Lys Pro Leu165<210>21
<211>307<212>PRT<213>人<300>
<308>sw_hum/Cope_human<309>2000-05-30<400>21Ala Pro Pro Ala Pro Gly Pro Ala Ser Gly Gly Ser Gly Glu Val Asp1 5 10 15Glu Leu Phe Asp Val Lys Asn Ala Phe Tyr Ile Gly Ser Tyr Gln Gln20 25 30Cys Ile Asn Glu Ala Gln Arg Val Lys Leu Ser Ser Pro Glu Arg Asp35 40 45Val Glu Arg Asp Val Phe Leu Tyr Arg Ala Tyr Leu Ala Gln Arg Lys50 55 60Phe Gly Val Val Leu Asp Glu Ile Lys Pro Ser Ser Ala Pro Glu Leu65 70 75 80Gln Ala Val Arg Met Phe Ala Asp Tyr Leu Ala His Glu Ser Arg Arg85 90 95Asp Ser Ile Val Ala Glu Leu Asp Arg Glu Met Ser Arg Ser Val Asp100 105 110Val Thr Asn Thr Thr Phe Leu Leu Met Ala Ala Ser Ile Tyr Leu His115 120 125Asp Gln Asn Pro Asp Ala Ala Leu Arg Ala Leu His Gln Gly Asp Ser130 135 140Leu Glu Cys Thr Ala Met Thr Val Gln Ile Leu Leu Lys Leu Asp Arg145 150 155 160Leu Asp Leu Ala Arg Lys Glu Leu Lys Arg Met Gln Asp Leu Asp Glu165 170 175Asp Ala Thr Leu Thr Gln Leu Ala Thr Ala Trp Val Ser Leu Ala Thr180 185 190Gly Gly Glu Lys Leu Gln Asp Ala Tyr Tyr Ile Phe Gln Glu Met Ala195 200 205
Asp Lys Cys Ser Pro Thr Leu Leu Leu Leu Asn Gly Gln Ala Ala Cys210 215 220His Met Ala Gln Gly Arg Trp Glu Ala Ala Glu Gly Leu Leu Gln Glu225 230 235 240Ala Leu Asp Lys Asp Ser Gly Tyr Pro Glu Thr Leu Val Asn Leu Ile245 250 255Val Leu Ser Gln His Leu Gly Lys Pro Pro Glu Val Thr Asn Arg Tyr260 265 270Leu Ser Gln Leu Lys Asp Ala His Arg Ser His Pro Phe Ile Lys Glu275 280 285Tyr Gln Ala Lys Glu Asn Asp Phe Asp Arg Leu Val Leu Gln Tyr Ala290 295 300Pro Ser Ala305<210>22<211>165<212>PRT<213>人<300>
<308>sw_hum/dest_human<309>1990-11-01<400>22Met Ala Ser Gly Val Gln Val Ala Asp Glu Val Cys Arg Ile Phe Tyr1 5 10 15Asp Met Lys Val Arg Lys Cys Ser Thr Pro Glu Glu Ile Lys Lys Arg20 25 30Lys Lys Ala Val Ile Phe Cys Leu Ser Ala Asp Lys Lys Cys Ile Ile35 40 45Val Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Val Thr Ile50 55 60Thr Asp Pro Phe Lys His Phe Val Gly Met Leu Pro Glu Lys Asp Cys65 70 75 80Arg Tyr Ala Leu Tyr Asp Ala Ser Phe Glu Thr Lys Glu Ser Arg Lys85 90 95
Glu Glu Leu Met Phe Phe Leu Trp Ala Pro Glu Leu Ala Pro Leu Lys100 105 110Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Phe115 120 125Gln Gly Ile Lys His Glu Cys Gln Ala Asn Gly Pro Glu Asp Leu Asn130 135 140Arg Ala Cys Ile Ala Glu Lys Leu Gly Gly Ser Leu Ile Val Ala Phe145 150 155 160Glu Gly Cys Pro Val165<210>23<211>517<212>PRT<213>人<300>
<308>sw_hum/dha5_human<309>1993-07-01<400>23Met Leu Arg Phe Leu Ala Pro Arg Leu Leu Ser Leu Gln Gly Arg Thr1 5 10 15Ala Leu Tyr Ser Ser Ala Ala Ala Leu Pro Ser Pro Ile Leu Asn Pro20 25 30Asp Ile Pro Tyr Asn Gln Leu Phe Ile Asn Asn Glu Trp Gln Asp Ala35 40 45Val Ser Lys Lys Thr Phe Pro Thr Val Asn Pro Thr Thr Gly Glu Val50 55 60Ile Gly His Val Ala Glu Gly Asp Arg Ala Asp Val Asp Arg Ala Val65 70 75 80Lys Ala Ala Arg Glu Ala Phe Arg Leu Gly Ser Pro Trp Arg Arg Met85 90 95Asp Ala Ser Glu Arg Gly Arg Leu Leu Asn Leu Leu Ala Asp Leu Val100 105 110Glu Arg Asp Arg Val Tyr Leu Ala Ser Leu Glu Thr Leu Asp Asn Gly115 120 125
Lys Pro Phe Gln Glu Ser Tyr Ala Leu Asp Leu Asp Glu Val Ile Lys130 135 140Val Tyr Arg Tyr Phe Ala Gly Trp Ala Asp Lys Trp His Gly Lys Thr145 150 155 160Ile Pro Met His Gly Gln His Phe Cys Phe Thr Arg His Glu Pro Val165 170 175Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Gln180 185 190Gly Trp Lys Leu Ala Pro Ala Leu Ala Thr Gly Asn Thr Val Val Met195 200 205Lys Val Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Leu Ala Ser Leu210 215 220Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Ile Thr Gly225 230 235 240Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ala Gln His Met Asp Val Asp245 250 255Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly His Leu Ile Gln Lys260 265 270Ala Ala Gly Asp Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly275 280 285Lys Ser Pro Ser Ile Val Leu Ala Asp Ala Asp Met Glu His Ala Val290 295 300Glu Gln Cys His Glu Ala Leu Phe Phe Asn Met Gly Gln Cys Cys Cys305 310 315 320Ala Gly Ser Arg Thr Phe Val Glu Glu Ser Ile Tyr Asn Glu Phe Leu325 330 335Glu Arg Thr Val Glu Lys Ala Lys Gln Arg Lys Val Gly Asn Pro Phe340 345 350Glu Leu Asp Thr Gln Gln Gly Pro Gln Val Asp Lys Glu Gln Phe Glu355 360 365
Arg Val Leu Gly Tyr Ile Gln Leu Gly Gln Lys Glu Gly Ala Lys Leu370 375 380Leu Cys Gly Gly Glu Arg Phe Gly Glu Arg Gly Phe Phe Ile Lys Pro385 390 395 400Thr Val Phe Gly Gly Val Gln Asp Asp Met Arg Ile Ala Lys Glu Glu405 410 415Ile Phe Gly Pro Val Gln Pro Leu Phe Lys Phe Lys Lys Ile Glu Glu420 425 430Val Val Glu Arg Ala Asn Asn Thr Arg Tyr Gly Leu Ala Ala Ala Val435 440 445Phe Thr Arg Asp Leu Asp Lys Ala Met Tyr Phe Thr Gln Ala Leu Gln450 455 460Ala Gly Thr Val Trp Val Asn Thr Tyr Asn Ile Val Thr Cys His Thr465 470 475 480Pro Phe Gly Gly Phe Lys Glu Ser Gly Asn Gly Arg Glu Leu Gly Glu485 490 495Asp Gly Leu Lys Ala Tyr Thr Glu Val Lys Thr Val Thr Ile Lys Val500 505 510Pro Gln Lys Asn Ser515<210>24<211>274<212>PRT<213>人<300>
<308>sw_hum/dhqu_human<309>1990-04-01<400>24Met Val Gly Arg Arg Ala Leu Ile Val Leu Ala His Ser Glu Arg Thr1 5 10 15Ser Phe Asn Tyr Ala Met Lys Glu Ala Ala Ala Ala Ala Leu Lys Lys20 25 30Lys Gly Trp Glu Val Val Glu Ser Asp Leu Tyr Ala Met Asn Phe Asn35 40 45
Pro Ile Ile Ser Arg Lys Asp Ile Thr Gly Lys Leu Lys Asp Pro Ala50 55 60Asn Phe Gln Tyr Pro Ala Glu Ser Val Leu Ala Tyr Lys Glu Gly His65 70 75 80Leu Ser Pro Asp Ile Val Ala Glu Gln Lys Lys Leu Glu Ala Ala Asp85 90 95Leu Val Ile Phe Gln Phe Pro Leu Gln Trp Phe Gly Val Pro Ala Ile100 105 110Leu Lys Gly Trp Phe Glu Arg Val Phe Ile Gly Glu Phe Ala Tyr Thr115 120 125Tyr Ala Ala Met Tyr Asp Lys Gly Pro Phe Arg Ser Lys Lys Ala Val130 135 140Leu Ser Ile Thr Thr Gly Gly Ser Gly Ser Met Tyr Ser Leu Gln Gly145 150 155 160Ile His Gly Asp Met Asn Val Ile Leu Trp Pro Ile Gln Ser Gly Ile165 170 175Leu His Phe Cys Gly Phe Gln Val Leu Glu Pro Gln Leu Thr Tyr Ser180 185 190Ile Gly His Thr Pro Ala Asp Ala Arg Ile Gln Ile Leu Glu Gly Trp195 200 205Lys Lys Arg Leu Glu Asn Ile Trp Asp Glu Thr Pro Leu Tyr Phe Ala210 215 220Pro Ser Ser Leu Phe Asp Leu Asn Phe Gln Ala Gly Phe Leu Met Lys225 230 235 240Lys Glu Val Gln Asp Glu Glu Lys Asn Lys Lys Phe Gly Leu Ser Val245 250 255Gly His His Leu Gly Lys Ser Ile Pro Thr Asp Asn Gln Ile Lys Ala260 265 270Arg Lys<210>25
<211>737<212>PRT<213>人<300>
<308>sw_hum/dpp3_human<309>2001-10-16<400>25Met Ala Asp Thr Gln Tyr Ile Leu Pro Asn Asp Ile Gly Val Ser Ser1 5 10 15Leu Asp Cys Arg Glu Ala Phe Arg Leu Leu Ser Pro Thr Glu Arg Leu20 25 30Tyr Ala Tyr His Leu Ser Arg Ala Ala Trp Tyr Gly Gly Leu Ala Val35 40 45Leu Leu Gln Thr Ser Pro Glu Ala Pro Tyr Ile Tyr Ala Leu Leu Ser50 55 60Arg Leu Phe Arg Ala Gln Asp Pro Asp Gln Leu Arg Gln His Ala Leu65 70 75 80Ala Glu Gly Leu Thr Glu Glu Glu Tyr Gln Ala Phe Leu Val Tyr Ala85 90 95Ala Gly Val Tyr Ser Asn Met Gly Asn Tyr Lys Ser Phe Gly Asp Thr100 105 110Lys Phe Val Pro Asn Leu Pro Lys Glu Lys Leu Glu Arg Val Ile Leu115 120 125Gly Ser Glu Ala Ala Gln Gln His Pro Glu Glu Val Arg Gly Leu Trp130 135 140Gln Thr Cys Gly Glu Leu Met Phe Ser Leu Glu Pro Arg Leu Arg His145 150 155 160Leu Gly Leu Gly Lys Glu Gly Ile Thr Thr Tyr Phe Ser Gly Asn Cys165 170 175Thr Met Glu Asp Ala Lys Leu Ala Gln Asp Phe Leu Asp Ser Gln Asn180 185 190Leu Ser Ala Tyr Asn Thr Arg Leu Phe Lys Glu Val Asp Gly Glu Gly195 200 205
Lys Pro Tyr Tyr Glu Val Arg Leu Ala Ser Val Leu Gly Ser Glu Pro210 215 220Ser Leu Asp Ser Glu Val Thr Ser Lys Leu Lys Ser Tyr Glu Phe Arg225 230 235 240Gly Ser Pro Phe Gln Val Thr Arg Gly Asp Tyr Ala Pro Ile Leu Gln245 250 255Lys Val Val Glu Gln Leu Glu Lys Ala Lys Ala Tyr Ala Ala Asn Ser260 265 270His Gln Gly Gln Met Leu Ala Gln Tyr Ile Glu Ser Phe Thr Gln Gly275 280 285Ser Ile Glu Ala His Lys Arg Gly Ser Arg Phe Trp Ile Gln Asp Lys290 295 300Gly Pro Ile Val Glu Ser Tyr Ile Gly Phe Ile Glu Ser Tyr Arg Asp305 310 315 320Pro Phe Gly Ser Arg Gly Glu Phe Glu Gly Phe Val Ala Val Val Asn325 330 335Lys Ala Met Ser Ala Lys Phe Glu Arg Leu Val Ala Ser Ala Glu Gln340 345 350Leu Leu Lys Glu Leu Pro Trp Pro Pro Thr Phe Glu Lys Asp Lys Phe355 360 365Leu Thr Pro Asp Phe Thr Ser Leu Asp Val Leu Thr Phe Ala Gly Ser370 375 380Gly Ile Pro Ala Gly Ile Asn Ile Pro Asn Tyr Asp Asp Leu Arg Gln385 390 395 400Thr Glu Gly Phe Lys Asn Val Ser Leu Gly Asn Val Leu Ala Val Ala405 410 415Tyr Ala Thr Gln Arg Glu Lys Leu Thr Phe Leu Glu Glu Asp Asp Lys420 425 430Asp Leu Tyr Ile Leu Trp Lys Gly Pro Ser Phe Asp Val Gln Val Gly435 440 445Leu His Glu Leu Leu Gly His Gly Ser Gly Lys Leu Phe Val Gln Asp450 455 460
Glu Lys Gly Ala Phe Asn Phe Asp Gln Glu Thr Val Ile Asn Pro Glu465 470 475 480Thr Gly Glu Gln Ile Gln Ser Trp Tyr Arg Ser Gly Glu Thr Trp Asp485 490 495Ser Lys Phe Ser Thr Ile Ala Ser Ser Tyr Glu Glu Cys Arg Ala Glu500 505 510Ser Val Gly Leu Tyr Leu Cys Leu His Pro Gln Val Leu Glu Ile Phe515 520 525Gly Phe Glu Gly Ala Asp Ala Glu Asp Val Ile Tyr Val Asn Trp Leu530 535 540Asn Met Val Arg Ala Gly Leu Leu Ala Leu Glu Phe Tyr Thr Pro Glu545 550 555 560Ala Phe Asn Trp Arg Gln Ala His Met Gln Ala Arg Phe Val Ile Leu565 570 575Arg Val Leu Leu Glu Ala Gly Glu Gly Leu Val Thr Ile Thr Pro Thr580 585 590Thr Gly Ser Asp Gly Arg Pro Asp Ala Arg Val Arg Leu Asp Arg Ser595 600 605Lys Ile Arg Ser Val Gly Lys Pro Ala Leu Glu Arg Phe Leu Arg Arg610 615 620Leu Gln Val Leu Lys Ser Thr Gly Asp Val Ala Gly Gly Arg Ala Leu625 630 635 640Tyr Glu Gly Tyr Ala Thr Val Thr Asp Ala Pro Pro Glu Cys Phe Leu645 650 655Thr Leu Arg Asp Thr Val Leu Leu Arg Lys Glu Ser Arg Lys Leu Ile660 665 670Val Gln Pro Asn Thr Arg Leu Glu Gly Ser Asp Val Gln Leu Leu Glu675 680 685Tyr Glu Ala Ser Ala Ala Gly Leu Ile Arg Ser Phe Ser Glu Arg phe690 695 700
Pro Glu Asp Gly Pro Glu Leu Glu Glu Ile Leu Thr Gln Leu Ala Thr705 710 715 720Ala Asp Ala Arg Phe Trp Lys Gly Pro Ser Glu Ala Pro Ser Gly Gln725 730 735Ala<210>26<211>328<212>PRT<213>人<300>
<308>sw_hum/ech1_human<309>1997-11-01<400>26Met Ala Ala Gly Ile Val Ala Ser Arg Arg Leu Arg Asp Leu Leu Thr1 5 10 15Arg Arg Leu Thr Gly Ser Asn Tyr Pro Gly Leu Ser Ile Ser Leu Arg20 25 30Leu Thr Gly Ser Ser Ala Gln Glu Glu Ala Ser Gly Val Ala Leu Gly35 40 45Glu Ala Pro Asp His Ser Tyr Glu Ser Leu Arg Val Thr Ser Ala Gln50 55 60Lys His Val Leu His Val Gln Leu Asn Arg Pro Asn Lys Arg Asn Ala65 70 75 80Met Asn Lys Val Phe Trp Arg Glu Met Val Glu Cys Phe Asn Lys Ile85 90 95Ser Arg Asp Ala Asp Cys Arg Ala Val Val Ile Ser Gly Ala Gly Lys100 105 110Met Phe Thr Ala Gly Ile Asp Leu Met Asp Met Ala Ser Asp Ile Leu115 120 125Gln Pro Lys Gly Asp Asp Val Ala Arg Ile Ser Trp Tyr Leu Arg Asp130 135 140Ile Ile Thr Arg Tyr Gln Glu Thr Phe Asn Val Ile Glu Arg Cys Pro145 150 155 160
Lys Pro Val Ile Ala Ala Val His Gly Gly Cys Ile Gly Gly Gly Val165 170 175Asp Leu Val Thr Ala Cys Asp Ile Arg Tyr Cys Ala Gln Asp Ala Phe180 185 190Phe Gln Val Lys Glu Val Asp Val Gly Leu Ala Ala Asp Val Gly Thr195 200 205Leu Glu Arg Leu Pro Lys Val Ile Gly Asn Gln Ser Leu Val Asn Glu210 215 220Leu Ala Phe Thr Ala His Lys Met Met Ala Asp Glu Ala Leu Asp Ser225 230 235 240Gly Leu Val Ser Arg Val Phe Pro Asp Lys Glu Val Met Leu Asp Ala245 250 255Ala Leu Pro Leu Ala Pro Glu Ile Ser Ser Lys Thr Thr Val Leu Val260 265 270Gln Ser Thr Lys Val Asn Leu Leu Tyr Ser Arg Asp His Ser Val Ala275 280 285Glu Ser Leu Asn Tyr Val Ala Ser Trp Asn Met Ser Met Leu Gln Thr290 295 300Gln Asp Leu Val Lys Ser Val Gln Pro Thr Thr Glu Asn Lys Glu Leu305 310 315 320Lys Thr Val Thr Phe Ser Lys Leu325<210>27<211>281<212>PRT<213>人<300>
<308>sw_hum/ef1d_human<309>1993-04-01<400>27Met Ala Thr Asn Phe Leu Ala His Glu Lys Ile Trp Phe Asp Lys Phe1 5 10 15Lys Tyr Asp Asp Ala Glu Arg Arg Phe Tyr Glu Gln Met Asn Gly Pro20 25 30
Val Ala Gly Ala Ser Arg Gln Glu Asn Gly Ala Ser Val Ile Leu Arg35 40 45Asp Ile Ala Arg Ala Arg Glu Asn Ile Gln Lys Ser Leu Ala Gly Ser50 55 60Ser Gly Pro Gly Ala Ser Ser Gly Thr Ser Gly Asp His Gly Glu Leu65 70 75 80Val Val Arg Ile Ala Ser Leu Glu Val Glu Asn Gln Ser Leu Arg Gly85 90 95Val Val Gln Glu Leu Gln Gln Ala Ile Ser Lys Leu Glu Ala Arg Leu100 105 110Asn Val Leu Glu Lys Ser Ser Pro Gly His Arg Ala Thr Ala Pro Gln115 120 125Thr Gln His Val Ser Pro Met Arg Gln Val Glu Pro Pro Ala Lys Lys130 135 140Pro Ala Thr Pro Ala Glu Asp Asp Glu Asp Asp Asp Ile Asp Leu Phe145 150 155 160Gly Ser Asp Asn Glu Glu Glu Asp Lys Glu Ala Ala Gln Leu Arg Glu165 170 175Glu Arg Leu Arg Gln Tyr Ala Glu Lys Lys Ala Lys Lys Pro Ala Leu180 185 190Val Ala Lys Ser Ser Ile Leu Leu Asp Val Lys Pro Trp Asp Asp Glu195 200 205Thr Asp Met Ala Gln Leu Glu Ala Cys Val Arg Ser Ile Gln Leu Asp210 215 220Gly Leu Val Trp Gly Ala Ser Lys Leu Val Pro Val Gly Tyr Gly Ile225 230 235 240Arg Lys Leu Gln Ile Gln Cys Val Val Glu Asp Asp Lys Val Gly Thr245 250 255Asp Leu Leu Glu Glu Glu Ile Thr Lys Phe Glu Glu His Val Gln Ser260 265 270
Val Asp Ile Ala Ala Phe Asn Lys Ile275 280<210>28<211>458<212>PRT<213>人<300>
<308>sw_hum/enol_human<309>1995-02-01<400>28Met Ser Ile Leu Lys Ile Ile His Ala Arg Asp Ile Phe Glu Ser Arg1 5 10 15Gly Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Asn Lys Gly Gly Leu20 25 30Phe Gly Arg Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu35 40 45Ala Leu Leu Glu Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Gly50 55 60Lys Gly Val Ser Lys Ala Val Glu His Ile Ile Asn Lys Thr Ile Ala65 70 75 80Pro Ala Leu Ile Ser Lys Asn Val Asn Val Val Glu Gln Asp Lys Ile85 90 95Asp Asn Leu Met Leu Asp Met Asp Gly Ser Glu Asn Lys Ser Lys Phe100 105 110Gly Ala Asn Ala Ile Leu Gly Val Ser Leu Ala Val Cys Ser Asn Ala115 120 125Gly Ala Thr Ala Glu Lys Gly Val Pro Leu Tyr Arg His Ile Ala Asp130 135 140Leu Ala Gly Asn Asn Pro Glu Val Ile Leu Pro Val Pro Ala Phe Asn145 150 155 160Val Ile Asn Gly Gly Ser His Ala Gly Asn Lys Leu Ala Met Gln Glu165 170 175Phe Met Ile Pro Pro Cys Gly Ala Asp Arg Phe Asn Asp Ala Ile Arg180 185 190
Ile Gly Ala Glu Val Tyr His Asn Leu Lys Asn Val Ile Lys Glu Lys195 200 205Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp Glu Gly Gly Phe Ala Pro210 215 220Asn Ile Leu Glu Asn Lys Glu Ala Leu Glu Leu Leu Lys Thr Ala Ile225 230 235 240Gly Lys Ala Gly Tyr Ser Asp Lys Val Val Ile Gly Met Asp Val Ala245 250 255Ala Ser Glu Phe Tyr Arg Asp Gly Lys Tyr Asp Leu Asp Phe Asn Ser260 265 270Pro Asp Asp Pro Ser Arg Tyr Ile Ser Pro Asp Gln Leu Ala Asp Leu275 280 285Tyr Lys Gly Phe Val Leu Gly His Ala Val Lys Asn Tyr Pro Val Gly290 295 300Val Ser Ile Glu Asp Pro Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp305 310 315 320Lys Lys Leu Phe Thr Gly Ser Leu Val Gly Ile Gln Val Val Gly Asp325 330 335Asp Leu Thr Val Thr Lys Pro Glu Ala Arg Ile Ala Lys Ala Val Glu340 345 350Glu Val Lys Ala Cys Asn Cys Leu Leu Leu Leu Lys Val Asn Gln Ile355 360 365Gly Ser Val Thr Glu Ser Leu Gln Ala Cys Lys Leu Ala Gln Ser Asn370 375 380Gly Trp Gly Val Met Pro Val Ser His Arg Leu Ser Gly Glu Thr Glu385 390 395 400Asp Thr Phe Met Ala Asp Leu Val Val Gly Leu Cys Thr Gly Gln Ile405 410 415Lys Thr Gly Pro Thr Cys Arg Ser Glu Arg Leu Ala Lys Tyr Asn Gln420 425 430Leu Leu Arg Ile Glu Glu Ala Glu Ala Gly Ser Lys Ala Arg Phe Ala
435 440 445Gly Arg Asn Phe Arg Asn Pro Arg Ile Asn450 455<210>29<211>453<212>PRT<213>人<300>
<308>sw_hum/fibg_human<309>1986-07-21<400>29Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala1 5 10 15Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp20 25 30Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr35 40 45Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys50 55 60Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr65 70 75 80Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro85 90 95Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser100 105 110Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr115 120 125His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn130 135 140Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln145 150 155 160Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly165 170 175
Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu180 185 190Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys195 200 205Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu210 215 220Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly225 230 235 240Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn245 250 255Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu260 265 270Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr275 280 285Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr290 295 300Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp305 310 315 320Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met325 330 335Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys340 345 350Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly355 360 365His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser370 375 380Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr385 390 395 400Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn405 410 415Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys420 425 430
Gln Val Arg Pro Glu His Pro Ala Glu Thr Glu Tyr Asp Ser Leu Tyr435 440 445Pro Glu Asp Asp Leu450<210>30<211>482<212>PRT<213>人<300>
<308>sw_humg3b2_human<309>2001-10-16<400>30Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val1 5 10 15Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg20 25 30Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser35 40 45Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys50 55 60Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val65 70 75 80Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly85 90 95Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe100 105 110Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn115 120 125Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser Glu Pro Glu130 135 140Leu Asp Glu Glu Ser Glu Asp Glu Val Glu Glu Glu Gln Glu Glu Arg145 150 155 160Gln Pro Ser Pro Glu Pro Val Gln Glu Asn Ala Asn Ser Gly Tyr Tyr
165 170 175Glu Ala His Pro Val Thr Asn Gly Ile Glu Glu Pro Leu Glu Glu Ser180 185 190Ser His Glu Pro Glu Pro Glu Pro Glu Ser Glu Thr Lys Thr Glu Glu195 200 205Leu Lys Pro Gln Val Glu Glu Lys Asn Leu Glu Glu Leu Glu Glu Lys210 215 220Ser Thr Thr Pro Pro Pro Ala Glu Pro Val Ser Leu Pro Gln Glu Pro225 230 235 240Pro Lys Ala Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro245 250 255Ser Gly Thr Val Ser Ser Ser Gly Ile Pro Ser His Val Lys Ala Pro260 265 270Val Ser Gln Pro Arg Val Glu Ala Lys Pro Glu Val Gln Ser Gln Pro275 280 285Pro Arg Val Arg Glu Gln Arg Pro Arg Glu Arg Pro Gly Phe Pro Pro290 295 300Arg Gly Pro Arg Pro Gly Arg Gly Asp Met Glu Gln Asn Asp Ser Asp305 310 315 320Asn Arg Arg Ile Ile Arg Tyr Pro Asp Ser His Gln Leu Phe Val Gly325 330 335Asn Leu Pro His Asp Ile Asp Glu Asn Glu Leu Lys Glu Phe Phe Met340 345 350Ser Phe Gly Asn Val Val Glu Leu Arg Ile Asn Thr Lys Gly Val Gly355 360 365Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro370 375 380Val Gln Arg Ile Leu Ile Ala Lys Pro Ile Met Phe Arg Gly Glu Val385 390 395 400Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Arg Glu405 410 415
Thr Arg Gly Gly Gly Asp Asp Arg Arg Asp Ile Arg Arg Asn Asp Arg420 425 430Gly Pro Gly Gly Pro Arg Gly Ile Val Gly Gly Gly Met Met Arg Asp435 440 445Arg Asp Gly Arg Gly Pro Pro Pro Arg Gly Gly Met Ala Gln Lys Leu450 455 460Gly Ser Gly Arg Gly Thr Gly Gln Met Glu Gly Arg Phe Thr Gly Gln465 470 475 480Arg Arg<210>31<211>466<212>PRT<213>人<300>
<308>sw_humg3bp_human<309>2001-10-16<400>31Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val1 5 10 15Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg20 25 30Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn35 40 45Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys50 55 60Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val65 70 75 80Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly85 90 95Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe100 105 110Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn115 120 125
Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu130 135 140Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln145 150 155 160Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln165 170 175Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala180 185 190Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser195 200 205Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro210 215 220Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln225 230 235 240Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser245 250 255Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro260 265 270His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro275 280 285Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg290 295 300Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg305 310 315 320Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His325 330 335Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp340 345 350Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu355 360 365
Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val370 375 380Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile385 390 395 400Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg405 410 415Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly420 425 430Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly435 440 445Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro450 455 460Arg Gln465<210>32<211>514<212>PRT<213>人<300>
<308>sw_hum/g6pd_human<309>1989-10-01<400>32Ala Glu Gln Val Ala Leu Ser Arg Thr His Val Cys Gly Ile Leu Arg1 5 10 15Glu Glu Leu Phe Gln Gly Asp Ala Phe His Gln Ser Asp Thr His Ile20 25 30Phe Ile Ile Met Gly Ala Ser Gly Asp Leu Ala Lys Lys Lys Ile Tyr35 40 45Pro Thr Ile Trp Trp Leu Phe Arg Asp Gly Leu Leu Pro Glu Asn Thr50 55 60Phe Ile Val Gly Tyr Ala Arg Ser Arg Leu Thr Val Ala Asp Ile Arg65 70 75 80Lys Gln Ser Glu Pro Phe Phe Lys Ala Thr Pro Glu Glu Lys Leu Lys85 90 95
Leu Glu Asp Phe Phe Ala Arg Asn Ser Tyr Val Ala Gly Gln Tyr Asp100 105 110Asp Ala Ala Ser Tyr Gln Arg Leu Asn Ser His Met Asn Ala Leu His115 120 125Leu Gly Ser Gln Ala Asn Arg Leu Phe Tyr Leu Ala Leu Pro Pro Thr130 135 140Val Tyr Glu Ala Val Thr Lys Asn Ile His Glu Ser Cys Met Ser Gln145 150 155 160Ile Gly Trp Asn Arg Ile Ile Val Glu Lys Pro Phe Gly Arg Asp Leu165 170 175Gln Ser Ser Asp Arg Leu Ser Asn His Ile Ser Ser Leu Phe Arg Glu180 185 190Asp Gln Ile Tyr Arg Ile Asp His Tyr Leu Gly Lys Glu Met Val Gln195 200 205Asn Leu Met Val Leu Arg Phe Ala Asn Arg Ile Phe Gly Pro Ile Trp210 215 220Asn Arg Asp Asn Ile Ala Cys Val Ile Leu Thr Phe Lys Glu Pro Phe225 230 235 240Gly Thr Glu Gly Arg Gly Gly Tyr Phe Asp Glu Phe Gly Ile Ile Arg245 250 255Asp Val Met Gln Asn His Leu Leu Gln Met Leu Cys Leu Val Ala Met260 265 270Glu Lys Pro Ala Ser Thr Asn Ser Asp Asp Val Arg Asp Glu Lys Val275 280 285Lys Val Leu Lys Cys Ile Ser Glu Val Gln Ala Asn Asn Val Val Leu290 295 300Gly Gln Tyr Val Gly Asn Pro Asp Gly Glu Gly Glu Ala Thr Lys Gly305 310 315 320Tyr Leu Asp Asp Pro Thr Val Pro Arg Gly Ser Thr Thr Ala Thr Phe325 330 335Ala Ala Val Val Leu Tyr Val Glu Asn Glu Arg Trp Asp Gly Val Pro
340 345 350Phe Ile Leu Arg Cys Gly Lys Ala Leu Asn Glu Arg Lys Ala Glu Val355 360 365Arg Leu Gln Phe His Asp Val Ala Gly Asp Ile Phe His Gln Gln Cys370 375 380Lys Arg Asn Glu Leu Val Ile Arg Val Gln Pro Asn Glu Ala Val Tyr385 390 395 400Thr Lys Met Met Thr Lys Lys Pro Gly Met Phe Phe Asn Pro Glu Glu405 410 415Ser Glu Leu Asp Leu Thr Tyr Gly Asn Arg Tyr Lys Asn Val Lys Leu420 425 430Pro Asp Ala Tyr Glu Arg Leu Ile Leu Asp Val Phe Cys Gly Ser Gln435 440 445Met His Phe Val Arg Ser Asp Glu Leu Arg Glu Ala Trp Arg Ile Phe450 455 460Thr Pro Leu Leu His Gln Ile Glu Leu Glu Lys Pro Lys Pro Ile Pro465 470 475 480Tyr Ile Tyr Gly Ser Arg Gly Pro Thr Glu Ala Asp Glu Leu Met Lys485 490 495Arg Val Gly Phe Gln Tyr Glu Gly Thr Tyr Lys Trp Val Asn Pro His500 505 510Lys Leu<210>33<211>236<212>PRT<213>人<300>
<308>sw_hum/gamt_human<309>1997-11-01<400>33Met Ser Ala Pro Ser Ala Thr Pro Ile Phe Ala Pro Gly Glu Asn Cys1 5 10 15
Ser Pro Ala Trp Gly Ala Ala Pro Ala Ala Tyr Asp Ala Ala Asp Thr20 25 30His Leu Arg Ile Leu Gly Lys Pro Val Met Glu Arg Trp Glu Thr Pro35 40 45Tyr Met His Ala Leu Ala Ala Ala Ala Ser Ser Lys Gly Gly Arg Val50 55 60Leu Glu Val Gly Phe Gly Met Ala Ile Ala Ala Ser Lys Val Gln Glu65 70 75 80Ala Pro Ile Asp Glu His Trp Ile Ile Glu Cys Asn Asp Gly Val Phe85 90 95Gln Arg Leu Arg Asp Trp Ala Pro Arg Gln Thr His Lys Val Ile Pro100 105 110Leu Lys Gly Leu Trp Glu Asp Val Ala Pro Thr Leu Pro Asp Gly His115 120 125Phe Asp Gly Ile Leu Tyr Asp Thr Tyr Pro Leu Ser Glu Glu Thr Trp130 135 140His Thr His Gln Phe Asn Phe Ile Lys Asn His Ala Phe Arg Leu Leul45 150 155 160Lys Pro Gly Gly Val Leu Thr Tyr Cys Asn Leu Thr Ser Trp Gly Glu165 170 175Leu Met Lys Ser Lys Tyr Ser Asp Ile Thr Ile Met Phe Glu Glu Thr180 185 190Gln Val Pro Ala Leu Leu Glu Ala Gly Phe Arg Arg Glu Asn Ile Arg195 200 205Thr Glu Val Met Ala Leu Val Pro Pro Ala Asp Cys Arg Tyr Tyr Ala210 215 220Phe Pro Gln Met Ile Thr Pro Leu Val Thr Lys Gly225 230 235<210>34<211>424<212>PRT<213>人<300>
<308>sw_hum/grf1_human<309>1997-11-01<400>34Met Ala Gly Thr Arg Trp Val Leu Gly Ala Leu Leu Arg Gly Cys Gly1 5 10 15Cys Asn Cys Ser Ser Cys Arg Arg Thr Gly Ala Ala Cys Leu Pro Phe20 25 30Tyr Ser Ala Ala Ser Tyr Pro Ala Leu Arg Ala Ser Leu Leu Pro Gln35 40 45Ser Leu Ala Ala Ala Ala Ala Val Pro Thr Arg Ser Tyr Ser Gln Glu50 55 60Ser Lys Thr Thr Tyr Leu Glu Asp Leu Pro Pro Pro Pro Glu Tyr Glu65 70 75 80Leu Ala Pro Ser Lys Leu Glu Glu Glu Val Asp Asp Val Phe Leu Ile85 90 95Arg Ala Gln Gly Leu Pro Trp Ser Cys Thr Met Glu Asp Val Leu Asn100 105 110Phe Phe Ser Asp Cys Arg Ile Arg Asn Gly Glu Asn Gly Ile His Phe115 120 125Leu Leu Asn Arg Asp Gly Lys Arg Arg Gly Asp Ala Leu Ile Glu Met130 135 140Glu Ser Glu Gln Asp Val Gln Lys Ala Leu Glu Lys His Arg Met Tyr145 150 155 160Met Gly Gln Arg Tyr Val Glu Val Tyr Glu Ile Asn Asn Glu Asp Val165 170 175Asp Ala Leu Met Lys Ser Leu Gln Val Lys Ser Ser Pro Val Val Asn180 185 190Asp Gly Val Val Arg Leu Arg Gly Leu Pro Tyr Ser Cys Asn Glu Lys195 200 205Asp Ile Val Asp Phe Phe Ala Gly Leu Asn Ile Val AspIle Thr Phe210 215 220Val Met Asp Tyr Arg Gly Arg Arg Lys Thr Gly Glu Ala Tyr Val Gln
225 230 235 240Phe Glu Glu Pro Glu Met Ala Asn Gln Ala Leu Leu Lys His Arg Glu245 250 255Glu Ile Gly Asn Arg Tyr Ile Glu Ile Phe Pro Ser Arg Arg Asn Glu260 265 270Val Arg Thr His Val Gly Ser Tyr Lys Gly Lys Lys Ile Ala Ser Phe275 280 285Pro Thr Ala Lys Tyr Ile Thr Glu Pro Glu Met Val Phe Glu Glu His290 295 300Glu Val Asn Glu Val Phe Gln Pro Met Thr Ala Phe Glu Ser Glu Lys305 310 315 320Glu Ile Glu Leu Pro Lys Glu Val Pro Glu Lys Leu Pro Glu Ala Ala325 330 335Asp Phe Gly Thr Thr Ser Ser Leu His Phe Val His Met Arg Gly Leu340 345 350Pro Phe Gln Ala Asn Ala Gln Asp Ile Ile Asn Phe Phe Ala Pro Leu355 360 365Lys Pro Val Arg Ile Thr Met Glu Tyr Ser Ser Ser Gly Lys Ala Thr370 375 380Gly Glu Ala Asp Val His Phe Glu Thr His Glu Asp Ala Val Ala Ala385 390 395 400Met Leu Lys Asp Arg Ser His Val His His Arg Tyr Ile Glu Leu Phe405 410 415Leu Asn Ser Cys Pro Lys Gly Lys420<210>35<211>241<212>PRT<213>人<300>
<308>sw_hum/gto1_hum<309>1999-07-15<400>35
Met Ser Gly Glu Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro1 5 10 15Gly Pro Val Pro Glu Gly Ser Ile Arg Ile Tyr Ser Met Arg Phe Cys20 25 30Pro Phe Ala Glu Arg Thr Arg Leu Val Leu Lys Ala Lys Gly Ile Arg35 40 45His Glu Val Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe50 55 60Lys Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Ser Gln Gly65 70 75 80Gln Leu Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr Leu Asp Glu Ala85 90 95Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr Glu Lys Ala Cys100 105 110Gln Lys Met Ile Leu Glu Leu Phe Ser Lys Val Pro Ser Leu Val Gly115 120 125Ser Phe Ile Arg Ser Gln Asn Lys Glu Asp Tyr Ala Gly Leu Lys Glu130 135 140Glu Phe Arg Lys Glu Phe Thr Lys Leu Glu Glu Val Leu Thr Asn Lys145 150 155 160Lys Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met Ile Asp Tyr Leu165 170 175Ile Trp Pro Trp Phe Glu Arg Leu Glu Ala Met Lys Leu Asn Glu Cys180 185 190Val Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Ala Met Lys Glu195 200 205Asp Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys Asp Trp Gln Gly210 215 220Phe Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala Cys Asp Tyr Gly225 230 235 240Leu
<210>36<211>858<212>PRT<213>人<300>
<308>sw_hum/h105_human<309>1997-11-01<400>36Met Ser Val Val Gly Leu Asp Val Gly Ser Gln Ser Cys Tyr Ile Ala1 5 10 15Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Phe Ser Asp20 25 30Arg Cys Thr Pro Ser Val Ile Ser Phe Gly Ser Lys Asn Arg Thr Ile35 40 45Gly Val Ala Ala Lys Asn Gln Gln Ile Thr His Ala Asn Asn Thr Val50 55 60Ser Asn Phe Lys Arg Phe His Gly Arg Ala Phe Asn Asp Pro Phe Ile65 70 75 80Gln Lys Glu Lys Glu Asn Leu Ser Tyr Asp Leu Val Pro Leu Lys Asn85 90 95Gly Gly Val Gly Ile Lys Val Met Tyr Met Gly Glu Glu His Leu Phe100 105 110Ser Val Glu Gln Ile Thr Ala Met Leu Leu Thr Lys Leu Lys Glu Thr115 120 125Ala Glu Asn Ser Leu Lys Lys Pro Val Thr Asp Cys Val Ile Ser Val130 135 140Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Leu Asp Ala Ala145 150 155 160Gln Ile Val Gly Leu Asn Cys Leu Arg Leu Met Asn Asp Met Thr Ala165 170 175Val Ala Leu Asn Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ser Leu Asp180 185 190Glu Lys Pro Arg Ile Val Val Phe Val Asp Met Gly His Ser Ala Phe
195 200 205Gln Val Ser Ala Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Gly210 215 220Thr Ala Phe Asp Pro Phe Leu Gly Gly Lys Asn Phe Asp Glu Lys Leu225 230 235 240Val Glu His Phe Cys Ala Glu Phe Lys Thr Lys Tyr Lys Leu Asp Ala245 250 255Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys260 265 270Leu Lys Lys Leu Met Ser Ser Asn Ser Thr Asp Leu Pro Leu Asn Ile275 280 285Glu Cys Phe Met Asn Asp Lys Asp Val Ser Gly Lys Met Asn Arg Ser290 295 300Gln Phe Glu Glu Leu Cys Ala Glu Leu Leu Gln Lys Ile Glu Val Pro305 310 315 320Leu Tyr Ser Leu Leu Glu Gln Thr His Leu Lys Val Glu Asp Val Ser325 330 335Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu340 345 350Arg Ile Ala Lys Phe Phe Gly Lys Asp Ile Ser Thr Thr Leu Asn Ala355 360 365Asp Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser370 375 380Pro Ala Phe Lys Val Arg Glu Phe Ser Val Thr Asp Ala Val Pro Phe385 390 395 400Pro Ile Ser Leu Ile Trp Asn His Asp Ser Glu Asp Thr Glu Gly Val405 410 415His Glu Val Phe Ser Arg Asn His Ala Ala Pro Phe Ser Lys Val Leu420 425 430Thr Phe Leu Arg Arg Gly Pro Phe Glu Leu Glu Ala Phe Tyr Ser Asp435 440 445
Pro Gln Gly Val Pro Tyr Pro Glu Ala Lys Ile Gly Arg Phe Val Val450 455 460Gln Asn Val Ser Ala Gln Lys Asp Gly Glu Lys Ser Arg Val Lys Val465 470 475 480Lys Val Arg Val Asn Thr His Gly Ile Phe Thr Ile Ser Thr Ala Ser485 490 495Met Val Glu Lys Val Pro Thr Glu Glu Asn Glu Met Ser Ser Glu Ala500 505 510Asp Met Glu Cys Leu Asn Gln Arg Pro Pro Glu Asn Pro Asp Thr Asp515 520 525Lys Asn Val Gln Gln Asp Asn Ser Glu Ala Gly Thr Gln Pro Gln Val530 535 540Gln Thr Asp Ala Gln Gln Thr Ser Gln Ser Pro Pro Ser Pro Glu Leu545 550 555 560Thr Ser Glu Glu Asn Lys Ile Pro Asp Ala Asp Lys Ala Asn Glu Lys565 570 575Lys Val Asp Gln Pro Pro Glu Ala Lys Lys Pro Lys Ile Lys Val Val580 585 590Asn Val Glu Leu Pro Ile Glu Ala Asn Leu Val Trp Gln Leu Gly Lys595 600 605Asp Leu Leu Asn Met Tyr Ile Glu Thr Glu Gly Lys Met Ile Met Gln610 615 620Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Glu Glu625 630 635 640Tyr Val Tyr Glu Phe Arg Asp Lys Leu Cys Gly Pro Tyr Glu Lys Phe645 650 655Ile Cys Glu Gln Asp His Gln Asn Phe Leu Arg Leu Leu Thr Glu Thr660 665 670Glu Asp Trp Leu Tyr Glu Glu Gly Glu Asp Gln Ala Lys Gln Ala Tyr675 680 685Val Asp Lys Leu Glu Glu Leu Met Lys Ile Gly Thr Pro Val Lys Val
690 695 700Arg Phe Gln Glu Ala Glu Glu Arg Pro Lys Met Phe Glu Glu Leu Gly705 710 715 720Gln Arg Leu Gln His Tyr Ala Lys Ile Ala Ala Asp Phe Arg Asn Lys725 730 735Asp Glu Lys Tyr Asn His Ile Asp Glu Ser Glu Met Lys Lys Val Glu740 745 750Lys Ser Val Asn Glu Val Met Glu Trp Met Asn Asn Val Met Asn Ala755 760 765Gln Ala Lys Lys Ser Leu Asp Gln Asp Pro Val Val Arg Ala Gln Glu770 775 780Ile Lys Thr Lys Ile Lys Glu Leu Asn Asn Thr Cys Glu Pro Val Val785 790 795 800Thr Gln Pro Lys Pro Lys Ile Glu Ser Pro Lys Leu Glu Arg Thr Pro805 810 815Asn Gly Pro Asn Ile Asp Lys Lys Glu Glu Asp Leu Glu Asp Lys Asn820 825 830Asn Phe Gly Ala Glu Pro Pro His Gln Asn Gly Glu Cys Tyr Pro Asn835 840 845Glu Lys Asn Ser Val Asn Met Asp Leu Asp850 855<210>37<211>240<212>PRT<213>人<300>
<308>sw_hum/hdgf_human<309>1996-10-01<400>37Met Ser Arg Ser Asn Arg Gln Lys Glu Tyr Lys Cys Gly Asp Leu Val1 5 10 15Phe Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu20 25 30
Met Pro Glu Ala Ala Val Lys Ser Thr Ala Asn Lys Tyr Gln Val Phe35 40 45Phe Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe50 55 60Pro Tyr Glu Glu Ser Lys Glu Lys Phe Gly Lys Pro Asn Lys Arg Lys65 70 75 80Gly Phe Ser Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Thr Val Lys85 90 95Ala Ser Gly Tyr Gln Ser Ser Gln Lys Lys Ser Cys Val Glu Glu Pro100 105 110Glu Pro Glu Pro Glu Ala Ala Glu Gly Asp Gly Asp Lys Lys Gly Asn115 120 125Ala Glu Gly Ser Ser Asp Glu Glu Gly Lys Leu Val Ile Asp Glu Pro130 135 140Ala Lys Glu Lys Asn Glu Lys Gly Ala Leu Lys Arg Arg Ala Gly Asp145 150 155 160Leu Leu Glu Asp Ser Pro Lys Arg Pro Lys Glu Ala Glu Asn Pro Glu165 170 175Gly Glu Glu Lys Glu Ala Ala Thr Leu Glu Val Glu Arg Pro Leu Pro180 185 190Met Glu Val Glu Lys Asn Ser Thr Pro Ser Glu Pro Gly Ser Gly Arg195 200 205Gly Pro Pro Gln Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Ala210 215 220Thr Lys Glu Asp Ala Glu Ala Pro Gly Ile Arg Asp His Glu Ser Leu225 230 235 240<210>38<211>520<212>PRT<213>人<300>
<308>sw_hum/hmcs_human<309>1993-07-01<400>38
Met Pro Gly Ser Leu Pro Leu Asn Ala Glu Ala Cys Trp Pro Lys Asp1 5 10 15Val Gly Ile Val Ala Leu Glu Ile Tyr Phe Pro Ser Gln Tyr Val Asp20 25 30Gln Ala Glu Leu Glu Lys Tyr Asp Gly Val Asp Ala Gly Lys Tyr Thr35 40 45Ile Gly Leu Gly Gln Ala Lys Met Gly Phe Cys Thr Asp Arg Glu Asp50 55 60Ile Asn Ser Leu Cys Met Thr Val Val Gln Asn Leu Met Glu Arg Asn65 70 75 80Asn Leu Ser Tyr Asp Cys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr85 90 95Ile Ile Asp Lys Ser Lys Ser Val Lys Thr Asn Leu Met Gln Leu Phe100 105 110Glu Glu Ser Gly Asn Thr Asp Ile Glu Gly Ile Asp Thr Thr Asn Ala115 120 125Cys Tyr Gly Gly Thr Ala Ala Val Phe Asn Ala Val Asn Trp Ile Glu130 135 140Ser Ser Ser Trp Asp Gly Arg Tyr Ala Leu Val Val Ala Gly Asp Ile145 150 155 160Ala Val Tyr Ala Thr Gly Asn Ala Arg Pro Thr Gly Gly Val Gly Ala165 170 175Val Ala Leu Leu Ile Gly Pro Asn Ala Pro Leu Ile Phe Glu Arg Gly180 185 190Leu Arg Gly Thr His Met Gln His Ala Tyr Asp Phe Tyr Lys Pro Asp195 200 205Met Leu Ser Glu Tyr Pro Ile Val Asp Gly Lys Leu Ser Ile Gln Cys210 215 220Tyr Leu Ser Ala Leu Asp Arg Cys Tyr Ser Val Tyr Cys Lys Lys Ile225 230 235 240His Ala Gln Trp Gln Lys Glu Gly Asn Asp Lys Asp Phe Thr Leu Asn
245 250 255Asp Phe Gly Phe Met Ile Phe His Ser Pro Tyr Cys Lys Leu Val Gln260 265 270Lys Ser Leu Ala Arg Met Leu Leu Asn Asp Phe Leu Asn Asp Gln Asn275 280 285Arg Asp Lys Asn Ser Ile Tyr Ser Gly Leu Glu Ala Phe Gly Asp Val290 295 300Lys Leu Glu Asp Thr Tyr Phe Asp Arg Asp Val Glu Lys Ala Phe Met305 310 315 320Lys Ala Ser Ser Glu Leu Phe Ser Gln Lys Thr Lys Ala Ser Leu Leu325 330 335Val Ser Asn Gln Asn Gly Asn Met Tyr Thr Ser Ser Val Tyr Gly Ser340 345 350Leu Ala Ser Val Leu Ala Gln Tyr Ser Pro Gln Gln Leu Ala Gly Lys355 360 365Arg Ile Gly Val Phe Ser Tyr Gly Ser Gly Leu Ala Ala Thr Leu Tyr370 375 380Ser Leu Lys Val Thr Gln Asp Ala Thr Pro Gly Ser Ala Leu Asp Lys385 390 395 400Ile Thr Ala Ser Leu Cys Asp Leu Lys Ser Arg Leu Asp Ser Arg Thr405 410 415Gly Val Ala Pro Asp Val Phe Ala Glu Asn Met Lys Leu Arg Glu Asp420 425 430Thr His His Leu Val Asn Tyr Ile Pro Gln Gly Ser Ile Asp Ser Leu435 440 445Phe Glu Gly Thr Trp Tyr Leu Val Arg Val Asp Glu Lys His Arg Arg450 455 460Thr Tyr Ala Arg Arg Pro Thr Pro Asn Asp Asp Thr Leu Asp Glu Gly465 470 475 480Val Gly Leu Val His Ser Asn Ile Ala Thr Glu His Ile Pro Ser Pro485 490 495
Ala Lys Lys Val Pro Arg Leu Pro Ala Thr Ala Ala Glu Pro Glu Ala500 505 5l0Ala Val Ile Ser Asn Gly Glu His515 520<210>39<211>314<212>PRT<213>人<300>
<308>sw_hum/if2a_human<309>1987-08-13<400>39Pro Gly Leu Ser Cys Arg Phe Tyr Gln His Lys Phe Pro Glu Val Glu1 5 10 15Asp Val Val Met Val Asn Val Arg Ser Ile Ala Glu Met Gly Ala Tyr20 25 30Val Ser Leu Leu Glu Tyr Asn Asn Ile Glu Gly Met Ile Leu Leu Ser35 40 45Glu Leu Ser Arg Arg Arg Ile Arg Ser Ile Asn Lys Leu Ile Arg Ile50 55 60Gly Arg Asn Glu Cys Val Val Val Ile Arg Val Asp Lys Glu Lys Gly65 70 75 80Tyr Ile Asp Leu Ser Lys Arg Arg Val Ser Pro Glu Glu Ala Ile Lys85 90 95Cys Glu Asp Lys Phe Thr Lys Ser Lys Thr Val Tyr Ser Ile Leu Arg100 105 110His Val Ala Glu Val Leu Glu Tyr Thr Lys Asp Glu Gln Leu Glu Ser115 120 125Leu Phe Gln Arg Thr Ala Trp Val Phe Asp Asp Lys Tyr Lys Arg Pro130 135 140Gly Tyr Gly Ala Tyr Asp Ala Phe Lys His Ala Val Ser Asp Pro Ser145 150 155 160Ile Leu Asp Ser Leu Asp Leu Asn Glu Asp Glu Arg Glu Val Leu Ile165 170 175
Asn Asn Ile Asn Arg Arg Leu Thr Pro Gln Ala Val Lys Ile Arg Ala180 185 190Asp Ile Glu Val Ala Cys Tyr Gly Tyr Glu Gly Ile Asp Ala Val Lys195 200 205Glu Ala Leu Arg Ala Gly Leu Asn Cys Ser Thr Glu Asn Met Pro Ile210 215 220Lys Ile Asn Leu Ile Ala Pro Pro Arg Tyr Val Met Thr Thr Thr Thr225 230 235 240Leu Glu Arg Thr Glu Gly Leu Ser Val Leu Ser Gln Ala Met Ala Val245 250 255Ile Lys Glu Lys Ile Glu Glu Lys Arg Gly Val Phe Asn Val Gln Met260 265 270Glu Pro Lys Val Val Thr Asp Thr Asp Glu Thr Glu Leu Ala Arg Gln275 280 285Met Glu Arg Leu Glu Arg Glu Asn Ala Glu Val Asp Gly Asp Asp Asp290 295 300Ala Glu Glu Met Glu Ala Lys Ala Glu Asp305 310<210>40<211>352<212>PRT<213>人<300>
<308>sw_hum/if33_human<309>2000-05-30<400>40Met Ala Ser Arg Lys Glu Gly Thr Gly Ser Thr Ala Thr Ser Ser Ser1 5 10 15Ser Thr Ala Gly Ala Ala Gly Lys Gly Lys Gly Lys Gly Gly Ser Gly20 25 30Asp Ser Ala Val Lys Gln Val Gln Ile Asp Gly Leu Val Val Leu Lys35 40 45Ile Ile Lys His Tyr Gln Glu Glu Gly Gln Gly Thr Glu Val Val Gln
50 55 60Gly Val Leu Leu Gly Leu Val Val Glu Asp Arg Leu Glu Ile Thr Asn65 70 75 80Cys Phe Pro Phe Pro Gln His Thr Glu Asp Asp Ala Asp Phe Asp Glu85 90 95Val Gln Tyr Gln Met Glu Met Met Arg Ser Leu Arg His Val Asn Ile100 105 110Asp His Leu His Val Gly Trp Tyr Gln Ser Thr Tyr Tyr Gly Ser Phe115 120 125Val Thr Arg Ala Leu Leu Asp Ser Gln Phe Ser Tyr Gln His Ala Ile130 135 140Glu Glu Ser Val Val Leu Ile Tyr Asp Pro Ile Lys Thr Ala Gln Gly145 150 155 160Ser Leu Ser Leu Lys Ala Tyr Arg Leu Thr Pro Lys Leu Met Glu Val165 170 175Cys Lys Glu Lys Asp Phe Ser Pro Glu Ala Leu Lys Lys Ala Asn Ile180 185 190Thr Phe Glu Tyr Met Phe Glu Glu Val Pro Ile Val Ile Lys Asn Ser195 200 205His Leu Ile Asn Val Leu Met Trp Glu Leu Glu Lys Lys Ser Ala Val210 215 220Ala Asp Lys His Glu Leu Leu Ser Leu Ala Ser Ser Asn His Leu Gly225 230 235 240Lys Asn Leu Gln Leu Leu Met Asp Arg Val Asp Glu Met Ser Gln Asp245 250 255Ile Val Lys Tyr Asn Thr Tyr Met Arg Asn Thr Ser Lys Gln Gln Gln260 265 270Gln Lys His Gln Tyr Gln Gln Arg Arg Gln Gln Glu Asn Met Gln Arg275 280 285Gln Ser Arg Gly Glu Pro Pro Leu Pro Glu Glu Asp Leu Ser Lys Leu290 295 300
Phe Lys Pro Pro Gln Pro Pro Ala Arg Met Asp Ser Leu Leu Ile Ala305 310 315 320Gly Gln Ile Asn Thr Tyr Cys Gln Asn Ile Lys Glu Phe Thr Ala Gln325 330 335Asn Leu Gly Lys Leu Phe Met Ala Gln Ala Leu Gln Glu Tyr Asn Asn340 345 350<210>41<211>406<212>PRT<213>人<300>
<308>sw_hum/if41_human<309>1987-08-13<400>41Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly1 5 10 15Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp20 25 30Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr35 40 45Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu50 55 60Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr65 70 75 80Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu85 90 95Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu100 105 110Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly115 120 125Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val130 135 140Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly145 150 155 160
Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile165 170 175Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe180 185 190Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln195 200 205Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr210 215 220Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu225 230 235 240Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu245 250 255Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile260 265 270Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu275 280 285Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met His Gly290 295 300Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser305 310 315 320Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Ala Arg Gly Ile325 330 335Asp Val Gln Gln Val Ser Leu Val Ile Asn Tyr Asp Leu Pro Thr Asn340 345 350Arg Glu Asn Tyr Ile His Arg Ile Gly Arg Gly Gly Arg Phe Gly Arg355 360 365Lys Gly Val Ala Ile Asn Met Val Thr Glu Glu Asp Lys Arg Thr Leu370 375 380Arg Asp Ile Glu Thr Phe Tyr Asn Thr Ser Ile Glu Glu Met Pro Leu385 390 395 400
Asn Val Ala Asp Leu Ile405<210>42<211>585<212>PRT<213>人<300>
<308>sw_hum/lam1_human<309>1991-02-01<400>42Ala Thr Ala Thr Pro Val Pro Pro Arg Met Gly Ser Arg Ala Gly Gly1 5 10 15Pro Thr Thr Pro Leu Ser Pro Thr Arg Leu Ser Arg Leu Gln Glu Lys20 25 30Glu Glu Leu Arg Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Lys35 40 45Val Arg Ser Leu Glu Thr Glu Asn Ser Ala Leu Gln Leu Gln Val Thr50 55 60Glu Arg Glu Glu Val Arg Gly Arg Glu Leu Thr Gly Leu Lys Ala Leu65 70 75 80Tyr Glu Thr Glu Leu Ala Asp Ala Arg Arg Ala Leu Asp Asp Thr Ala85 90 95Arg Glu Arg Ala Lys Leu Gln Ile Glu Leu Gly Lys Cys Lys Ala Glu100 105 110His Asp Gln Leu Leu Leu Asn Tyr Ala Lys Lys Glu Ser Asp Leu Asn115 120 125Gly Ala Gln Ile Lys Leu Arg Glu Tyr Glu Ala Ala Leu Asn Ser Lys130 135 140Asp Ala Ala Leu Ala Thr Ala Leu Gly Asp Lys Lys Ser Leu Glu Gly145 150 155 160Asp Leu Glu Asp Leu Lys Asp Gln Ile Ala Gln Leu Glu Ala Ser Leu165 170 175Ala Ala Ala Lys Lys Gln Leu Ala Asp Glu Thr Leu Leu Lys Val Asp180 185 190
Leu Glu Asn Arg Cys Gln Ser Leu Thr Glu Asp Leu Glu Phe Arg Lys195 200 205Ser Met Tyr Glu Glu Glu Ile Asn Glu Thr Arg Arg Lys His Glu Thr210 215 220Arg Leu Val Glu Val Asp Ser Gly Arg Gln Ile Glu Tyr Glu Tyr Lys225 230 235 240Leu Ala Gln Ala Leu His Glu Met Arg Glu Gln His Asp Ala Gln Val245 250 255Arg Leu Tyr Lys Glu Glu Leu Glu Gln Thr Tyr His Ala Lys Leu Glu260 265 270Asn Ala Arg Leu Ser Ser Glu Met Asn Thr Ser Thr Val Asn Ser Ala275 280 285Arg Glu Glu Leu Met Glu Ser Arg Met Arg Ile Glu Ser Leu Ser Ser290 295 300Gln Leu Ser Asn Leu Gln Lys Glu Ser Arg Ala Cys Leu Glu Arg Ile305 310 315 320Gln Glu Leu Glu Asp Leu Leu Ala Lys Glu Lys Asp Asn Ser Arg Arg325 330 335Met Leu Thr Asp Lys Glu Arg Glu Met Ala Glu Ile Arg Asp Gln Met340 345 350Gln Gln Gln Leu Asn Asp Tyr Glu Gln Leu Leu Asp Val Lys Leu Ala355 360 365Leu Asp Met Glu Ile Ser Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu370 375 380Glu Arg Leu Lys Leu Ser Pro Ser Pro Ser Ser Arg Val Thr Val Ser385 390 395 400Arg Ala Ser Ser Ser Arg Ser Val Arg Thr Thr Arg Gly Lys Arg Lys405 410 415Arg Val Asp Val Glu Glu Ser Glu Ala Ser Ser Ser Val Ser Ile Ser420 425 430His Ser Ala Ser Ala Thr Gly Asn Val Cys Ile Glu Glu Ile Asp Val
435 440 445Asp Gly Lys Phe Ile Arg Leu Lys Asn Thr Ser Glu Gln Asp Gln Pro450 455 460Met Gly Gly Trp Glu Met Ile Arg Lys Ile Gly Asp Thr Ser Val Ser465 470 475 480Tyr Lys Tyr Thr Ser Arg Tyr Val Leu Lys Ala Gly Gln Thr Val Thr485 490 495Ile Trp Ala Ala Asn Ala Gly Val Thr Ala Ser Pro Pro Thr Asp Leu500 505 510Ile Trp Lys Asn Gln Asn Ser Trp Gly Thr Gly Glu Asp Val Lys Val515 520 525Ile Leu Lys Asn Ser Gln Gly Glu Glu Val Ala Gln Arg Ser Thr Val530 535 540Phe Lys Thr Thr Ile Pro Glu Glu Glu Glu Glu Glu Glu Glu Ala Ala545 550 555 560Gly Val Val Val Glu Glu Glu Leu Phe His Gln Gln Gly Thr Pro Arg565 570 575Ala Ser Asn Arg Ser Cys Ala Ile Met580 585<210>43<211>600<212>PRT<213>人<300>
<308>sw_hum/lam2_human<309>1994-06-01<400>43Met Ala Thr Pro Leu Pro Gly Arg Ala Gly Gly Pro Ala Thr Pro Leu1 5 10 15Ser Pro Thr Arg Leu Ser Arg Leu Gln Glu Lys Glu Glu Leu Arg Glu20 25 30Leu Asn Asp Arg Leu Ala His Tyr Ile Asp Arg Val Arg Ala Leu Glu35 40 45
Leu Glu Asn Asp Arg Leu Leu Leu Lys Ile Ser Glu Lys Glu Glu Val50 55 60Thr Thr Arg Glu Val Ser Gly Ile Lys Ala Leu Tyr Glu Ser Glu Leu65 70 75 80Ala Asp Ala Arg Arg Val Leu Asp Glu Thr Ala Arg Glu Arg Ala Arg85 90 95Leu Gln Ile Glu Ile Gly Lys Leu Arg Ala Glu Leu Asp Glu Val Asn100 105 110Lys Ser Ala Lys Lys Arg Glu Gly Glu Leu Thr Val Ala Gln Gly Arg115 120 125Val Lys Asp Leu Glu Ser Leu Phe His Arg Ser Glu Val Glu Leu Ala130 135 140Ala Ala Leu Ser Asp Lys Arg Gly Leu Glu Ser Asp Val Ala Glu Leu145 150 155 160Arg Ala Gln Leu Ala Lys Ala Glu Asp Gly His Ala Val Ala Lys Lys165 170 175Gln Leu Glu Lys Glu Thr Leu Met Arg Val Asp Leu Glu Asn Arg Cys180 185 190Gln Ser Leu Gln Glu Glu Leu Asp Phe Arg Lys Ser Val Phe Glu Glu195 200 205Glu Val Arg Glu Thr Arg Arg Arg His Glu Arg Arg Leu Val Glu Val210 215 220Asp Ser Ser Arg Gln Gln Glu Tyr Asp Phe Lys Met Ala Gln Ala Leu225 230 235 240Glu Glu Leu Arg Ser Gln His Asp Glu Gln Val Arg Leu Tyr Lys Leu245 250 255Glu Leu Glu Gln Thr Tyr Gln Ala Lys Leu Asp Ser Ala Lys Leu Ser260 265 270Ser Asp Gln Asn Asp Lys Ala Ala Ser Ala Ala Arg Glu Glu Leu Lys275 280 285Glu Ala Arg Met Arg Leu Glu Ser Leu Ser Tyr Gln Leu Ser Gly Leu290 295 300
Gln Lys Gln Ala Ser Ala Ala Glu Asp Arg Ile Arg Glu Leu Glu Glu305 310 315 320Ala Met Ala Gly Glu Arg Asp Lys Phe Arg Lys Met Leu Asp Ala Lys325 330 335Glu Gln Glu Met Thr Glu Met Arg Asp Val Met Gln Gln Gln Leu Ala340 345 350Glu Tyr Gln Glu Leu Leu Asp Val Lys Leu Ala Leu Asp Met Glu Ile355 360 365Asn Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Glu Arg Leu Lys Leu370 375 380Ser Pro Ser Pro Ser Ser Arg Val Thr Val Ser Arg Ala Thr Ser Ser385 390 395 400Ser Ser Gly Ser Leu Ser Ala Thr Gly Arg Leu Gly Arg Ser Lys Arg405 410 415Lys Arg Leu Glu Val Glu Glu Pro Leu Gly Ser Gly Pro Ser Val Leu420 425 430Gly Thr Gly Thr Gly Gly Ser Gly Gly Phe His Leu Ala Gln Gln Ala435 440 445Ser Ala Ser Gly Ser Val Ser Ile Glu Glu Ile Asp Leu Glu Gly Lys450 455 460Phe Val Gln Leu Lys Asn Asn Ser Asp Lys Asp Gln Ser Leu Gly Asn465 470 475 480Trp Arg Ile Lys Arg Gln Val Leu Glu Gly Glu Glu Ile Ala Tyr Lys485 490 495Phe Thr Pro Lys Tyr Ile Leu Arg Ala Gly Gln Met Val Thr Val Trp500 505 510Ala Ala Gly Ala Gly Val Ala His Ser Pro Pro Ser Thr Leu Val Trp515 520 525Lys Gly Gln Ser Ser Trp Gly Thr Gly Glu Ser Phe Arg Thr Val Leu530 535 540
Val Asn Ala Asp Gly Glu Glu Val Ala Met Arg Thr Val Lys Lys Ser545 550 555 560Ser Val Met Arg Glu Asn Glu Asn Gly Glu Glu Glu Glu Glu Glu Ala565 570 575Glu Phe Gly Glu Glu Asp Leu Phe His Gln Gln Gly Asp pro Arg Thr580 585 590Thr Ser Arg Gly Cys Tyr Val Met595 600<210>44<211>664<212>PRT<213>人<300>
<308>sw_hum/lama_human<309>1986-07-21<400>44Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala1 5 10 15Ser Ser Thr pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys20 25 30Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg35 40 45Val Arg Ser Leu Glu Thr Glu Asn Ala Glv Leu Arg Leu Arg Ile Thr50 55 60Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala65 70 75 80Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala85 90 95Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu100 105 110Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile115 120 125Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys130 135 140
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly145 150 155 160Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu165 170 175Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp180 185 190Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys195 200 205Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr210 215 220Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg225 230 235 240Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val245 250 255Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp260 265 270Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala275 280 285His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala290 295 300Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu305 310 315 320Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg325 330 335Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met340 345350Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala355 360 365Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu370 375 380Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly
385 390 395 400Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr405 410 415Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln420 425 430His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu435 440 445Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met450 455 460Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr465 470 475 480Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr485 490 495Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu500 505 510Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr515 520 525Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val530 535 540Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp545 550 555 560Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro565 570 575Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly580 585 590Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln Val Gly595 600 605Gly Pro Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val Thr Arg610 615 620Ser Tyr Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp Asn625 630 635 640
Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr Gln645 650 655Ser Pro Gln Asn Cys Ser Ile Met660<210>45<211>331<212>PRT<213>人<300>
<308>sw_hum/ldha_human<309>1986-07-21<400>45Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu Gln1 5 10 15Thr Pro Gln Asn Lys Ile Thr Val Val Gly Val Gly Ala Val Gly Met20 25 30Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu Ala35 40 45Leu Val Asp Val Ile Glu Asp Lys Leu Lys Gly Glu Met Met Asp Leu50 55 60Gln His Gly Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser Gly Lys65 70 75 80Asp Tyr Asn Val Thr Ala Asn Ser Lys Leu Val Ile Ile Thr Ala Gly85 90 95Ala Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg Asn100 105 110Val Asn Ile Phe Lys Phe Ile Ile Pro Asn Val Val Lys Tyr Ser Pro115 120 125Asn Cys Lys Leu Leu Ile Val Ser Asn Pro Val Asp Ile Leu Thr Tyr130 135 140Val Ala Trp Lys Ile Ser Gly Phe Pro Lys Asn Arg Val Ile Gly Ser145 150 155 160Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Gly Glu Arg165 170 175
Leu Gly Val His Pro Leu Ser Cys His Gly Trp Val Leu Gly Glu His180 185 190Gly Asp Ser Ser Val Pro Val Trp Ser Gly Met Asn Val Ala Gly Val195 200 205Ser Leu Lys Thr Leu His Pro Asp Leu Gly Thr Asp Lys Asp Lys Glu210 215 220Gln Trp Lys Glu Val His Lys Gln Val Val Glu Ser Ala Tyr Glu Val225 230 235 240Ile Lys Leu Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser Val Ala245 250 255Asp Leu Ala Glu Ser Ile Met Lys Asn Leu Arg Arg Val His Pro Val260 265 270Ser Thr Met Ile Lys Gly Leu Tyr Gly Ile Lys Asp Asp Val Phe Leu275 280 285Ser Val Pro Cys Ile Leu Gly Gln Asn Gly Ile Ser Asp Leu Val Lys290 295 300Val Thr Leu Thr Ser Glu Glu Glu Ala Arg Leu Lys Lys Ser Ala Asp305 310 315 320Thr Leu Trp Gly Ile Gln Lys Glu Leu Gln Phe325 330<210>46<211>268<212>PRT<213>人<300>
<308>sw_hum/mae1_human<309>2003-02-28<400>46Met Ala Val Asn Val Tyr Ser Thr Ser Val Thr Ser Asp Asn Leu Ser1 5 10 15Arg His Asp Met Leu Ala Trp Ile Asn Glu Ser Leu Gln Leu Asn Leu20 25 30Thr Lys Ile Glu Gln Leu Cys Ser Gly Ala Ala Tyr Cys Gln Phe Met
35 40 45Asp Met Leu Phe Pro Gly Ser Ile Ala Leu Lys Lys Val Lys Phe Gln50 55 60Ala Lys Leu Glu His Glu Tyr Ile Gln Asn Phe Lys Ile Leu Gln Ala65 70 75 80Gly Phe Lys Arg Met Gly Val Asp Lys Ile Ile Pro Val Asp Lys Leu85 90 95Val Lys Gly Lys Phe Gln Asp Asn Phe Glu Phe Val Gln Trp Phe Lys100 105 110Lys Phe Phe Asp Ala Asn Tyr Asp Gly Lys Asp Tyr Asp Pro Val Ala115 120 125Ala Arg Gln Gly Gln Glu Thr Ala Val Ala Pro Ser Leu Val Ala Pro130 135 140Ala Leu Asn Lys Pro Lys Lys Pro Leu Thr Ser Ser Ser Ala Ala Pro145 150 155 160Gln Arg Pro Ile Ser Thr Gln Arg Thr Ala Ala Ala Pro Lys Ala Gly165 170 175Pro Gly Val Val Arg Lys Asn Pro Gly Val Gly Asn Gly Asp Asp Glu180 185 190Ala Ala Glu Leu Met Gln Gln Val Asn Val Leu Lys Leu Thr Val Glu195 200 205Asp Leu Glu Lys Glu Arg Asp Phe Tyr Phe Gly Lys Leu Arg Asn Ile210 215 220Glu Leu Ile Cys Gln Glu Asn Glu Gly Glu Asn Asp Pro Val Leu Gln225 230 235 240Arg Ile Val Asp Ile Leu Tyr Ala Thr Asp Glu Gly Phe Val Ile Pro245 250 255Asp Glu Gly Gly Pro Gln Glu Glu Gln Glu Glu Tyr260 265<210>47<211>572<212>PRT
<213>人<300>
<308>sw_hum/maox_human<309>1996-02-01<400>47Met Glu Pro Glu Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr1 5 10 15Leu Leu Thr Arg Asn Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu20 25 30Glu Glu Arg Gln Gln Leu Asn Ile His Gly Leu Leu Pro Pro Ser Phe35 40 45Asn Ser Gln Glu Ile Gln Val Leu Arg Val Val Lys Asn Phe Glu His50 55 60Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp65 70 75 80Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp Ile Glu Lys85 90 95Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln100 105 110Tyr Ser Leu Val Phe Arg Lys Pro Arg Gly Leu Phe Ile Thr Ile His115 120 125Asp Arg Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val130 135 140Ile Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly145 150 155 160Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu165 170 175Tyr Thr Ala Cys Gly Gly Met Asn Pro Gln Glu Cys Leu Pro Val Ile180 185 190Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr195 200 205Ile Gly Leu Arg Gln Arg Arg Val Arg Gly Ser Glu Tyr Asp Asp Phe210 215 220
Leu Asp Glu Phe Met Glu Ala Val Ser Ser Lys Tyr Gly Met Asn Cys225 230 235 240Leu Ile Gln Phe Glu Asp Phe Ala Asn Val Asn Ala Phe Arg Leu Leu245 250 255Asn Lys Tyr Arg Asn Gln Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly260 265 270Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr275 280 285Lys Asn Lys Leu Ser Asp Gln Thr Ile Leu Phe Gln Gly Ala Gly Glu290 295 300Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Leu Glu Lys Glu305 310 315 320Gly Leu Pro Lys Glu Lys Ala Ile Lys Lys Ile Trp Leu Val Asp Ser325 330 335Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Gln Glu Lys Glu340 345 350Lys Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val355 360 365Gln Glu Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly370 375 380Ala Phe Ser Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg385 390 395 400Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser405 410 415Ala Glu Gln Cys Tyr Lys Ile Thr Lys Gly Arg Ala Ile Phe Ala Ser420 425 430Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asn Gly Gln Thr Leu Tyr435 440 445Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly450 455 460
Val Val Ala Cys Gly Leu Arg Gln Ile Thr Asp Asn Ile Phe Leu Thr465 470 475 480Thr Ala Glu Val Ile Ala Gln Gln Val Ser Asp Lys His Leu Glu Glu485 490 495Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys500 505 510Ile Ala Glu Lys Ile Val Lys Asp Ala Tyr Gln Glu Lys Thr Ala Thr515 520 525Val Tyr Pro Glu Pro Gln Asn Lys Glu Ala Phe Val Arg Ser Gln Met530 535 540Tyr Ser Thr Asp Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Ser Trp Pro545 550 555 560Glu Glu Val Gln Lys Ile Gln Thr Lys Val Asp Gln565 570<210>48<211>333<212>PRT<213>人<300>
<308>sw_hum/mdhc_human<309>1995-02-01<400>48Ser Glu Pro Ile Arg Val Leu Val Thr Gly Ala Ala Gly Gln Ile Ala1 5 10 15Tyr Ser Leu Leu Tyr Ser Ile Gly Asn Gly Ser Val Phe Gly Lys Asp20 25 30Gln Pro Ile Ile Leu Val Leu Leu Asp Ile Thr Pro Met Met Gly Val35 40 45Leu Asp Gly Val Leu Met Glu Leu Gln Asp Cys Ala Leu Pro Leu Leu50 55 60Lys Asp Val Ile Ala Thr Asp Lys Glu Asp Val Ala Phe Lys Asp Leu65 70 75 80Asp Val Ala Ile Leu Val Gly Ser Met Pro Arg Arg Glu Gly Met Glu85 90 95
Arg Lys Asp Leu Leu Lys Ala Asn Val Lys Ile Phe Lys Ser Gln Gly100 105 110Ala Ala Leu Asp Lys Tyr Ala Lys Lys Ser Val Lys Val Ile Val Val115 120 125Gly Asn Pro Ala Asn Thr Asn Cys Leu Thr Ala Ser Lys Ser Ala Pro130 135 140Ser Ile Pro Lys Glu Asn Phe Ser Cys Leu Thr Arg Leu Asp His Asn145 150 155 160Arg Ala Lys Ala Gln Ile Ala Leu Lys Leu Gly Val Thr Ala Asn Asp165 170 175Val Lys Asn Val Ile Ile Trp Gly Asn His Ser Ser Thr Gln Tyr Pro180 185 190Asp Val Asn His Ala Lys Val Lys Leu Gln Gly Lys Glu Val Gly Val195 200 205Tyr Glu Ala Leu Lys Asp Asp Ser Trp Leu Lys Gly Glu Phe Val Thr210 215 220Thr Val Gln Gln Arg Gly Ala Ala Val Ile Lys Ala Arg Lys Leu Ser225 230 235 240Ser Ala Met Ser Ala Ala Lys Ala Ile Cys Asp His Val Arg Asp Ile245 250 255Trp Phe Gly Thr Pro Glu Gly Glu Phe Val Ser Met Gly Val Ile Ser260 265 270Asp Gly Asn Ser Tyr Gly Val Pro Asp Asp Leu Leu Tyr Ser Phe Pro275 280 285Val Val Ile Lys Asn Lys Thr Trp Lys Phe Val Glu Gly Leu Pro Ile290 295 300Asn Asp Phe Ser Arg Glu Lys Met Asp Leu Thr Ala Lys Glu Leu Thr305 310 315 320Glu Glu Lys Glu Ser Ala Phe Glu Phe Leu Ser Ser Ala325 330<210>49
<211>152<212>PRT<213>人<300>
<308>sw_hum/ndka_human<309>1990-04-01<400>49Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val1 5 10 15Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly20 25 30Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu35 40 45Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu50 55 60Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly65 70 75 80Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro85 90 95Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val100 105 110Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys115 120 125Glu Ile Gly Leu Trp Phe His Pro Glu Glu Leu Val Asp Tyr Thr Ser130 135 140Cys Ala Gln Asn Trp Ile Tyr Glu145 150<210>50<211>394<212>PRT<213>人<300>
<308>sw_hum/ndr1_human<309>1999-07-15<400>50
Met Ser Arg Glu Met Gln Asp Val Asp Leu Ala Glu Val Lys Pro Leu1 5 10 15Val Glu Lys Gly Glu Thr Ile Thr Gly Leu Leu Gln Glu Phe Asp Val20 25 30Gln Glu Gln Asp Ile Glu Thr Leu His Gly Ser Val His Val Thr Leu35 40 45Cys Gly Thr Pro Lys Gly Asn Arg Pro Val Ile Leu Thr Tyr His Asp50 55 60Ile Gly Met Asn His Lys Thr Cys Tyr Asn Pro Leu Phe Asn Tyr Glu65 70 75 80Asp Met Gln Glu Ile Thr Gln His Phe Ala Val Cys His Val Asp Ala85 90 95Pro Gly Gln Gln Asp Gly Ala Ala Ser Phe Pro Ala Gly Tyr Met Tyr100 105 110Pro Ser Met Asp Gln Leu Ala Glu Met Leu Pro Gly Val Leu Gln Gln115 120 125Phe Gly Leu Lys Ser Ile Ile Gly Met Gly Thr Gly Ala Gly Ala Tyr130 135 140Ile Leu Thr Arg Phe Ala Leu Asn Asn Pro Glu Met Val Glu Gly Leu145 150 155 160Val Leu Ile Asn Val Asn Pro Cys Ala Glu Gly Trp Met Asp Trp Ala165 170 175Ala Ser Lys Ile Ser Gly Trp Thr Gln Ala Leu Pro Asp Met Val Val180 185 190Ser His Leu Phe Gly Lys Glu Glu Met Gln Ser Asn Val Glu Val Val195 200 205His Thr Tyr Arg Gln His Ile Val Asn Asp Met Asn Pro Gly Asn Leu210 215 220His Leu Phe Ile Asn Ala Tyr Asn Ser Arg Arg Asp Leu Glu Ile Glu225 230 235 240Arg Pro Met Pro Gly Thr His Thr Val Thr Leu Gln Cys Pro Ala Leu245 250 255
Leu Val Val Gly Asp Ser Ser Pro Ala Val Asp Ala Val Val Glu Cys260 265 270Asn Ser Lys Leu Asp Pro Thr Lys Thr Thr Leu Leu Lys Met Ala Asp275 280 285Cys Gly Gly Leu Pro Gln Ile Ser Gln Pro Ala Lys Leu Ala Glu Ala290 295 300Phe Lys Tyr Phe Val Gln Gly Met Gly Tyr Met Pro Ser Ala Ser Met305 310 315 320Thr Arg Leu Met Arg Ser Arg Thr Ala Ser Gly Ser Ser Val Thr Ser325 330 335Leu Asp Gly Thr Arg Ser Arg Ser His Thr Ser Glu Gly Thr Arg Ser340 345 350Arg Ser His Thr Ser Glu Gly Thr Arg Ser Arg Ser His Thr Ser Glu355 360 365Gly Ala His Leu Asp Ile Thr Pro Asn Ser Gly Ala Ala Gly Asn Ser370 375 380Ala Gly Pro Lys Ser Met Glu Val Ser Cys385 390<210>51<211>261<212>PRT<213>人<300>
<308>sw_hum/pcna_human<309>1989-10-01<400>51Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu1 5 10 15Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser20 25 30Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val35 40 45Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg
50 55 60Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys65 70 75 80Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala85 90 95Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser100 105 110Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile115 120 125Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe130 135 140Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile145 150 155 160Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly165 170 175Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu180 185 190Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala195 200 205Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr210 215 220Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys225 230 235 240Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu245 250 255Asp Glu Glu Gly Ser260<210>52<211>417<212>PRT<213>人<300>
<308>sw_hum/pgk1_human
<309>1986-07-21<400>52Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly Lys1 5 10 15Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn Gln20 25 30Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys Phe35 40 45Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met Ser His Leu Gly50 55 60Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro Val65 70 75 80Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu Lys85 90 95Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala Asn Pro Ala Ala100 105 110Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu Glu115 120 125Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro Ala130 135 140Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val Tyr145 150 155 160Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met Val165 170 175Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys Glu180 185 190Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe Leu195 200 205Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile Asn210 215 220Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met Ala225 230 235 240
Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser Leu245 250 255Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Ser Lys Ala260 265 270Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr Ala275 280 285Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala Ser290 295 300Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu Ser Ser305 310 315 320Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln Ile Val Trp Asn325 330 335Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr Lys340 345 350Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile Thr355 360 365Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn Thr370 375 380Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu Glu385 390 395 400Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser Asn Ile405 410 415Leu<210>53<211>418<212>PRT<213>人<300>
<308>sw_hum/prs6_human<309>1995-11-01<400>53Met Glu Glu Ile Gly Ile Leu Val Glu Lys Ala Gln Asp Glu Ile Pro
1 5 10 15Ala Leu Ser Val Ser Arg Pro Gln Thr Gly Leu Ser Phe Leu Gly Pro20 25 30Glu Pro Glu Asp Leu Glu Asp Leu Tyr Ser Arg Tyr Lys Lys Leu Gln35 40 45Gln Glu Leu Glu Phe Leu Glu Val Gln Glu Glu Tyr Ile Lys Asp Glu50 55 60Gln Lys Asn Leu Lys Lys Glu Phe Leu His Ala Gln Glu Glu Val Lys65 70 75 80Arg Ile Gln Ser Ile Pro Leu Val Ile Gly Gln Phe Leu Glu Ala Val85 90 95Asp Gln Asn Thr Ala Ile Val Gly Ser Thr Thr Gly Ser Asn Tyr Tyr100 105 110Val Arg Ile Leu Ser Thr Ile Asp Arg Glu Leu Leu Lys Pro Asn Ala115 120 125Ser Val Ala Leu His Lys His Ser Asn Ala Leu Val Asp Val Leu Pro130 135 140Pro Glu Ala Asp Ser Ser Ile Met Met Leu Thr Ser Asp Gln Lys Pro145 150 155 160Asp Val Met Tyr Ala Asp Ile Gly Gly Met Asp Ile Gln Lys Gln Glu165 170 175Val Arg Glu Ala Val Glu Leu Pro Leu Thr His Phe Glu Leu Tyr Lys180 185 190Gln Ile Gly Ile Asp Pro Pro Arg Gly Val Leu Met Tyr Gly Pro Pro195 200 205Gly Cys Gly Lys Thr Met Leu Ala Lys Ala Val Ala His His Thr Thr210 215 220Ala Ala Phe Ile Arg Val Val Gly Ser Glu Phe Val Gln Lys Tyr Leu225 230 235 240Gly Glu Gly Pro Arg Met Val Arg Asp Val Phe Arg Leu Ala Lys Glu245 250 255
Asn Ala Pro Ala Ile Ile Phe Ile Asp Glu Ile Asp Ala Ile Ala Thr260 265 270Lys Arg Phe Asp Ala Gln Thr Gly Ala Asp Arg Glu Val Gln Arg Ile275 280 285Leu Leu Glu Leu Leu Asn Gln Met Asp Gly Phe Asp Gln Asn Val Asn290 295 300Val Lys Val Ile Met Ala Thr Asn Arg Ala Asp Thr Leu Asp Pro Ala305 310 315 320Leu Leu Arg Pro Gly Arg Leu Asp Arg Lys Ile Glu Phe Pro Leu Pro325 330 335Asp Arg Arg Gln Lys Arg Leu Ile Phe Ser Thr Ile Thr Ser Lys Met340 345 350Asn Leu Ser Glu Glu Val Asp Leu Glu Asp Tyr Val Ala Arg Pro Asp355 360 365Lys Ile Ser Gly Ala Asp Ile Asn Ser Ile Cys Gln Glu Ser Gly Met370 375 380Leu Ala Val Arg Glu Asn Arg Tyr Ile Val Leu Ala Lys Asp Phe Glu385 390 395 400Lys Ala Tyr Lys Thr Val Ile Lys Lys Asp Glu Gln Glu His Glu Phe405 410 415Tyr Lys<210>54<211>277<212>PRT<213>人<300>
<308>sw_hum/psb7_human<309>2001-10-16<400>54Met Ala Ala Val Ser Val Tyr Ala Pro Pro Val Gly Gly Phe Ser Phe1 5 10 15Asp Asn Cys Arg Arg Asn Ala Val Leu Glu Ala Asp Phe Ala Lys Arg20 25 30
Gly Tyr Lys Leu Pro Lys Val Arg Lys Thr Gly Thr Thr Ile Ala Gly35 40 45Val Val Tyr Lys Asp Gly Ile Val Leu Gly Ala Asp Thr Arg Ala Thr50 55 60Glu Gly Met Val Val Ala Asp Lys Asn Cys Ser Lys Ile His Phe Ile65 70 75 80Ser Pro Asn Ile Tyr Cys Cys Gly Ala Gly Thr Ala Ala Asp Thr Asp85 90 95Met Thr Thr Gln Leu Ile Ser Ser Asn Leu Glu Leu His Ser Leu Ser100 105 110Thr Gly Arg Leu Pro Arg Val Val Thr Ala Asn Arg Met Leu Lys Gln115 120 125Met Leu Phe Arg Tyr Gln Gly Tyr Ile Gly Ala Ala Leu Val Leu Gly130 135 140Gly Val Asp Val Thr Gly Pro His Leu Tyr Ser Ile Tyr Pro His Gly145 150 155 160Ser Thr Asp Lys Leu Pro Tyr Val Thr Met Gly Ser Gly Ser Leu Ala165 170 175Ala Met Ala Val Phe Glu Asp Lys Phe Arg Pro Asp Met Glu Glu Glu180 185 190Glu Ala Lys Asn Leu Val Ser Glu Ala Ile Ala Ala Gly Ile Phe Asn195 200 205Asp Leu Gly Ser Gly Ser Asn Ile Asp Leu Cys Val Ile Ser Lys Asn210 215 220Lys Leu Asp Phe Leu Arg Pro Tyr Thr Val Pro Asn Lys Lys Gly Thr225 230 235 240Arg Leu Gly Arg Tyr Arg Cys Glu Lys Gly Thr Thr Ala Val Leu Thr245 250 255Glu Lys Ile Thr Pro Leu Glu Ile Glu Val Leu Glu Glu Thr Val Gln260 265 270
Thr Met Asp Thr Ser275<210>55<211>409<212>PRT<213>人<300>
<308>sw_hum/r23b_human<309>1996-10-01<400>55Met Gln Val Thr Leu Lys Thr Leu Gln Gln Gln Thr Phe Lys Ile Asp1 5 10 15Ile Asp Pro Glu Glu Thr Val Lys Ala Leu Lys Glu Lys Ile Glu Ser20 25 30Glu Lys Gly Lys Asp Ala Phe Pro Val Ala Gly Gln Lys Leu Ile Tyr35 40 45Ala Gly Lys Ile Leu Asn Asp Asp Thr Ala Leu Lys Glu Tyr Lys Ile50 55 60Asp Glu Lys Asn Phe Val Val Val Met Val Thr Lys Pro Lys Ala Val65 70 75 80Ser Thr Pro Ala Pro Ala Thr Thr Gln Gln Ser Ala Pro Ala Ser Thr85 90 95Thr Ala Val Thr Ser Ser Thr Thr Thr Thr Val Ala Gln Ala Pro Thr100 105 110Pro Val Pro Ala Leu Ala Pro Thr Ser Thr Pro Ala Ser Ile Thr Pro115 120 125Ala Ser Ala Thr Ala Ser Ser Glu Pro Ala Pro Ala Ser Ala Ala Lys130 135 140Gln Glu Lys Pro Ala Glu Lys Pro Ala Glu Thr Pro Val Ala Thr Ser145 150 155 160Pro Thr Ala Thr Asp Ser Thr Ser Gly Asp Ser Ser Arg Ser Asn Leu165 170 175Phe Glu Asp Ala Thr Ser Ala Leu Val Thr Gly Gln Ser Tyr Glu Asn180 185 190
Met Val Thr Glu Ile Met Ser Met Gly Tyr Glu Arg Glu Gln Val Ile195 200 205Ala Ala Leu Arg Ala Ser Phe Asn Asn Pro Asp Arg Ala Val Glu Tyr210 215 220Leu Leu Met Gly Ile Pro Gly Asp Arg Glu Ser Gln Ala Val Val Asp225 230 235 240Pro Pro Gln Ala Ala Ser Thr Gly Ala Pro Gln Ser Ser Ala Val Ala245 250 255Ala Ala Ala Ala Thr Thr Thr Ala Thr Thr Thr Thr Thr Ser Ser Gly260 265 270Gly His Pro Leu Glu Phe Leu Arg Asn Gln Pro Gln Phe Gln Gln Met275 280 285Arg Gln Ile Ile Gln Gln Asn Pro Ser Leu Leu Pro Ala Leu Leu Gln290 295 300Gln Ile Gly Arg Glu Asn Pro Gln Leu Leu Gln Gln Ile Ser Gln His305 310 315 320Gln Glu His Phe Ile Gln Met Leu Asn Glu Pro Val Gln Glu Ala Gly325 330 335Gly Gln Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Ala Glu Ala340 345 350Gly Ser Gly His Met Asn Tyr Ile Gln Val Thr Pro Gln Glu Lys Glu355 360 365Ala Ile Glu Arg Leu Lys Ala Leu Gly Phe Pro Glu Gly Leu Val Ile370 375 380Gln Ala Tyr Phe Ala Cys Glu Lys Asn Glu Asn Leu Ala Ala Asn Phe385 390 395 400Leu Leu Gln Gln Asn Phe Asp Glu Asp405<2l0>56<211>306<212>PRT<213>人
<300>
<308>sw_hum/roc_human<309>1988-08-01<400>56Met Ala Ser Asn Val Thr Asn Lys Thr Asp Pro Arg Ser Met Asn Ser1 5 10 15Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp20 25 30Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Val Gly Cys Ser Val35 40 45His Lys Gly Phe Ala Phe Val Gln Tyr Val Asn Glu Arg Asn Ala Arg50 55 60Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Gly Gln Val Leu65 70 75 80Asp Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Lys Ala Gly85 90 95Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Val Thr Glu His Pro100 105 110Ser Pro Ser Pro Leu Leu Ser Ser Ser Phe Asp Leu Asp Tyr Asp Phe115 120 125Gln Arg Asp Tyr Tyr Asp Arg Met Tyr Ser Tyr Pro Ala Arg Val Prol30 l35 l40Pro Pro Pro Pro Ile Ala Arg Ala Val Val Pro Ser Lys Arg Gln Arg145 150 155 160Val Ser Gly Asn Thr Ser Arg Arg Gly Lys Ser Gly Phe Asn Ser Lys165 170 175Ser Gly Gln Arg Gly Ser Ser Lys Ser Gly Lys Leu Lys Gly Asp Asp180 185 190Leu Gln Ala Ile Lys Lys Glu Leu Thr Gln Ile Lys Gln Lys Val Asp195 200 205Ser Leu Leu Glu Asn Leu Glu Lys Met Glu Lys Glu Gln Ser Lys Gln210 215 220
Ala Val Glu Met Lys Asn Asp Lys Ser Glu Glu Glu Gln Ser Ser Ser225 230 235 240Ser Val Lys Lys Asp Glu Thr Asn Val Lys Met Glu Ser Glu Gly Gly245 250 255Ala Asp Asp Ser Ala Glu Glu Gly Asp Leu Leu Asp Asp Asp Asp Asn260 265 270Glu Asp Arg Gly Asp Asp Gln Leu Glu Leu Ile Lys Asp Asp Glu Lys275 280 285Glu Ala Glu Glu Gly Glu Asp Asp Arg Asp Ser Ala Asn Gly Glu Asp290 295 300Asp Ser305<210>57<211>449<212>PRT<213>人<300>
<308>sw_hum/roh2_human<309>1997-11-01<400>57Met Met Leu Ser Thr Glu Gly Arg Glu Gly Phe Val Val Lys Val Arg1 5 10 15Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Met Arg Phe Phe Ser20 25 30Asp Cys Lys Ile Gln Asn Gly Thr Ser Gly Ile Arg Phe Ile Tyr Thr35 40 45Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu50 55 60Glu Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His65 70 75 80Arg Tyr Val Glu Val Phe Lys Ser Asn Ser Val Glu Met Asp Trp Val85 90 95Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe100 105 110
Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val115 120 125Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Met Thr Leu Pro130 135 140Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala145 150 155 160Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile165 170 175Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg180 185 190Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly195 200 205Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg210 215 220Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr225 230 235 240Gly Gly Tyr Asp Asp Tyr Gly Gly Tyr Asn Asp Gly Tyr Gly Phe Gly245 250 255Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser260 265 270Asp His Arg Tyr Gly Asp Gly Gly Ser Ser Phe Gln Ser Thr Thr Gly275 280 285His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp290 295 300Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Met Arg Val His Ile Glu305 310 315 320Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala325 330 335Thr His Glu Asp Ala Val Ala Ala Met Ala Lys Asp Lys Ala Asn Met340 345 350Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Thr Ser
355 360 365Gly Gly Ala Tyr Asp His Ser Tyr Val Glu Leu Phe Leu Asn Ser Thr370 375 380Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met385 390 395 400Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu405 410 415Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly420 425 430Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Tyr Gln Ser Asn Leu435 440 445Ala<210>58<211>346<212>PRT<213>人<300>
<308>sw_hum/roh3_human<309>1993-07-01<400>58Met Asp Trp Val Met Lys His Asn Gly Pro Asn Asp Ala Ser Asp Gly1 5 10 15Thr Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile20 25 30Val Gln Phe Phe Gln Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu35 40 45Thr Met Asp Tyr Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe50 55 60Ala Ser Lys Glu Ile Ala Glu Asn Ala Leu Gly Lys His Lys Glu Arg65 70 75 80Ile Gly His Arg Tyr Ile Glu Ile Phe Arg Ser Ser Arg Ser Glu Ile85 90 95
Lys Gly Phe Tyr Asp Pro Pro Arg Arg Leu Leu Gly Gln Arg Pro Gly100 105 110Pro Tyr Asp Arg Pro Ile Gly Gly Arg Gly Gly Tyr Tyr Gly Ala Gly115 120 125Arg Gly Ser Met Tyr Asp Arg Met Arg Arg Gly Gly Asp Gly Tyr Asp130 135 140Gly Gly Tyr Gly Gly Phe Asp Asp Tyr Gly Gly Tyr Asn Asn Tyr Gly145 150 155 160Tyr Gly Asn Asp Gly Phe Asp Asp Arg Met Arg Asp Gly Arg Gly Met165 170 175Gly Gly His Gly Tyr Gly Gly Ala Gly Asp Ala Ser Ser Gly Phe His180 185 190Gly Gly His Phe Val His Met Arg Gly Leu Pro Phe Arg Ala Thr Glu195 200 205Asn Asp Ile Ala Asn Phe Phe Ser Pro Leu Asn Pro Ile Arg Val His210 215 220Ile Asp Ile Gly Ala Asp Gly Arg Ala Thr Gly Glu Ala Asp Val Glu225 230 235 240Phe Val Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Asn245 250 255Asn Met Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Pro Gly260 265 270Gly Gly Ser Gly Met Gly Gly Ser Gly Met Gly Gly Tyr Gly Arg Asp275 280 285Gly Met Asp Asn Gln Gly Gly Tyr Gly Ser Val Gly Arg Met Gly Met290 295 300Gly Asn Asn Tyr Ser Gly Gly Tyr Gly Thr Pro Asp Gly Leu Gly Gly305 310 315 320Tyr Gly Arg Gly Gly Gly Gly Ser Gly Gly Tyr Tyr Gly Gln Gly Gly325 330 335Met Ser Gly Gly Gly Trp Arg Gly Met Tyr340 345
<210>59<211>322<212>PRT<213>人<300>
<308>sw_hum/sc13_human<309>1997-11-01<400>59Met Val Ser Val Ile Asn Thr Val Asp Thr Ser His Glu Asp Met Ile1 5 10 15His Asp Ala Gln Met Asp Tyr Tyr Gly Thr Arg Leu Ala Thr Cys Ser20 25 30Ser Asp Arg Ser Val Lys Ile Phe Asp Val Arg Asn Gly Gly Gln Ile35 40 45Leu Ile Val Asp Leu Arg Gly His Glu Gly Pro Val Trp Gln Val Ala50 55 60Trp Ala His Pro Met Tyr Gly Asn Ile Leu Ala Ser Cys Ser Tyr Asp65 70 75 80Arg Lys Val Ile Ile Trp Arg Glu Glu Asn Gly Thr Trp Glu Lys Ser85 90 95His Glu His Ala Gly His Asp Ser Ser Val Asn Ser Val Cys Trp Ala100 105 110Pro His Asp Tyr Gly Leu Ile Leu Ala Cys Gly Ser Ser Asp Gly Ala115 120 125Ile Ser Leu Leu Thr Tyr Thr Gly Glu Gly Gln Trp Glu Val Lys Lys130 135 140Ile Asn Asn Ala His Thr Ile Gly Cys Asn Ala Val Ser Trp Ala Pro145 150 155 160Ala Val Val Pro Gly Ser Leu Ile Asp His Pro Ser Gly Gln Lys Pro165 170 175Asn Tyr Ile Lys Arg Phe Ala Ser Gly Gly Cys Asp Asn Leu Ile Lys180 185 190Leu Trp Lys Glu Glu Glu Asp Gly Gln Trp Lys Glu Glu Gln Lys Leu
195 200 205Glu Ala His Ser Asp Trp Val Arg Asp Val Ala Trp Ala Pro Ser Ile210 215 220Gly Leu Pro Thr Ser Thr Ile Ala Ser Cys Ser Gln Asp Gly Arg Val225 230 235 240Phe Ile Trp Thr Cys Asp Asp Ala Ser Ser Asn Thr Trp Ser Pro Lys245 250 255Leu Leu His Lys Phe Asn Asp Val Val Trp His Val Ser Trp Ser Ile260 265 270Thr Ala Asn Ile Leu Ala Val Ser Gly Gly Asp Asn Lys Val Thr Leu275 280 285Trp Lys Glu Ser Val Asp Gly Gln Trp Val Cys Ile Ser Asp Val Asn290 295 300Lys Gly Gln Gly Ser Val Ser Ala Ser Val Thr Glu Gly Gln Gln Asn305 310 315 320Glu Gln<210>60<211>295<212>PRT<213>人<300>
<308>sw_hum/snaa_human<309>1996-10-01<400>60Met Asp Asn Ser Gly Lys Glu Ala Glu Ala Met Ala Leu Leu Ala Glu1 5 10 15Ala Glu Arg Lys Val Lys Asn Ser Gln Ser Phe Phe Ser Gly Leu Phe20 25 30Gly Gly Ser Ser Lys Ile Glu Glu Ala Cys Glu Ile Tyr Ala Arg Ala35 40 45Ala Asn Met Phe Lys Met Ala Lys Asn Trp Ser Ala Ala Gly Asn Ala50 55 60
Phe Cys Gln Ala Ala Gln Leu His Leu Gln Leu Gln Ser Lys His Asp65 70 75 80Ala Ala Thr Cys Phe Val Asp Ala Gly Asn Ala Phe Lys Lys Ala Asp85 90 95Pro Gln Glu Ala Ile Asn Cys Leu Met Arg Ala Ile Glu Ile Tyr Thr100 105 110Asp Met Gly Arg Phe Thr Ile Ala Ala Lys His His Ile Ser Ile Ala115 120 125Glu Ile Tyr Glu Thr Glu Leu Val Asp Ile Glu Lys Ala Ile Ala His130 135 140Tyr Glu Gln Ser Ala Asp Tyr Tyr Lys Gly Glu Glu Ser Asn Ser Ser145 150 155 160Ala Asn Lys Cys Leu Leu Lys Val Ala Gly Tyr Ala Ala Leu Leu Glu165 170 175Gln Tyr Gln Lys Ala Ile Asp Ile Tyr Glu Gln Val Gly Thr Asn Ala180 185 190Met Asp Thr Pro Leu Leu Lys Tyr Ser Ala Lys Asp Tyr Phe Phe Lys195 200 205Ala Ala Leu Cys His Phe Cys Ile Asp Met Leu Asn Ala Lys Leu Ala210 215 220Val Gln Lys Tyr Glu Glu Leu Phe Pro Ala Phe Ser Asp Ser Arg Glu225 230 235 240Cys Lys Leu Met Lys Lys Leu Leu Glu Ala His Glu Glu Gln Asn Val245 250 255Asp Ser Tyr Thr Glu Ser Val Lys Glu Tyr Asp Ser Ile Ser Arg Leu260 265 270Asp Gln Trp Leu Thr Thr Met Leu Leu Arg Ile Lys Lys Thr Ile Gln275 280 285Gly Asp Glu Glu Asp Leu Arg290 295<210>61<211>302
<212>PRT<213>人<300>
<308>sw_hum/spee_human<309>1991-02-01<400>61Met Glu Pro Gly Pro Asp Gly Pro Ala Ala Ser Gly Pro Ala Ala Ile1 5 10 15Arg Glu Gly Trp Phe Arg Glu Thr Cys Ser Leu Trp Pro Gly Gln Ala20 25 30Leu Ser Leu Gln Val Glu Gln Leu Leu His His Arg Arg Ser Arg Tyr35 40 45Gln Asp Ile Leu Val Phe Arg Ser Lys Thr Tyr Gly Asn Val Leu Val50 55 60Leu Asp Gly Val Ile Gln Cys Thr Glu Arg Asp Glu Phe Ser Tyr Gln65 70 75 80Glu Met Ile Ala Asn Leu Pro Leu Cys Ser His Pro Asn Pro Arg Lys85 90 95Val Leu Ile Ile Gly Gly Gly Asp Gly Gly Val Leu Arg Glu Val Val100 105 110Lys His Pro Ser Val Glu Ser Val Val Gln Cys Glu Ile Asp Glu Asp115 120 125Val Ile Gln Val Ser Lys Lys Phe Leu Pro Gly Met Ala Ile Gly Tyr130 135 140Ser Ser Ser Lys Leu Thr Leu His Val Gly Asp Gly Phe Glu Phe Met145 150 155 160Lys Gln Asn Gln Asp Ala Phe Asp Val Ile Ile Thr Asp Ser Ser Asp165 170 175Pro Met Gly Pro Ala Glu Ser Leu Phe Lys Glu Ser Tyr Tyr Gln Leu180 185 190Met Lys Thr Ala Leu Lys Glu Asp Gly Val Leu Cys Cys Gln Gly Glu195 200 205Cys Gln Trp Leu His Leu Asp Leu Ile Lys Glu Met Arg Gln Phe Cys
210 215 220Gln Ser Leu Phe Pro Val Val Ala Tyr Ala Tyr Cys Thr Ile Pro Thr225 230 235 240Tyr Pro Ser Gly Gln Ile Gly Phe Met Leu Cys Ser Lys Asn Pro Ser245 250 255Thr Asn Phe Gln Glu Pro Val Gln Pro Leu Thr Gln Gln Gln Val Ala260 265 270Gln Met Gln Leu Lys Tyr Tyr Asn Ser Asp Val His Arg Ala Ala Phe275 280 285Val Leu Pro Glu Phe Ala Arg Lys Ala Leu Asn Asp Val Ser290 295 300<210>62<211>623<212>PRT<213>人<300>
<308>sw_hum/tkt_human<309>1992-12-01<400>62Met Glu Ser Tyr His Lys Pro Asp Gln Gln Lys Leu Gln Ala Leu Lys1 5 10 15Asp Thr Ala Asn Arg Leu Arg Ile Ser Ser Ile Gln Ala Thr Thr Ala20 25 30Ala Gly Ser Gly His Pro Thr Ser Cys Cys Ser Ala Ala Glu Ile Met35 40 45Ala Val Leu Phe Phe His Thr Met Arg Tyr Lys Ser Gln Asp Pro Arg50 55 60Asn Pro His Asn Asp Arg Phe Val Leu Ser Lys Gly His Ala Ala Pro65 70 75 80Ile Leu Tyr Ala Val Trp Ala Glu Ala Gly Phe Leu Ala Glu Ala Glu85 90 95Leu Leu Asn Leu Arg Lys Ile Ser Ser Asp Leu Asp Gly His Pro Val100 105 110
Pro Lys Gln Ala Phe Thr Asp Val Ala Thr Gly Ser Leu Gly Gln Gly115 120 125Leu Gly Ala Ala Cys Gly Met Ala Tyr Thr Gly Lys Tyr Phe Asp Lys130 135 140Ala Ser Tyr Arg Val Tyr Cys Leu Leu Gly Asp Gly Glu Leu Ser Glu145 150 155 160Gly Ser Val Trp Glu Ala Met Ala Phe Ala Ser Ile Tyr Lys Leu Asp165 170 175Asn Leu Val Ala Ile Leu Asp Ile Asn Arg Leu Gly Gln Ser Asp Pro180 185 190Ala Pro Leu Gln His Gln Met Asp Ile Tyr Gln Lys Arg Cys Glu Ala195 200 205Phe Gly Trp His Ala Ile Ile Val Asp Gly His Ser Val Glu Glu Leu210 215 220Cys Lys Ala Phe Gly Gln Ala Lys His Gln Pro Thr Ala Ile Ile Ala225 230 235 240Lys Thr Phe Lys Gly Arg Gly Ile Thr Gly Val Glu Asp Lys Glu Ser245 250 255Trp His Gly Lys Pro Leu Pro Lys Asn Met Ala Glu Gln Ile Ile Gln260 265 270Glu Ile Tyr Ser Gln Ile Gln Ser Lys Lys Lys Ile Leu Ala Thr Pro275 280 285Pro Gln Glu Asp Ala Pro Ser Val Asp Ile Ala Asn Ile Arg Met Pro290 295 300Ser Leu Pro Ser Tyr Lys Val Gly Asp Lys Ile Ala Thr Arg Lys Ala305 310 315 320Tyr Gly Gln Ala Leu Ala Lys Leu Gly His Ala Ser Asp Arg Ile Ile325 330 335Ala Leu Asp Gly Asp Thr Lys Asn Ser Thr Phe Ser Glu Ile Phe Lys340 345 350Lys Glu His Pro Asp Arg Phe Ile Glu Cys Tyr Ile Ala Glu Gln Asn355 360 365
Met Val Ser Ile Ala Val Gly Cys Ala Thr Arg Asn Arg Thr Val Pro370 375 380Phe Cys Ser Thr Phe Ala Ala Phe Phe Thr Arg Ala Phe Asp Gln Ile385 390 395 400Arg Met Ala Ala Ile Ser Glu Ser Asn Ile Asn Leu Cys Gly Ser His405 410 415Cys Gly Val Ser Ile Gly Glu Asp Gly Pro Ser Gln Met Ala Leu Glu420 425 430Asp Leu Ala Met Phe Arg Ser Val Pro Thr Ser Thr Val Phe Tyr Pro435 440 445Ser Asp Gly Val Ala Thr Glu Lys Ala Val Glu Leu Ala Ala Asn Thr450 455 460Lys Gly Ile Cys Phe Ile Arg Thr Ser Arg Pro Glu Asn Ala Ile Ile465 470 475 480Tyr Asn Asn Asn Glu Asp Phe Gln Val Gly Gln Ala Lys Val Val Leu485 490 495Lys Ser Lys Asp Asp Gln Val Thr Val Ile Gly Ala Gly Val Thr Leu500 505 510His Glu Ala Leu Ala Ala Ala Glu Leu Leu Lys Lys Glu Lys Ile Asn5l5 520 525Ile Arg Val Leu Asp Pro Phe Thr Ile Lys Pro Leu Asp Arg Lys Leu530 535 540Ile Leu Asp Ser Ala Arg Ala Thr Lys Gly Arg Ile Leu Thr Val Glu545 550 555 560Asp His Tyr Tyr Glu Gly Gly Ile Gly Glu Ala Val Ser Ser Ala Val565 570 575Val Gly Glu Pro Gly Ile Thr Val Thr His Leu Ala Val Asn Arg Val580 585 590Pro Arg Ser Gly Lys Pro Ala Glu Leu Leu Lys Met Phe Gly Ile Asp595 600 605
Arg Asp Ala Ile Ala Gln Ala Val Arg Gly Leu Ile Thr Lys Ala610 615 620<210>63<211>1058<212>PRT<213>人<300>
<308>w_hum/ubal_human<309>1991-08-01<400>63Met Ser Ser Ser Pro Leu Ser Lys Lys Arg Arg Val Ser Gly Pro Asp1 5 10 15Pro Lys Pro Gly Ser Asn Cys Ser Pro Ala Gln Ser Val Leu Ser Glu20 25 30Val Pro Ser Val Pro Thr Asn Gly Met Ala Lys Asn Gly Ser Glu Ala35 40 45Asp Ile Asp Glu Gly Leu Tyr Ser Arg Gln Leu Tyr Val Leu Gly His50 55 60Glu Ala Met Lys Arg Leu Gln Thr Ser Ser Val Leu Val Ser Gly Leu65 70 75 80Arg Gly Leu Gly Val Glu Ile Ala Lys Asn Ile Ile Leu Gly Gly Val85 90 95Lys Ala Val Thr Leu His Asp Gln Gly Thr Ala Gln Trp Ala Asp Leu100 105 110Ser Ser Gln Phe Tyr Leu Arg Glu Glu Asp Ile Gly Lys Asn Arg Ala115 120 125Glu Val Ser Gln Pro Arg Leu Ala Glu Leu Asn Ser Tyr Val Pro Val130 135 140Thr Ala Tyr Thr Gly Pro Leu Val Glu Asp Phe Leu Ser Gly Phe Gln145 150 155 160Val Val Val Leu Thr Asn Thr Pro Leu Glu Asp Gln Leu Arg Val Gly165 170 175Glu Phe Cys His Asn Arg Gly Ile Lys Leu Val Val Ala Asp Thr Arg180 185 190
Gly Leu Phe Gly Gln Leu Phe Cys Asp Phe Gly Glu Glu Met Ile Leu195 200 205Thr Asp Ser Asn Gly Glu Gln Pro Leu Ser Ala Met Val Ser Met Val210 215 220Thr Lys Asp Asn Pro Gly Val Val Thr Cys Leu Asp Glu Ala Arg His225 230 235 240Gly Phe Glu Ser Gly Asp Phe Val Ser Phe Ser Glu Val Gln Gly Met245 250 255Val Glu Leu Asn Gly Asn Gln Pro Met Glu Ile Lys Val Leu Gly Pro260 265 270Tyr Thr Phe Ser Ile Cys Asp Thr Ser Asn Phe Ser Asp Tyr Ile Arg275 280 285Gly Gly Ile Val Ser Gln Val Lys Val Pro Lys Lys Ile Ser Phe Lys290 295 300Ser Leu Val Ala Ser Leu Ala Glu Pro Asp Phe Val Val Thr Asp Phe305 310 315 320Ala Lys Phe Ser Arg Pro Ala Gln Leu His Ile Gly Phe Gln Ala Leu325 330 335His Gln Phe Cys Ala Gln His Gly Arg Pro Pro Arg Pro Arg Asn Glu340 345 350Glu Asp Ala Ala Glu Leu Val Ala Leu Ala Gln Ala Val Asn Ala Arg355 360 365Ala Leu Pro Ala Val Gln Gln Asn Asn Leu Asp Glu Asp Leu Ile Arg370 375 380Lys Leu Ala Tyr Val Ala Ala Gly Asp Leu Ala Pro Ile Asn Ala Phe385 390 395 400Ile Gly Gly Leu Ala Ala Gln Glu Val Met Lys Ala Cys Ser Gly Lys405 410 415Phe Met Pro Ile Met Gln Trp Leu Tyr Phe Asp Ala Leu Glu Cys Leu420 425 430Pro Glu Asp Lys Glu Val Leu Thr Glu Asp Lys Cys Leu Gln Arg Gln
435 440 445Asn Arg Tyr Asp Gly Gln Val Ala Val Phe Gly Ser Asp Leu Gln Glu450 455 460Lys Leu Gly Lys Gln Lys Tyr Phe Leu Val Gly Ala Gly Ala Ile Gly465 470 475 480Cys Glu Leu Leu Lys Asn Phe Ala Met Ile Gly Leu Gly Cys Gly Glu485 490 495Gly Gly Glu Ile Ile Val Thr Asp Met Asp Thr Ile Glu Lys Ser Asn500 505 510Leu Asn Arg Gln Phe Leu Phe Arg Pro Trp Asp Val Thr Lys Leu Lys515 520 525Ser Asp Thr Ala Ala Ala Ala Val Arg Gln Met Asn Pro His Ile Arg530 535 540Val Thr Ser His Gln Asn Arg Val Gly Pro Asp Thr Glu Arg Ile Tyr545 550 555 560Asp Asp Asp Phe Phe Gln Asn Leu Asp Gly Val Ala Asn Ala Leu Asp565 570 575Asn Val Asp Ala Arg Met Tyr Met Asp Arg Arg Cys Val Tyr Tyr Arg580 585 590Lys Pro Leu Leu Glu Ser Gly Thr Leu Gly Thr Lys Gly Asn Val Gln595 600 605Val Val Ile Pro Phe Leu Thr Glu Ser Tyr Ser Ser Ser Gln Asp Pro610 615 620Pro Glu Lys Ser Ile Pro Ile Cys Thr Leu Lys Asn Phe Pro Asn Ala625 630 635 640Ile Glu His Thr Leu Gln Trp Ala Arg Asp Glu Phe Glu Gly Leu Phe645 650 655Lys Gln Pro Ala Glu Asn Val Asn Gln Tyr Leu Thr Asp Pro Lys Phe660 665 670Val Glu Arg Thr Leu Arg Leu Ala Gly Thr Gln Pro Leu Glu Val Leu675 680 685
Glu Ala Val Gln Arg Ser Leu Val Leu Gln Arg Pro Gln Thr Trp Ala690 695 700Asp Cys Val Thr Trp Ala Cys His His Trp His Thr Gln Tyr Ser Asn705 710 715 720Asn Ile Arg Gln Leu Leu His Asn Phe Pro Pro Asp Gln Leu Thr Ser725 730 735Ser Gly Ala Pro Phe Trp Ser Gly Pro Lys Arg Cys Pro His Pro Leu740 745 750Thr Phe Asp Val Asn Asn Pro Leu His Leu Asp Tyr Val Met Ala Ala755 760 765Ala Asn Leu Phe Ala Gln Thr Tyr Gly Leu Thr Gly Ser Gln Asp Arg770 775 780Ala Ala Val Ala Thr Phe Leu Gln Ser Val Gln Val Pro Glu Phe Thr785 790 795 800Pro Lys Ser Gly Val Lys Ile His Val Ser Asp Gln Glu Leu Gln Ser805 810 815Ala Asn Ala Ser Val Asp Asp Ser Arg Leu Glu Glu Leu Lys Ala Thr820 825 830Leu Pro Ser Pro Asp Lys Leu Pro Gly Phe Lys Met Tyr Pro Ile Asp835 840 845Phe Glu Lys Asp Asp Asp Ser Asn Phe His Met Asp Phe Ile Val Ala850 855 860Ala Ser Asn Leu Arg Ala Glu Asn Tyr Asp Ile Pro Ser Ala Asp Arg865 870 875 880His Lys Ser Lys Leu Ile Ala Gly Lys Ile Ile Pro Ala Ile Ala Thr885 890 895Thr Thr Ala Ala Val Val Gly Leu Val Cys Leu Glu Leu Tyr Lys Val900 905 910Val Gln Gly His Arg Gln Leu Asp Ser Tyr Lys Asn Gly Phe Leu Asn915 920 925Leu Ala Leu Pro Phe Phe Gly Phe Ser Glu Pro Leu Ala Ala Pro Arg
930 935 940His Gln Tyr Tyr Asn Gln Glu Trp Thr Leu Trp Asp Arg Phe Glu Val945 950 955 960Gln Gly Leu Gln Pro Asn Gly Glu Glu Met Thr Leu Lys Gln Phe Leu965 970 975Asp Tyr Phe Lys Thr Glu His Lys Leu Glu Ile Thr Met Leu Ser Gln980 985 990Gly Val Ser Met Leu Tyr Ser Phe Phe Met Pro Ala Ala Lys Leu Lys995 1000 1005Glu Arg Leu Asp Gln Pro Met Thr Glu Ile Val Ser Arg Val Ser1010 1015 1020Lys Arg Lys Leu Gly Arg His Val Arg Ala Leu Val Leu Glu Leu1025 1030 1035Cys Cys Asn Asp Glu Ser Gly Glu Asp Val Glu Val Pro Tyr Val1040 1045 1050Arg Tyr Thr Ile Arg1055<210>64<211>200<212>PRT<213>人<300>
<308>sw_hum/ubc1_human<309>1992-08-01<400>64Met Ala Asn Ile Ala Val Gln Arg Ile Lys Arg Glu Phe Lys Glu Val1 5 10 15Leu Lys Ser Glu Glu Thr Ser Lys Asn Gln Ile Lys Val Asp Leu Val20 25 30Asp Glu Asn Phe Thr Glu Leu Arg Gly Glu Ile Ala Gly Pro Pro Asp35 40 45Thr Pro Tyr Glu Gly Gly Arg Tyr Gln Leu Glu Ile Lys Ile Pro Glu50 55 60
Thr Tyr Pro Phe Asn Pro Pro Lys Val Arg Phe Ile Thr Lys Ile Trp65 70 75 80His Pro Asn Ile Ser Ser Val Thr Gly Ala Ile Cys Leu Asp Ile Leu85 90 95Lys Asp Gln Trp Ala Ala Ala Met Thr Leu Arg Thr Val Leu Leu Ser100 105 110Leu Gln Ala Leu Leu Ala Ala Ala Glu Pro Asp Asp Pro Gln Asp Ala115 120 125Val Val Ala Asn Gln Tyr Lys Gln Asn Pro Glu Met Phe Lys Gln Thr130 135 140Ala Arg Leu Trp Ala His Val Tyr Ala Gly Ala Pro Val Ser Ser Pro145 150 155 160Glu Tyr Thr Lys Lys Ile Glu Asn Leu Cys Ala Met Gly Phe Asp Arg165 170 175Asn Ala Val Ile Val Ala Leu Ser Ser Lys Ser Trp Asp Val Glu Thr180 185 190Ala Thr Glu Leu Leu Leu Ser Asn195 200<210>65<211>493<212>PRT<213>人<300>
<308>sw_hum/ubpe_human<309>1996-10-01<400>65Pro Leu Tyr Ser Val Thr Val Lys Trp Gly Lys Glu Lys Phe Glu Gly1 5 10 15Val Glu Leu Asn Thr Asp Glu Pro Pro Met Val Phe Lys Ala Gln Leu20 25 30Phe Ala Leu Thr Gly Val Gln Pro Ala Arg Gln Lys Val Met Val Lys35 40 45Gly Gly Thr Leu Lys Asp Asp Asp Trp Gly Asn Ile Lys Ile Lys Asn50 55 60
Gly Met Thr Leu Leu Met Met Gly Ser Ala Asp Ala Leu Pro Glu Glu65 70 75 80Pro Ser Ala Lys Thr Val Phe Val Glu Asp Met Thr Glu Glu Gln Leu85 90 95Ala Ser Ala Met Glu Leu Pro Cys Gly Leu Thr Asn Leu Gly Asn Thr100 105 110Cys Tyr Met Asn Ala Thr Val Gln Cys Ile Arg Ser Val Pro Glu Leu115 120 125Lys Asp Ala Leu Lys Arg Tyr Ala Gly Ala Leu Arg Ala Ser Gly Glu130 135 140Met Ala Ser Ala Gln Tyr Ile Thr Ala Ala Leu Arg Asp Leu Phe Asp145 150 155 160Ser Met Asp Lys Thr Ser Ser Ser Ile Pro Pro Ile Ile Leu Leu Gln165 170 175Phe Leu His Met Ala Phe Pro Gln Phe Ala Glu Lys Gly Glu Gln Gly180 185 190Gln Tyr Leu Gln Gln Asp Ala Asn Glu Cys Trp Ile Gln Met Met Arg195 200 205Val Leu Gln Gln Lys Leu Glu Ala Ile Glu Asp Asp Ser Val Lys Glu210 215 220Thr Asp Ser Ser Ser Ala Ser Ala Ala Thr Pro Ser Lys Lys Lys Ser225 230 235 240Leu Ile Asp Gln Phe Phe Gly Val Glu Phe Glu Thr Thr Met Lys Cys245 250 255Thr Glu Ser Glu Glu Glu Glu Val Thr Lys Gly Lys Glu Asn Gln Leu260 265 270Gln Leu Ser Cys Phe Ile Asn Gln Glu Val Lys Tyr Leu Phe Thr Gly275 280 285Leu Lys Leu Arg Leu Gln Glu Glu Ile Thr Lys Gln Ser Pro Thr Leu290 295 300Gln Arg Asn Ala Leu Tyr Ile Lys Ser Ser Lys Ile Ser Arg Leu Pro
305 310 315 320Ala Tyr Leu Thr Ile Gln Met Val Arg Phe Phe Tyr Lys Glu Lys Glu325 330 335Ser Val Asn Ala Lys Val Leu Lys Asp Val Lys Phe Pro Leu Met Leu340 345 350Asp Met Tyr Glu Leu Cys Thr Pro Glu Leu Gln Glu Lys Met Val Ser355 360 365Phe Arg Ser Lys Phe Lys Asp Leu Glu Asp Lys Lys Val Asn Gln Gln370 375 380Pro Asn Thr Ser Asp Lys Lys Ser Ser Pro Gln Lys Glu Val Lys Tyr385 390 395 400Glu Pro Phe Ser Phe Ala Asp Asp Ile Gly Ser Asn Asn Cys Gly Tyr405 410 415Tyr Asp Leu Gln Ala Val Leu Thr His Gln Gly Arg Ser Ser Ser Ser420 425 430Gly His Tyr Val Ser Trp Val Lys Arg Lys Gln Asp Glu Trp Ile Lys435 440 445Phe Asp Asp Asp Lys Val Ser Ile Val Thr Pro Glu Asp Ile Leu Arg450 455 460Leu Ser Gly Gly Gly Asp Trp His Ile Ala Tyr Val Leu Leu Tyr Gly465 470 475 480Pro Arg Arg Val Glu Ile Met Glu Glu Glu Ser Glu Gln485 490<210>66<211>350<212>PRT<213>人<300>
<308>sw_hum/unri_human<309>2001-10-16<400>66Met Ala Met Arg Gln Thr Pro Leu Thr Cys Ser Gly His Thr Arg Pro1 5 10 15
Val Val Asp Leu Ala Phe Ser Gly Ile Thr Pro Tyr Gly Tyr Phe Leu20 25 30Ile Ser Ala Cys Lys Asp Gly Lys Pro Met Leu Arg Gln Gly Asp Thr35 40 45Gly Asp Trp Ile Gly Thr Phe Leu Gly His Lys Gly Ala Val Trp Gly50 55 60Ala Thr Leu Asn Lys Asp Ala Thr Lys Ala Ala Thr Ala Ala Ala Asp65 70 75 80Phe Thr Ala Lys Val Trp Asp Ala Val Ser Gly Asp Glu Leu Met Thr85 90 95Leu Ala His Lys His Ile Val Lys Thr Val Asp Phe Thr Gln Asp Ser100 105 110Asn Tyr Leu Leu Thr Gly Gly Gln Asp Lys Leu Leu Arg Ile Tyr Asp115 120 125Leu Asn Lys Pro Glu Ala Glu Pro Lys Glu Ile Ser Gly His Thr Ser130 135 140Gly Ile Lys Lys Ala Leu Trp Cys Ser Glu Asp Lys Gln Ile Leu Ser145 150 155 160Ala Asp Asp Lys Thr Val Arg Leu Trp Asp His Ala Thr Met Thr Glu165 170 175Val Lys Ser Leu Asn Phe Asn Met Ser Val Ser Ser Met Glu Tyr Ile180 185 190Pro Glu Gly Glu Ile Leu Val Ile Thr Tyr Gly Arg Ser Ile Ala Phe195 200 205His Ser Ala Val Ser Leu Asp Pro Ile Lys Ser Phe Glu Ala Pro Ala210 215 220Thr Ile Asn Ser Ala Ser Leu His Pro Glu Lys Glu Phe Leu Val Ala225 230 235 240Gly Gly Glu Asp Phe Lys Leu Tyr Lys Tyr Asp Tyr Asn Ser Gly Glu245 250 255Glu Leu Glu Ser Tyr Lys Gly His Phe Gly Pro Ile His Cys Val Arg260 265 270
Phe Ser Pro Asp Gly Glu Leu Tyr Ala Ser Gly Ser Glu Asp Gly Thr275 280 285Leu Arg Leu Trp Gln Thr Val Val Gly Lys Thr Tyr Gly Leu Trp Lys290 295 300Cys Val Leu Pro Glu Glu Asp Ser Gly Glu Leu Ala Lys Pro Lys Ile305 310 315 320Gly Phe Pro Glu Thr Thr Glu Glu Glu Leu Glu Glu Ile Ala Ser Glu325 330 335Asn Ser Asp Cys Ile Phe Pro Ser Ala Pro Asp Val Lys Ala340 345 350<210>67<211>617<212>PRT<213>人<300>
<308>sw_hum/vaa1_human<309>1994-10-01<400>67Met Asp Phe Ser Lys Leu Pro Lys Ile Leu Asp Glu Asp Lys Glu Ser1 5 10 15Thr Phe Gly Tyr Val His Gly Val Ser Gly Pro Val Val Thr Ala Cys20 25 30Asp Met Ala Gly Ala Ala Met Tyr Glu Leu Val Arg Val Gly His Ser35 40 45Glu Leu Val Gly Glu Ile Ile Arg Leu Glu Gly Asp Met Ala Thr Ile50 55 60Gln Val Tyr Glu Glu Thr Ser Gly Val Ser Val Gly Asp Pro Val Leu65 70 75 80Arg Thr Gly Lys Pro Leu Ser Val Glu Leu Gly Pro Gly Ile Met Gly85 90 95Ala Ile Phe Asp Gly Ile Gln Arg Pro Leu Ser Asp Ile Ser Ser Gln100 105 110Thr Gln Ser Ile Tyr Ile Pro Arg Gly Val Asn Val Ser Ala Leu Ser
115 120 125Arg Asp Ile Lys Trp Asp Phe Thr Pro Cys Lys Asn Leu Arg Val Gly130 135 140Ser His Ile Thr Gly Gly Asp Ile Tyr Gly Ile Val Ser Glu Asn Ser145 150 155 160Leu Ile Lys His Lys Ile Met Leu Pro Pro Arg Asn Arg Gly Thr Val165 170 175Thr Tyr Ile Ala Pro Pro Gly Asn Tyr Asp Thr Ser Asp Val Val Leu180 185 190Glu Leu Glu Phe Glu Gly Val Lys Glu Lys Phe Thr Met Val Gln Val195 200 205Trp Pro Val Arg Gln Val Arg Pro Val Thr Glu Lys Leu Pro Ala Asn210 215 220His Pro Leu Leu Thr Gly Gln Arg Val Leu Asp Ala Leu Phe Pro Cys225 230 235 240Val Gln Gly Gly Thr Thr Ala Ile Pro Gly Ala Phe Gly Cys Gly Lys245 250 255Thr Val Ile Ser Gln Ser Leu Ser Lys Tyr Ser Asn Ser Asp Val Ile260 265 270Ile Tyr Val Gly Cys Gly Glu Arg Gly Asn Glu Met Ser Glu Val Leu275 280 285Arg Asp Phe Pro Glu Leu Thr Met Glu Val Asp Gly Lys Val Glu Ser290 295 300Ile Met Lys Arg Thr Ala Leu Val Ala Asn Thr Ser Asn Met Pro Val305 310 315 320Ala Ala Arg Glu Ala Ser Ile Tyr Thr Gly Ile Thr Leu Ser Glu Tyr325 330 335Phe Arg Asp Met Gly Tyr His Val Ser Met Met Ala Asp Ser Thr Ser340 345 350Arg Trp Ala Glu Ala Leu Arg Glu Ile Ser Gly Arg Leu Ala Glu Met355 360 365
Pro Ala Asp Ser Gly Tyr Pro Ala Tyr Leu Gly Ala Arg Leu Ala Ser370 375 380Phe Tyr Glu Arg Ala Gly Arg Val Lys Cys Leu Gly Asn Pro Glu Arg385 390 395 400Glu Gly Ser Val Ser Ile Val Gly Ala Val Ser Pro Pro Gly Gly Asp405 410 415Phe Ser Asp Pro Val Thr Ser Ala Thr Leu Gly Ile Val Gln Val Phe420 425 430Trp Gly Leu Asp Lys Lys Leu Ala Gln Arg Lys His Phe Pro Ser Val435 440 445Asn Trp Leu Ile Ser Tyr Ser Lys Tyr Met Arg Ala Leu Asp Glu Tyr450 455 460Tyr Asp Lys His Phe Thr Glu Phe Val Pro Leu Arg Thr Lys Ala Lys465 470 475 480Glu Ile Leu Gln Glu Glu Glu Asp Leu Ala Glu Ile Val Gln Leu Val485 490 495Gly Lys Ala Ser Leu Ala Glu Thr Asp Lys Ile Thr Leu Glu Val Ala500 505 510Lys Leu Ile Lys Asp Asp Phe Leu Gln Gln Asn Gly Tyr Thr Pro Tyr515 520 525Asp Arg Phe Cys Pro Phe Tyr Lys Thr Val Gly Met Leu Ser Asn Met530 535 540Ile Ala Phe Tyr Asp Met Ala Arg Arg Ala Val Glu Thr Thr Ala Gln545 550 555 560Ser Asp Asn Lys Ile Thr Trp Ser Ile Ile Arg Glu His Met Gly Asp565 570 575Ile Leu Tyr Lys Leu Ser Ser Met Lys Phe Lys Asp Pro Leu Lys Asp580 585 590Gly Glu Ala Lys Ile Lys Ser Asp Tyr Ala Gln Leu Leu Glu Asp Met595 600 605Gln Asn Ala Phe Arg Ser Leu Glu Asp
610 615<210>68<211>826<212>PRT<213>人<300>
<308>sw_hum/vil1_human<309>1989-03-01<400>68Thr Lys Leu Ser Ala Gln Val Lys Gly Ser Leu Asn Ile Thr Thr Pro1 5 10 15Gly Leu Gln Ile Trp Arg Ile Glu Ala Met Gln Met Val Pro Val Pro20 25 30Ser Ser Thr Phe Gly Ser Phe Phe Asp Gly Asp Cys Tyr Ile Ile Leu35 40 45Ala Ile His Lys Thr Ala Ser Ser Leu Ser Tyr Asp Ile His Tyr Trp50 55 60Ile Gly Gln Asp Ser Ser Leu Asp Glu Gln Gly Ala Ala Ala Ile Tyr65 70 75 80Thr Thr Gln Met Asp Asp Phe Leu Lys Gly Arg Ala Val Gln His Arg85 90 95Glu Val Gln Gly Asn Glu Ser Glu Ala Phe Arg Gly Tyr Phe Lys Gln100 105 110Gly Leu Val Ile Arg Lys Gly Gly Val Ala Ser Gly Met Lys His Val115 120 125Glu Thr Asn Ser Tyr Asp Val Gln Arg Leu Leu His Val Lys Gly Lys130 135 140Arg Asn Val Val Ala Gly Glu Val Glu Met Ser Trp Lys Ser Phe Asn145 150 155 160Arg Gly Asp Val Phe Leu Leu Asp Leu Gly Lys Leu Ile Ile Gln Trp165 170 175Asn Gly Pro Glu Ser Thr Arg Met Glu Arg Leu Arg Gly Met Thr Leu180 185 190
Ala Lys Glu Ile Arg Asp Gln Glu Arg Gly Gly Arg Thr Tyr Val Gly195 200 205Val Val Asp Gly Glu Asn Glu Leu Ala Ser Pro Lys Leu Met Glu Val210 215 220Met Asn His Val Leu Gly Lys Arg Arg Glu Leu Lys Ala Ala Val Pro225 230 235 240Asp Thr Val Val Glu Pro Ala Leu Lys Ala Ala Leu Lys Leu Tyr His245 250 255Val Ser Asp Ser Glu Gly Asn Leu Val Val Arg Glu Val Ala Thr Arg260 265 270Pro Leu Thr Gln Asp Leu Leu Ser His Glu Asp Cys Tyr Ile Leu Asp275 280 285Gln Gly Gly Leu Lys Ile Tyr Val Trp Lys Gly Lys Lys Ala Asn Glu290 295 300Gln Glu Lys Lys Gly Ala Met Ser His Ala Leu Asn Phe Ile Lys Ala305 310 315 320Lys Gln Tyr Pro Pro Ser Thr Gln Val Glu Val Gln Asn Asp Gly Ala325 330 335Glu Ser Ala Val Phe Gln Gln Leu Phe Gln Lys Trp Thr Ala Ser Asn340 345 350Arg Thr Ser Gly Leu Gly Lys Thr His Thr Val Gly Ser Val Ala Lys355 360 365Val Glu Gln Val Lys Phe Asp Ala Thr Ser Met His Val Lys Pro Gln370 375 380Val Ala Ala Gln Gln Lys Met Val Asp Asp Gly Ser Gly Glu Val Gln385 390 395 400Val Trp Arg Ile Glu Asn Leu Glu Leu Val Pro Val Asp Ser Lys Trp405 410 415Leu Gly His Phe Tyr Gly Gly Asp Cys Tyr Leu Leu Leu Tyr Thr Tyr420 425 430Leu Ile Gly Glu Lys Gln His Tyr Leu Leu Tyr Val Trp Gln Gly Ser435 440 445
Gln Ala Ser Gln Asp Glu Ile Thr Ala Ser Ala Tyr Gln Ala Val Ile450 455 460Leu Asp Gln Lys Tyr Asn Gly Glu Pro Val Gln Ile Arg Val Pro Met465 470 475 480Gly Lys Glu Pro Pro His Leu Met Ser Ile Phe Lys Gly Arg Met Val485 490 495Val Tyr Gln Gly Gly Thr Ser Arg Thr Asn Asn Leu Glu Thr Gly Pro500 505 510Ser Thr Arg Leu Phe Gln Val Gln Gly Thr Gly Ala Asn Asn Thr Lys515 520 525Ala Phe Glu Val Pro Ala Arg Ala Asn Phe Leu Asn Ser Asn Asp Val530 535 540Phe Val Leu Lys Thr Gln Ser Cys Cys Tyr Leu Trp Cys Gly Lys Gly545 550 555 560Cys Ser Gly Asp Glu Arg Glu Met Ala Lys Met Val Ala Asp Thr Ile565 570 575Ser Arg Thr Glu Lys Gln Val Val Val Glu Gly Gln Glu Pro Ala Asn580 585 590Phe Trp Met Ala Leu Gly Gly Lys Ala Pro Tyr Ala Asn Thr Lys Arg595 600 605Leu Gln Glu Glu Asn Leu Val Ile Thr Pro Arg Leu Phe Glu Cys Ser610 615 620Asn Lys Thr Gly Arg Phe Leu Ala Thr Glu Ile Pro Asp Phe Asn Gln625 630 635 640Asp Asp Leu Glu Glu Asp Asp Val Phe Leu Leu Asp Val Trp Asp Gln645 650 655Val Phe Phe Trp Ile Gly Lys His Ala Asn Glu Glu Glu Lys Lys Ala660 665 670Ala Ala Thr Thr Ala Gln Glu Tyr Leu Lys Thr His Pro Ser Gly Arg675 680 685
Asp Pro Glu Thr Pro Ile Ile Val Val Lys Gln Gly His Glu Pro Pro690 695 700Thr Phe Thr Gly Trp Phe Leu Ala Trp Asp Pro Phe Lys Trp Ser Asn705 710 715 720Thr Lys Ser Tyr Glu Asp Leu Lys Ala Glu Ser Gly Asn Leu Arg Asp725 730 735Trp Ser Gln Ile Thr Ala Glu Val Thr Ser Pro Lys Val Asp Val Phe740 745 750Asn Ala Asn Ser Asn Leu Ser Ser Gly Pro Leu Pro Ile Phe Pro Leu755 760 765Glu Gln Leu Val Asn Lys Pro Val Glu Glu Leu Pro Glu Gly Val Asp770 775 780Pro Ser Arg Lys Glu Glu His Leu Ser Ile Glu Asp Phe Thr Gln Ala785 790 795 800Phe Gly Met Thr Pro Ala Ala Phe Ser Ala Leu Pro Arg Trp Lys Gln805 810 815Gln Asn Leu Lys Lys Glu Lys Gly Leu Phe820 825<210>69<211>227<212>PRT<213>人<300>
<308>tr_hum/q96hx0<309>2001-12-01<400>69Thr Pro Thr Tyr Gly Asp Leu Asn His Leu Val Ser Ala Thr Met Ser1 5 10 15Gly Val Thr Thr Cys Leu Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu20 25 30Arg Lys Leu Ala Val Asn Met Val Pro Phe Pro Arg Leu His Phe Phe35 40 45Met Pro Gly Phe Ala Pro Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg50 55 60
Ala Leu Thr Val Pro Glu Leu Thr Gln Gln Met Phe Asp Ala Lys Asn65 70 75 80Met Met Ala Ala Cys Asp Pro Arg His Gly Arg Tyr Leu Thr Val Ala85 90 95Ala Val Phe Arg Gly Arg Met Ser Met Lys Glu Val Asp Glu Gln Met100 105 110Leu Asn Val Gln Asn Lys Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro115 120 125Asn Asn Val Lys Thr Ala Val Cys Asp Ile Pro Pro Arg Gly Leu Lys130 135 140Met Ser Ala Thr Phe Ile Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe145 150 155 160Lys Arg Ile Ser Glu Gln Phe Thr Ala Met Phe Arg Arg Lys Ala Phe165 170 175Leu His Trp Tyr Thr Gly Glu Gly Met Asp Glu Met Glu Phe Thr Glu180 185 190Ala Glu Ser Asn Met Asn Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln195 200 205Asp Ala Thr Ala Glu Glu Glu Gly Glu Phe Glu Glu Glu Ala Glu Glu210 215 220Glu Val Ala225<210>70<211>531<212>PRT<213>人<300>
<308>sw_hum/ptb_human<309>1992-08-01<400>70Met Asp Gly Ile Val Pro Asp Ile Ala Val Gly Thr Lys Arg Gly Ser1 5 10 15Asp Glu Leu Phe Ser Thr Cys Val Thr Asn Gly Pro Phe Ile Met Ser20 25 30
Ser Asn Ser Ala Ser Ala Ala Asn Gly Asn Asp Ser Lys Lys Phe Lys35 40 45Gly Asp Ser Arg Ser Ala Gly Val Pro Ser Arg Val Ile His Ile Arg50 55 60Lys Leu Pro Ile Asp Val Thr Glu Gly Glu Val Ile Ser Leu Gly Leu65 70 75 80Pro Phe Gly Lys Val Thr Asn Leu Leu Met Leu Lys Gly Lys Asn Gln85 90 95Ala Phe Ile Glu Met Asn Thr Glu Glu Ala Ala Asn Thr Met Val Asn100 105 110Tyr Tyr Thr Ser Val Thr Pro Val Leu Arg Gly Gln Pro Ile Tyr Ile115 120 125Gln Phe Ser Asn His Lys Glu Leu Lys Thr Asp Ser Ser Pro Asn Gln130 135 140Ala Arg Ala Gln Ala Ala Leu Gln Ala Val Asn Ser Val Gln Ser Gly145 150 155 160Asn Leu Ala Leu Ala Ala Ser Ala Ala Ala Val Asp Ala Gly Met Ala165 170 175Met Ala Gly Gln Ser Pro Val Leu Arg Ile Ile Val Glu Asn Leu Phe180 185 190Tyr Pro Val Thr Leu Asp Val Leu His Gln Ile Phe Ser Lys Phe Gly195 200 205Thr Val Leu Lys Ile Ile Thr Phe Thr Lys Asn Asn Gln Phe Gln Ala210 215 220Leu Leu Gln Tyr Ala Asp Pro Val Ser Ala Gln His Ala Lys Leu Ser225 230 235 240Leu Asp Gly Gln Asn Ile Tyr Asn Ala Cys Cys Thr Leu Arg Ile Asp245 250 255Phe Ser Lys Leu Thr Ser Leu Asn Val Lys Tyr Asn Asn Asp Lys Ser260 265 270
Arg Asp Tyr Thr Arg Pro Asp Leu Pro Ser Gly Asp Ser Gln Pro Ser275 280 285Leu Asp Gln Thr Met Ala Ala Ala Phe Gly Leu Ser Val Pro Asn Val290 295 300His Gly Ala Leu Ala Pro Leu Ala Ile Pro Ser Ala Ala Ala Ala Ala305 310 315 320Ala Ala Ala Gly Arg Ile Ala Ile Pro Gly Leu Ala Gly Ala Gly Asn325 330 335Ser Val Leu Leu Val Ser Asn Leu Asn Pro Glu Arg Val Thr Pro Gln340 345 350Ser Leu Phe Ile Leu Phe Gly Val Tyr Gly Asp Val Gln Arg Val Lys355 360 365Ile Leu Phe Asn Lys Lys Glu Asn Ala Leu Val Gln Met Ala Asp Gly370 375 380Asn Gln Ala Gln Leu Ala Met Ser His Leu Asn Gly His Lys Leu His385 390 395 400Gly Lys Pro Ile Arg Ile Thr Leu Ser Lys His Gln Asn Val Gln Leu405 410 415Pro Arg Glu Gly Gln Glu Asp Gln Gly Leu Thr Lys Asp Tyr Gly Asn420 425 430Ser Pro Leu His Arg Phe Lys Lys Pro Gly Ser Lys Asn Phe Gln Asn435 440 445Ile Phe Pro Pro Ser Ala Thr Leu His Leu Ser Asn Ile Pro Pro Ser450 455 460Val Ser Glu Glu Asp Leu Lys Val Leu Phe Ser Ser Asn Gly Gly Val465 470 475 480Val Lys Gly Phe Lys Phe Phe Gln Lys Asp Arg Lys Met Ala Leu Ile485 490 495Gln Met Gly Ser Val Glu Glu Ala Val Gln Ala Leu Ile Asp Leu His500 505 510Asn His Asp Leu Gly Glu Asn His His Leu Arg Val Ser Phe Ser Lys515 520 525
Ser Thr Ile530<210>71<211>530<212>PRT<213>人<300>
<308>sw_hum/kpy2_human<309>1990-04-01<400>71Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln Gln1 5 10 15Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg Leu20 25 30Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile Cys35 40 45Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met Ile50 55 60Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr His65 70 75 80Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu Ser85 90 95Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu Asp100 105 110Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly Thr115 120 125Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu Asp130 135 140Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp Tyr145 150 155 160Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val Asp165 170 175Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe Leu
180 185 190Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly Val195 200 205Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys Asp210 215 220Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val Phe225 230 235 240Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys Val245 250 255Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu Asn260 265 270His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp Gly275 280 285Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu Lys290 295 300Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala Gly305 310 315 320Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys Lys325 330 335Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val Leu340 345 350Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly Asp355 360 365Tyr Pro Leu Glu Ala Val Arg Met Gln Asn Leu Ile Ala Arg Glu Ala370 375 380Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg Leu385 390 395 400Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala Val405 410 415Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr Lys420 425 430
Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala Pro435 440 445Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His Leu450 455 460Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu Ala465 470 475 480Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val Gly485 490 495Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu Thr500 505 510Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val Pro515 520 525Val Pro530<210>72<211>432<212>PRT<213>人<300>
<308>sw_hum/acdb_human<309>1995-11-01<400>72Met Glu Gly Leu Ala Val Arg Leu Leu Arg Gly Ser Arg Leu Leu Arg1 5 10 15Arg Asn Phe Leu Thr Cys Leu Ser Ser Trp Lys Ile Pro Pro His Val20 25 30Ser Lys Ser Ser Gln Ser Glu Ala Leu Leu Asn Ile Thr Asn Asn Gly35 40 45Ile His Phe Ala Pro Leu Gln Thr Phe Thr Asp Glu Glu Met Met Ile50 55 60Lys Ser Ser Val Lys Lys Phe Ala Gln Glu Gln Ile Ala Pro Leu Val65 70 75 80Ser Thr Met Asp Glu Asn Ser Lys Met Glu Lys Ser Val Ile Gln Gly85 90 95
Leu Phe Gln Gln Gly Leu Met Gly Ile Glu Val Asp Pro Glu Tyr Gly100 105 110Gly Thr Gly Ala Ser Phe Leu Ser Thr Val Leu Val Ile Glu Glu Leu115 120 125Ala Lys Val Asp Ala Ser Val Ala Val Phe Cys Glu Ile Gln Asn Thr130 135 140Leu Ile Asn Thr Leu Ile Arg Lys His Gly Thr Glu Glu Gln Lys Ala145 150 155 160Thr Tyr Leu Pro Gln Leu Thr Thr Glu Lys Val Gly Ser Phe Cys Leu165 170 175Ser Glu Ala Gly Ala Gly Ser Asp Ser Phe Ala Leu Lys Thr Arg Ala180 185 190Asp Lys Glu Gly Asp Tyr Tyr Val Leu Asn Gly Ser Lys Met Trp Ile195 200 205Ser Ser Ala Glu His Ala Gly Leu Phe Leu Val Met Ala Asn Val Asp210 215 220Pro Thr Ile Gly Tyr Lys Gly Ile Thr Ser Phe Leu Val Asp Arg Asp225 230 235 240Thr Pro Gly Leu His Ile Gly Lys Pro Glu Asn Lys Leu Gly Leu Arg245 250 255Ala Ser Ser Thr Cys Pro Leu Thr Phe Glu Asn Val Lys Val Pro Glu260 265 270Ala Asn Ile Leu Gly Gln Ile Gly His Gly Tyr Lys Tyr Ala Ile Gly275 280 285Ser Leu Asn Glu Gly Arg Ile Gly Ile Ala Ala Gln Met Leu Gly Leu290 295 300Ala Gln Gly Cys Phe Asp Tyr Thr Ile Pro Tyr Ile Lys Glu Arg Ile305 310 315 320Gln Phe Gly Lys Arg Leu Phe Asp Phe Gln Gly Leu Gln His Gln Val325 330 335
Ala His Val Ala Thr Gln Leu Glu Ala Ala Arg Leu Leu Thr Tyr Asn340 345 350Ala Ala Arg Leu Leu Glu Ala Gly Lys Pro Phe Ile Lys Glu Ala Ser355 360 365Met Ala Lys Tyr Tyr Ala Ser Glu Ile Ala Gly Gln Thr Thr Ser Lys370 375 380Cys Ile Glu Trp Met Gly Gly Val Gly Tyr Thr Lys Asp Tyr Pro Val385 390 395 400Glu Lys Tyr Phe Arg Asp Ala Lys Ile Gly Thr Ile Tyr Glu Gly Ala405 410 415Ser Asn Ile Gln Leu Asn Thr Ile Ala Lys His Ile Asp Ala Glu Tyr420 425 430<210>73<211>262<212>PRT<213>人<300>
<308>sw_hum/rs4_human<309>1989-10-01<400>73Ala Arg Gly Pro Lys Lys His Leu Lys Arg Val Ala Ala Pro Lys His1 5 10 15Trp Met Leu Asp Lys Leu Thr Gly Val Phe Ala Pro Arg Pro Ser Thr20 25 30Gly Pro His Lys Leu Arg Glu Cys Leu Pro Leu Ile Ile Phe Leu Arg35 40 45Asn Arg Leu Lys Tyr Ala Leu Thr Gly Asp Glu Val Lys Lys Ile Cys50 55 60Met Gln Arg Phe Ile Lys Ile Asp Gly Lys Val Arg Thr Asp Ile Thr65 70 75 80Tyr Pro Ala Gly Phe Met Asp Val Ile Ser Ile Asp Lys Thr Gly Glu85 90 95Asn Phe Arg Leu Ile Tyr Asp Thr Lys Gly Arg Phe Ala Val His Arg100 105 110
Ile Thr Pro Glu Glu Ala Lys Tyr Lys Leu Cys Lys Val Arg Lys Ile115 120 125Phe Val Gly Thr Lys Gly Ile Pro His Leu Val Thr His Asp Ala Arg130 135 140Thr Ile Arg Tyr Pro Asp Pro Leu Ile Lys Val Asn Asp Thr Ile Gln145 150 155 160Ile Asp Leu Glu Thr Gly Lys Ile Thr Asp Phe Ile Lys Phe Asp Thr165 170 175Gly Asn Leu Cys Met Val Thr Gly Gly Ala Asn Leu Gly Arg Ile Gly180 185 190Val Ile Thr Asn Arg Glu Arg His Pro Gly Ser Phe Asp Val Val His195 200 205Val Lys Asp Ala Asn Gly Asn Ser Phe Ala Thr Arg Leu Ser Asn Ile210 215 220Phe Val Ile Gly Lys Gly Asn Lys Pro Trp Ile Ser Leu Pro Arg Gly225 230 235 240Lys Gly Ile Arg Leu Thr Ile Ala Glu Glu Arg Asp Lys Arg Leu Ala245 250 255Ala Lys Gln Ser Ser Gly260<210>74<211>303<212>PRT<213>人<300>
<308>sw_hum/crkl_human<309>1995-11-01<400>74Met Ser Ser Ala Arg Phe Asp Ser Ser Asp Arg Ser Ala Trp Tyr Met1 5 10 15Gly Pro Val Ser Arg Gln Glu Ala Gln Thr Arg Leu Gln Gly Gln Arg20 25 30His Gly Met Phe Leu Val Arg Asp Ser Ser Thr Cys Pro Gly Asp Tyr35 40 45
Val Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn50 55 60Ser Leu Pro Asn Arg Arg Phe Lys Ile Gly Asp Gln Glu Phe Asp His65 70 75 80Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr85 90 95Thr Leu Ile Glu Pro Ala Pro Arg Tyr Pro Ser Pro Pro Met Gly Ser100 105 110Val Ser Ala Pro Asn Leu Pro Thr Ala Glu Asp Asn Leu Glu Tyr Val115 120 125Arg Thr Leu Tyr Asp Phe Pro Gly Asn Asp Ala Glu Asp Leu Pro Phe130 135 140Lys Lys Gly Glu Ile Leu Val Ile Ile Glu Lys Pro Glu Glu Gln Trp145 150 155 160Trp Ser Ala Arg Asn Lys Asp Gly Arg Val Gly Met Ile Pro Val Pro165 170 175Tyr Val Glu Lys Leu Val Arg Ser Ser Pro His Gly Lys His Gly Asn180 185 190Arg Asn Ser Asn Ser Tyr Gly Ile Pro Glu Pro Ala His Ala Tyr Ala195 200 205Gln Pro Gln Thr Thr Thr Pro Leu Pro Ala Val Ser Gly Ser Pro Gly210 215 220Ala Ala Ile Thr Pro Leu Pro Ser Thr Gln Asn Gly Pro Val Phe Ala225 230 235 240Lys Ala Ile Gln Lys Arg Val Pro Cys Ala Tyr Asp Lys Thr Ala Leu245 250 255Ala Leu Glu Val Gly Asp Ile Val Lys Val Thr Arg Met Asn Ile Asn260 265 270Gly Gln Trp Glu Gly Glu Val Asn Gly Arg Lys Gly Leu Phe Pro Phe275 280 285
Thr His Val Lys Ile Phe Asp Pro Gln Asn Pro Asp Glu Asn Glu290 295 300<210>75<211>614<212>PRT<213>人<300>
<308>sw_hum/ddx5_human<309>1990-08-01<400>75Met Ser Gly Tyr Ser Ser Asp Arg Asp Arg Gly Arg Asp Arg Gly Phe1 5 10 15Gly Ala Pro Arg Phe Gly Gly Ser Arg Ala Gly Pro Leu Ser Gly Lys20 25 30Lys Phe Gly Asn Pro Gly Glu Lys Leu Val Lys Lys Lys Trp Asn Leu35 40 45Asp Glu Leu Pro Lys Phe Glu Lys Asn Phe Tyr Gln Glu His Pro Asp50 55 60Leu Ala Arg Arg Thr Ala Gln Glu Val Glu Thr Tyr Arg Arg Ser Lys65 70 75 80Glu Ile Thr Val Arg Gly His Asn Cys Pro Lys Pro Val Leu Asn Phe85 90 95Tyr Glu Ala Asn Phe Pro Ala Asn Val Met Asp Val Ile Ala Arg Gln100 105 110Asn Phe Thr Glu Pro Thr Ala Ile Gln Ala Gln Gly Trp Pro Val Ala115 120 125Leu Ser Gly Leu Asp Met Val Gly Val Ala Gln Thr Gly Ser Gly Lys130 135 140Thr Leu Ser Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro145 150 155 160Phe Leu Glu Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr165 170 175Arg Glu Leu Ala Gln Gln Val Gln Gln Val Ala Ala Glu Tyr Cys Arg180 185 190
Ala Cys Arg Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly195 200 205Pro Gln Ile Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr210 215 220Pro Gly Arg Leu Ile Asp Phe Leu Glu Cys Gly Lys Thr Asn Leu Arg225 230 235 240Arg Thr Thr Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met245 250 255Gly Phe Glu Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp260 265 270Arg Gln Thr Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln275 280 285Leu Ala Glu Asp Phe Leu Lys Asp Tyr Ile His Ile Asn Ile Gly Ala290 295 300Leu Glu Leu Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys305 310 315 320His Asp Val Glu Lys Asp Glu Lys Leu Ile Arg Leu Met Glu Glu Ile325 330 335Met Ser Glu Lys Glu Asn Lys Thr Ile Val Phe Val Glu Thr Lys Arg340 345 350Arg Cys Asp Glu Leu Thr Arg Lys Met Arg Arg Asp Gly Trp Pro Ala355 360 365Met Gly Ile His Gly Asp Lys Ser Gln Gln Glu Arg Asp Trp Val Leu370 375 380Asn Glu Phe Lys His Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val385 390 395 400Ala Ser Arg Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr405 410 415Asp Tyr Pro Asn Ser Ser Glu Asp Tyr Ile His Arg Ile Gly Arg Thr420 425 430Ala Arg Ser Thr Lys Thr Gly Thr Ala Tyr Thr Phe Phe Thr Pro Asn
435 440 445Asn Ile Lys Gln Val Ser Asp Leu Ile Ser Val Leu Arg Glu Ala Asn450 455 460Gln Ala Ile Asn Pro Lys Leu Leu Gln Leu Val Glu Asp Arg Gly Ser465 470 475 480Gly Arg Ser Arg Gly Arg Gly Gly Met Lys Asp Asp Arg Arg Asp Arg485 490 495Tyr Ser Ala Gly Lys Arg Gly Gly Phe Asn Thr Phe Arg Asp Arg Glu500 505 510Asn Tyr Asp Arg Gly Tyr Ser Ser Leu Leu Lys Arg Asp Phe Gly Ala515 520 525Lys Thr Gln Asn Gly Val Tyr Ser Ala Ala Asn Tyr Thr Asn Gly Ser530 535 540Phe Gly Ser Asn Phe Val Ser Ala Gly Ile Gln Thr Ser Phe Arg Thr545 550 555 560Gly Asn Pro Thr Gly Thr Tyr Gln Asn Gly Tyr Asp Ser Thr Gln Gln565 570 575Tyr Gly Ser Asn Val Pro Asn Met His Asn Gly Met Asn Gln Gln Ala580 585 590Tyr Ala Tyr Pro Ala Thr Ala Ala Ala Pro Met Ile Gly Tyr Pro Met595 600 605Pro Thr Gly Tyr Ser Gln610<210>76<211>261<212>PRT<213>人<300>
<308>sw_hum/las1_human<309>1998-07-15<400>76Met Asn Pro Asn Cys Ala Arg Cys Gly Lys Ile Val Tyr Pro Thr Glu1 5 10 15
Lys Val Asn Cys Leu Asp Lys Phe Trp His Lys Ala Cys Phe His Cys20 25 30Glu Thr Cys Lys Met Thr Leu Asn Met Lys Asn Tyr Lys Gly Tyr Glu35 40 45Lys Lys Pro Tyr Cys Asn Ala His Tyr Pro Lys Gln Ser Phe Thr Met50 55 60Val Ala Asp Thr Pro Glu Asn Leu Arg Leu Lys Gln Gln Ser Glu Leu65 70 75 80Gln Ser Gln Val Arg Tyr Lys Glu Glu Phe Glu Lys Asn Lys Gly Lys85 90 95Gly Phe Ser Val Val Ala Asp Thr Pro Glu Leu Gln Arg Ile Lys Lys100 105 110Thr Gln Asp Gln Ile Ser Asn Ile Lys Tyr His Glu Glu Phe Glu Lys115 120 125Ser Arg Met Gly Pro Ser Gly Gly Glu Gly Met Glu Pro Glu Arg Arg130 135 140Asp Ser Gln Asp Gly Ser Ser Tyr Arg Arg Pro Leu Glu Gln Gln Gln145 150 155 160Pro His His Ile Pro Thr Ser Ala Pro Val Tyr Gln Gln Pro Gln Gln165 170 175Gln Pro Val Ala Gln Ser Tyr Gly Gly Tyr Lys Glu Pro Ala Ala Pro180 185 190Val Ser Ile Gln Arg Ser Ala Pro Gly Gly Gly Gly Lys Arg Tyr Arg195 200 205Ala Val Tyr Asp Tyr Ser Ala Ala Asp Glu Asp Glu Val Ser Phe Gln210 215 220Asp Gly Asp Thr Ile Val Asn Val Gln Gln Ile Asp Asp Gly Trp Met225 230 235 240Tyr Gly Thr Val Glu Arg Thr Gly Asp Thr Gly Met Leu Pro Ala Asn245 250 255Tyr Val Glu Ala Ile260
<210>77<211>528<212>PRT<213>人<300>
<308>sw_hum/syy_human<309>1996-10-01<400>77Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg1 5 10 15Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys20 25 30Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro35 40 45His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys50 55 60Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu65 70 75 80Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr85 90 95Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu100 105 110Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu115 120 125Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp130 135 140Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu145 150 155 160Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr165 170 175Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe180 185 190Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
195 200 205His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser210 215 220Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp225 230 235 240Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu245 250 255Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys260 265 270Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr275 280 285Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val290 295 300His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu305 310 315 320Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu325 330 335Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys340 345 350Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu355 360 365Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala370 375 380Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg385 390 395 400Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln405 410 415Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg420 425 430Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile435 440 445
Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly450 455 460Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu465 470 475 480Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys485 490 495Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr500 505 510Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser515 520 525<210>78<211>418<212>PRT<213>人<300>
<308>sw_hum/sep7_human<309>1997-11-01<400>78Met Val Ala Gln Gln Lys Asn Leu Glu Gly Tyr Val Gly Phe Ala Asn1 5 10 15Leu Pro Asn Gln Val Tyr Arg Lys Ser Val Lys Arg Gly Phe Glu Phe20 25 30Thr Leu Met Val Val Gly Glu Ser Gly Leu Gly Lys Ser Thr Leu Ile35 40 45Asn Ser Leu Phe Leu Thr Asp Leu Tyr Ser Pro Glu Tyr Pro Gly Pro50 55 60Ser His Arg Ile Lys Lys Thr Val Gln Val Glu Gln Ser Lys Val Leu65 70 75 80Ile Lys Glu Gly Gly Val Gln Leu Leu Leu Thr Ile Val Asp Thr Pro85 90 95Gly Phe Gly Asp Ala Val Asp Asn Ser Asn Cys Trp Gln Pro Val Ile100 105 110Asp Tyr Ile Asp Ser Lys Phe Glu Asp Tyr Leu Asn Ala Glu Ser Arg115 120 125
Val Asn Arg Arg Gln Met Pro Asp Asn Arg Val Gln Cys Cys Leu Tyr130 135 140Phe Ile Ala Pro Ser Gly His Gly Leu Lys Pro Leu Asp Ile Glu Phe145 150 155 160Met Lys Arg Leu His Glu Lys Val Asn Ile Ile Pro Leu Ile Ala Lys165 170 175Ala Asp Thr Leu Thr Pro Glu Glu Cys Gln Gln Phe Lys Lys Gln Ile180 185 190Met Lys Glu Ile Gln Glu His Lys Ile Lys Ile Tyr Glu Phe Pro Glu195 200 205Thr Asp Asp Glu Glu Glu Asn Lys Leu Val Lys Lys Ile Lys Asp Arg210 215 220Leu Pro Leu Ala Val Val Gly Ser Asn Thr Ile Ile Glu Val Asn Gly225 230 235 240Lys Arg Val Arg Gly Arg Gln Tyr Pro Trp Gly Ile Ala Glu Val Glu245 250 255Asn Gly Glu His Cys Asp Phe Thr Ile Leu Arg Asn Met Lys Ile Arg260 265 270Thr His Met Gln Asp Leu Lys Asp Val Thr Asn Asn Val His Tyr Glu275 280 285Asn Tyr Arg Ser Arg Lys Leu Ala Ala Val Thr Tyr Asn Gly Val Asp290 295 300Asn Asn Lys Asn Lys Gly Gln Leu Thr Lys Ser Pro Leu Ala Gln Met305 310 315 320Glu Glu Glu Arg Arg Glu His Val Ala Lys Met Lys Lys Met Glu Met325 330 335Glu Met Glu Gln Val Phe Glu Met Lys Val Lys Glu Lys Val Gln Lys340 345 350Leu Lys Asp Ser Glu Ala Glu Leu Gln Arg Arg His Glu Gln Met Lys355 360 365
Lys Asn Leu Glu Ala Gln His Lys Glu Leu Glu Glu Lys Arg Arg Gln370 375 380Phe Glu Asp Glu Lys Ala Asn Trp Glu Ala Gln Gln Arg Ile Leu Glu385 390 395 400Gln Gln Asn Ser Ser Arg Thr Leu Glu Lys Asn Lys Lys Lys Gly Lys405 410 415Ile Phe<210>79<21l>213<212>PRT<213>人<300>
<308>sw_hum/atpo_human<309>1996-02-01<400>79Met Ala Ala Pro Ala Val Ser Gly Leu Ser Arg Gln Val Arg Cys Phe1 5 10 15Ser Thr Ser Val Val Arg Pro Phe Ala Lys Leu Val Arg Pro Pro Val20 25 30Gln Val Tyr Gly Ile Glu Gly Arg Tyr Ala Thr Ala Leu Tyr Ser Ala35 40 45Ala Ser Lys Gln Asn Lys Leu Glu Gln Val Glu Lys Glu Leu Leu Arg50 55 60Val Ala Gln Ile Leu Lys Glu Pro Lys Val Ala Ala Ser Val Leu Asn65 70 75 80Pro Tyr Val Lys Arg Ser Ile Lys Val Lys Ser Leu Asn Asp Ile Thr85 90 95Ala Lys Glu Arg Phe Ser Pro Leu Thr Thr Asn Leu Ile Asn Leu Leu100 105 110Ala Glu Asn Gly Arg Leu Ser Asn Thr Gln Gly Val Val Ser Ala Phe115 120 125Ser Thr Met Met Ser Val His Arg Gly Glu Val Pro Cys Thr Val Thr130 135 140
Ser Ala Ser Pro Leu Glu Glu Ala Thr Leu Ser Glu Leu Lys Thr Val145 150 155 160Leu Lys Ser Phe Leu Ser Gln Gly Gln Val Leu Lys Leu Glu Ala Lys165 170 175Thr Asp Pro Ser Ile Leu Gly Gly Met Ile Val Arg Ile Gly Glu Lys180 185 190Tyr Val Asp Met Ser Val Lys Thr Lys Ile Gln Lys Leu Gly Arg Ala195 200 205Met Arg Glu Ile Val210<210>80<211>808<212>PRT<213>人<300>
<308>sw_hum/mcm3_human<309>1992-05-01<400>80Met Ala Gly Thr Val Val Leu Asp Asp Val Glu Leu Arg Glu Ala Gln1 5 10 15Arg Asp Tyr Leu Asp Phe Leu Asp Asp Glu Glu Asp Gln Gly Ile Tyr20 25 30Gln Ser Lys Val Arg Glu Leu Ile Ser Asp Asn Gln Tyr Arg Leu Ile35 40 45Val Asn Val Asn Asp Leu Arg Arg Lys Asn Glu Lys Arg Ala Asn Arg50 55 60Leu Leu Asn Asn Ala Phe Glu Glu Leu Val Ala Phe Gln Arg Ala Leu65 70 75 80Lys Asp Phe Val Ala Ser Ile Asp Ala Thr Tyr Ala Lys Gln Tyr Glu85 90 95Glu Phe Tyr Val Gly Leu Glu Gly Ser Phe Gly Ser Lys His Val Ser100 105 110Pro Arg Thr Leu Thr Ser Cys Phe Leu Ser Cys Val Val Cys Val Glu115 120 125
Gly Ile Val Thr Lys Cys Ser Leu Val Arg Pro Lys Val Val Arg Ser130 135 140Val His Tyr Cys Pro Ala Thr Lys Lys Thr Ile Glu Arg Arg Tyr Ser145 150 155 160Asp Leu Thr Thr Leu Val Ala Phe Pro Ser Ser Ser Val Tyr Pro Thr165 170 175Lys Asp Glu Glu Asn Asn Pro Leu Glu Thr Glu Tyr Gly Leu Ser Val180 185 190Tyr Lys Asp His Gln Thr Ile Thr Ile Gln Glu Met Pro Glu Lys Ala195 200 205Pro Ala Gly Gln Leu Pro Arg Ser Val Asp Val Ile Leu Asp Asp Asp210 215 220Leu Val Asp Lys Ala Lys Pro Gly Asp Arg Val Gln Val Val Gly Thr225 230 235 240Tyr Arg Cys Leu Pro Gly Lys Lys Gly Gly Tyr Thr Ser Gly Thr Phe245 250 255Arg Thr Val Leu Ile Ala Cys Asn Val Lys Gln Met Ser Lys Asp Ala260 265 270Gln Pro Ser Phe Ser Ala Glu Asp Ile Ala Lys Ile Lys Lys Phe Ser275 280 285Lys Thr Arg Ser Lys Asp Ile Phe Asp Gln Leu Ala Lys Ser Leu Ala290 295 300Pro Ser Ile His Gly His Asp Tyr Val Lys Lys Ala Ile Leu Cys Leu305 310 315 320Leu Leu Gly Gly Val Glu Arg Asp Leu Glu Asn Gly Ser His Ile Arg325 330 335Gly Asp Ile Asn Ile Leu Leu Ile Gly Asp Pro Ser Val Ala Lys Ser340 345 350Gln Leu Leu Arg Tyr Val Leu Cys Thr Ala Pro Arg Ala Ile Pro Thr355 360 365
Thr Gly Arg Gly Ser Ser Gly Val Gly Leu Thr Ala Ala Val Thr Thr370 375 380Asp Gln Glu Thr Gly Glu Arg Arg Leu Glu Ala Gly Ala Met Val Leu385 390 395 400Ala Asp Arg Gly Val Val Cys Ile Asp Glu Phe Asp Lys Met Ser Asp405 410 415Met Asp Arg Thr Ala Ile His Glu Val Met Glu Gln Gly Arg Val Thr420 425 430Ile Ala Lys Ala Gly Ile His Ala Arg Leu Asn Ala Arg Cys Ser Val435 440 445Leu Ala Ala Ala Asn Pro Val Tyr Gly Arg Tyr Asp Gln Tyr Lys Thr450 455 460Pro Met Glu Asn Ile Gly Leu Gln Asp Ser Leu Leu Ser Arg Phe Asp465 470 475 480Leu Leu Phe Ile Met Leu Asp Gln Met Asp Pro Glu Gln Asp Arg Glu485 490 495Ile Ser Asp His Val Leu Arg Met His Arg Tyr Arg Ala Pro Gly Glu500 505 510Gln Asp Gly Asp Ala Met Pro Leu Gly Ser Ala Val Asp Ile Leu Ala515 520 525Thr Asp Asp Pro Asn Phe Ser Gln Glu Asp Gln Gln Asp Thr Gln Ile530 535 540Tyr Glu Lys His Asp Asn Leu Leu His Gly Thr Lys Lys Lys Lys Glu545 550 555 560Lys Met Val Ser Ala Ala Phe Met Lys Lys Tyr Ile His Val Ala Lys565 570 575Ile Ile Lys Pro Val Leu Thr Gln Glu Ser Ala Thr Tyr Ile Ala Glu580 585 590Glu Tyr Ser Arg Leu Arg Ser Gln Asp Ser Met Ser Ser Asp Thr Ala595 600 605Arg Thr Ser Pro Val Thr Ala Arg Thr Leu Glu Thr Leu Ile Arg Leu610 615 620
Ala Thr Ala His Ala Lys Ala Arg Met Ser Lys Thr Val Asp Leu Gln625 630 635 640Asp Ala Glu Glu Ala Val Glu Leu Val Gln Tyr Ala Tyr Phe Lys Lys645 650 655Val Leu Glu Lys Glu Lys Lys Arg Lys Lys Arg Ser Glu Asp Glu Ser660 665 670Glu Thr Glu Asp Glu Glu Glu Lys Ser Gln Glu Asp Gln Glu Gln Lys675 680 685Arg Lys Arg Arg Lys Thr Arg Gln Pro Asp Ala Lys Asp Gly Asp Ser690 695 700Tyr Asp Pro Tyr Asp Phe Ser Asp Thr Glu Glu Glu Met Pro Gln Val705 710 715 720His Thr Pro Lys Thr Ala Asp Ser Gln Glu Thr Lys Glu Ser Gln Lys725 730 735Val Glu Leu Ser Glu Ser Arg Leu Lys Ala Phe Lys Val Ala Leu Leu740 745 750Asp Val Phe Arg Glu Ala His Ala Gln Ser Ile Gly Met Asn Arg Leu755 760 765Thr Glu Ser Ile Asn Arg Asp Ser Glu Glu Pro Phe Ser Ser Val Glu770 775 780Ile Gln Ala Ala Leu Ser Lys Met Gln Asp Asp Asn Gln Val Met Val785 790 795 800Ser Glu Gly Ile Ile Phe Leu Ile805<210>81<211>165<212>PRT<213>人<300>
<308>sw_hum/rl12_human<309>1993-04-01<400>81Met Pro Pro Lys Phe Asp Pro Asn Glu Ile Lys Val Val Tyr Leu Arg
1 5 10 15Cys Thr Gly Gly Glu Val Gly Ala Thr Ser Ala Leu Ala Pro Lys Ile20 25 30Gly Pro Leu Gly Leu Ser Pro Lys Lys Val Gly Asp Asp Ile Ala Lys35 40 45Ala Thr Gly Asp Trp Lys Gly Leu Arg Ile Thr Val Lys Leu Thr Ile50 55 60Gln Asn Arg Gln Ala Gln Ile Glu Val Val Pro Ser Ala Ser Ala Leu65 70 75 80Ile Ile Lys Ala Leu Lys Glu Pro Pro Arg Asp Arg Lys Lys Gln Lys85 90 95Asn Ile Lys His Ser Gly Asn Ile Thr Phe Asp Glu Ile Val Asn Ile100 105 110Ala Arg Gln Met Arg His Arg Ser Leu Ala Arg Glu Leu Ser Gly Thr115 120 125Ile Lys Glu Ile Leu Gly Thr Ala Gln Ser Val Gly Cys Asn Val Asp130 135 140Gly Arg His Pro His Asp Ile Ile Asp Asp Ile Asn Ser Gly Ala Val145 150 155 160Glu Cys Pro Ala Ser165<210>82<211>918<212>PRT<213>人<220>
<221>MISC_FEATURE<222>(614)..(614)<223>x<220>
<221>MISC_FEATURE<222>(648)..(648)<223>x<300>
<308>tr_hum/q9y280
<309>1999-11-01<400>82Met Ala Ser Leu Ser Arg Ala Leu Arg Val Ala Ala Ala His Pro Arg1 5 10 15Gln Ser Pro Thr Arg Gly Met Gly Pro Cys Asn Leu Ser Ser Ala Ala20 25 30Gly Pro Thr Ala Glu Lys Ser Val Pro Tyr Gln Arg Thr Leu Lys Glu35 40 45Gly Gln Gly Thr Ser Val Val Ala Gln Gly Pro Ser Arg Pro Leu Pro50 55 60Ser Thr Ala Asn Val Val Val Ile Gly Gly Gly Ser Leu Gly Cys Gln65 70 75 80Thr Leu Tyr His Leu Ala Lys Leu Gly Met Ser Gly Ala Val Leu Leu85 90 95Glu Arg Glu Arg Leu Thr Ser Gly Thr Thr Trp His Thr Ala Gly Leu100 105 110Leu Trp Gln Leu Arg Pro Ser Asp Val Glu Val Glu Leu Leu Ala His115 120 125Thr Arg Arg Val Val Ser Arg Glu Leu Glu Glu Glu Thr Gly Leu His130 135 140Thr Gly Trp Ile Gln Asn Gly Gly Leu Phe Ile Ala Ser Asn Arg Gln145 150 155 160Arg Leu Asp Glu Tyr Lys Arg Leu Met Ser Leu Gly Lys Ala Tyr Gly165 170 175Val Glu Ser His Val Leu Ser Pro Ala Glu Thr Lys Thr Leu Tyr Pro180 185 190Leu Met Asn Val Asp Asp Leu Tyr Gly Thr Leu Tyr Val Pro His Asp195 200 205Gly Thr Met Asp Pro Ala Gly Thr Cys Thr Thr Leu Ala Arg Ala Ala210 215 220Ser Ala Arg Gly Ala Gln Val Ile Glu Asn Cys Pro Val Thr Gly Ile225 230 235 240
Arg Val Trp Thr Asp Asp Phe Gly Val Arg Arg Val Ala Gly Val Glu245 250 255Thr Gln His Gly Ser Ile Gln Thr Pro Cys Val Val Asn Cys Ala Gly260 265 270Val Trp Ala Ser Ala Val Gly Arg Met Ala Gly Val Lys Val Pro Leu275 280 285Val Ala Met His His Ala Tyr Val Val Thr Glu Arg Ile Glu Gly Ile290 295 300Gln Asn Met Pro Asn Val Arg Asp His Asp Ala Ser Val Tyr Leu Arg305 310 315 320Leu Gln Gly Asp Ala Leu Ser Val Gly Gly Tyr Glu Ala Asn Pro Ile325 330 335Phe Trp Glu Glu Val Ser Asp Lys Phe Ala Phe Gly Leu Phe Asp Leu340 345 350Asp Trp Glu Val Phe Thr Gln His Ile Glu Gly Ala Ile Asn Arg Val355 360 365Pro Val Leu Glu Lys Thr Gly Ile Lys Ser Thr Val Cys Gly Pro Glu370 375 380Ser Phe Thr Pro Asp His Lys Pro Leu Met Gly Glu Ala Pro Glu Leu385 390 395 400Arg Gly Phe Phe Leu Gly Cys Gly Phe Asn Ser Ala Gly Met Met Leu405 410 415Gly Gly Gly Cys Gly Gln Glu Leu Ala His Trp Ile Ile His Gly Arg420 425 430Pro Glu Lys Asp Met His Gly Tyr Asp Ile Arg Arg Phe His His Ser435 440 445Leu Thr Asp His Pro Arg Trp Ile Arg Glu Arg Ser His Glu Ser Tyr450 455 460Ala Lys Asn Tyr Ser Val Val Phe Pro His Asp Glu Pro Leu Ala Gly465 470 475 480
Arg Asn Met Arg Arg Asp Pro Leu His Glu Glu Leu Leu Gly Gln Gly485 490 495Cys Val Phe Gln Glu Arg His Gly Trp Glu Arg Pro Gly Trp Phe His500 505 510Pro Arg Gly Pro Ala Pro Val Leu Glu Tyr Asp Tyr Tyr Gly Ala Tyr515 520 525Gly Ser Arg Ala His Glu Asp Tyr Ala Tyr Arg Arg Leu Leu Ala Asp530 535 540Glu Tyr Thr Phe Ala Phe Pro Pro His His Asp Thr Ile Lys Lys Glu545 550 555 560Cys Leu Ala Cys Arg Gly Ala Ala Ala Val Phe Asp Met Ser Tyr Phe565 570 575Gly Lys Phe Tyr Leu Val Gly Leu Asp Ala Arg Lys Ala Ala Asp Trp580 585 590Leu Phe Ser Ala Asp Val Ser Arg Pro Pro Gly Ser Thr Val Tyr Thr595 600 605Cys Met Leu Asn His Xaa Gly Gly Thr Glu Ser Asp Leu Thr Val Ser610 615 620Arg Leu Ala Pro Ser His Gln Ala Ser Pro Leu Ala Pro Ala Phe Glu625 630 635 640Gly Asp Gly Tyr Tyr Leu Ala Xaa Gly Gly Ala Val Ala Gln His Asn645 650 655Trp Ser His Ile Thr Thr Val Leu Gln Asp Gln Lys Ser Gln Cys Gln660 665 670Leu Ile Asp Ser Ser Glu Asp Leu Gly Met Ile Ser Ile Gln Gly Pro675 680 685Ala Ser Arg Ala Ile Leu Gln Glu Val Leu Asp Ala Asp Leu Ser Asn690 695 700Glu Ala Phe Pro Phe Ser Thr His Lys Leu Leu Arg Ala Ala Gly His705 710 715 720Leu Val Arg Ala Met Arg Leu Ser Phe Val Gly Glu Leu Gly Trp Glu725 730 735
Leu His Ile Pro Lys Ala Ser Cys Val Pro Val Tyr Arg Ala Val Met740 745 750Ala Ala Gly Ala Lys His Gly Leu Ile Asn Ala Gly Tyr Arg Ala Ile755 760 765Asp Ser Leu Ser Ile Glu Lys Gly Tyr Arg His Trp His Ala Asp Leu770 775 780Arg Pro Asp Asp Ser Pro Leu Glu Ala Gly Leu Ala Phe Thr Cys Lys785 790 795 800Leu Lys Ser Pro Val Pro Phe Leu Gly Arg Glu Ala Leu Glu Gln Gln805 810 815Arg Ala Ala Gly Leu Arg Arg Arg Leu Val Cys Phe Thr Met Glu Asp820 825 830Lys Val Pro Met Phe Gly Leu Glu Ala Ile Trp Arg Asn Gly Gln Val835 840 845Val Gly His Val Arg Arg Ala Asp Phe Gly Phe Ala Ile Asp Lys Thr850 855 860Ile Ala Tyr Gly Tyr Ile His Asp Pro Ser Gly Gly Pro Val Ser Leu865 870 875 880Asp Phe Val Lys Ser Gly Asp Tyr Ala Leu Glu Arg Met Gly Val Thr885 890 895Tyr Gly Ala Gln Ala His Leu Lys Ser Pro Phe Asp Pro Asn Asn Lys900 905 910Arg Val Lys Gly Ile Tyr915<210>83<211>357<212>PRT<213>人<300>
<308>sw_hum/amrp_human<309>1993-04-01<400>83Met Ala Pro Arg Arg Val Arg Ser Phe Leu Arg Gly Leu Pro Ala Leu
1 5 10 15Leu Leu Leu Leu Leu Phe Leu Gly Pro Trp Pro Ala Ala Ser His Gly20 25 30Gly Lys Tyr Ser Arg Glu Lys Asn Gln Pro Lys Pro Ser Pro Lys Arg35 40 45Glu Ser Gly Glu Glu Phe Arg Met Glu Lys Leu Asn Gln Leu Trp Glu50 55 60Lys Ala Gln Arg Leu His Leu Pro Pro Val Arg Leu Ala Glu Leu His65 70 75 80Ala Asp Leu Lys Ile Gln Glu Arg Asp Glu Leu Ala Trp Lys Lys Leu85 90 95Lys Leu Asp Gly Leu Asp Glu Asp Gly Glu Lys Glu Ala Arg Leu Ile100 105 110Arg Asn Leu Asn Val Ile Leu Ala Lys Tyr Gly Leu Asp Gly Lys Lys115 120 125Asp Ala Arg Gln Val Thr Ser Asn Ser Leu Ser Gly Thr Gln Glu Asp130 135 140Gly Leu Asp Asp Pro Arg Leu Glu Lys Leu Trp His Lys Ala Lys Thr145 150 155 160Ser Gly Lys Phe Ser Gly Glu Glu Leu Asp Lys Leu Trp Arg Glu Phe165 170 175Leu His His Lys Glu Lys Val His Glu Tyr Asn Val Leu Leu Glu Thr180 185 190Leu Ser Arg Thr Glu Glu Ile His Glu Asn Val Ile Ser Pro Ser Asp195 200 205Leu Ser Asp Ile Lys Gly Ser Val Leu His Ser Arg His Thr Glu Leu210 215 220Lys Glu Lys Leu Arg Ser Ile Asn Gln Gly Leu Asp Arg Leu Arg Arg225 230 235 240Val Ser His Gln Gly Tyr Ser Thr Glu Ala Glu Phe Glu Glu Pro Arg245 250 255
Val Ile Asp Leu Trp Asp Leu Ala Gln Ser Ala Asn Leu Thr Asp Lys260 265 270Glu Leu Glu Ala Phe Arg Glu Glu Leu Lys His Phe Glu Ala Lys Ile275 280 285Glu Lys His Asn His Tyr Gln Lys Gln Leu Glu Ile Ala His Glu Lys290 295 300Leu Arg His Ala Glu Ser Val Gly Asp Gly Glu Arg Val Ser Arg Ser305 310 315 320Arg Glu Lys His Ala Leu Leu Glu Gly Arg Thr Lys Glu Leu Gly Tyr325 330 335Thr Val Lys Lys His Leu Gln Asp Leu Ser Gly Arg Ile Ser Arg Ala340 345 350Arg His Asn Glu Leu355<210>84<211>354<212>PRT<213>人<300>
<308>sw_hum/arg2_human<309>1997-11-01<400>84Met Ser Leu Arg Gly Ser Leu Ser Arg Leu Leu Gln Thr Arg Val His1 5 10 15Ser Ile Leu Lys Lys Ser Val His Ser Val Ala Val Ile Gly Ala Pro20 25 30Phe Ser Gln Gly Gln Lys Arg Lys Gly Val Glu His Gly Pro Ala Ala35 40 45Ile Arg Glu Ala Gly Leu Met Lys Arg Leu Ser Ser Leu Gly Cys His50 55 60Leu Lys Asp Phe Gly Asp Leu Ser Phe Thr Pro Val Pro Lys Asp Asp65 70 75 80Leu Tyr Asn Asn Leu Ile Val Asn Pro Arg Ser Val Gly Leu Ala Asn85 90 95
Gln Glu Leu Ala Glu Val Val Ser Arg Ala Val Ser Asp Gly Tyr Ser100 105 110Cys Val Thr Leu Gly Gly Asp His Ser Leu Ala Ile Gly Thr Ile Ser115 120 125Gly His Ala Arg His Cys Pro Asp Leu Cys Val Val Trp Val Asp Ala130 135 140His Ala Asp Ile Asn Thr Pro Leu Thr Thr Ser Ser Gly Asn Leu His145 150 155 160Gly Gln Pro Val Ser Phe Leu Leu Arg Glu Leu Gln Asp Lys Val Pro165 170 175Gln Leu Pro Gly Phe Ser Trp Ile Lys Pro Cys Ile Ser Ser Ala Ser180 185 190Ile Val Tyr Ile Gly Leu Arg Asp Val Asp Pro Pro Glu His Phe Ile195 200 205Leu Lys Asn Tyr Asp Ile Gln Tyr Phe Ser Met Arg Asp Ile Asp Arg210 215 220Leu Gly Ile Gln Lys Val Met Glu Arg Thr Phe Asp Leu Leu Ile Gly225 230 235 240Lys Arg Gln Arg Pro Ile His Leu Ser Phe Asp Ile Asp Ala Phe Asp245 250 255Pro Thr Leu Ala Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr260 265 270Tyr Arg Glu Gly Met Tyr Ile Ala Glu Glu Ile His Asn Thr Gly Leu275 280 285Leu Ser Ala Leu Asp Leu Val Glu Val Asn Pro Gln Leu Ala Thr Ser290 295 300Glu Glu Glu Ala Lys Thr Thr Ala Asn Leu Ala Val Asp Val Ile Ala305 310 315 320Ser Ser Phe Gly Gln Thr Arg Glu Gly Gly His Ile Val Tyr Asp Gln325 330 335
Leu Pro Thr Pro Ser Ser Pro Asp Glu Ser Glu Asn Gln Ala Arg Val340 345 350Arg Ile<210>85<211>333<212>PRT<213>人<300>
<308>sw_hum/if2b_human<309>1991-02-01<400>85Met Ser Gly Asp Glu Met Ile Phe Asp Pro Thr Met Ser Lys Lys Lys1 5 10 15Lys Lys Lys Lys Lys Pro Phe Met Leu Asp Glu Glu Gly Asp Thr Gln20 25 30Thr Glu Glu Thr Gln Pro Ser Glu Thr Lys Glu Val Glu Pro Glu Pro35 40 45Thr Glu Asp Lys Asp Leu Glu Ala Asp Glu Glu Asp Thr Arg Lys Lys50 55 60Asp Ala Ser Asp Asp Leu Asp Asp Leu Asn Phe Phe Asn Gln Lys Lys65 70 75 80Lys Lys Lys Lys Thr Lys Lys Ile Phe Asp Ile Asp Glu Ala Glu Glu85 90 95Gly Val Lys Asp Leu Lys Ile Glu Ser Asp Val Gln Glu Pro Thr Glu100 105 110Pro Glu Asp Asp Leu Asp Ile Met Leu Gly Asn Lys Lys Lys Lys Lys115 120 125Lys Asn Val Lys Phe Pro Asp Glu Asp Glu Ile Leu Glu Lys Asp Glu130 135 140Ala Leu Glu Asp Glu Asp Asn Lys Lys Asp Asp Gly Ile Ser Phe Ser145 150 155 160Asn Gln Thr Gly Pro Ala Trp Ala Gly Ser Glu Arg Asp Tyr Thr Tyr165 170 175
Glu Glu Leu Leu Asn Arg Val Phe Asn Ile Met Arg Glu Lys Asn Pro180 185 190Asp Met Val Ala Gly Glu Lys Arg Lys Phe Val Met Lys Pro Pro Gln195 200 205Val Val Arg Val Gly Thr Lys Lys Thr Ser Phe Val Asn Phe Thr Asp210 215 220Ile Cys Lys Leu Leu His Arg Gln Pro Lys His Leu Leu Ala Phe Leu225 230 235 240Leu Ala Glu Leu Gly Thr Ser Gly Ser Ile Asp Gly Asn Asn Gln Leu245 250 255Val Ile Lys Gly Arg Phe Gln Gln Lys Gln Ile Glu Asn Val Leu Arg260 265 270Arg Tyr Ile Lys Glu Tyr Val Thr Cys His Thr Cys Arg Ser Pro Asp275 280 285Thr Ile Leu Gln Lys Asp Thr Arg Leu Tyr Phe Leu Gln Cys Glu Thr290 295 300Cys His Ser Arg Cys Ser Val Ala Ser Ile Lys Thr Gly Phe Gln Ala305 310 315 320Val Thr Gly Lys Arg Ala Gln Leu Arg Ala Lys Ala Asn325 330<210>86<211>391<212>PRT<213>人<300>
<308>sw_hum/rog_human<309>1994-10-01<400>86Met Val Glu Ala Asp Arg Pro Gly Lys Leu Phe Ile Gly Gly Leu Asn1 5 10 15Thr Glu Thr Asn Glu Lys Ala Leu Glu Ala Val Phe Gly Lys Tyr Gly20 25 30Arg Ile Val Glu Val Leu Leu Met Lys Asp Arg Glu Thr Asn Lys Ser35 40 45
Arg Gly Phe Ala Phe Val Thr Phe Glu Ser Pro Ala Asp Ala Lys Asp50 55 60Ala Ala Arg Asp Met Asn Gly Lys Ser Leu Asp Gly Lys Ala Ile Lys65 70 75 80Val Glu Gln Ala Thr Lys Pro Ser Phe Glu Ser Gly Arg Arg Gly Pro85 90 95Pro Pro Pro Pro Arg Ser Arg Gly Pro Pro Arg Gly Leu Arg Gly Gly100 105 110Arg Gly Gly Ser Gly Gly Thr Arg Gly Pro Pro Ser Arg Gly Gly His115 120 125Met Asp Asp Gly Gly Tyr Ser Met Asn Phe Asn Met Ser Ser Ser Arg130 135 140Gly Pro Leu Pro Val Lys Arg Gly Pro Pro Pro Arg Ser Gly Gly Pro145 150 155 160Pro Pro Lys Arg Ser Ala Pro Ser Gly Pro Val Arg Ser Ser Ser Gly165 170 175Met Gly Gly Arg Ala Pro Val Ser Arg Gly Arg Asp Ser Tyr Gly Gly180 185 190Pro Pro Arg Arg Glu Pro Leu Pro Ser Arg Arg Asp Val Tyr Leu Ser195 200 205Pro Arg Asp Asp Gly Tyr Ser Thr Lys Asp Ser Tyr Ser Ser Arg Asp210 215 220Tyr Pro Ser Ser Arg Asp Thr Arg Asp Tyr Ala Pro Pro Pro Arg Asp225 230 235 240Tyr Thr Tyr Arg Asp Tyr Gly His Ser Ser Ser Arg Asp Asp Tyr Pro245 250 255Ser Arg Gly Tyr Ser Asp Arg Asp Gly Tyr Gly Arg Asp Arg Asp Tyr260 265 270Ser Asp His Pro Ser Gly Gly Ser Tyr Arg Asp Ser Tyr Glu Ser Tyr275 280 285
Gly Asn Ser Arg Ser Ala Pro Pro Thr Arg Gly Pro Pro Pro Ser Tyr290 295 300Gly Gly Ser Ser Arg Tyr Asp Asp Tyr Ser Ser Ser Arg Asp Gly Tyr305 310 315 320Gly Gly Ser Arg Asp Ser Tyr Ser Ser Ser Arg Ser Asp Leu Tyr Ser325 330 335Ser Gly Arg Asp Arg Val Gly Arg Gln Glu Arg Gly Leu Pro Pro Ser340 345 350Met Glu Arg Gly Tyr Pro Pro Pro Arg Asp Ser Tyr Ser Ser Ser Ser355 360 365Arg Gly Ala Pro Arg Gly Gly Gly Arg Gly Gly Ser Arg Ser Asp Arg370 375 380Gly Gly Gly Arg Ser Arg Tyr385 390<210>87<211>669<212>PRT<213>人<300>
<308>humangp/chr11-075932<309>2003-04-22<400>87Met Lys Ile Phe Val Gly Asn Val Asp Gly Ala Asp Thr Thr Pro Glu1 5 10 15Glu Leu Ala Ala Leu Phe Ala Pro Tyr Gly Thr Val Met Ser Cys Ala20 25 30Val Met Lys Gln Phe Ala Phe Val His Met Arg Glu Asn Ala Gly Ala35 40 45Leu Arg Ala Ile Glu Ala Leu His Gly His Glu Leu Arg Pro Gly Arg50 55 60Ala Leu Val Val Glu Met Ser Arg Pro Arg Pro Leu Asn Thr Trp Lys65 70 75 80Ile Phe Val Gly Asn Val Ser Ala Ala Cys Thr Ser Gln Glu Leu Arg85 90 95
Ser Leu Phe Glu Arg Arg Gly Arg Val Ile Glu Cys Asp Val Val Lys100 105 110Asp Tyr Ala Phe Val His Met Glu Lys Glu Ala Asp Ala Lys Ala Ala115 120 125Ile Ala Gln Leu Asn Gly Lys Glu Val Lys Gly Lys Arg Ile Asn Val130 135 140Glu Leu Ser Thr Lys Gly Gln Lys Lys Gly Pro Gly Leu Ala Val Gln145 150 155 160Ser Gly Asp Lys Thr Lys Lys Pro Gly Ala Gly Asp Thr Ala Phe Pro165 170 175Gly Thr Gly Gly Phe Ser Ala Thr Phe Asp Tyr Gln Gln Ala Phe Gly180 185 190Asn Ser Thr Gly Gly Phe Asp Gly Gln Ala Arg Gln Pro Thr Pro Pro195 200 205Phe Phe Gly Arg Asp Arg Ser Pro Leu Arg Arg Ser Pro Pro Arg Ala210 215 220Ser Tyr Val Ala Pro Leu Thr Ala Gln Pro Ala Thr Tyr Arg Ala Gln225 230 235 240Pro Ser Val Ser Leu Gly Ala Ala Tyr Arg Ala Gln Pro Ser Ala Ser245 250 255Leu Gly Val Gly Tyr Arg Thr Gln Pro Met Thr Ala Gln Ala Ala Ser260 265 270Tyr Arg Ala Gln Pro Ser Val Ser Leu Gly Ala Pro Tyr Arg Gly Gln275 280 285Leu Ala Ser Pro Ser Ser Gln Ser Ala Ala Ala Ser Ser Leu Gly Pro290 295 300Tyr Gly Gly Ala Gln Pro Ser Ala Ser Ala Leu Ser Ser Tyr Gly Gly305 310 315 320Gln Ala Ala Ala Ala Ser Ser Leu Asn Ser Tyr Gly Ala Gln Gly Ser325 330 335Ser Leu Ala Ser Tyr Gly Asn Gln Pro Ser Ser Tyr Gly Ala Gln Ala
340 345 350Ala Ser Ser Tyr Gly Val Arg Ala Ala Ala Ser Ser Tyr Asn Thr Gln355 360 365Gly Ala Ala Ser Ser Leu Gly Ser Tyr Gly Ala Gln Ala Ala Ser Tyr370 375 380Gly Ala Gln Ser Ala Ala Ser Ser Leu Ala Tyr Gly Ala Gln Ala Ala385 390 395 400Ser Tyr Asn Ala Gln Pro Ser Ala Ser Tyr Asn Ala Gln Ser Ala Pro405 410 415Tyr Ala Ala Gln Gln Ala Ala Ser Tyr Ser Ser Gln Pro Ala Ala Tyr420 425 430Val Ala Gln Pro Ala Thr Ala Ala Ala Tyr Ala Ser Gln Pro Ala Ala435 440 445Tyr Ala Ala Gln Ala Thr Thr Pro Met Ala Gly Ser Tyr Gly Ala Gln450 455 460Pro Val Val Gln Thr Gln Leu Asn Ser Tyr Gly Ala Gln Ala Ser Met465 470 475 480Gly Leu Ser Gly Ser Tyr Gly Ala Gln Ser Ala Ala Ala Ala Thr Gly485 490 495Ser Tyr Gly Ala Ala Ala Ala Tyr Gly Ala Gln Pro Ser Ala Thr Leu500 505 510Ala Ala Pro Tyr Arg Thr Gln Ser Ser Ala Ser Leu Ala Ala Ser Tyr515 520 525Ala Ala Gln Gln His Pro Gln Ala Ala Ala Ser Tyr Arg Gly Gln Pro530 535 540Gly Asn Ala Tyr Asp Gly Ala Gly Gln Pro Ser Ala Ala Tyr Leu Ser545 550 555 560Met Ser Gln Gly Ala Val Ala Asn Ala Asn Ser Thr Pro Pro Pro Tyr565 570 575Glu Arg Thr Arg Leu Ser Pro Pro Arg Ala Ser Tyr Asp Asp Pro Tyr580 585 590
Lys Lys Ala Val Ala Met Ser Lys Arg Tyr Gly Ser Asp Arg Arg Leu595 600 605Ala Glu Leu Ser Asp Tyr Arg Arg Leu Ser Glu Ser Gln Leu Ser Phe610 615 620Arg Arg Ser Pro Thr Lys Ser Ser Leu Asp Tyr Arg Arg Leu Pro Asp625 630 635 640Ala His Ser Asp Tyr Ala Arg Tyr Ser Gly Ser Tyr Asn Asp Tyr Leu645 650 655Arg Ala Ala Gln Met His Ser Gly Tyr Gln Arg Arg Met660 665<210>88<211>539<212>PRT<213>人<300>
<308>sw_hum/tcpd_human<309>1996-10-01<400>88Met Pro Glu Asn Val Ala Pro Arg Ser Gly Ala Thr Ala Gly Ala Ala1 5 10 15Gly Gly Arg Gly Lys Gly Ala Tyr Gln Asp Arg Asp Lys Pro Ala Gln20 25 30Ile Arg Phe Ser Asn Ile Ser Ala Ala Lys Ala Val Ala Asp Ala Ile35 40 45Arg Thr Ser Leu Gly Pro Lys Gly Met Asp Lys Met Ile Gln Asp Gly50 55 60Lys Gly Asp Val Thr Ile Thr Asn Asp Gly Ala Thr Ile Leu Lys Gln65 70 75 80Met Gln Val Leu His Pro Ala Ala Arg Met Leu Val Glu Leu Ser Lys85 90 95Ala Gln Asp Ile Glu Ala Gly Asp Gly Thr Thr Ser Val Val Ile Ile100 105 110Ala Gly Ser Leu Leu Asp Ser Cys Thr Lys Leu Leu Gln Lys Gly Ile115 120 125
His Pro Thr Ile Ile Ser Glu Ser Phe Gln Lys Ala Leu Glu Lys Gly130 135 140Ile Glu Ile Leu Thr Asp Met Ser Arg Pro Val Glu Leu Ser Asp Arg145 150 155 160Glu Thr Leu Leu Asn Ser Ala Thr Thr Ser Leu Asn Ser Lys Val Val165 170 175Ser Gln Tyr Ser Ser Leu Leu Ser Pro Met Ser Val Asn Ala Val Met180 185 190Lys Val Ile Asp Pro Ala Thr Ala Thr Ser Val Asp Leu Arg Asp Ile195 200 205Lys Ile Val Lys Lys Leu Gly Gly Thr Ile Asp Asp Cys Glu Leu Val210 215 220Glu Gly Leu Val Leu Thr Gln Lys Val Ser Asn Ser Gly Ile Thr Arg225 230 235 240Val Glu Lys Ala Lys Ile Gly Leu Ile Gln Phe Cys Leu Ser Ala Pro245 250 255Lys Thr Asp Met Asp Asn Gln Ile Val Val Ser Asp Tyr Ala Gln Met260 265 270Asp Arg Val Leu Arg Glu Glu Arg Ala Tyr Ile Leu Asn Leu Val Lys275 280 285Gln Ile Lys Lys Thr Gly Cys Asn Val Leu Leu Ile Gln Lys Ser Ile290 295 300Leu Arg Asp Ala Leu Ser Asp Leu Ala Leu His Phe Leu Asn Lys Met305 310 315 320Lys Ile Met Val Ile Lys Asp Ile Glu Arg Glu Asp Ile Glu Phe Ile325 330 335Cys Lys Thr Ile Gly Thr Lys Pro Val Ala His Ile Asp Gln Phe Thr340 345 350Ala Asp Met Leu Gly Ser Ala Glu Leu Ala Glu Glu Val Asn Leu Asn355 360 365
Gly Ser Gly Lys Leu Leu Lys Ile Thr Gly Cys Ala Ser Pro Gly Lys370 375 380Thr Val Thr Ile Val Val Arg Gly Ser Asn Lys Leu Val Ile Glu Glu385 390 395 400Ala Glu Arg Ser Ile His Asp Ala Leu Cys Val Ile Arg Cys Leu Val405 410 415Lys Lys Arg Ala Leu Ile Ala Gly Gly Gly Ala Pro Glu Ile Glu Leu420 425 430Ala Leu Ala Leu Thr Glu Tyr Ser Arg Thr Leu Ser Gly Met Glu Ser435 440 445Tyr Cys Val Arg Ala Phe Ala Asp Ala Met Glu Val Ile Pro Ser Thr450 455 460Leu Ala Glu Asn Ala Gly Leu Asn Pro Ile Ser Thr Val Thr Glu Leu465 470 475 480Arg Asn Arg His Ala Gln Gly Glu Lys Thr Ala Gly Ile Asn Val Arg485 490 495Lys Gly Gly Ile Ser Asn Ile Leu Glu Glu Leu Val Val Gln Pro Leu500 505 510Leu Val Ser Val Ser Ala Leu Thr Leu Ala Thr Glu Thr Val Arg Ser515 520 525Ile Leu Lys Ile Asp Asp Val Val Asn Thr Arg530 535<210>89<211>306<212>PRT<213>人<220>
<221>MISC_FEATURE<222>(30)..(30)<223>x<220>
<221>MISC_FEATURE<222>(114)..(114)<223>x<220>
<221>MISC_FEATURE<222>(117)..(117)<223>x<220>
<221>MISC_FEATURE<222>(126)..(126)<223>x<220>
<221>MISC_FEATURE<222>(131)..(131)<223>x<220>
<221>MISC_FEATURE<222>(132)..(132)<223>x<220>
<221>MISC_FEATURE<222>(139)..(139)<223>x<220>
<221>MISC_FEATURE<222>(141)..(141)<223>x<220>
<221>MISC_FEATURE<222>(152)..(152)<223>x<220>
<221>MISC_FEATURE<222>(157)..(157)<223>x<220>
<221>MISC_FEATURE<222>(172)..(172)<223>x<220>
<221>MISC_FEATURE<222>(174)..(174)<223>x<220>
<221>MISC_FEATURE<222>(175)..(175)
<223>x<220>
<221>MISC_FEATURE<222>(176)..(176)<223>x<220>
<221>MISC_FEATURE<222>(177)..(177)<223>x<220>
<221>MISC_FEATURE<222>(179)..(179)<223>x<220>
<221>MISC_FEATURE<222>(189)..(189)<223>x<220>
<221>MISC_FEATURE<222>(193)..(193)<223>x<220>
<221>MISC_FEATURE<222>(198)..(198)<223>x<220>
<221>MISC_FEATURE<222>(199)..(199)<223>x<220>
<221>MISC_FEATURE<222>(201)..(201)<223>x<220>
<221>MISC_FEATURE<222>(202)..(202)<223>x<220>
<221>MISC_FEATURE<222>(204)..(204)<223>x
<220>
<221>MISC_FEATURE<222>(206)..(206)<223>x<220>
<221>MISC_FEATURE<222>(209)..(209)<223>x<220>
<221>MISC_FEATURE<222>(211)..(211)<223>x<220>
<221>MISC_FEATURE<222>(214)..(214)<223>x<220>
<221>MISC_FEATURE<222>(217)..(217)<223>x<220>
<221>MISC_FEATURE<222>(234)..(234)<223>x<300>
<308>hsugp/075546-8-0<309>2003-02-16<400>89Arg Trp Pro Leu Pro Pro Pro Pro Pro Gly Cys Arg Gln Lys Glu Asp1 5 10 15Ala Asp Leu Glu Glu Gln Leu Ser Asp Glu Glu Lys Val Xaa Tyr Arg20 25 30Ala Lys Phe Ile Ile His Ala Pro Pro Gly Glu Phe Asn Glu Val Phe35 40 45Asn Asp Val Arg Leu Leu Leu Asn Asn Asp Asn Leu Leu Arg Glu Gly50 55 60Ala Ala His Ala Phe Ala Gln Tyr Asn Leu Asp Gln Phe Thr Pro Val65 70 75 80
Lys Ile Glu Gly Tyr Glu Asp Gln Val Leu Ile Thr Asn Met Gly Asp85 90 95Leu Gly Asn Gly Lys Val Phe Gly Ile Gln Arg Thr Glu Ser Val Leu100 105 110Asn Xaa Asp His Xaa Lys Glu Gly Gly Gln Leu Ile Gln Xaa Pro Cys115 120 125Glu Val Xaa Xaa Met Gln Leu Asn His Gly Xaa Thr Xaa Ser Arg Asn130 135 140Cys Ser Glu Ser Leu Arg Lys Xaa Asn Ile Thr Arg Xaa Gly Val Cys145 150 155 160Thr Val Tyr Gly Lys Lys Ile Asp Gly Gln Gln Xaa Ile Xaa Xaa Xaa165 170 175Xaa Ile Xaa Lys Pro Ser Val Pro Ser Lys Lys Phe Xaa Asn Gly Arg180 185 190Xaa Arg Ser Glu Trp Xaa Xaa Thr Xaa Xaa Pro Xaa Asn Xaa Ser Ser195 200 205Xaa Trp Xaa Leu Glu Xaa Pro Val Xaa Tyr Tyr Asp Asp Gly Tyr Val210 215 220Gln Leu Val Ser His Asn Gly Phe Gln Xaa Ser Leu Thr Val Ser Asn225 230 235 240Gly Val His Gln Pro Lys Asn Tyr Lys Val Val Thr Val Arg Met Asn245 250 255Ser Met Leu Gly Glu Phe Arg His Val Ala Tyr Ser Ser Leu Val Lys260 265 270Gly Arg Pro Gln Arg Trp Glu Asp Phe Asn Gly Ser Ala Leu Lys Arg275 280 285Arg Ser Ser Thr Asn Lys Gly Arg Gly Thr Lys Arg Thr Pro Leu Pro290 295 300Asp Phe305<210>90
<211>531<212>PRT<213>人<300>
<308>humangp/chr3-075191<309>2003-04-22<400>90Met Ala Glu His Ala Pro Arg Arg Cys Cys Leu Gly Trp Asp Phe Ser1 5 10 15Thr Gln Gln Val Lys Val Val Ala Val Asp Ala Glu Leu Asn Val Phe20 25 30Tyr Glu Glu Ser Val His Phe Asp Arg Asp Leu Pro Glu Phe Gly Tyr35 40 45Val Leu Asp Val His Val Thr Gln Gly Gly Val His Val His Lys Asp50 55 60Gly Leu Thr Val Thr Ser Pro Val Leu Met Trp Val Gln Ala Leu Asp65 70 75 80Ile Ile Leu Glu Lys Met Lys Ala Ser Gly Phe Asp Phe Ser Gln Val85 90 95Leu Ala Leu Ser Gly Ala Gly Gln Gln His Gly Ser Ile Tyr Trp Lys100 105 110Ala Gly Ala Gln Gln Ala Leu Thr Ser Leu Ser Pro Asp Leu Arg Leu115 120 125His Gln Gln Leu Gln Asp Cys Phe Ser Ile Ser Asp Cys Pro Val Trp130 135 140Met Asp Ser Ser Thr Thr Ala Gln Cys Arg Gln Leu Glu Ala Ala Val145 150 155 160Gly Gly Ala Gln Ala Leu Ser Cys Leu Thr Gly Ser Arg Ala Tyr Glu165 170 175Arg Phe Thr Gly Asn Gln Ile Ala Lys Ile Tyr Gln Gln Asn Pro Glu180 185 190Ala Tyr Ser His Thr Glu Arg Ile Ser Leu Val Ser Ser Phe Ala Ala195 200 205
Ser Leu Phe Leu Gly Ser Tyr Ser Pro Ile Asp Tyr Ser Asp Gly Ser210 215 220Gly Met Asn Leu Leu Gln Ile Gln Asp Lys Val Trp Ser Gln Ala Cys225 230 235 240Leu Gly Ala Cys Ala Pro His Leu Glu Glu Lys Leu Ser Pro Pro Val245 250 255Pro Ser Cys Ser Val Val Gly Ala Ile Ser Ser Tyr Tyr Val Gln Arg260 265 270Tyr Gly Phe Pro Pro Gly Cys Lys Val Val Ala Phe Thr Gly Asp Asn275 280 285Pro Ala Ser Leu Ala Gly Met Arg Leu Glu Glu Gly Asp Ile Ala Val290 295 300Ser Leu Gly Thr Ser Asp Thr Leu Phe Leu Trp Leu Gln Glu Pro Met305 310 315 320Pro Ala Leu Glu Gly His Ile Phe Cys Asn Pro Val Asp Ser Gln His325 330 335Tyr Met Ala Leu Leu Cys Phe Lys Asn Gly Ser Leu Met Arg Glu Lys340 345 350Ile Arg Asn Glu Ser Val Ser Arg Ser Trp Ser Asp Phe Ser Lys Ala355 360 365Leu Gln Ser Thr Glu Met Gly Asn Gly Gly Asn Leu Gly Phe Tyr Phe370 375 380Asp Val Met Glu Ile Thr Pro Glu Ile Ile Gly Arg His Arg Phe Asn385 390 395 400Thr Glu Asn His Lys Val Ala Ala Phe Pro Gly Asp Val Glu Val Arg405 410 415Ala Leu Ile Glu Gly Gln Phe Met Ala Lys Arg Ile His Ala Glu Gly420 425 430Leu Gly Tyr Arg Val Met Ser Lys Thr Lys Ile Leu Ala Thr Gly Gly435 440 445Ala Ser His Asn Arg Glu Ile Leu Gln Val Leu Ala Asp Val Phe Asp450 455 460
Ala Pro Val Tyr Val Ile Asp Thr Ala Asn Ser Ala Cys Val Gly Ser465 470 475 480Ala Tyr Arg Ala Phe His Gly Leu Ala Gly Gly Thr Asp Val Pro Phe485 490 495Ser Glu Val Val Lys Leu Ala Pro Asn Pro Arg Leu Ala Ala Thr Pro500 505 510Ser Pro Gly Ala Ser Gln Val Arg Asp His Arg Asn Leu Phe Val Ala515 520 525Phe Ala Leu530<210>91<211>384<212>PRT<213>人<300>
<308>sw_hum/dus9_human<309>1998-12-15<400>91Met Glu Gly Leu Gly Arg Ser Cys Leu Trp Leu Arg Arg Glu Leu Ser1 5 10 15Pro Pro Arg Pro Arg Leu Leu Leu Leu Asp Cys Arg Ser Arg Glu Leu20 25 30Tyr Glu Ser Ala Arg Ile Gly Gly Ala Leu Ser Val Ala Leu Pro Ala35 40 45Leu Leu Leu Arg Arg Leu Arg Arg Gly Ser Leu Ser Val Arg Ala Leu50 55 60Leu Pro Gly Pro Pro Leu Gln Pro Pro Pro Pro Ala Pro Val Leu Leu65 70 75 80Tyr Asp Gln Gly Gly Gly Arg Arg Arg Arg Gly Glu Ala Glu Ala Glu85 90 95Ala Glu Glu Trp Glu Ala Glu Ser Val Leu Gly Thr Leu Leu Gln Lys100 105 110Leu Arg Glu Glu Gly Tyr Leu Ala Tyr Tyr Leu Gln Gly Gly Phe Ser
115 120 125Arg Phe Gln Ala Glu Cys Pro His Leu Cys Glu Thr Ser Leu Ala Gly130 135 140Arg Ala Gly Ser Ser Met Ala Pro Val Pro Gly Pro Val Pro Val Val145 150 155 160Gly Leu Gly Ser Leu Cys Leu Gly Ser Asp Cys Ser Asp Ala Glu Ser165 170 175Glu Ala Asp Arg Asp Ser Met Ser Cys Gly Leu Asp Ser Glu Gly Ala180 185 190Thr Pro Pro Pro Val Gly Leu Arg Ala Ser Phe Pro Val Gln Ile Leu195 200 205Pro Asn Leu Tyr Leu Gly Ser Ala Arg Asp Ser Ala Asn Leu Glu Ser210 215 220Leu Ala Lys Leu Gly Ile Arg Tyr Ile Leu Asn Val Thr Pro Asn Leu225 230 235 240Pro Asn Phe Phe Glu Lys Asn Gly Asp Phe His Tyr Lys Gln Ile Pro245 250 255Ile Ser Asp His Trp Ser Gln Asn Leu Ser Arg Phe Phe Pro Glu Ala260 265 270Ile Glu Phe Ile Asp Glu Ala Leu Ser Gln Asn Cys Gly Val Leu Val275 280 285His Cys Leu Ala Gly Val Ser Arg Ser Val Thr Val Thr Val Ala Tyr290 295 300Leu Met Gln Lys Leu His Leu Ser Leu Asn Asp Ala Tyr Asp Leu Val305 310 315 320Lys Arg Lys Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe Met Gly Gln325 330 335Leu Leu Asp Phe Glu Arg Ser Leu Arg Leu Glu Glu Arg His Ser Gln340 345 350Glu Gln Gly Ser Gly Gly Gln Ala Ser Ala Ala Ser Asn Pro Pro Ser355 360 365
Phe Phe Thr Thr Pro Thr Ser Asp Gly Ala Phe Glu Leu Ala Pro Thr370 375 380<210>92<211>218<212>PRT<213>人<300>
<308>sw_hum/gtm4_human<309>1995-11-01<400>92Met Ser Met Thr Leu Gly Tyr Trp Asp Ile Arg Gly Leu Ala His Ala1 5 10 15Ile Arg Leu Leu Leu Glu Tyr Thr Asp Ser Ser Tyr Glu Glu Lys Lys20 25 30Tyr Thr Met Gly Asp Ala Pro Asp Tyr Asp Arg Ser Gln Trp Leu Asn35 40 45Glu Lys Phe Lys Leu Gly Leu Asp Phe Pro Asn Leu Pro Tyr Leu Ile50 55 60Asp Gly Ala His Lys Ile Thr Gln Ser Asn Ala Ile Leu Cys Tyr Ile65 70 75 80Ala Arg Lys His Asn Leu Cys Gly Glu Thr Glu Glu Glu Lys Ile Arg85 90 95Val Asp Ile Leu Glu Asn Gln Ala Met Asp Val Ser Asn Gln Leu Ala100 105 110Arg Val Cys Tyr Ser Pro Asp Phe Glu Lys Leu Lys Pro Glu Tyr Leu115 120 125Glu Glu Leu Pro Thr Met Met Gln His Phe Ser Gln Phe Leu Gly Lys130 135 140Arg Pro Trp Phe Val Gly Asp Lys Ile Thr Phe Val Asp Phe Leu Ala145 150 155 160Tyr Asp Val Leu Asp Leu His Arg Ile Phe Glu Pro Asn Cys Leu Asp165 170 175Ala Phe Pro Asn Leu Lys Asp Phe Ile Ser Arg Phe Glu Gly Leu Glu180 185 190
Lys Ile Ser Ala Tyr Met Lys Ser Ser Arg Phe Leu Pro Lys Pro Leu195 200 205Tyr Thr Arg Val Ala Val Trp Gly Asn Lys210 215<210>93<211>207<212>PRT<213>人<300>
<308>sw_hum/rs8_humam<309>1988-11-01<400>93Gly Ile Ser Arg Asp Asn Trp His Lys Arg Arg Lys Thr Gly Gly Lys1 5 10 15Arg Lys Pro Tyr His Lys Lys Arg Lys Tyr Glu Leu Gly Arg Pro Ala20 25 30Ala Asn Thr Lys Ile Gly Pro Arg Arg Ile His Thr Val Arg Val Arg35 40 45Gly Gly Asn Lys Lys Tyr Arg Ala Leu Arg Leu Asp Val Gly Asn Phe50 55 60Ser Trp Gly Ser Glu Cys Cys Thr Arg Lys Thr Arg Ile Ile Asp Val65 70 75 80Val Tyr Asn Ala Ser Asn Asn Glu Leu Val Arg Thr Lys Thr Leu Val85 90 95Lys Asn Cys Ile Val Leu Ile Asp Ser Thr Pro Tyr Arg Gln Trp Tyr100 105 110Glu Ser His Tyr Ala Leu Pro Leu Gly Arg Lys Lys Gly Ala Lys Leu115 120 125Thr Pro Glu Glu Glu Glu Ile Leu Asn Lys Lys Arg Ser Lys Lys Ile130 135 140Gln Lys Lys Tyr Asp Glu Arg Lys Lys Asn Ala Lys Ile Ser Ser Leu145 150 155 160Leu Glu Glu Gln Phe Gln Gln Gly Lys Leu Leu Ala Cys Ile Ala Ser
165 170 175Arg Pro Gly Gln Cys Gly Arg Ala Asp Gly Tyr Val Leu Glu Gly Lys180 185 190Glu Leu Glu Phe Tyr Leu Arg Lys Ile Lys Ala Arg Lys Gly Lys195 200 205<210>94<211>299<212>PRT<213>人<300>
<308>sw_hum/sm30_human<309>1998-07-15<400>94Met Ser Ser Ile Lys Ile Glu Cys Val Leu Pro Glu Asn Cys Arg Cys1 5 10 15Gly Glu Ser Pro Val Trp Glu Glu Val Ser Asn Ser Leu Leu Phe Val20 25 30Asp Ile Pro Ala Lys Lys Val Cys Arg Trp Asp Ser Phe Thr Lys Gln35 40 45Val Gln Arg Val Thr Met Asp Ala Pro Val Ser Ser Val Ala Leu Arg50 55 60Gln Ser Gly Gly Tyr Val Ala Thr Ile Gly Thr Lys Phe Cys Ala Leu65 70 75 80Asn Trp Lys Glu Gln Ser Ala Val Val Leu Ala Thr Val Asp Asn Asp85 90 95Lys Lys Asn Asn Arg Phe Asn Asp Gly Lys Val Asp Pro Ala Gly Arg100 105 110Tyr Phe Ala Gly Thr Met Ala Glu Glu Thr Ala Pro Ala Val Leu Glu115 120 125Arg His Gln Gly Ala Leu Tyr Ser Leu Phe Pro Asp His His Val Lys130 135 140Lys Tyr Phe Asp Gln Val Asp Ile Ser Asn Gly Leu Asp Trp Ser Leu145 150 155 160
Asp His Lys Ile Phe Tyr Tyr Ile Asp Ser Leu Ser Tyr Ser Val Asp165 170 175Ala Phe Asp Tyr Asp Leu Gln Thr Gly Gln Ile Ser Asn Arg Arg Ser180 185 190Val Tyr Lys Leu Glu Lys Glu Glu Gln Ile Pro Asp Gly Met Cys Ile195 200 205Asp Ala Glu Gly Lys Leu Trp Val Ala Cys Tyr Asn Gly Gly Arg Val210 215 220Ile Arg Leu Asp Pro Val Thr Gly Lys Arg Leu Gln Thr Val Lys Leu225 230 235 240Pro Val Asp Lys Thr Thr Ser Cys Cys Phe Gly Gly Lys Asn Tyr Ser245 250 255Glu Met Tyr Val Thr Cys Ala Arg Asp Gly Met Asp Pro Glu Gly Leu260 265 270Leu Arg Gln Pro Glu Ala Gly Gly Ile Phe Lys Ile Thr Gly Leu Gly275 280 285Val Lys Gly Ile Ala Pro Tyr Ser Tyr Ala Gly290 295<210>95<211>253<212>PRT<213>人<220>
<221>MISC_FEATURE<222>(76)..(76)<223>x<220>
<221>MISC_FEATURE<222>(114)..(114)<223>x<300>
<308>hsugp/013561-2-0<309>2003-02-16<400>95Cys Val Val Asp Asn Pro Tyr Tyr Pro Pro Phe Glu Trp Ser Leu Lys1 5 10 15
Pro Val Arg Pro Gln Pro Glu Arg Pro Glu Pro Ser Glu Phe Arg Glu20 25 30Arg Gly Lys Arg Lys Glu Pro Pro Ile Arg Gln Pro Ala Ser Pro Arg35 40 45Gly Val Ala Gly Leu Ile Asn Ala Asp Gly His Asp Arg Phe Pro Asp50 55 60Trp Lys Pro Ala Ser Glu Arg Asn Ala Ile Asn Xaa Glu Leu Ala His65 70 75 80Ser Leu Gly Thr Pro Gly Phe Thr Leu Tyr Ala Ser Gly Ser Tyr Val85 90 95Val Trp Asn Cys Glu Arg Ile Thr Ile Ser Thr Gly Asn Ser Tyr Asp100 105 110Met Xaa Tyr Glu Phe Asn Thr Thr His Tyr Arg Glu Phe Gly Pro Arg115 120 125Asp Gln Glu Phe Gly Thr Arg Gly Thr Asn Met Asp Asn Arg Leu Pro130 135 140Leu Glu Asn Gly Arg Phe Ile Ala Gly Thr Gly Cys Leu Val Arg Ala145 150 155 160Val Glu Met Ala Ala Gln Arg Gln Ala Asp Ile Ile Gly Lys Pro Ser165 170 175Arg Phe Ile Phe Asp Cys Val Ser Gln Glu Tyr Gly Ile Asn Pro Glu180 185 190Arg Thr Val Met Val Gly Asp Arg Leu Asp Thr Asp Ile Leu Leu Gly195 200 205Ala Thr Cys Gly Leu Lys Thr Ile Leu Thr Leu Thr Gly Val Ser Thr210 215 220Leu Gly Asp Val Lys Asn Asn Gln Glu Ser Asp Cys Val Ser Lys Lys225 230 235 240Lys Met Val Pro Asp Phe Tyr Val Asp Ser Ile Ala Asp245 250<210>96
<211>236<212>PRT<213>人<300>
<308>humangp/chr2-q9uqe6<309>2003-01-07<400>96Met Ala Ala Glu Arg Gly Ala Gly Gln Gln Gln Ser Gln Glu Met Met1 5 10 15Glu Glu Glu His Glu Leu Pro Val Asp Met Glu Thr Ile Asn Leu Asp20 25 30Arg Asp Ala Glu Asp Val Asp Leu Asn His Tyr Arg Ile Gly Lys Ile35 40 45Glu Gly Phe Glu Val Leu Lys Lys Val Lys Thr Leu Cys Leu Arg Gln50 55 60Asn Leu Ile Lys Cys Ile Glu Asn Leu Glu Glu Leu Gln Ser Leu Arg65 70 75 80Glu Leu Asp Leu Tyr Asp Asn Gln Ile Lys Lys Ile Glu Asn Leu Glu85 90 95Ala Leu Thr Glu Leu Glu Ile Leu Asp Ile Ser Phe Asn Leu Leu Arg100 105 110Asn Ile Glu Gly Val Asp Lys Leu Thr Arg Leu Lys Lys Leu Phe Leu115 120 125Val Asn Asn Lys Ile Ser Lys Ile Glu Asn Leu Ser Asn Leu His Gln130 135 140Leu Gln Met Leu Glu Leu Gly Ser Asn Arg Ile Arg Ala Ile Glu Asn145 150 155 160Ile Asp Thr Leu Thr Asn Leu Glu Ser Leu Phe Leu Gly Lys Asn Lys165 170 175Ile Thr Lys Leu Gln Asn Leu Asp Ala Leu Thr Asn Leu Thr Val Leu180 185 190Ser Met Gln Ser Asn Arg Leu Thr Lys Ile Glu Gly Leu Gln Asn Leu195 200 205
Val Asn Leu Arg Glu Leu Tyr Leu Ser His Asn Gly Ile Glu Val Ile210 215 220Glu Gly Leu Glu Asn Asn Val Arg His Pro Leu Ser225 230 235<210>97<211>718<212>PRT<213>人<300>
<308>humangp/chr7-q9unh0<309>2003-01-07<400>97Met Glu Asp Leu Gly Glu Asn Thr Met Val Leu Ser Thr Leu Arg Ser1 5 10 15Leu Asn Asn Phe Ile Ser Gln Arg Val Glu Gly Gly Ser Gly Leu Asp20 25 30Ile Ser Thr Ser Ala Pro Gly Ser Leu Gln Met Gln Tyr Gln Gln Ser35 40 45Met Gln Leu Glu Glu Arg Ala Glu Gln Ile Arg Ser Lys Ser His Leu50 55 60Ile Gln Val Glu Arg Glu Lys Met Gln Met Glu Leu Ser His Lys Arg65 70 75 80Ala Arg Val Glu Leu Glu Arg Ala Ala Ser Thr Ser Ala Arg Asn Tyr85 90 95Glu Arg Glu Val Asp Arg Asn Gln Glu Leu Leu Thr Arg Ile Arg Gln100 105 110Leu Gln Glu Arg Glu Ala Gly Ala Glu Glu Lys Met Gln Glu Gln Leu115 120 125Glu Arg Asn Arg Gln Cys Gln Gln Asn Leu Asp Ala Ala Ser Lys Arg130 135 140Leu Arg Glu Lys Glu Asp Ser Leu Ala Gln Ala Gly Glu Thr Ile Asn145 150 155 160Ala Leu Lys Gly Arg Ile Ser Glu Leu Gln Trp Ser Val Met Asp Gln165 170 175
Glu Met Arg Val Lys Arg Leu Glu Ser Glu Lys Gln Glu Leu Gln Glu180 185 190Gln Leu Asp Leu Gln His Lys Lys Cys Gln Glu Ala Asn Gln Lys Ile195 200 205Gln Glu Leu Gln Ala Ser Gln Glu Ala Arg Ala Asp His Glu Gln Gln210 215 220Ile Lys Asp Leu Glu Gln Lys Leu Ser Leu Gln Glu Gln Asp Ala Ala225 230 235 240Ile Val Lys Asn Met Lys Ser Glu Leu Val Arg Leu Pro Arg Leu Glu245 250 255Arg Glu Leu Lys Gln Leu Arg Glu Glu Ser Ala His Leu Arg Glu Met260 265 270Arg Glu Thr Asn Gly Leu Leu Gln Glu Glu Leu Glu Gly Leu Gln Arg275 280 285Lys Leu Gly Arg Gln Glu Lys Met Gln Glu Thr Leu Val Gly Leu Glu290 295 300Leu Glu Asn Glu Arg Leu Leu Ala Lys Leu Gln Ser Trp Glu Arg Leu305 310 315 320Asp Gln Thr Met Gly Leu Ser Ile Arg Thr Pro Glu Asp Leu Ser Arg325 330 335Phe Val Val Glu Leu Gln Gln Arg Glu Leu Ala Leu Lys Asp Lys Asn340 345 350Ser Ala Val Thr Ser Ser Ala Arg Gly Leu Glu Lys Ala Arg Gln Gln355 360 365Leu Gln Glu Glu Leu Arg Gln Val Ser Gly Gln Leu Leu Glu Glu Arg370 375 380Lys Lys Arg Glu Thr His Glu Ala Leu Ala Arg Arg Leu Gln Lys Arg385 390 395 400Val Leu Leu Leu Thr Lys Glu Arg Asp Gly Met Arg Ala Ile Leu Gly405 410 415Ser Tyr Asp Ser Glu Leu Thr Pro Ala Glu Tyr Ser Pro Gln Leu Thr
420 425 430Arg Arg Met Arg Glu Ala Glu Asp Met Val Gln Lys Val His Ser His435 440 445Ser Ala Glu Met Glu Ala Gln Leu Ser Gln Ala Leu Glu Glu Leu Gly450 455 460Gly Gln Lys Gln Arg Ala Asp Met Leu Glu Met Glu Leu Lys Met Leu465 470 475 480Lys Ser Gln Ser Ser Ser Ala Glu Gln Ser Phe Leu Phe Ser Arg Glu485 490 495Glu Ala Asp Thr Leu Arg Leu Lys Val Glu Glu Leu Glu Gly Glu Arg500 505 510Ser Arg Leu Glu Glu Glu Lys Arg Met Leu Glu Ala Gln Leu Glu Arg515 520 525Arg Ala Leu Gln Gly Asp Tyr Asp Gln Ser Arg Thr Lys Val Leu His530 535 540Met Ser Leu Asn Pro Thr Ser Val Ala Arg Gln Arg Leu Arg Glu Asp545 550 555 560His Ser Gln Leu Gln Ala Glu Cys Glu Arg Leu Arg Gly Leu Leu Arg565 570 575Ala Met Glu Arg Gly Gly Thr Val Pro Ala Asp Leu Glu Ala Ala Ala580 585 590Ala Ser Leu Pro Ser Ser Lys Glu Val Ala Glu Leu Lys Lys Gln Val595 600 605Glu Ser Ala Glu Leu Lys Asn Gln Arg Leu Lys Glu Val Phe Gln Thr610 615 620Lys Ile Gln Glu Phe Arg Lys Ala Cys Tyr Thr Leu Thr Gly Tyr Gln625 630 635 640Ile Asp Ile Thr Thr Glu Asn Gln Tyr Arg Leu Thr Ser Leu Tyr Ala645 650 655Glu His Pro Gly Asp Cys Leu Ile Phe Lys Ala Thr Ser Pro Ser Gly660 665 670
Ser Lys Met Gln Leu Leu Glu Thr Glu Phe Ser His Thr Val Gly Glu675 680 685Leu Ile Glu Val His Leu Arg Arg Gln Asp Ser Ile Pro Ala Phe Leu690 695 700Ser Ser Leu Thr Leu Glu Leu Phe Ser Arg Gln Thr Val Ala705 710 715<210>98<211>182<212>PRT<213>人<300>
<308>sw_hum/pebb_human<309>1997-11-01<400>98Met Pro Arg Val Val Pro Asp Gln Arg Ser Lys Phe Glu Asn Glu Glu1 5 10 15Phe Phe Arg Lys Leu Ser Arg Glu Cys Glu Ile Lys Tyr Thr Gly Phe20 25 30Arg Asp Arg Pro His Glu Glu Arg Gln Ala Arg Phe Gln Asn Ala Cys35 40 45Arg Asp Gly Arg Ser Glu Ile Ala Phe Val Ala Thr Gly Thr Asn Leu50 55 60Ser Leu Gln Phe Phe Pro Ala Ser Trp Gln Gly Glu Gln Arg Gln Thr65 70 75 80Pro Ser Arg Glu Tyr Val Asp Leu Glu Arg Glu Ala Gly Lys Val Tyr85 90 95Leu Lys Ala Pro Met Ile Leu Asn Gly Val Cys Val Ile Trp Lys Gly100 105 110Trp Ile Asp Leu Gln Arg Leu Asp Gly Met Gly Cys Leu Glu Phe Asp115 120 125Glu Glu Arg Ala Gln Gln Glu Asp Ala Leu Ala Gln Gln Ala Phe Glu130 135 140Glu Ala Arg Arg Arg Thr Arg Glu Phe Glu Asp Arg Asp Arg Ser His145 150 155 160
Arg Glu Glu Met Glu Val Arg Val Ser Gln Leu Leu Ala Val Thr Gly165 170 175Lys Lys Thr Thr Arg Pro180<210>99<211>737<212>PRT<213>人<220>
<221>MISC_FEATURE<222>(98)..(98)<223>x<220>
<221>MISC_FEATURE<222>(242)..(242)<223>x<220>
<221>MISC_FEATURE<222>(259)..(259)<223>x<220>
<221>MISC_FEATURE<222>(262)..(262)<223>x<220>
<221>MISC_FEATURE<222>(263)..(263)<223>x<220>
<221>MISC_FEATURE<222>(264)..(264)<223>x<220>
<221>MISC_FEATURE<222>(269)..(269)<223>x<220>
<221>MISC_FEATURE<222>(282)..(282)<223>x
<220>
<221>MISC_FEATURE<222>(283)..(283)<223>x<220>
<221>MISC_FEATURE<222>(284)..(284)<223>x<220>
<221>MISC_FEATURE<222>(337)..(337)<223>x<220>
<221>MISC_FEATURE<222>(368)..(368)<223>x<220>
<221>MISC_FEATURE<222>(418)..(418)<223>x<220>
<221>MISC_FEATURE<222>(419)..(419)<223>x<220>
<221>MISC_FEATURE<222>(425)..(425)<223>x<220>
<221>MISC_FEATURE<222>(428)..(428)<223>x<220>
<221>MISC_FEATURE<222>(429)..(429)<223>x<220>
<221>MISC_FEATURE<222>(430)..(430)<223>x<220>
<221>MISC_FEATURE<222>(432)..(432)<223>x<220>
<221>MISC_FEATURE<222>(439)..(439)<223>x<220>
<221>MISC_FEATURE<222>(443)..(443)<223>x<220>
<221>MISC_FEATURE<222>(499)..(499)<223>x<220>
<221>MISC_FEATURE<222>(500)..(500)<223>x<220>
<221>MISC_FEATURE<222>(502)..(502)<223>x<220>
<221>MISC_FEATURE<222>(506)..(506)<223>x<220>
<221>MISC_FEATURE<222>(507)..(507)<223>x<220>
<221>MISC_FEATURE<222>(511)..(511)<223>x<220>
<221>MISC_FEATURE<222>(513)..(513)<223>x<300>
<308>hsugp/075309-23-0<309>2003-02-16
<400>99Leu Val Gln Leu Glu Val Leu Met Val Thr Pro His Arg Thr Ser Cys1 5 10 15Leu Leu Glu Ile Ile Tyr Pro Arg Val Pro Phe Pro Phe Leu Gly Gln20 25 30Lys Pro Leu Arg Ala Met Tyr Pro Asn Lys Pro Leu Asn Ala Phe Val35 40 45Lys Ile Ser Leu Asp Ile Glu Phe Pro Ser Glu Glu Met Glu Lys Val50 55 60Leu Gly Val Pro Ser Arg Leu Pro Leu Pro Asp Arg Pro Ile Lys Ser65 70 75 80Leu Leu Arg Gly Arg Val Cys Cys Leu Leu Phe Leu Glu Ile His Asp85 90 95Arg Xaa Lys His Leu Glu Asp Gly Val Gln Asp Gln Leu Ala Glu Gly100 105 110Ala Gly Ser Phe Phe Pro Ser Gly Leu Val Ala Asp Leu Leu Asn Leu115 120 125Pro Leu Ala Gly Ser Lys Tyr Leu Ser Pro His Ser Phe Phe Ile Met130 135 140Ser Ser Thr Phe Leu Ala Arg Ser Ala Gly Pro Lys Ala Pro Asp Leu145 150 155 160Ala Gly Leu Ser His Val Pro Leu Val Leu Leu Gly Gln Val Ala Arg165 170 175Pro Leu Leu Glu Leu Leu Thr Gly Gly His Leu Ala Phe Ile Asp Val180 185 190Leu Gly Gln Ala Ser Gly Asp Gln Pro Arg Glu Asp Ser Ser Lys Gly195 200 205Val Glu Pro Thr Phe Val Gly Gly Trp His His Phe Gly Asn Ile His210 215 220His Lys Arg Ala Phe Gly Val Thr Ala Phe Asn Ala His Gly Ser Leu225 230 235 240
Val Xaa Ser Gly Gly Pro Phe Asp Thr Gly Ala Arg Ser Arg Tyr Phe245 250 255Trp Ala Xaa Glu Thr Xaa Xaa Xaa Glu Arg Arg Cys Xaa Arg Asp Ser260 265 270Leu Gln Val Arg Leu Arg Ile Arg Gly Xaa Xaa Xaa Glu Asp Val Leu275 280 285Leu Trp Val Leu Arg Val Pro Gly Ala Ala Gly Ala Ala Gly Arg Ala290 295 300Ala Tyr Asn Leu Ser Arg Lys Leu Ser Arg Ala Gly Met Pro Ser Phe305 310 315 320Arg Pro Leu Arg Leu Arg Val Ser Ala Thr Thr Trp Leu Gly Arg Leu325 330 335Xaa Val Val Glu Gly Val Ser Gly Gln Asp Leu Pro Val Val Lys His340 345 350Thr Leu Gly Glu Arg Leu Ala Ala Arg Val Gly Pro Gln Val Ser Xaa355 360 365Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys Met Val Pro Thr370 375 380Ser Asp Lys Gly Arg Phe Tyr Ala Phe Glu Arg Val Phe Ser Gly Leu385 390 395 400Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro Asn Tyr Thr Pro405 410 415Gly Xaa Xaa Glu Asp Leu Tyr Leu Xaa Ala Asn Xaa Xaa Xaa Thr Xaa420 425 430Leu Asp Asp Gly Pro Leu Xaa Gly Ala His Xaa Gly Cys Ala Leu Gly435 440 445Ala Ile Thr Phe Val Ala Ser Val Ser Val Asp His Val Pro Gly Glu450 455 460Asp Gly Ser Ile Thr Thr Phe Glu Lys Ala Arg Lys Met Arg Val Met465 470 475 480Lys Phe Arg Val Asn Pro Val Val Arg Arg Gly Arg Glu Thr Ala Lys
485 490 495Asn Pro Xaa Xaa Thr Xaa Pro Lys Leu Xaa Xaa Gly Ala Glu Xaa Gly500 505 510Xaa Ala Lys Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly515 520 525Glu His Ile Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu530 535 540Lys Asp Leu Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp545 550 555 560Pro Val Val Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu565 570 575Cys Leu Ser Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala580 585 590Arg Pro Phe Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val595 600 605Ser Ala Arg Gln Glu Leu Lys Gln Arg Ala Arg Tyr Leu Ala Glu Lys610 615 620Tyr Glu Trp Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro625 630 635 640Asp Gly Thr Glu His Gln Thr Ile His Ser Pro Thr Tyr Thr Lys Gly645 650 655Cys Ser Lys Tyr Leu Asn Glu Ile Lys Ala Gln Lys Trp Ile Gly Gln660 665 670Ala Tyr Gln Trp Gly Asn His Arg Arg Ala His Cys Cys Glu Arg Glu675 680 685His Cys Val Gly Val Arg Tyr Glu Tyr His Glu Ser Lys Pro Leu Gln690 695 700Ala Glu Ala Ile His Thr Glu Gly Ala Lys Ile Ile Thr Arg Gly Gly705 710 715 720Ser Cys Leu Tyr Ala Ser Val Leu Asp Ala Gln Pro Arg Leu Met Asp725 730 735
Pro<210>100<211>268<212>PRT<213>人<220>
<221>MISC_FEATURE<222>(209)..(209)<223>x<220>
<221>MISC_FEATURE<222>(221)..(221)<223>x<220>
<221>MISC_FEATURE<222>(233)..(233)<223>x<220>
<221>MISC_FEATURE<222>(240)..(240)<223>x<220>
<221>MISC_FEATURE<222>(243)..(243)<223>x<220>
<221>MISC_FEATURE<222>(244)..(244)<223>x<220>
<221>MISC_FEATURE<222>(245)..(245)<223>x<220>
<221>MISC_FEATURE<222>(246)..(246)<223>x<220>
<221>MISC_FEATURE<222>(247)..(247)<223>x
<220>
<221>MISC_FEATURE<222>(268)..(268)<223>x<300>
<308>hsugp/075309-24-0<309>2003-02-16<400>100Lys Lys Ser Ser Ala Val Val Ala Ala Ile Leu Gly Ala Thr Arg Phe1 5 10 15Phe Arg Phe Tyr Leu Gly Glu Ser Thr Ala Ile Arg His Leu Val Asn20 25 30Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys Ala Asn Ile35 40 45Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys Ser Thr Leu50 55 60Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser Ala Arg Ala65 70 75 80Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln Glu Arg Cys85 90 95Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu Leu Ser Glu100 105 110Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ala Gly Phe Leu115 120 125Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser Ser Glu Val130 135 140Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val Val Asp Cys145 150 155 160Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg Gln Ala Ile165 170 175Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met Asp Arg Ala180 185 190
Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Asn Arg Leu Ser Ser195 200 205Xaa Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Xaa Arg Arg Gly210 215 220Ala Lys Ser Arg Pro Pro Trp Gly Xaa His His Glu Ser Ile Leu Xaa225 230 235 240Leu Arg Xaa Xaa Xaa Xaa Xaa Trp Asp Phe Gly Pro Pro Thr Gly Trp245 250 255Gly Pro Cys His Pro Arg Lys Ala Val Phe Pro Xaa260 265<210>101<211>470<212>PRT<213>人<300>
<308>sw_hum/nr54_human<309>1993-07-01<400>101Gln Ser Asn Lys Thr Phe Asn Leu Glu Lys Gln Asn His Thr Pro Arg1 5 10 15Lys His His Gln His His His Gln Gln Gln His His Gln Gln Gln Gln20 25 30Gln Gln Pro Pro Pro Pro Pro Ile Pro Ala Asn Gly Gln Gln Ala Ser35 40 45Ser Gln Asn Glu Gly Leu Thr Ile Asp Leu Lys Asn Phe Arg Lys Pro50 55 60Gly Glu Lys Thr Phe Thr Gln Arg Ser Arg Leu Phe Val Gly Asn Leu65 70 75 80Pro Pro Asp Ile Thr Glu Glu Glu Met Arg Lys Leu Phe Glu Lys Tyr85 90 95Gly Lys Ala Gly Glu Val Phe Ile His Lys Asp Lys Gly Phe Gly Phe100 105 110Ile Arg Leu Glu Thr Arg Thr Leu Ala Glu Ile Ala Lys Val Glu Leu115 120 125
Asp Asn Met Pro Leu Arg Gly Lys Gln Leu Arg Val Arg Phe Ala Cys130 135 140His Ser Ala Ser Leu Thr Val Arg Asn Leu Pro Gln Tyr Val Ser Asn145 150 155 160Glu Leu Leu Glu Glu Ala Phe Ser Val Phe Gly Gln Val Glu Arg Ala165 170 175Val Val Ile Val Asp Asp Arg Gly Arg Pro Ser Gly Lys Gly Ile Val180 185 190Glu Phe Ser Gly Lys Pro Ala Ala Arg Lys Ala Leu Asp Arg Cys Ser195 200 205Glu Gly Ser Phe Leu Leu Thr Thr Phe Pro Arg Pro Val Thr Val Glu210 215 220Pro Met Asp Gln Leu Asp Asp Glu Glu Gly Leu Pro Glu Lys Leu Val225 230 235 240Ile Lys Asn Gln Gln Phe His Lys Glu Arg Glu Gln Pro Pro Arg Phe245 250 255Ala Gln Pro Gly Ser Phe Glu Tyr Glu Tyr Ala Met Arg Trp Lys Ala260 265 270Leu Ile Glu Met Glu Lys Gln Gln Gln Asp Gln Val Asp Arg Asn Ile275 280 285Lys Glu Ala Arg Glu Lys Leu Glu Met Glu Met Glu Ala Ala Arg His290 295 300Glu His Gln Val Met Leu Met Arg Gln Asp Leu Met Arg Arg Gln Glu305 310 315 320Glu Leu Arg Arg Met Glu Glu Leu His Asn Gln Glu Val Gln Lys Arg325 330 335Lys Gln Leu Glu Leu Arg Gln Glu Glu Glu Arg Arg Arg Arg Glu Glu340 345 350Glu Met Arg Arg Gln Gln Glu Glu Met Met Arg Arg Gln Gln Glu Gly355 360 365Phe Lys Gly Thr Phe Pro Asp Ala Arg Glu Gln Glu Ile Arg Met Gly
370 375 380Gln Met Ala Met Gly Gly Ala Met Gly Ile Asn Asn Arg Gly Ala Met385 390 395 400Pro Pro Ala Pro Val Pro Ala Gly Thr Pro Ala Pro Pro Gly Pro Ala405 410 415Thr Met Met Pro Asp Gly Thr Leu Gly Leu Thr Pro Pro Thr Thr Glu420 425 430Arg Phe Gly Gln Ala Ala Thr Met Glu Gly Ile Gly Ala Ile Gly Gly435 440 445Thr Pro Pro Ala Phe Asn Arg Ala Ala Pro Gly Ala Glu Phe Ala Pro450 455 460Asn Lys Arg Arg Arg Tyr465 470<210>102<211>660<212>PRT<213>人<300>
<308>sw_hum/ddxy_human<309>1999-07-15<400>102Met Ser His Val Val Val Lys Asn Asp Pro Glu Leu Asp Gln Gln Leu1 5 10 15Ala Asn Leu Asp Leu Asn Ser Glu Lys Gln Ser Gly Gly Ala Ser Thr20 25 30Ala Ser Lys Gly Arg Tyr Ile Pro Pro His Leu Arg Asn Lys Glu Ala35 40 45Ser Lys Gly Phe His Asp Lys Asp Ser Ser Gly Trp Ser Cys Ser Lys50 55 60Asp Lys Asp Ala Tyr Ser Ser Phe Gly Ser Arg Asp Ser Arg Gly Lys65 70 75 80Pro Gly Tyr Phe Ser Glu Arg Gly Ser Gly Ser Arg Gly Arg Phe Asp85 90 95
Asp Arg Gly Arg Ser Asp Tyr Asp Gly Ile Gly Asn Arg Glu Arg Pro100 105 110Gly Phe Gly Arg Phe Glu Arg Ser Gly His Ser Arg Trp Cys Asp Lys115 120 125Ser Val Glu Asp Asp Trp Ser Lys Pro Leu Pro Pro Ser Glu Arg Leu130 135 140Glu Gln Glu Leu Phe Ser Gly Gly Asn Thr Gly Ile Asn Phe Glu Lys145 150 155 160Tyr Asp Asp Ile Pro Val Glu Ala Thr Gly Ser Asn Cys Pro Pro His165 170 175Ile Glu Asn Phe Ser Asp Ile Asp Met Gly Glu Ile Ile Met Gly Asn180 185 190Ile Glu Leu Thr Arg Tyr Thr Arg Pro Thr Pro Val Gln Lys His Ala195 200 205Ile Pro Ile Ile Lys Gly Lys Arg Asp Leu Val Ala Cys Ala Gln Thr210 215 220Gly Ser Gly Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser Gln Ile225 230 235 240Tyr Thr Asp Gly Pro Gly Glu Ala Leu Lys Ala Val Lys Glu Asn Gly245 250 255Arg Tyr Gly Arg Arg Lys Gln Tyr Pro Ile Ser Leu Val Leu Ala Pro260 265 270Thr Arg Glu Leu Ala Val Gln Ile Tyr Glu Glu Ala Arg Lys Phe Ser275 280 285Tyr Arg Ser Arg Val Arg Pro Cys Val Val Tyr Gly Gly Ala Asp Ile290 295 300Gly Gln Gln Ile Arg Asp Leu Glu Arg Gly Cys His Leu Leu Val Ala305 310 315 320Thr Pro Gly Arg Leu Val Asp Met Met Glu Arg Gly Lys Ile Gly Leu325 330 335Asp Phe Cys Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp340 345 350
Met Gly Phe Glu Pro Gln Ile Arg Arg Ile Val Glu Gln Asp Thr Met355 360 365Pro Pro Lys Gly Val Arg His Thr Met Met Phe Ser Ala Thr Phe Pro370 375 380Lys Glu Ile Gln Met Leu Ala Arg Asp Phe Leu Asp Glu Tyr Ile Phe385 390 395 400Leu Ala Val Gly Arg Val Gly Ser Thr Ser Glu Asn Ile Thr Gln Lys405 410 415Val Val Trp Val Glu Asp Leu Asp Lys Arg Ser Phe Leu Leu Asp Ile420 425 430Leu Gly Ala Thr Gly Ser Asp Ser Leu Thr Leu Val Phe Val Glu Thr435 440 445Lys Lys Gly Ala Asp Ser Leu Glu Asp Phe Leu Tyr His Glu Gly Tyr450 455 460Ala Cys Thr Ser Ile His Gly Asp Arg Ser Gln Arg Asp Arg Glu Glu465 470 475 480Ala Leu His Gln Phe Arg Ser Gly Lys Ser Pro Ile Leu Val Ala Thr485 490 495Ala Val Ala Ala Arg Gly Leu Asp Ile Ser Asn Val Arg His Val Ile500 505 510Asn Phe Asp Leu Pro Ser Asp Ile Glu Glu Tyr Val His Arg Ile Gly515 520 525Arg Thr Gly Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe Phe Asn530 535 540Glu Lys Asn Met Asn Ile Thr Lys Asp Leu Leu Asp Leu Leu Val Glu545 550 555 560Ala Lys Gln Glu Val Pro Ser Trp Leu Glu Asn Met Ala Tyr Glu His565 570 575His Tyr Lys Gly Gly Ser Arg Gly Arg Ser Lys Ser Asn Arg Phe Ser580 585 590
Gly Gly Phe Gly Ala Arg Asp Tyr Arg Gln Ser Ser Gly Ser Ser Ser595 600 605Ser Gly Phe Gly Ala Ser Arg Gly Ser Ser Ser Arg Ser Gly Gly Gly610 615 620Gly Tyr Gly Asp Ser Arg Gly Phe Gly Gly Gly Gly Tyr Gly Gly Phe625 630 635 640Tyr Asn Ser Asp Gly Tyr Gly Gly Asn Tyr Asn Ser Gln Gly Val Asp645 650 655Trp Trp Gly Asn660<210>103<211>339<212>PRT<213>人<300>
<308>humangp/chr8-094905<309>2003-04-22<400>103Met Ala Gln Leu Gly Ala Val Val Ala Val Ala Ser Ser Phe Phe Cys1 5 10 15Ala Ser Leu Phe Ser Ala Val His Lys Ile Glu Glu Gly His Ile Gly20 25 30Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Thr Ser Gly Pro Gly35 40 45Phe His Leu Met Leu Pro Phe Ile Thr Ser Tyr Lys Ser Val Gln Thr50 55 60Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr Ser Gly65 70 75 80Gly Val Met Ile Tyr Phe Asp Arg Ile Glu Val Val Asn Phe Leu Val85 90 95Pro Asn Ala Val Tyr Asp Ile Val Lys Asn Tyr Thr Ala Asp Tyr Asp100 105 110Lys Ala Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln Phe Cys115 120 125
Ser Val His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Asp Gln Ile130 135 140Asp Glu Asn Leu Lys Leu Ala Leu Gln Gln Asp Leu Thr Ser Met Ala145 150 155 160Pro Gly Leu Val Ile Gln Ala Val Arg Val Thr Lys Pro Asn Ile Pro165 170 175Glu Ala Ile Arg Arg Asn Tyr Glu Leu Met Glu Ser Glu Lys Thr Lys180 185 190Leu Leu Ile Ala Ala Gln Lys Gln Lys Val Val Glu Lys Glu Ala Glu195 200 205Thr Glu Arg Lys Lys Ala Leu Ile Glu Ala Glu Lys Val Ala Gln Val210 215 220Ala Glu Ile Thr Tyr Gly Gln Lys Val Met Glu Lys Glu Thr Glu Lys225 230 235 240Lys Ile Ser Glu Ile Glu Asp Ala Ala Phe Leu Ala Arg Glu Lys Ala245 250 255Lys Ala Asp Ala Glu Cys Tyr Thr Ala Met Lys Ile Ala Glu Ala Asn260 265 270Lys Leu Lys Leu Thr Pro Glu Tyr Leu Gln Leu Met Lys Tyr Lys Ala275 280 285Ile Ala Ser Asn Ser Lys Ile Tyr Phe Gly Lys Asp Ile Pro Asn Met290 295 300Phe Met Asp Ser Ala Gly Ser Val Ser Lys Gln Phe Glu Gly Leu Ala305 310 315 320Asp Lys Leu Ser Phe Gly Leu Glu Asp Glu Pro Leu Glu Thr Ala Thr325 330 335Lys Glu Asn<210>104<211>511<212>PRT<213>人
<300>
<308>sw_hum/copd_human<309>1996-02-01<400>104Met Val Leu Leu Ala Ala Ala Val Cys Thr Lys Ala Gly Lys Ala Ile1 5 10 15Val Ser Arg Gln Phe Val Glu Met Thr Arg Thr Arg Ile Glu Gly Leu20 25 30Leu Ala Ala Phe Pro Lys Leu Met Asn Thr Gly Lys Gln His Thr Phe35 40 45Val Glu Thr Glu Ser Val Arg Tyr Val Tyr Gln Pro Met Glu Lys Leu50 55 60Tyr Met Val Leu Ile Thr Thr Lys Asn Ser Asn Ile Leu Glu Asp Leu65 70 75 80Glu Thr Leu Arg Leu Phe Ser Arg Val Ile Pro Glu Tyr Cys Arg Ala85 90 95Leu Glu Glu Asn Glu Ile Ser Glu His Cys Phe Asp Leu Ile Phe Ala100 105 110Phe Asp Glu Ile Val Ala Leu Gly Tyr Arg Glu Asn Val Asn Leu Ala115 120 125Gln Ile Arg Thr Phe Thr Glu Met Asp Ser His Glu Glu Lys Val Phe130 135 140Arg Ala Val Arg Glu Thr Gln Glu Arg Glu Ala Lys Ala Glu Met Arg145 150 155 160Arg Lys Ala Lys Glu Leu Gln Gln Ala Arg Arg Asp Ala Glu Arg Gln165 170 175Gly Lys Lys Ala Pro Gly Phe Gly Gly Phe Gly Ser Ser Ala Val Ser180 185 190Gly Gly Ser Thr Ala Ala Met Ile Thr Glu Thr Ile Ile Glu Thr Asp195 200 205Lys Pro Lys Val Ala Pro Ala Pro Ala Arg Pro Ser Gly Pro Ser Lys210 215 220
Ala Leu Lys Leu Gly Ala Lys Gly Lys Glu Val Asp Asn Phe Val Asp225 230 235 240Lys Leu Lys Ser Glu Gly Glu Thr Ile Met Ser Ser Ser Met Gly Lys245 250 255Arg Thr Ser Glu Ala Thr Lys Met His Ala Pro Pro Ile Asn Met Glu260 265 270Ser Val His Met Lys Ile Glu Glu Lys Ile Thr Leu Thr Cys Gly Arg275 280 285Asp Gly Gly Leu Gln Asn Met Glu Leu His Gly Met Ile Met Leu Arg290 295 300Ile Ser Asp Asp Lys Tyr Gly Arg Ile Arg Leu His Val Glu Asn Glu305 310 315 320Asp Lys Lys Gly Val Gln Leu Gln Thr His Pro Asn Val Asp Lys Lys325 330 335Leu Phe Thr Ala Glu Ser Leu Ile Gly Leu Lys Asn Pro Glu Lys Ser340 345 350Phe Pro Val Asn Ser Asp Val Gly Val Leu Lys Trp Arg Leu Gln Thr355 360 365Thr Glu Glu Ser Phe Ile Pro Leu Thr Ile Asn Cys Trp Pro Ser Glu370 375 380Ser Gly Asn Gly Cys Asp Val Asn Ile Glu Tyr Glu Leu Gln Glu Asp385 390 395 400Asn Leu Glu Leu Asn Asp Val Val Ile Thr Ile Pro Leu Pro Ser Gly405 410 415Val Gly Ala Pro Val Ile Gly Glu Ile Asp Gly Glu Tyr Arg His Asp420 425 430Ser Arg Arg Asn Thr Leu Glu Trp Cys Leu Pro Val Ile Asp Ala Lys435 440 445Asn Lys Ser Gly Ser Leu Glu Phe Ser Ile Ala Gly Gln Pro Asn Asp450 455 460Phe Phe Pro Val Gln Val Ser Phe Val Ser Lys Lys Asn Tyr Cys Asn465 470 475 480
Ile Gln Val Thr Lys Val Thr Gln Val Asp Gly Asn Ser Pro Val Arg485 490 495Phe Ser Thr Glu Thr Thr Phe Leu Val Asp Lys Tyr Glu Ile Leu500 505 510<210>105<211>277<212>PRT<213>人<300>
<308>sw_jum/capb_human<309>1996-02-01<400>105Met Ser Asp Gln Gln Leu Asp Cys Ala Leu Asp Leu Met Arg Arg Leu1 5 10 15Pro Pro Gln Gln Ile Glu Lys Asn Leu Ser Asp Leu Ile Asp Leu Val20 25 30Pro Ser Leu Cys Glu Asp Leu Leu Ser Ser Val Asp Gln Pro Leu Lys35 40 45Ile Ala Arg Asp Lys Val Val Gly Lys Asp Tyr Leu Leu Cys Asp Tyr50 55 60Asn Arg Asp Gly Asp Ser Tyr Arg Ser Pro Trp Ser Asn Lys Tyr Asp65 70 75 80Pro Pro Leu Glu Asp Gly Ala Met Pro Ser Ala Arg Leu Arg Lys Leu85 90 95Glu Val Glu Ala Asn Asn Ala Phe Asp Gln Tyr Arg Asp Leu Tyr Phe100 105 110Glu Gly Gly Val Ser Ser Val Tyr Leu Trp Asp Leu Asp His Gly Phe115 120 125Ala Gly Val Ile Leu Ile Lys Lys Ala Gly Asp Gly Ser Lys Lys Ile130 135 140Lys Gly Cys Trp Asp Ser Ile His Val Val Glu Val Gln Glu Lys Ser145 150 155 160Ser Gly Arg Thr Ala His Tyr Lys Leu Thr Ser Thr Val Met Leu Trp
165 170 175Leu Gln Thr Asn Lys Ser Gly Ser Gly Thr Met Asn Leu Gly Gly Ser180 185 190Leu Thr Arg Gln Met Glu Lys Asp Glu Thr Val Ser Asp Cys Ser Pro195 200 205His Ile Ala Asn Ile Gly Arg Leu Val Glu Asp Met Glu Asn Lys Ile210 215 220Arg Ser Thr Leu Asn Glu Ile Tyr Phe Gly Lys Thr Lys Asp Ile Val225 230 235 240Asn Gly Leu Arg Ser Ile Asp Ala Ile Pro Asp Asn Gln Lys Phe Lys245 250 255Gln Leu Gln Arg Glu Leu Ser Gln Val Leu Thr Gln Arg Gln Ile Tyr260 265 270Ile Gln Pro Asp Asn275<210>106<211>226<212>PRT<213>人<300>
<308>sw_hum/vate_human<309>1994-06-01<400>106Met Ala Leu Ser Asp Ala Asp Val Gln Lys Gln Ile Lys His Met Met1 5 10 15Ala Phe Ile Glu Gln Glu Ala Asn Glu Lys Ala Glu Glu Ile Asp Ala20 25 30Lys Ala Glu Glu Glu Phe Asn Ile Glu Lys Gly Arg Leu Val Gln Thr35 40 45Gln Arg Leu Lys Ile Met Glu Tyr Tyr Glu Lys Lys Glu Lys Gln Ile50 55 60Glu Gln Gln Lys Lys Ile Gln Met Ser Asn Leu Met Asn Gln Ala Arg65 70 75 80
Leu Lys Val Leu Arg Ala Arg Asp Asp Leu Ile Thr Asp Leu Leu Asn85 90 95Glu Ala Lys Gln Arg Leu Ser Lys Val Val Lys Asp Thr Thr Arg Tyr100 105 110Gln Val Leu Leu Asp Gly Leu Val Leu Gln Gly Leu Tyr Gln Leu Leu115 120 125Glu Pro Arg Met Ile Val Arg Cys Arg Lys Gln Asp Phe Pro Leu Val130 135 140Lys Ala Ala Val Gln Lys Ala Ile Pro Met Tyr Lys Ile Ala Thr Lys145 150 155 160Asn Asp Val Asp Val Gln Ile Asp Gln Glu Ser Tyr Leu Pro Glu Asp165 170 175Ile Ala Gly Gly Val Glu Ile Tyr Asn Gly Asp Arg Lys Ile Lys Val180 185 190Ser Asn Thr Leu Glu Ser Arg Leu Asp Leu Ile Ala Gln Gln Met Met195 200 205Pro Glu Val Arg Gly Ala Leu Phe Gly Ala Asn Ala Asn Arg Lys Phe210 215 220Leu Asp225<210>107<211>1101<212>PRT<213>人<300>
<308>sw_hum/acly_human<309>1996-10-01<400>107Met Ser Ala Lys Ala Ile Ser Glu Gln Thr Gly Lys Glu Leu Leu Tyr1 5 10 15Lys Phe Ile Cys Thr Thr Ser Ala Ile Gln Asn Arg Phe Lys Tyr Ala20 25 30Arg Val Thr Pro Asp Thr Asp Trp Ala Arg Leu Leu Gln Asp His Pro35 40 45
Trp Leu Leu Ser Gln Asn Leu Val Val Lys Pro Asp Gln Leu Ile Lys50 55 60Arg Arg Gly Lys Leu Gly Leu Val Gly Val Asn Leu Thr Leu Asp Gly65 70 75 80Val Lys Ser Trp Leu Lys Pro Arg Leu Gly Gln Glu Ala Thr Val Gly85 90 95Lys Ala Thr Gly Phe Leu Lys Asn Phe Leu Ile Glu Pro Phe Val Pro100 105 110His Ser Gln Ala Glu Glu Phe Tyr Val Cys Ile Tyr Ala Thr Arg Glu115 120 125Gly Asp Tyr Val Leu Phe His His Glu Gly Gly Val Asp Val Gly Asp130 135 140Val Asp Ala Lys Ala Gln Lys Leu Leu Val Gly Val Asp Glu Lys Leu145 150 155 160Asn Pro Glu Asp Ile Lys Lys His Leu Leu Val His Ala Pro Asp Asp165 170 175Lys Lys Glu Ile Leu Ala Ser Phe Ile Ser Gly Leu Phe Asn Phe Tyr180 185 190Glu Asp Leu Tyr Phe Thr Tyr Leu Glu Ile Asn Pro Leu Val Val Thr195 200 205Lys Asp Gly Val Tyr Val Leu Asp Leu Ala Ala Lys Val Asp Ala Thr210 215 220Ala Asp Tyr Ile Cys Lys Val Lys Trp Gly Asp Ile Glu Phe Pro Pro225 230 235 240Pro Phe Gly Arg Glu Ala Tyr Pro Glu Glu Ala Tyr Ile Ala Asp Leu245 250 255Asp Ala Lys Ser Gly Ala Ser Leu Lys Leu Thr Leu Leu Asn Pro Lys260 265 270Gly Arg Ile Trp Thr Met Val Ala Gly Gly Gly Ala Ser Val Val Tyr275 280 285Ser Asp Thr Ile Cys Asp Leu Gly Gly Val Asn Glu Leu Ala Asn Tyr
290 295 300Gly Glu Tyr Ser Gly Ala Pro Ser Glu Gln Gln Thr Tyr Asp Tyr Ala305 310 315 320Lys Thr Ile Leu Ser Leu Met Thr Arg Glu Lys His Pro Asp Gly Lys325 330 335Ile Leu Ile Ile Gly Gly Ser Ile Ala Asn Phe Thr Asn Val Ala Ala340 345 350Thr Phe Lys Gly Ile Val Arg Ala Ile Arg Asp Tyr Gln Gly Pro Leu355 360 365Lys Glu His Glu Val Thr Ile Phe Val Arg Arg Gly Gly Pro Asn Tyr370 375 380Gln Glu Gly Leu Arg Val Met Gly Glu Val Gly Lys Thr Thr Gly Ile385 390 395 400Pro Ile His Val Phe Gly Thr Glu Thr His Met Thr Ala Ile Val Gly405 410 415Met Ala Leu Gly His Arg Pro Ile Pro Asn Gln Pro Pro Thr Ala Ala420 425 430His Thr Ala Asn Phe Leu Leu Asn Ala Ser Gly Ser Thr Ser Thr Pro435 440 445Ala Pro Ser Arg Thr Ala Ser Phe Ser Glu Ser Arg Ala Asp Glu Val450 455 460Ala Pro Ala Lys Lys Ala Lys Pro Ala Met Pro Gln Asp Ser Val Pro465 470 475 480Ser Pro Arg Ser Leu Gln Gly Lys Ser Thr Thr Leu Phe Ser Arg His485 490 495Thr Lys Ala Ile Val Trp Gly Met Gln Thr Arg Ala Val Gln Gly Met500 505 510Leu Asp Phe Asp Tyr Val Cys Ser Arg Asp Glu Pro Ser Val Ala Ala515 520 525Met Val Tyr Pro Phe Thr Gly Asp His Lys Gln Lys Phe Tyr Trp Gly530 535 540
His Lys Glu Ile Leu Ile Pro Val Phe Lys Asn Met Ala Asp Ala Met545 550 555 560Arg Lys His Pro Glu Val Asp Val Leu Ile Asn Phe Ala Ser Leu Arg565 570 575Ser Ala Tyr Asp Ser Thr Met Glu Thr Met Asn Tyr Ala Gln Ile Arg580 585 590Thr Ile Ala Ile Ile Ala Glu Gly Ile Pro Glu Ala Leu Thr Arg Lys595 600 605Leu Ile Lys Lys Ala Asp Gln Lys Gly Val Thr Ile Ile Gly Pro Ala610 615 620Thr Val Gly Gly Ile Lys Pro Gly Cys Phe Lys Ile Gly Asn Thr Gly625 630 635 640Gly Met Leu Asp Asn Ile Leu Ala Ser Lys Leu Tyr Arg Pro Gly Ser645 650 655Val Ala Tyr Val Ser Arg Ser Gly Gly Met Ser Asn Glu Leu Asn Asn660 665 670Ile Ile Ser Arg Thr Thr Asp Gly Val Tyr Glu Gly Val Ala Ile Gly675 680 685Gly Asp Arg Tyr Pro Gly Ser Thr Phe Met Asp His Val Leu Arg Tyr690 695 700Gln Asp Thr Pro Gly Val Lys Met Ile Val Val Leu Gly Glu Ile Gly705 710 715 720Gly Thr Glu Glu Tyr Lys Ile Cys Arg Gly Ile Lys Glu Gly Arg Leu725 730 735Thr Lys Pro Ile Val Cys Trp Cys Ile Gly Thr Cys Ala Thr Met Phe740 745 750Ser Ser Glu Val Gln Phe Gly His Ala Gly Ala Cys Ala Asn Gln Ala755 760 765Ser Glu Thr Ala Val Ala Lys Asn Gln Ala Leu Lys Glu Ala Gly Val770 775 780Phe Val Pro Arg Ser Phe Asp Glu Leu Gly Glu Ile Ile Gln Ser Val
785 790 795 800Tyr Glu Asp Leu Val Ala Asn Gly Val Ile Val Pro Ala Gln Glu Val805 810 815Pro Pro Pro Thr Val Pro Met Asp Tyr Ser Trp Ala Arg Glu Leu Gly820 825 830Leu Ile Arg Lys Pro Ala Ser Phe Met Thr Ser Ile Cys Asp Glu Arg835 840 845Gly Gln Glu Leu Ile Tyr Ala Gly Met Pro Ile Thr Glu Val Phe Lys850 855 860Glu Glu Met Gly Ile Gly Gly Val Leu Gly Leu Leu Trp Phe Gln Lys865 870 875 880Arg Leu Pro Lys Tyr Ser Cys Gln Phe Ile Glu Met Cys Leu Met Val885 890 895Thr Ala Asp His Gly Pro Ala Val Ser Gly Ala His Asn Thr Ile Ile900 905 910Cys Ala Arg Ala Gly Lys Asp Leu Val Ser Ser Leu Thr Ser Gly Leu915 920 925Leu Thr Ile Gly Asp Arg Phe Gly Gly Ala Leu Asp Ala Ala Ala Lys930 935 940Met Phe Ser Lys Ala Phe Asp Ser Gly Ile Ile Pro Met Glu Phe Val945 950 955 960Asn Lys Met Lys Lys Glu Gly Lys Leu Ile Met Gly Ile Gly His Arg965 970 975Val Lys Ser Ile Asn Asn Pro Asp Met Arg Val Gln Ile Leu Lys Asp980 985 990Tyr Val Arg Gln His Phe Pro Ala Thr Pro Leu Leu Asp Tyr Ala Leu995 1000 1005Glu Val Glu Lys Ile Thr Thr Ser Lys Lys Pro Asn Leu Ile Leu1010 1015 1020Asn Val Asp Gly Leu Ile Gly Val Ala Phe Val Asp Met Leu Arg1025 1030 1035
Asn Cys Gly Ser Phe Thr Arg Glu Glu Ala Asp Glu Tyr Ile Asp1040 1045 1050Ile Gly Ala Leu Asn Gly Ile Phe Val Leu Gly Arg Ser Met Gly1055 1060 1065Phe Ile Gly His Tyr Leu Asp Gln Lys Arg Leu Lys Gln Gly Leu1070 1075 1080Tyr Arg His Pro Trp Asp Asp Ile Ser Tyr Val Leu Pro Glu His1085 1090 1095Met Ser Met1100<210>108<211>197<212>PRT<213>人<220>
<221>MISC_FEATURE<222>(21)..(21)<223>x<220>
<221>MISC_FEATURE<222>(75)..(75)<223>x<220>
<221>MISC_FEATURE<222>(91)..(91)<223>x<220>
<221>MISC_FEATURE<222>(104)..(104)<223>x<220>
<221>MISC_FEATURE<222>(106)..(106)<223>x<220>
<221>MISC_FEATURE<222>(117)..(117)<223>x
<220>
<221>MISC_FEATURE<222>(133)..(133)<223>x<220>
<221>MISC_FEATURE<222>(152)..(152)<223>x<300>
<308>hsugp/008768-9-0<309>2002-12-05<400>108Val Ser Gly Ile Leu Thr Ile Val Leu Pro Val Lys Thr Asp Ser Ile1 5 10 15Asp Ile Lys Leu Xaa Leu Tyr Asp Asp Ser Lys Glu Ser Phe Lys Ser20 25 30Gln Glu Asn Val Lys Gly Gly Leu Asn Leu Pro Leu Val Ser Ala Ala35 40 45Ala Thr Gly Val Ser Gln Glu Val Thr Asn Ser Arg Ala Glu Ser Asp50 55 60Pro Leu Ala His Asp Ile Lys Thr Leu Phe Xaa Lys Lys Pro Phe Met65 70 75 80Asn Gly Phe Arg Phe Gly Leu Arg Val Ala Xaa Gly Val Asn Trp Ile85 90 95Gly Ile Trp Ile His Phe Thr Xaa Lys Xaa Phe Ile Ile Leu Asn Phe100 105 110Glu Glu Thr Ser Xaa Pro Leu Ala Ala Leu Pro Asn Val Ser Phe Trp115 120 125Glu Arg Glu Phe Xaa Val Thr Gly Leu Arg Ser Leu Thr Thr Gln Asn130 135 140Arg Lys Ile Ile Leu Thr Ile Xaa Asp Phe Arg Met Leu Ser Ile Lys145 150 155 160Ser His Glu Asn Cys Leu Gln Arg Val Leu Lys Arg His Gln Pro Val165 170 175
Phe Phe Glu Thr Pro Ser Val Gly Val Glu Asp Ala Thr Gly Asp Asn180 185 190Arg Phe Leu Gln Ala195<210>109<211>56<212>PRT<213>人<300>
<308>hsugp/075546-6-0<309>2003-02-16<400>109Leu Leu Glu Ala Ala Glu Asn Glu Tyr Gln Thr Ala Ile Ser Glu Asn1 5 10 15Tyr Gln Thr Met Ser Asp Thr Thr Phe Lys Ala Leu Arg Arg Gln Leu20 25 30Pro Val Thr Arg Thr Lys Ile Asp Trp Asn Lys Ile Leu Ser Tyr Lys35 40 45Ile Gly Lys Glu Met Gln Asn Ala50 55<210>110<211>650<212>PRT<213>人<300>
<308>sw_hum/dd17_human<309>1998-07-15<400>110Met Arg Gly Gly Gly Phe Gly Asp Arg Asp Arg Asp Arg Asp Arg Gly1 5 10 15Gly Phe Gly Ala Arg Gly Gly Gly Gly Leu Pro Pro Lys Lys Phe Gly20 25 30Asn Pro Gly Glu Arg Leu Arg Lys Lys Lys Trp Asp Leu Ser Glu Leu35 40 45Pro Lys Phe Glu Lys Asn Phe Tyr Val Glu His Pro Glu Val Ala Arg50 55 60
Leu Thr Pro Tyr Glu Val Asp Glu Leu Arg Arg Lys Lys Glu Ile Thr65 70 75 80Val Arg Gly Gly Asp Val Cys Pro Lys Pro Val Phe Ala Phe His His85 90 95Ala Asn Phe Pro Gln Tyr Val Met Asp Val Leu Met Asp Gln His Phe100 105 110Thr Glu Pro Thr Pro Ile Gln Cys Gln Gly Phe Pro Leu Ala Leu Ser115 120 125Gly Arg Asp Met Val Gly Ile Ala Gln Thr Gly Ser Gly Lys Thr Leu130 135 140Ala Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro Tyr Leu145 150 155 160Glu Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr Arg Glu165 170 175Leu Ala Gln Gln Val Gln Gln Val Ala Asp Asp Tyr Gly Lys Cys Ser180 185 190Arg Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly Pro Gln195 200 205Ile Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr Pro Gly210 215 220Arg Leu Ile Asp Phe Leu Glu Ser Gly Lys Thr Asn Leu Arg Arg Cys225 230 235 240Thr Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met Gly Phe245 250 255Glu Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp Arg Gln260 265 270Thr Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln Leu Ala275 280 285Glu Asp Phe Leu Arg Asp Tyr Thr Gln Ile Asn Val Gly Asn Leu Glu290 295 300Leu Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys Met Glu
305 310 315 320Ser Glu Lys Asp His Lys Leu Ile Gln Leu Met Glu Glu Ile Met Ala325 330 335Glu Lys Glu Asn Lys Thr Ile Ile Phe Val Glu Thr Lys Arg Arg Cys340 345 350Asp Asp Leu Thr Arg Arg Met Arg Arg Asp Gly Trp Pro Ala Met Cys355 360 365Ile His Gly Asp Lys Ser Gln Pro Glu Arg Asp Trp Val Leu Asn Glu370 375 380Phe Arg Ser Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val Ala Ser385 390 395 400Arg Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr Asp Tyr405 410 415Pro Asn Ser Ser Glu Asp Tyr Val His Arg Ile Gly Arg Thr Ala Arg420 425 430Ser Thr Asn Lys Gly Thr Ala Tyr Thr Phe Phe Thr Pro Gly Asn Leu435 440 445Lys Gln Ala Arg Glu Leu Ile Lys Val Leu Glu Glu Ala Asn Gln Ala450 455 460Ile Asn Pro Lys Leu Met Gln Leu Val Asp His Arg Gly Gly Gly Gly465 470 475 480Gly Gly Gly Gly Arg Ser Arg Tyr Arg Thr Thr Ser Ser Ala Asn Asn485 490 495Pro Asn Leu Met Tyr Gln Asp Glu Cys Asp Arg Arg Leu Arg Gly Val500 505 510Lys Asp Gly Gly Arg Arg Asp Ser Ala Ser Tyr Arg Asp Arg Ser Glu515 520 525Thr Asp Arg Ala Gly Tyr Ala Asn Gly Ser Gly Tyr Gly Ser Pro Asn530 535 540Ser Ala Phe Gly Ala Gln Ala Gly Gln Tyr Thr Tyr Gly Gln Gly Thr545 550 555 560
Tyr Gly Ala Ala Ala Tyr Gly Thr Ser Ser Tyr Thr Ala Gln Glu Tyr565 570 575Gly Ala Gly Thr Tyr Gly Ala Ser Ser Thr Thr Ser Thr Gly Arg Ser580 585 590Ser Gln Ser Ser Ser Gln Gln Phe Ser Gly Ile Gly Arg Ser Gly Gln595 600 605Gln Pro Gln Pro Leu Met Ser Gln Gln Phe Ala Gln Pro Pro Gly Ala610 615 620Thr Asn Met Ile Gly Tyr Met Gly Gln Thr Ala Tyr Gln Tyr Pro Pro625 630 635 640Pro Pro Pro Pro Pro Pro Pro Ser Arg Lys645 650<210>111<211>348<212>PRT<213>人<300>
<308>sw_hum/capg_human<309>1995-02-01<400>111Met Tyr Thr Ala Ile Pro Gln Ser Gly Ser Pro Phe Pro Gly Ser Val1 5 10 15Gln Asp Pro Gly Leu His Val Trp Arg Val Glu Lys Leu Lys Pro Val20 25 30Pro Val Ala Gln Glu Asn Gln Gly Val Phe Phe Ser Gly Asp Ser Tyr35 40 45Leu Val Leu His Asn Gly Pro Glu Glu Val Ser His Leu His Leu Trp50 55 60Ile Gly Gln Gln Ser Ser Arg Asp Glu Gln Gly Ala Cys Ala Val Leu65 70 75 80Ala Val His Leu Asn Thr Leu Leu Gly Glu Arg Pro Val Gln His Arg85 90 95Glu Val Gln Gly Asn Glu Ser Asp Leu Phe Met Ser Tyr Phe Pro Arg100 105 110
Gly Leu Lys Tyr Gln Glu Gly Gly Val Glu Ser Ala Phe His Lys Thr115 120 125Ser Thr Gly Ala Pro Ala Ala Ile Lys Lys Leu Tyr Gln Val Lys Gly130 135 140Lys Lys Asn Ile Arg Ala Thr Glu Arg Ala Leu Asn Trp Asp Ser Phe145 150 155 160Asn Thr Gly Asp Cys Phe Ile Leu Asp Leu Gly Gln Asn Ile Phe Ala165 170 175Trp Cys Gly Gly Lys Ser Asn Ile Leu Glu Arg Asn Lys Ala Arg Asp180 185 190Leu Ala Leu Ala Ile Arg Asp Ser Glu Arg Gln Gly Lys Ala Gln Val195 200 205Glu Ile Val Thr Asp Gly Glu Glu Pro Ala Glu Met Ile Gln Val Leu210 215 220Gly Pro Lys Pro Ala Leu Lys Glu Gly Asn Pro Glu Glu Asp Leu Thr225 230 235 240Ala Asp Lys Ala Asn Ala Gln Ala Ala Ala Leu Tyr Lys Val Ser Asp245 250 255Ala Thr Gly Gln Met Asn Leu Thr Lys Val Ala Asp Ser Ser Pro Phe260 265 270Ala Leu Glu Leu Leu Ile Ser Asp Asp Cys Phe Val Leu Asp Asn Gly275 280 285Leu Cys Gly Lys Ile Tyr Ile Trp Lys Gly Arg Lys Ala Asn Glu Lys290 295 300Glu Arg Gln Ala Ala Leu Gln Val Ala Glu Gly Phe Ile Ser Arg Met305 310 315 320Gln Tyr Ala Pro Asn Thr Gln Val Glu Ile Leu Pro Gln Gly Arg Glu325 330 335Ser Pro Ile Phe Lys Gln Phe Phe Lys Asp Trp Lys340 345
<210>112<211>513<212>PRT<213>人<300>
<308>sw_hum/vab1_human<309>1990-04-01<400>112Met Ala Met Glu Ile Asp Ser Arg Pro Gly Gly Leu Pro Gly Ser Ser1 5 10 15Cys Asn Leu Gly Ala Ala Arg Glu His Met Gln Ala Val Thr Arg Asn20 25 30Tyr Ile Thr His Pro Arg Val Thr Tyr Arg Thr Val Cys Ser Val Asn35 40 45Gly Pro Leu Val Val Leu Asp Arg Val Lys Phe Ala Gln Tyr Ala Glu50 55 60Ile Val His Phe Thr Leu Pro Asp Gly Thr Gln Arg Ser Gly Gln Val65 70 75 80Leu Glu Val Ala Gly Thr Lys Ala Ile Val Gln Val Phe Glu Gly Thr85 90 95Ser Gly Ile Asp Ala Arg Lys Thr Thr Cys Glu Phe Thr Gly Asp Ile100 105 110Leu Arg Thr Pro Val Ser Glu Asp Met Leu Gly Arg Val Phe Asn Gly115 120 125Ser Gly Lys Pro Ile Asp Lys Gly Pro Val Val Met Ala Glu Asp Phe130 135 140Leu Asp Ile Asn Gly Gln Pro Ile Asn Pro His Ser Arg Ile Tyr Pro145 150 155 160Glu Glu Met Ile Gln Thr Gly Ile Ser Pro Ile Asp Val Met Asn Ser165 170 175Ile Ala Arg Gly Gln Lys Ile Pro Ile Phe Ser Ala Ala Gly Leu Pro180 185 190His Asn Glu Ile Ala Ala Gln Ile Cys Arg Gln Ala Gly Leu Val Lys195 200 205
Lys Ser Lys Ala Val Leu Asp Tyr His Asp Asp Asn Phe Ala Ile Val210 215 220Phe Ala Ala Met Gly Val Asn Met Glu Thr Ala Arg Phe Phe Lys Ser225 230 235 240Asp Phe Glu Gln Asn Gly Thr Met Gly Asn Val Cys Leu Phe Leu Asn245 250 255Leu Ala Asn Asp Pro Thr Ile Glu Arg Ile Ile Thr Pro Arg Leu Ala260 265 270Leu Thr Thr Ala Glu Phe Leu Ala Tyr Gln Cys Glu Lys His Val Leu275 280 285Val Ile Leu Thr Asp Met Ser Ser Tyr Ala Glu Ala Leu Arg Glu Val290 295 300Ser Ala Ala Arg Glu Glu Val Pro Gly Arg Arg Gly Phe Pro Gly Tyr305 310 315 320Met Tyr Thr Asp Leu Ala Thr Ile Tyr Glu Arg Ala Gly Arg Val Glu325 330 335Gly Arg Gly Gly Ser Ile Thr Gln Ile Pro Ile Leu Thr Met Pro Asn340 345 350Asp Asp Ile Thr His Pro Ile Pro Asp Leu Thr Gly Phe Ile Thr Glu355 360 365Gly Gln Ile Tyr Val Asp Arg Gln Leu His Asn Arg Gln Ile Tyr Pro370 375 380Pro Ile Asn Val Leu Pro Ser Leu Ser Arg Leu Met Lys Ser Ala Ile385 390 395 400Gly Glu Gly Met Thr Arg Lys Asp His Gly Asp Val Ser Asn Gln Leu405 410 415Tyr Ala Cys Tyr Ala Ile Gly Lys Asp Val Gln Ala Met Lys Ala Val420 425 430Val Gly Glu Glu Ala Leu Thr Ser Glu Asp Leu Leu Tyr Leu Glu Phe435 440 445Leu Gln Lys Phe Glu Lys Asn Phe Ile Asn Gln Gly Pro Tyr Glu Asn
450 455 460Arg Ser Met Phe Glu Ser Leu Asp Leu Ser Trp Lys Leu Leu Arg Ile465 470 475 480Phe Pro Lys Glu Met Leu Lys Arg Ile Pro Gln Ala Val Ile Asp Glu485 490 495Phe Tyr Ser Arg Glu Gly Arg Leu Gln Asp Leu Ala Pro Asp Thr Ala500 505 510Leu<210>113<211>858<212>PRT<213>人<300>
<308>sw_hum/ubp5_human<309>1996-02-01<400>113Met Ala Glu Leu Ser Glu Glu Ala Leu Leu Ser Val Leu Pro Thr Ile1 5 10 15Arg Val Pro Lys Ala Gly Asp Arg Val His Lys Asp Glu Cys Ala Phe20 25 30Ser Phe Asp Thr Pro Glu Ser Glu Gly Gly Leu Tyr Ile Cys Met Asn35 40 45Thr Phe Leu Gly Phe Gly Lys Gln Tyr Val Glu Arg His Phe Asn Lys50 55 60Thr Gly Gln Arg Val Tyr Leu His Leu Arg Arg Thr Arg Arg Pro Lys65 70 75 80Glu Glu Asp Pro Ala Thr Gly Thr Gly Asp Pro Pro Arg Lys Lys Pro85 90 95Thr Arg Leu Ala Ile Gly Val Glu Gly Gly Phe Asp Leu Ser Glu Glu100 105 110Lys Phe Glu Leu Asp Glu Asp Val Lys Ile Val Ile Leu Pro Asp Tyr115 120 125
Leu Glu Ile Ala Arg Asp Gly Leu Gly Gly Leu Pro Asp Ile Val Arg130 135 140Asp Arg Val Thr Ser Ala Val Glu Ala Leu Leu Ser Ala Asp Ser Ala145 150 155 160Ser Arg Lys Gln Glu Val Gln Ala Trp Asp Gly Glu Val Arg Gln Val165 170 175Ser Lys His Ala Phe Ser Leu Lys Gln Leu Asp Asn Pro Ala Arg Ile180 185 190Pro Pro Cys Gly Trp Lys Cys Ser Lys Cys Asp Met Arg Glu Asn Leu195 200 205Trp Leu Asn Leu Thr Asp Gly Ser Ile Leu Cys Gly Arg Arg Tyr Phe210 215 220Asp Gly Ser Gly Gly Asn Asn His Ala Val Glu His Tyr Arg Glu Thr225 230 235 240Gly Tyr Pro Leu Ala Val Lys Leu Gly Thr Ile Thr Pro Asp Gly Ala245 250 255Asp Val Tyr Ser Tyr Asp Glu Asp Asp Met Val Leu Asp Pro Ser Leu260 265 270Ala Glu His Leu Ser His Phe Gly Ile Asp Met Leu Lys Met Gln Lys275 280 285Thr Asp Lys Thr Met Thr Glu Leu Glu Ile Asp Met Asn Gln Arg Ile290 295 300Gly Glu Trp Glu Leu Ile Gln Glu Ser Gly Val Pro Leu Lys Pro Leu305 310 315 320Phe Gly Pro Gly Tyr Thr Gly Ile Arg Asn Leu Gly Asn Ser Cys Tyr325 330 335Leu Asn Ser Val Val Gln Val Leu Phe Ser Ile Pro Asp Phe Gln Arg340 345 350Lys Tyr Val Asp Lys Leu Glu Lys Ile Phe Gln Asn Ala Pro Thr Asp355 360 365Pro Thr Gln Asp Phe Ser Thr Gln Val Ala Lys Leu Gly His Gly Leu370 375 380
Leu Ser Gly Glu Tyr Ser Lys Pro Val Pro Glu Ser Gly Asp Gly Glu385 390 395 400Arg Val Pro Glu Gln Lys Glu Val Gln Asp Gly Ile Ala Pro Arg Met405 410 415Phe Lys Ala Leu Ile Gly Lys Gly His Pro Glu Phe Ser Thr Asn Arg420 425 430Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Ile Asn Met Val Glu435 440 445Arg Asn Cys Arg Ser Ser Glu Asn Pro Asn Glu Val Phe Arg Phe Leu450 455 460Val Glu Glu Lys Ile Lys Cys Leu Ala Thr Glu Lys Val Lys Tyr Thr465 470 475 480Gln Arg Val Asp Tyr Ile Met Gln Leu Pro Val Pro Met Asp Ala Ala485 490 495Leu Asn Lys Glu Glu Leu Leu Glu Tyr Glu Glu Lys Lys Arg Gln Ala500 505 510Glu Glu Glu Lys Met Ala Leu Pro Glu Leu Val Arg Ala Gln Val Pro515 520 525Phe Ser Ser Cys Leu Glu Ala Tyr Gly Ala Pro Glu Gln Val Asp Asp530 535 540Phe Trp Ser Thr Ala Leu Gln Ala Lys Ser Val Ala Val Lys Thr Thr545 550 555 560Arg Phe Ala Ser Phe Pro Asp Tyr Leu Val Ile Gln Ile Lys Lys Phe565 570 575Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Leu Asp Val Ser Ile Glu580 585 590Met Pro Glu Glu Leu Asp Ile Ser Gln Leu Arg Gly Thr Gly Leu Gln595 600 605Pro Gly Glu Glu Glu Leu Pro Asp Ile Ala Pro Pro Leu Val Thr Pro610 615 620
Asp Glu Pro Lys Gly Ser Leu Gly Phe Tyr Gly Asn Glu Asp Glu Asp625 630 635 640Ser Phe Cys Ser Pro His Phe Ser Ser Pro Thr Ser Pro Met Leu Asp645 650 655Glu Ser Val Ile Ile Gln Leu Val Glu Met Gly Phe Pro Met Asp Ala660 665 670Cys Arg Lys Ala Val Tyr Tyr Thr Gly Asn Ser Gly Ala Glu Ala Ala675 680 685Met Asn Trp Val Met Ser His Met Asp Asp Pro Asp Phe Ala Asn Pro690 695 700Leu Ile Leu Pro Gly Ser Ser Gly Pro Gly Ser Thr Ser Ala Ala Ala705 710 715 720Asp Pro Pro Pro Glu Asp Cys Val Thr Thr Ile Val Ser Met Gly Phe725 730 735Ser Arg Asp Gln Ala Leu Lys Ala Leu Arg Ala Thr Asn Asn Ser Leu740 745 750Glu Arg Ala Val Asp Trp Ile Phe Ser His Ile Asp Asp Leu Asp Ala755 760 765Glu Ala Ala Met Asp Ile Ser Glu Gly Arg Ser Ala Ala Asp Ser Ile770 775 780Ser Glu Ser Val Pro Val Gly Pro Lys Val Arg Asp Gly Pro Gly Lys785 790 795 800Tyr Gln Leu Phe Ala Phe Ile Ser His Met Gly Thr Ser Thr Met Cys805 810 815Gly His Tyr Val Cys His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr820 825 830Asn Asp Gln Lys Val Cys Ala Ser Glu Lys Pro Pro Lys Asp Leu Gly835 840 845Tyr Ile Tyr Phe Tyr Gln Arg Val Ala Ser850 855<210>114<211>324
<212>PRT<213>人<300>
<308>tr_hum/q9bvh9<309>2001-06-01<400>114Met Glu Asp Ala Lys Val Tyr Val Ala Lys Val Asp Cys Thr Ala His1 5 10 15Ser Asp Val Cys Ser Ala Gln Gly Val Arg Gly Tyr Pro Thr Leu Lys20 25 30Leu Phe Lys Pro Gly Gln Glu Ala Val Lys Tyr Gln Gly Pro Arg Asp35 40 45Phe Gln Thr Leu Glu Asn Trp Met Leu Gln Thr Leu Asn Glu Glu Pro50 55 60Val Thr Pro Glu Pro Glu Val Glu Pro Pro Ser Ala Pro Glu Leu Lys65 70 75 80Gln Gly Leu Tyr Glu Leu Ser Ala Ser Asn Phe Glu Leu His Val Ala85 90 95Gln Gly Asp His Phe Ile Lys Phe Phe Ala Pro Trp Cys Gly His Cys100 105 110Lys Ala Leu Ala Pro Thr Trp Glu Gln Leu Ala Leu Gly Leu Glu His115 120 125Ser Glu Thr Val Lys Ile Gly Lys Val Asp Cys Thr Gln His Tyr Glu130 135 140Leu Cys Ser Gly Asn Gln Val Arg Gly Tyr Pro Thr Leu Leu Trp Phe145 150 155 160Arg Asp Gly Lys Lys Val Asp Gln Tyr Lys Gly Lys Arg Asp Leu Glu165 170 175Ser Leu Arg Glu Tyr Val Glu Ser Gln Leu Gln Arg Thr Glu Thr Gly180 185 190Ala Thr Glu Thr Val Thr Pro Ser Glu Ala Pro Val Leu Ala Ala Glu195 200 205Pro Glu Ala Asp Lys Gly Thr Val Leu Ala Leu Thr Glu Asn Asn Phe
210 215 220Asp Asp Thr Ile Ala Glu Gly Ile Thr Phe Ile Lys Phe Tyr Ala Pro225 230 235 240Trp Cys Gly His Cys Lys Thr Leu Ala Pro Thr Trp Glu Glu Leu Ser245 250 255Lys Lys Glu Phe Pro Gly Leu Ala Gly Val Lys Ile Ala Glu Val Asp260 265 270Cys Thr Ala Glu Arg Asn Ile Cys Ser Lys Tyr Ser Val Arg Gly Tyr275 280 285Pro Thr Leu Leu Leu Phe Arg Gly Gly Lys Lys Val Ser Glu His Ser290 295 300Gly Gly Arg Asp Leu Asp Ser Leu His Arg Phe Val Leu Ser Gln Ala305 310 315 320Lys Asp Glu Leu<210>115<211>475<212>PRT<213>人<300>
<308>sw_hum/cgl1_human<309>2003-02-28<400>115Met Ala Ala Leu Thr Thr Leu Phe Lys Tyr Ile Asp Glu Asn Gln Asp1 5 10 15Arg Tyr Ile Lys Lys Leu Ala Lys Trp Val Ala Ile Gln Ser Val Ser20 25 30Ala Trp Pro Glu Lys Arg Gly Glu Ile Arg Arg Met Met Glu Val Ala35 40 45Ala Ala Asp Val Lys Gln Leu Gly Gly Ser Val Glu Leu Val Asp Ile50 55 60Gly Lys Gln Lys Leu Pro Asp Gly Ser Glu Ile Pro Leu Pro Pro Ile65 70 75 80
Leu Leu Gly Arg Leu Gly Ser Asp Pro Gln Lys Lys Thr Val Cys Ile85 90 95Tyr Gly His Leu Asp Val Gln Pro Ala Ala Leu Glu Asp Gly Trp Asp100 105 110Ser Glu Pro Phe Thr Leu Val Glu Arg Asp Gly Lys Leu Tyr Gly Arg115 120 125Gly Ser Thr Asp Asp Lys Gly Pro Val Ala Gly Trp Ile Asn Ala Leu130 135 140Glu Ala Tyr Gln Lys Thr Gly Gln Glu Ile Pro Val Asn Val Arg Phe145 150 155 160Cys Leu Glu Gly Met Glu Glu Ser Gly Ser Glu Gly Leu Asp Glu Leu165 170 175Ile Phe Ala Arg Lys Asp Thr Phe Phe Lys Asp Val Asp Tyr Val Cys180 185 190Ile Ser Asp Asn Tyr Trp Leu Gly Lys Lys Lys Pro Cys Ile Thr Tyr195 200 205Gly Leu Arg Gly Ile Cys Tyr Phe Phe Ile Glu Val Glu Cys Ser Asn210 215 220Lys Asp Leu His Ser Gly Val Tyr Gly Gly Ser Val His Glu Ala Met225 230 235 240Thr Asp Leu Ile Leu Leu Met Gly Ser Leu Val Asp Lys Arg Gly Asn245 250 255Ile Leu Ile Pro Gly Ile Asn Glu Ala Val Ala Ala Val Thr Glu Glu260 265 270Glu His Lys Leu Tyr Asp Asp Ile Asp Phe Asp Ile Glu Glu Phe Ala275 280 285Lys Asp Val Gly Ala Gln Ile Leu Leu His Ser His Lys Lys Asp Ile290 295 300Leu Met His Arg Trp Arg Tyr Pro Ser Leu Ser Leu His Gly Ile Glu305 310 315 320Gly Ala Phe Ser Gly Ser Gly Ala Lys Thr Val Ile Pro Arg Lys Val325 330 335
Val Gly Lys Phe Ser Ile Arg Leu Val Pro Asn Met Thr Pro Glu Val340 345 350Val Gly Glu Gln Val Thr Ser Tyr Leu Thr Lys Lys Phe Ala Glu Leu355 360 365Arg Ser Pro Asn Glu Phe Lys Val Tyr Met Gly His Gly Gly Lys Pro370 375 380Trp Val Ser Asp Phe Ser His Pro His Tyr Leu Ala Gly Arg Arg Ala385 390 395 400Met Lys Thr Val Phe Gly Val Glu Pro Asp Leu Thr Arg Glu Gly Gly405 410 415Ser Ile Pro Val Thr Leu Thr Phe Gln Glu Ala Thr Gly Lys Asn Val420 425 430Met Leu Leu Pro Val Gly Ser Ala Asp Asp Gly Ala His Ser Gln Asn435 440 445Glu Lys Leu Asn Arg Tyr Asn Tyr Ile Glu Gly Thr Lys Met Leu Ala450 455 460Ala Tyr Leu Tyr Glu Val Ser Gln Leu Lys Asp465 470 475<210>116<211>465<212>PRT<213>人<300>
<308>sw_hum/vime_human<309>1988-01-01<400>116Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly Gly1 5 10 15Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr Thr20 25 30Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr Ser35 40 45Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg Ser
50 55 60Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu Gln65 70 75 80Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe Lys85 90 95Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp Arg100 105 110Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys115 120 125Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser Arg130 135 140Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln Val145 150 155 160Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp Asn165 170 175Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu Met180 185 190Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln Asp195 200 205Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val Glu210 215 220Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu Glu225 230 235 240Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile Asp245 250 255Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val Arg260 265 270Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu Glu275 280 285Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg Asn290 295 300
Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg Arg305 310 315 320Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr Asn325 330 335Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala Val340 345 350Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu Ile355 360 365Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln Asp370 375 380Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg385 390 395 400Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro Asn405 410 415Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro Leu420 425 430Val Asp Thr His Ser Lys Arg Thr Phe Leu Ile Lys Thr Val Glu Thr435 440 445Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp Leu450 455 460Glu465<210>117<211>139<212>PRT<213>人<300>
<308>sw_hum/pro1_human<309>1988-08-01<400>117Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr Cys1 5 10 15Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp Ala20 25 30
Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val Gly35 40 45Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu Thr50 55 60Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln Asp65 70 75 80Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala Pro85 90 95Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu Leu100 105 110Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys Tyr115 120 125Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr130 135<210>118<211>243<212>PRT<213>人<300>
<308>sw_hum/rs3_human<309>1991-11-01<400>118Met Ala Val Gln Ile Ser Lys Lys Arg Lys Phe Val Ala Asp Gly Ile1 5 10 15Phe Lys Ala Glu Leu Asn Glu Phe Leu Thr Arg Glu Leu Ala Glu Asp20 25 30Gly Tyr Ser Gly Val Glu Val Arg Val Thr Pro Thr Arg Thr Glu Ile35 40 45Ile Ile Leu Ala Thr Arg Thr Gln Asn Val Leu Gly Glu Lys Gly Arg50 55 60Arg Ile Arg Glu Leu Thr Ala Val Val Gln Lys Arg Phe Gly Phe Pro65 70 75 80Glu Gly Ser Val Glu Leu Tyr Ala Glu Lys Val Ala Thr Arg Gly Leu
85 90 95Cys Ala Ile Ala Gln Ala Glu Ser Leu Arg Tyr Lys Leu Leu Gly Gly100 105 110Leu Ala Val Arg Arg Ala Cys Tyr Gly Val Leu Arg Phe Ile Met Glu115 120 125Ser Gly Ala Lys Gly Cys Glu Val Val Val Ser Gly Lys Leu Arg Gly130 135 140Gln Arg Ala Lys Ser Met Lys Phe Val Asp Gly Leu Met Ile His Ser145 150 155 160Gly Asp Pro Val Asn Tyr Tyr Val Asp Thr Ala Val Arg His Val Leu165 170 175Leu Arg Gln Gly Val Leu Gly Ile Lys Val Lys Ile Met Leu Pro Trp180 185 190Asp Pro Thr Gly Lys Ile Gly Pro Lys Lys Pro Leu Pro Asp His Val195 200 205Ser Ile Val Glu Pro Lys Asp Glu Ile Leu Pro Thr Thr Pro Ile Ser210 215 220Glu Gln Lys Gly Gly Lys Pro Glu Pro Pro Ala Met Pro Gln Pro Val225 230 235 240Pro Thr Ala<210>119<211>297<212>PRT<213>人<300>
<308>sw_hum/nadc_human<309>1997-11-01<400>119Met Asp Ala Glu Gly Leu Ala Leu Leu Leu Pro Pro Val Thr Leu Ala1 5 10 15Ala Leu Val Asp Ser Trp Leu Arg Glu Asp Cys Pro Gly Leu Asn Tyr20 25 30
Ala Ala Leu Val Ser Gly Ala Gly Pro Ser Gln Ala Ala Leu Trp Ala35 40 45Lys Ser Pro Gly Val Leu Ala Gly Gln Pro Phe Phe Asp Ala Ile Phe50 55 60Thr Gln Leu Asn Cys Gln Val Ser Trp Phe Leu Pro Glu Gly Ser Lys65 70 75 80Leu Val Pro Val Ala Arg Val Ala Glu Val Arg Gly Pro Ala His Cys85 90 95Leu Leu Leu Gly Glu Arg Val Ala Leu Asn Thr Leu Ala Arg Cys Ser100 105 110Gly Ile Ala Ser Ala Ala Ala Ala Ala Val Glu Ala Ala Arg Gly Ala115 120 125Gly Trp Thr Gly His Val Ala Gly Thr Arg Lys Thr Thr Pro Gly Phe130 135 140Arg Leu Val Glu Lys Tyr Gly Leu Leu Val Gly Gly Ala Ala Ser His145 150 155 160Arg Tyr Asp Leu Gly Gly Leu Val Met Val Lys Asp Asn His Val Val165 170 175Ala Ala Gly Gly Val Glu Lys Ala Val Arg Ala Ala Arg Gln Ala Ala180 185 190Asp Phe Ala Leu Lys Val Glu Val Glu Cys Ser Ser Leu Gln Glu Ala195 200 205Val Gln Ala Ala Glu Ala Gly Ala Asp Leu Val Leu Leu Asp Asn Phe210 215 220Lys Pro Glu Glu Leu His Pro Thr Ala Thr Val Leu Lys Ala Gln Phe225 230 235 240Pro Ser Val Ala Val Glu Ala Ser Gly Gly Ile Thr Leu Asp Asn Leu245 250 255Pro Gln Phe Cys Gly Pro His Ile Asp Val Ile Ser Met Gly Met Leu260 265 270Thr Gln Ala Ala Pro Ala Leu Asp Phe Ser Leu Lys Leu Phe Ala Lys275 280 285
Glu Val Ala Pro Val Pro Lys Ile His290 295<210>120<211>279<212>PRT<213>人<300>
<308>humangp/chr5-q96nm0<309>2003-04-22<400>120Met Leu Leu Ala Ala Ser Lys Val Leu Asp Arg Leu Lys Pro Val Ile1 5 10 15Gly Val Asn Thr Asp Pro Glu Arg Ser Glu Gly His Leu Cys Leu Pro20 25 30Val Arg Tyr Thr His Ser Phe Pro Glu Ala Leu Gln Lys Phe Tyr Arg35 40 45Gly Glu Phe Arg Trp Leu Trp Arg Gln Arg Ile Arg Leu Tyr Leu Glu50 55 60Gly Thr Gly Ile Asn Pro Val Pro Val Asp Leu His Glu Gln Gln Leu65 70 75 80Ser Leu Asn Gln His Asn Arg Ala Leu Asn Ile Glu Arg Ala His Asp85 90 95Glu Arg Ser Glu Ala Ser Gly Pro Gln Leu Leu Pro Val Arg Ala Leu100 105 110Asn Glu Val Phe Ile Gly Glu Ser Leu Ser Ser Arg Ala Ser Tyr Tyr115 120 125Glu Ile Ser Val Asp Asp Gly Pro Trp Glu Lys Gln Lys Ser Ser Gly130 135 140Leu Asn Leu Cys Thr Gly Thr Gly Ser Lys Ala Trp Ser Phe Asn Ile145 150 155 160Asn Arg Val Ala Thr Gln Ala Val Glu Asp Val Leu Asn Ile Ala Lys165 170 175Arg Gln Gly Asn Leu Ser Leu Pro Leu Asn Arg Glu Leu Val Glu Lys
180 185 190Val Thr Asn Glu Tyr Asn Glu Ser Leu Leu Tyr Ser Pro Glu Glu Pro195 200 205Lys Ile Leu Phe Ser Ile Arg Glu Pro Ile Ala Asn Arg Val Phe Ser210 215 220Ser Ser Arg Gln Arg Cys Phe Ser Ser Lys Val Cys Val Arg Ser Arg225 230 235 240Cys Trp Asp Ala Cys Met Val Val Asp Gly Gly Thr Ser Phe Glu Phe245 250 255Asn Asp Gly Ala Ile Ala Ser Met Met Ile Asn Lys Glu Asp Glu Leu260 265 270Arg Thr Val Leu Leu Glu Gln275<210>121<211>346<212>PRT<213>人<300>
<308>humangp/chr19-095717<309>2003-04-22<400>121Met Val Glu Lys Glu Glu Ala Gly Gly Gly Ile Ser Glu Glu Glu Ala1 5 10 15Ala Gln Tyr Asp Arg Gln Ile Arg Leu Trp Gly Leu Glu Ala Gln Lys20 25 30Arg Leu Arg Ala Ser Arg Val Leu Leu Val Gly Leu Lys Gly Leu Gly35 40 45Ala Glu Ile Ala Lys Asn Leu Ile Leu Ala Gly Val Lys Gly Leu Thr50 55 60Met Leu Asp His Glu Gln Val Thr Pro Glu Asp Pro Gly Ala Gln Phe65 70 75 80Leu Ile Arg Thr Gly Ser Val Gly Arg Asn Arg Ala Glu Ala Ser Leu85 90 95
Glu Arg Ala Gln Asn Leu Asn Pro Met Val Asp Val Lys Val Asp Thr100 105 110Glu Asp Ile Glu Lys Lys Pro Glu Ser Phe Phe Thr Gln Phe Asp Ala115 120 125Val Cys Leu Thr Cys Cys Ser Arg Asp Val Ile Val Lys Val Asp Gln130 135 140Ile Cys His Lys Asn Ser Ile Lys Phe Phe Thr Gly Asp Val Phe Gly145 150 155 160Tyr His Gly Tyr Thr Phe Ala Asn Leu Gly Glu His Glu Phe Val Glu165 170 175Glu Lys Thr Lys Val Ala Lys Val Ser Gln Gly Val Glu Asp Gly Pro180 185 190Asp Thr Lys Arg Ala Lys Leu Asp Ser Ser Glu Thr Thr Met Val Lys195 200 205Lys Lys Val Val Phe Cys Pro Val Lys Glu Ala Leu Glu Val Asp Trp210 215 220Ser Ser Glu Lys Ala Lys Ala Ala Leu Lys Arg Thr Thr Ser Asp Tyr225 230 235 240Phe Leu Leu Gln Val Leu Leu Lys Phe Arg Thr Asp Lys Gly Arg Asp245 250 255Pro Ser Ser Asp Thr Tyr Glu Glu Asp Ser Glu Leu Leu Leu Gln Ile260 265 270Arg Asn Asp Val Leu Asp Ser Leu Gly Ile Ser Pro Asp Leu Leu Pro275 280 285Glu Asp Phe Val Arg Tyr Cys Phe Ser Glu Met Ala Pro Val Cys Ala290 295 300Val Val Gly Gly Ile Leu Ala Gln Glu Ile Val Lys Ala Leu Ser Gln305 310 315 320Arg Asp Pro Pro His Asn Asn Phe Phe Phe Phe Asp Gly Met Lys Gly325 330 335Asn Gly Ile Val Glu Cys Leu Gly Pro Lys340 345
<210>122<211>289<212>PRT<213>人<300>
<308>sw_hum/gnpi_human<309>1995-11-01<400>122Met Lys Leu Ile Ile Leu Glu His Tyr Ser Gln Ala Ser Glu Trp Ala1 5 10 15Ala Lys Tyr Ile Arg Asn Arg Ile Ile Gln Phe Asn Pro Gly Pro Glu20 25 30Lys Tyr Phe Thr Leu Gly Leu Pro Thr Gly Ser Thr Pro Leu Gly Cys35 40 45Tyr Lys Lys Leu Ile Glu Tyr Tyr Lys Asn Gly Asp Leu Ser Phe Lys50 55 60Tyr Val Lys Thr Phe Asn Met Asp Glu Tyr Val Gly Leu Pro Arg Asp65 70 75 80His Pro Glu Ser Tyr His Ser Phe Met Trp Asn Asn Phe Phe Lys His85 90 95Ile Asp Ile His Pro Glu Asn Thr His Ile Leu Asp Gly Asn Ala Val100 105 110Asp Leu Gln Ala Glu Cys Asp Ala Phe Glu Glu Lys Ile Lys Ala Ala115 120 125Gly Gly Ile Glu Leu Phe Val Gly Gly Ile Gly Pro Asp Gly His Ile130 135 140Ala Phe Asn Glu Pro Gly Ser Ser Leu Val Ser Arg Thr Arg Val Lys145 150 155 160Thr Leu Ala Met Asp Thr Ile Leu Ala Asn Ala Arg Phe Phe Asp Gly165 170 175Glu Leu Thr Lys Val Pro Thr Met Ala Leu Thr Val Gly Val Gly Thr180 185 190Val Met Asp Ala Arg Glu Val Met Ile Leu Ile Thr Gly Ala His Lys
195 200 205Ala Phe Ala Leu Tyr Lys Ala Ile Glu Glu Gly Val Asn His Met Trp210 215 220Thr Val Ser Ala Phe Gln Gln His Pro Arg Thr Val Phe Val Cys Asp225 230 235 240Glu Asp Ala Thr Leu Glu Leu Lys Val Lys Thr Val Lys Tyr Phe Lys245 250 255Gly Leu Met Leu Val His Asn Lys Leu Val Asp Pro Leu Tyr Ser Ile260 265 270Lys Glu Lys Glu Thr Glu Lys Ser Gln Ser Ser Lys Lys Pro Tyr Ser275 280 285Asp<210>123<211>344<212>PRT<213>人<300>
<308>sw_hum/nagk_human<309>2003-02-28<400>123Met Ala Ala Ile Tyr Gly Gly Val Glu Gly Gly Gly Thr Arg Ser Glu1 5 10 15Val Leu Leu Val Ser Glu Asp Gly Lys Ile Leu Ala Glu Ala Asp Gly20 25 30Leu Ser Thr Asn His Trp Leu Ile Gly Thr Asp Lys Cys Val Glu Arg35 40 45Ile Asn Glu Met Val Asn Arg Ala Lys Arg Lys Ala Gly Val Asp Pro50 55 60Leu Val Pro Leu Arg Ser Leu Gly Leu Ser Leu Ser Gly Gly Asp Gln65 70 75 80Glu Asp Ala Gly Arg Ile Leu Ile Glu Glu Leu Arg Asp Arg Phe Pro85 90 95
Tyr Leu Ser Glu Ser Tyr Leu Ile Thr Thr Asp Ala Ala Gly Ser Ile100 105 110Ala Thr Ala Thr Pro Asp Gly Gly Val Val Leu Ile Ser Gly Thr Gly115 120 125Ser Asn Cys Arg Leu Ile Asn Pro Asp Gly Ser Glu Ser Gly Cys Gly130 135 140Gly Trp Gly His Met Met Gly Asp Glu Gly Ser Ala Tyr Trp Ile Ala145 150 155 160His Gln Ala Val Lys Ile Val Phe Asp Ser Ile Asp Asn Leu Glu Ala165 170 175Ala Pro His Asp Ile Gly Tyr Val Lys Gln Ala Met Phe His Tyr Phe180 185 190Gln Val Pro Asp Arg Leu Gly Ile Leu Thr His Leu Tyr Arg Asp Phe195 200 205Asp Lys Cys Arg Phe Ala Gly Phe Cys Arg Lys Ile Ala Glu Gly Ala210 215 220Gln Gln Gly Asp Pro Leu Ser Arg Tyr Ile Phe Arg Lys Ala Gly Glu225 230 235 240Met Leu Gly Arg His Ile Val Ala Val Leu Pro Glu Ile Asp Pro Val245 250 255Leu Phe Gln Gly Lys Ile Gly Leu Pro Ile Leu Cys Val Gly Ser Val260 265 270Trp Lys Ser Trp Glu Leu Leu Lys Glu Gly Phe Leu Leu Ala Leu Thr275 280 285Gln Gly Arg Glu Ile Gln Ala Gln Asn Phe Phe Ser Ser Phe Thr Leu290 295 300Met Lys Leu Arg His Ser Ser Ala Leu Gly Gly Ala Ser Leu Gly Ala305 310 315 320Arg His Ile Gly His Leu Leu Pro Met Asp Tyr Ser Ala Asn Ala Ile325 330 335Ala Phe Tyr Ser Tyr Thr Phe Ser340
<210>124<211>222<212>PRT<213>人<300>
<308>sw_hum/sodm_human<309>1987-03-20<400>124Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Ala1 5 10 15Leu Gly Tyr Leu Gly Ser Arg Gln Lys His Ser Leu Pro Asp Leu Pro20 25 30Tyr Asp Tyr Gly Ala Leu Glu Pro His Ile Asn Ala Gln Ile Met Gln35 40 45Leu His His Ser Lys His His Ala Ala Tyr Val Asn Asn Leu Asn Val50 55 60Thr Glu Glu Lys Tyr Gln Glu Ala Leu Ala Lys Gly Asp Val Thr Ala65 70 75 80Gln Ile Ala Leu Gln Pro Ala Leu Lys Phe Asn Gly Gly Gly His Ile85 90 95Asn His Ser Ile Phe Trp Thr Asn Leu Ser Pro Asn Gly Gly Gly Glu100 105 110Pro Lys Gly Glu Leu Leu Glu Ala Ile Lys Arg Asp Phe Gly Ser Phe115 120 125Asp Lys Phe Lys Glu Lys Leu Thr Ala Ala Ser Val Gly Val Gln Gly130 135 140Ser Gly Trp Gly Trp Leu Gly Phe Asn Lys Glu Arg Gly His Leu Gln145 150 155 160Ile Ala Ala Cys Pro Asn Gln Asp Pro Leu Gln Gly Thr Thr Gly Leu165 170 175Ile Pro Leu Leu Gly Ile Asp Val Trp Glu His Ala Tyr Tyr Leu Gln180 185 190Tyr Lys Asn Val Arg Pro Asp Tyr Leu Lys Ala Ile Trp Asn Val Ile
195 200 205Asn Trp Glu Asn Val Thr Glu Arg Tyr Met Ala Cys Lys Lys210 215 220<210>125<211>282<212>PRT<213>人<300>
<308>sw_hum/estd_human<309>1989-07-01<400>125Met Ala Leu Lys Gln Ile Ser Ser Asn Lys Cys Phe Gly Gly Leu Gln1 5 10 15Lys Val Phe Glu His Asp Ser Val Glu Leu Asn Cys Lys Met Lys Phe20 25 30Ala Val Tyr Leu Pro Pro Lys Ala Glu Thr Gly Lys Cys Pro Ala Leu35 40 45Tyr Trp Leu Ser Gly Leu Thr Cys Thr Glu Gln Asn Phe Ile Ser Lys50 55 60Ser Gly Tyr His Gln Ser Ala Ser Glu His Gly Leu Val Val Ile Ala65 70 75 80Pro Asp Thr Ser Pro Arg Gly Cys Asn Ile Lys Gly Glu Asp Glu Ser85 90 95Trp Asp Phe Gly Thr Gly Ala Gly Phe Tyr Val Asp Ala Thr Glu Asp100 105 110Pro Trp Lys Thr Asn Tyr Arg Met Tyr Ser Tyr Val Thr Glu Glu Leu115 120 125Pro Gln Leu Ile Asn Ala Asn Phe Pro Val Asp Pro Gln Arg Met Ser130 135 140Ile Phe Gly His Ser Met Gly Gly His Gly Ala Leu Ile Cys Ala Leu145 150 155 160Lys Asn Pro Gly Lys Tyr Lys Ser Val Ser Ala Phe Ala Pro Ile Cys165 170 175
Asn Pro Val Leu Cys Pro Trp Gly Lys Lys Ala Phe Ser Gly Tyr Leu180 185 190Gly Thr Asp Gln Ser Lys Trp Lys Ala Tyr Asp Ala Thr His Leu Val195 200 205Lys Ser Tyr Pro Gly Ser Gln Leu Asp Ile Leu Ile Asp Gln Gly Lys210 215 220Asp Asp Gln Phe Leu Leu Asp Gly Gln Leu Leu Pro Asp Asn Phe Ile225 230 235 240Ala Ala Cys Thr Glu Lys Lys Ile Pro Val Val Phe Arg Leu Gln Glu245 250 255Gly Tyr Asp His Ser Tyr Tyr Phe Ile Ala Thr Phe Ile Thr Asp His260 265 270Ile Arg His His Ala Lys Tyr Leu Asn Ala275 280<210>126<211>504<212>PRT<213>人<300>
<308>sw_hum/glym_human<309>1994-02-01<400>126Met Leu Tyr Phe Ser Leu Phe Trp Ala Ala Arg Pro Leu Gln Arg Cys1 5 10 15Gly Gln Leu Val Arg Met Ala Ile Arg Ala Gln His Ser Asn Ala Ala20 25 30Gln Thr Gln Thr Gly Glu Ala Asn Arg Gly Trp Thr Gly Gln Glu Ser35 40 45Leu Ser Asp Ser Asp Pro Glu Met Trp Glu Leu Leu Gln Arg Glu Lys50 55 60Asp Arg Gln Cys Arg Gly Leu Glu Leu Ile Ala Ser Glu Asn Phe Cys65 70 75 80Ser Arg Ala Ala Leu Glu Ala Leu Gly Ser Cys Leu Asn Asn Lys Tyr85 90 95
Ser Glu Gly Tyr Pro Gly Lys Arg Tyr Tyr Gly Gly Ala Glu Val Val100 105 110Asp Glu Ile Glu Leu Leu Cys Gln Arg Arg Ala Leu Glu Ala Phe Asp115 120 125Leu Asp Pro Ala Gln Trp Gly Val Asn Val Gln Pro Tyr Ser Gly Ser130 135 140Pro Ala Asn Leu Ala Val Tyr Thr Ala Leu Leu Gln Pro His Asp Arg145 150 155 160Ile Met Gly Leu Asp Leu Pro Asp Gly Gly His Leu Thr His Gly Tyr165 170 175Met Ser Asp Val Lys Arg Ile Ser Ala Thr Ser Ile Phe Phe Glu Ser180 185 190Met Pro Tyr Lys Leu Asn Pro Lys Thr Gly Leu Ile Asp Tyr Asn Gln195 200 205Leu Ala Leu Thr Ala Arg Leu Phe Arg Pro Arg Leu Ile Ile Ala Gly210 215 220Thr Ser Ala Tyr Ala Arg Leu Ile Asp Tyr Ala Arg Met Arg Glu Val225 230 235 240Cys Asp Glu Val Lys Ala His Leu Leu Ala Asp Met Ala His Ile Ser245 250 255Gly Leu Val Ala Ala Lys Val Ile Pro Ser Pro Phe Lys His Ala Asp260 265 270Ile Val Thr Thr Thr Thr His Lys Thr Leu Arg Gly Ala Arg Ser Gly275 280 285Leu Ile Phe Tyr Arg Lys Gly Val Lys Ala Val Asp Pro Lys Thr Gly290 295 300Arg Glu Ile Pro Tyr Thr Phe Glu Asp Arg Ile Asn Phe Ala Val Phe305 310 315 320Pro Ser Leu Gln Gly Gly Pro His Asn His Ala Ile Ala Ala Val Ala325 330 335Val Ala Leu Lys Gln Ala Cys Thr Pro Met Phe Arg Glu Tyr Ser Leu
340 345 350Gln Val Leu Lys Asn Ala Arg Ala Met Ala Asp Ala Leu Leu Glu Arg355 360 365Gly Tyr Ser Leu Val Ser Gly Gly Thr Asp Asn His Leu Val Leu Val370 375 380Asp Leu Arg Pro Lys Gly Leu Asp Gly Ala Arg Ala Glu Arg Val Leu385 390 395 400Glu Leu Val Ser Ile Thr Ala Asn Lys Asn Thr Cys Pro Gly Asp Arg405 410 415Ser Ala Ile Thr Pro Gly Gly Leu Arg Leu Gly Ala Pro Ala Leu Thr420 425 430Ser Arg Gln Phe Arg Glu Asp Asp Phe Arg Arg Val Val Asp Phe Ile435 440 445Asp Glu Gly Val Asn Ile Gly Leu Glu Val Lys Ser Lys Thr Ala Lys450 455 460Leu Gln Asp Phe Lys Ser Phe Leu Leu Lys Asp Ser Glu Thr Ser Gln465 470 475 480Arg Leu Ala Asn Leu Arg Gln Arg Val Glu Gln Phe Ala Arg Ala Phe485 490 495Pro Met Pro Gly Phe Asp Glu His500<210>127<211>452<212>PRT<213>人<300>
<308>sw_hum/idhp_human<309>1996-02-01<400>127Met Ala Gly Tyr Leu Arg Val Val Arg Ser Leu Cys Arg Ala Ser Gly1 5 10 15Ser Arg Pro Ala Trp Ala Pro Ala Ala Leu Thr Ala Pro Thr Ser Gln20 25 30
Glu Gln Pro Arg Arg His Tyr Ala Asp Lys Arg Ile Lys Val Ala Lys35 40 45Pro Val Val Glu Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln50 55 60Phe Ile Lys Glu Lys Leu Ile Leu Pro His Val Asp Ile Gln Leu Lys65 70 75 80Tyr Phe Asp Leu Gly Leu Pro Asn Arg Asp Gln Thr Asp Asp Gln Val85 90 95Thr Ile Asp Ser Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys100 105 110Cys Ala Thr Ile Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu115 120 125Lys Lys Met Trp Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly130 135 140Gly Thr Val Phe Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu145 150 155 160Val Pro Gly Trp Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly165 170 175Asp Gln Tyr Lys Ala Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe180 185 190Lys Met Val Phe Thr Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu195 200 205Val Tyr Asn Phe Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr210 215 220Asp Glu Ser Ile Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ala Ile225 230 235 240Gln Lys Lys Trp Pro Leu Tyr Met Ser Thr Lys Asn Thr Ile Leu Lys245 250 255Ala Tyr Asp Gly Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys260 265 270His Tyr Lys Thr Asp Phe Asp Lys Asn Lys Ile Trp Tyr Glu His Arg275 280 285
Leu Ile Asp Asp Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe290 295 300Val Trp Ala Cys Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu305 310 315 320Ala Gln Gly Phe Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys325 330 335Pro Asp Gly Lys Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr340 345 350Arg His Tyr Arg Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro355 360 365Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys370 375 380Leu Asp Gly Asn Gln Asp Leu Ile Arg Phe Ala Gln Met Leu Glu Lys385 390 395 400Val Cys Val Glu Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala405 410 415Gly Cys Ile His Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu420 425 430Asn Thr Thr Asp Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala435 440 445Leu Gly Arg Gln450<210>128<211>263<212>PRT<213>人<300>
<308>sw_hum/psa1_human<309>1992-05-01<400>128Met Phe Arg Asn Gln Tyr Asp Asn Asp Val Thr Val Trp Ser Pro Gln1 5 10 15Gly Arg Ile His Gln Ile Glu Tyr Ala Met Glu Ala Val Lys Gln Gly
20 25 30Ser Ala Thr Val Gly Leu Lys Ser Lys Thr His Ala Val Leu Val Ala35 40 45Leu Lys Arg Ala Gln Ser Glu Leu Ala Ala His Gln Lys Lys Ile Leu50 55 60His Val Asp Asn His Ile Gly Ile Ser Ile Ala Gly Leu Thr Ala Asp65 70 75 80Ala Arg Leu Leu Cys Asn Phe Met Arg Gln Glu Cys Leu Asp Ser Arg85 90 95Phe Val Phe Asp Arg Pro Leu Pro Val Ser Arg Leu Val Ser Leu Ile100 105 110Gly Ser Lys Thr Gln Ile Pro Thr Gln Arg Tyr Gly Arg Arg Pro Tyr115 120 125Gly Val Gly Leu Leu Ile Ala Gly Tyr Asp Asp Met Gly Pro His Ile130 135 140Phe Gln Thr Cys Pro Ser Ala Asn Tyr Phe Asp Cys Arg Ala Met Ser145 150 155 160Ile Gly Ala Arg Ser Gln Ser Ala Arg Thr Tyr Leu Glu Arg His Met165 170 175Ser Glu Phe Met Glu Cys Asn Leu Asn Glu Leu Val Lys His Gly Leu180 185 190Arg Ala Leu Arg Glu Thr Leu Pro Ala Glu Gln Asp Leu Thr Thr Lys195 200 205Asn Val Ser Ile Gly Ile Val Gly Lys Asp Leu Glu Phe Thr Ile Tyr210 215 220Asp Asp Asp Asp Val Ser Pro Phe Leu Glu Gly Leu Glu Glu Arg Pro225 230 235 240Gln Arg Lys Ala Gln Pro Ala Gln Pro Ala Asp Glu Pro Ala Glu Lys245 250 255Ala Asp Glu Pro Met Glu His260
<210>129<211>740<212>PRT<213>人<300>
<308>sw_hum/k6a3_human<309>1996-10-01<400>129Met Pro Leu Ala Gln Leu Ala Asp Pro Trp Gln Lys Met Ala Val Glu1 5 10 15Ser Pro Ser Asp Ser Ala Glu Asn Gly Gln Gln Ile Met Asp Glu Pro20 25 30Met Gly Glu Glu Glu Ile Asn Pro Gln Thr Glu Glu Val Ser Ile Lys35 40 45Glu Ile Ala Ile Thr His His Val Lys Glu Gly His Glu Lys Ala Asp50 55 60Pro Ser Gln Phe Glu Leu Leu Lys Val Leu Gly Gln Gly Ser Phe Gly65 70 75 80Lys Val Phe Leu Val Lys Lys Ile Ser Gly Ser Asp Ala Arg Gln Leu85 90 95Tyr Ala Met Lys Val Leu Lys Lys Ala Thr Leu Lys Val Arg Asp Arg100 105 110Val Arg Thr Lys Met Glu Arg Asp Ile Leu Val Glu Val Asn His Pro115 120 125Phe Ile Val Lys Leu His Tyr Ala Phe Gln Thr Glu Gly Lys Leu Tyr130 135 140Leu Ile Leu Asp Phe Leu Arg Gly Gly Asp Leu Phe Thr Arg Leu Ser145 150 155 160Lys Glu Val Met Phe Thr Glu Glu Asp Val Lys Phe Tyr Leu Ala Glu165 170 175Leu Ala Leu Ala Leu Asp His Leu His Ser Leu Gly Ile Ile Tyr Arg180 185 190Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp Glu Glu Gly His Ile Lys195 200 205
Leu Thr Asp Phe Gly Leu Ser Lys Glu Ser Ile Asp His Glu Lys Lys210 215 220Ala Tyr Ser Phe Cys Gly Thr Val Glu Tyr Met Ala Pro Glu Val Val225 230 235 240Asn Arg Arg Gly His Thr Gln Ser Ala Asp Trp Trp Ser Phe Gly Val245 250 255Leu Met Phe Glu Met Leu Thr Gly Thr Leu Pro Phe Gln Gly Lys Asp260 265 270Arg Lys Glu Thr Met Thr Met Ile Leu Lys Ala Lys Leu Gly Met Pro275 280 285Gln Phe Leu Ser Pro Glu Ala Gln Ser Leu Leu Arg Met Leu Phe Lys290 295 300Arg Asn Pro Ala Asn Arg Leu Gly Ala Gly Pro Asp Gly Val Glu Glu305 310 315 320Ile Lys Arg His Ser Phe Phe Ser Thr Ile Asp Trp Asn Lys Leu Tyr325 330 335Arg Arg Glu Ile His Pro Pro Phe Lys Pro Ala Thr Gly Arg Pro Glu340 345 350Asp Thr Phe Tyr Phe Asp Pro Glu Phe Thr Ala Lys Thr Pro Lys Asp355 360 365Ser Pro Gly Ile Pro Pro Ser Ala Asn Ala His Gln Leu Phe Arg Gly370 375 380Phe Ser Phe Val Ala Ile Thr Ser Asp Asp Glu Ser Gln Ala Met Gln385 390 395 400Thr Val Gly Val His Ser Ile Val Gln Gln Leu His Arg Asn Ser Ile405 410 415Gln Phe Thr Asp Gly Tyr Glu Val Lys Glu Asp Ile Gly Val Gly Ser420 425 430Tyr Ser Val Cys Lys Arg Cys Ile His Lys Ala Thr Asn Met Glu Phe435 440 445
Ala Val Lys Ile Ile Asp Lys Ser Lys Arg Asp Pro Thr Glu Glu Ile450 455 460Glu Ile Leu Leu Arg Tyr Gly Gln His Pro Asn Ile Ile Thr Leu Lys465 470 475 480Asp Val Tyr Asp Asp Gly Lys Tyr Val Tyr Val Val Thr Glu Leu Met485 490 495Lys Gly Gly Glu Leu Leu Asp Lys Ile Leu Arg Gln Lys Phe Phe Ser500 505 510Glu Arg Glu Ala Ser Ala Val Leu Phe Thr Ile Thr Lys Thr Val Glu515 520 525Tyr Leu His Ala Gln Gly Val Val His Arg Asp Leu Lys Pro Ser Asn530 535 540Ile Leu Tyr Val Asp Glu Ser Gly Asn Pro Glu Ser Ile Arg Ile Cys545 550 555 560Asp Phe Gly Phe Ala Lys Gln Leu Arg Ala Glu Asn Gly Leu Leu Met565 570 575Thr Pro Cys Tyr Thr Ala Asn Phe Val Ala Pro Glu Val Leu Lys Arg580 585 590Gln Gly Tyr Asp Ala Ala Cys Asp Ile Trp Ser Leu Gly Val Leu Leu595 600 605Tyr Thr Met Leu Thr Gly Tyr Thr Pro Phe Ala Asn Gly Pro Asp Asp610 615 620Thr Pro Glu Glu Ile Leu Ala Arg Ile Gly Ser Gly Lys Phe Ser Leu625 630 635 640Ser Gly Gly Tyr Trp Asn Ser Val Ser Asp Thr Ala Lys Asp Leu Val645 650 655Ser Lys Met Leu His Val Asp Pro His Gln Arg Leu Thr Ala Ala Leu660 665 670Val Leu Arg His Pro Trp Ile Val His Trp Asp Gln Leu Pro Gln Tyr675 680 685Gln Leu Asn Arg Gln Asp Ala Pro His Leu Val Lys Gly Ala Met Ala690 695 700
Ala Thr Tyr Ser Ala Leu Asn Arg Asn Gln Ser Pro Val Leu Glu Pro705 710 715 720Val Gly Arg Ser Thr Leu Ala Gln Arg Arg Gly Ile Lys Lys Ile Thr725 730 735Ser Thr Ala Leu740<210>130<211>194<212>PRT<213>人<300>
<308>humangp/chr20-014878<309>2003-04-22<400>130Met Ala Ala Ser Leu Val Gly Lys Lys Ile Val Phe Val Thr Gly Asn1 5 10 15Ala Lys Lys Leu Glu Glu Val Val Gln Ile Leu Gly Asp Lys Phe Pro20 25 30Cys Thr Leu Val Ala Gln Lys Ile Asp Leu Pro Glu Tyr Gln Gly Glu35 40 45Pro Asp Glu Ile Ser Ile Gln Lys Cys Gln Glu Ala Val Arg Gln Val50 55 60Gln Gly Pro Val Leu Val Glu Asp Thr Cys Leu Cys Phe Asn Ala Leu65 70 75 80Gly Gly Leu Pro Gly Pro Tyr Ile Lys Trp Phe Leu Glu Lys Leu Lys85 90 95Pro Glu Gly Leu His Gln Leu Leu Ala Gly Phe Glu Asp Lys Ser Ala100 105 110Tyr Ala Leu Cys Thr Phe Ala Leu Ser Thr Gly Asp Pro Ser Gln Pro115 120 125Val Arg Leu Phe Arg Gly Arg Thr Ser Gly Arg Ile Val Ala Pro Arg130 135 140Gly Cys Gln Asp Phe Gly Trp Asp Pro Cys Phe Gln Pro Asp Gly Tyr
145 150 155 160Glu Gln Thr Tyr Ala Glu Met Pro Lys Ala Glu Lys Asn Ala Val Ser165 170 175His Arg Phe Arg Ala Leu Leu Glu Leu Gln Glu Tyr Phe Gly Ser Leu180 185 190Ala Ala<210>131<211>524<212>PRT<213>人<300>
<308>sw_hum/pak2_human<309>1997-11-01<400>131Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val1 5 10 15Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser20 25 30Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys35 40 45Pro Arg His Lys Ile Ile Ser Ile Phe Ser Gly Thr Glu Lys Gly Ser50 55 60Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe65 70 75 80Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr85 90 95Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr100 105 110Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys115 120 125Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro130 135 140
Pro Glu Lys Asp Gly Leu Pro Ser Gly Thr Pro Ala Leu Asn Ala Lys145 150 155 160Gly Thr Glu Ala Pro Ala Val Val Thr Glu Glu Glu Asp Asp Asp Glu165 170 175Glu Thr Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser180 185 190Ile Tyr Thr Arg Ser Val Ile Asp Pro Val Pro Ala Pro Val Gly Asp195 200 205Ser His Val Asp Gly Ala Ala Lys Ser Leu Asp Lys Gln Lys Lys Lys210 215 220Pro Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val225 230 235 240Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly245 250 255Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly260 265 270Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys275 280 285Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro290 295 300Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe305 310 315 320Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr325 330 335Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys340 345 350Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp355 360 365Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu370 375 380Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg385 390 395 400
Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr405 410 415Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met420 425 430Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro435 440 445Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln450 455 460Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys465 470 475 480Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln485 490 495His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu500 505 510Ile Met Ala Ala Lys Glu Ala Met Lys Ser Asn Arg515 520<210>132<211>688<212>PRT<213>人<300>
<308>sw_hum/mepd_human<309>1996-10-01<400>132Lys Pro Pro Ala Ala Cys Ala Gly Asp Met Ala Asp Ala Ala Ser Pro1 5 10 15Cys Ser Val Val Asn Asp Leu Arg Trp Asp Leu Ser Ala Gln Gln Ile20 25 30Glu Glu Arg Thr Arg Glu Leu Ile Glu Gln Thr Lys Arg Val Tyr Asp35 40 45Gln Val Gly Thr Gln Glu Phe Glu Asp Val Ser Tyr Glu Ser Thr Leu50 55 60Lys Ala Leu Ala Asp Val Glu Val Thr Tyr Thr Val Gln Arg Asn Ile
65 70 75 80Leu Asp Phe Pro Gln His Val Ser Pro Ser Lys Asp Ile Arg Thr Ala85 90 95Ser Thr Glu Ala Asp Lys Lys Leu Ser Glu Phe Asp Val Glu Met Ser100 105 110Met Arg Glu Asp Val Tyr Gln Arg Ile Val Trp Leu Gln Glu Lys Val115 120 125Gln Lys Asp Ser Leu Arg Pro Glu Ala Ala Arg Tyr Leu Glu Arg Leu130 135 140Ile Lys Leu Gly Arg Arg Asn Gly Leu His Leu Pro Arg Glu Thr Gln145 150 155 160Glu Asn Ile Lys Arg Ile Lys Lys Lys Leu Ser Leu Leu Cys Ile Asp165 170 175Phe Asn Lys Asn Leu Asn Glu Asp Thr Thr Phe Leu Pro Phe Thr Leu180 185 190Gln Glu Leu Gly Gly Leu Pro Glu Asp Phe Leu Asn Ser Leu Glu Lys195 200 205Met Glu Asp Gly Lys Leu Lys Val Thr Leu Lys Tyr Pro His Tyr Phe210 215 220Pro Leu Leu Lys Lys Cys His Val Pro Glu Thr Arg Arg Lys Val Glu225 230 235 240Glu Ala Phe Asn Cys Arg Cys Lys Glu Glu Asn Cys Ala Ile Leu Lys245 250 255Glu Leu Val Thr Leu Arg Ala Gln Lys Ser Arg Leu Leu Gly Phe His260 265 270Thr His Ala Asp Tyr Val Leu Glu Met Asn Met Ala Lys Thr Ser Gln275 280 285Thr Val Ala Thr Phe Leu Asp Glu Leu Ala Gln Lys Leu Lys Pro Leu290 295 300Gly Glu Gln Glu Arg Ala Val Ile Leu Glu Leu Lys Arg Ala Glu Cys305 310 315 320
Glu Arg Arg Gly Leu Pro Phe Asp Gly Arg Ile Arg Ala Trp Asp Met325 330 335Arg Tyr Tyr Met Asn Gln Val Glu Glu Thr Arg Tyr Cys Val Asp Gln340 345 350Asn Leu Leu Lys Glu Tyr Phe Pro Val Gln Val Val Thr His Gly Leu355 360 365Leu Gly Ile Tyr Gln Glu Leu Leu Gly Leu Ala Phe His His Glu Glu370 375 380Gly Ala Ser Ala Trp His Glu Asp Val Arg Leu Tyr Thr Ala Arg Asp385 390 395 400Ala Ala Ser Gly Glu Val Val Gly Lys Phe Tyr Leu Asp Leu Tyr Pro405 410 415Arg Glu Gly Lys Tyr Gly His Ala Ala Cys Phe Gly Leu Gln Pro Gly420 425 430Cys Leu Arg Gln Asp Gly Ser Arg Gln Ile Ala Ile Ala Ala Met Val435 440 445Ala Asn Phe Thr Lys Pro Thr Ala Asp Ala Pro Ser Leu Leu Gln His450 455 460Asp Glu Val Glu Thr Tyr Phe His Glu Phe Gly His Val Met His Gln465 470 475 480Leu Cys Ser Gln Ala Glu Phe Ala Met Phe Ser Gly Thr His Val Glu485 490 495Arg Asp Phe Val Glu Ala Pro Ser Gln Met Leu Glu Asn Trp Val Trp500 505 510Glu Gln Glu Pro Leu Leu Arg Met Ser Arg His Tyr Arg Thr Gly Ser515 520 525Ala Val Pro Arg Glu Leu Leu Glu Lys Leu Ile Glu Ser Arg Gln Ala530 535 540Asn Thr Gly Leu Phe Asn Leu Arg Gln Ile Val Leu Ala Lys Val Asp545 550 555 560Gln Ala Leu His Thr Gln Thr Asp Ala Asp Pro Ala Glu Glu Tyr Ala
565 570 575Arg Leu Cys Gln Glu Ile Leu Gly Val Pro Ala Thr Pro Gly Thr Asn580 585 590Met Pro Ala Thr Phe Gly His Leu Ala Gly Gly Tyr Asp Ala Gln Tyr595 600 605Tyr Gly Tyr Leu Trp Ser Glu Val Tyr Ser Met Asp Met Phe His Thr610 615 620Arg Phe Lys Gln Glu Gly Val Leu Asn Ser Lys Val Gly Met Asp Tyr625 630 635 640Arg Ser Cys Ile Leu Arg Pro Gly Gly Ser Glu Asp Ala Ser Ala Met645 650 655Leu Arg Arg Phe Leu Gly Arg Asp Pro Lys Gln Asp Ala Phe Leu Leu660 665 670Ser Lys Gly Leu Gln Val Gly Gly Cys Glu Pro Glu Pro Gln Val Cys675 680 685<210>133<211>208<212>PRT<213>人<300>
<308>sw_hum/psb5_human<309>1992-08-01<400>133Met Leu His Gly Thr Thr Thr Leu Ala Phe Lys Phe Arg His Gly Val1 5 10 15Ile Val Ala Ala Asp Ser Arg Ala Thr Ala Gly Ala Tyr Ile Ala Ser20 25 30Gln Thr Val Lys Lys Val Ile Glu Ile Asn Pro Tyr Leu Leu Gly Thr35 40 45Met Ala Gly Gly Ala Ala Asp Cys Ser Phe Trp Glu Arg Leu Leu Ala50 55 60Arg Gln Cys Arg Ile Tyr Glu Leu Arg Asn Lys Glu Arg Ile Ser Val65 70 75 80
Ala Ala Ala Ser Lys Leu Leu Ala Asn Met Val Tyr Gln Tyr Lys Gly85 90 95Met Gly Leu Ser Met Gly Thr Met Ile Cys Gly Trp Asp Lys Arg Gly100 105 110Pro Gly Leu Tyr Tyr Val Asp Ser Glu Gly Asn Arg Ile Ser Gly Ala115 120 125Thr Phe Ser Val Gly Ser Gly Ser Val Tyr Ala Tyr Gly Val Met Asp130 135 140Arg Gly Tyr Ser Tyr Asp Leu Glu Val Glu Gln Ala Tyr Asp Leu Ala145 150 155 160Arg Arg Ala Ile Tyr Gln Ala Thr Tyr Arg Asp Ala Tyr Ser Gly Gly165 170 175Ala Val Asn Leu Tyr His Val Arg Glu Asp Gly Trp Ile Arg Val Ser180 185 190Ser Asp Asn Val Ala Asp Leu His Glu Lys Tyr Ser Gly Ser Thr Pro195 200 205<210>134<211>360<212>PRT<213>人<300>
<308>sw_hum/mk01_human<309>1992-12-01<400>134Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly1 5 10 15Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly20 25 30Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys35 40 45Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr50 55 60Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His65 70 75 80
Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu85 90 95Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu100 105 110Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr115 120 125Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn130 135 140Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr145 150 155 160Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro165 170 175Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp180 185 190Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser195 200 205Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn210 215 220Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile225 230 235 240Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile245 250 255Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys260 265 270Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp275 280 285Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val290 295 300Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser305 310 315 320Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp
325 330 335Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala340 345 350Arg Phe Gln Pro Gly Tyr Arg Ser355 360<210>135<211>563<212>PRT<213>人<300>
<308>sw_hum/mccb_human<309>2003-02-28<400>135Met Trp Ala Val Leu Arg Leu Ala Leu Arg Pro Cys Ala Arg Ala Ser1 5 10 15Pro Ala Gly Pro Arg Ala Tyr His Gly Asp Ser Val Ala Ser Leu Gly20 25 30Thr Gln Pro Asp Leu Gly Ser Ala Leu Tyr Gln Glu Asn Tyr Lys Gln35 40 45Met Lys Ala Leu Val Asn Gln Leu His Glu Arg Val Glu His Ile Lys50 55 60Leu Gly Gly Gly Glu Lys Ala Arg Ala Leu His Ile Ser Arg Gly Lys65 70 75 80Leu Leu Pro Arg Glu Arg Ile Asp Asn Leu Ile Asp Pro Gly Ser Pro85 90 95Phe Leu Glu Leu Ser Gln Phe Ala Gly Tyr Gln Leu Tyr Asp Asn Glu100 105 110Glu Val Pro Gly Gly Gly Ile Ile Thr Gly Ile Gly Arg Val Ser Gly115 120 125Val Glu Cys Met Ile Ile Ala Asn Asp Ala Thr Val Lys Gly Gly Ala130 135 140Tyr Tyr Pro Val Thr Val Lys Lys Gln Leu Arg Ala Gln Glu Ile Ala145 150 155 160
Met Gln Asn Arg Leu Pro Cys Ile Tyr Leu Val Asp Ser Gly Gly Ala165 170 175Tyr Leu Pro Arg Gln Ala Asp Val Phe Pro Asp Arg Asp His Phe Gly180 185 190Arg Thr Phe Tyr Asn Gln Ala Ile Met Ser Ser Lys Asn Ile Ala Gln195 200 205Ile Ala Val Val Met Gly Ser Cys Thr Ala Gly Gly Ala Tyr Val Pro210 215 220Ala Met Ala Asp Glu Asn Ile Ile Val Arg Lys Gln Gly Thr Ile Phe225 230 235 240Leu Ala Gly Pro Pro Leu Val Lys Ala Ala Thr Gly Glu Glu Val Ser245 250 255Ala Glu Asp Leu Gly Gly Ala Asp Leu His Cys Arg Lys Ser Gly Val260 265 270Ser Asp His Trp Ala Leu Asp Asp His His Ala Leu His Leu Thr Arg275 280 285Lys Val Val Arg Asn Leu Asn Tyr Gln Lys Lys Leu Asp Val Thr Ile290 295 300Glu Pro Ser Glu Glu Pro Leu Phe Pro Ala Asp Glu Leu Tyr Gly Ile305 310 315 320Val Gly Ala Asn Leu Lys Arg Ser Phe Asp Val Arg Glu Val Ile Ala325 330 335Arg Ile Val Asp Gly Ser Arg Phe Thr Glu Phe Lys Ala Phe Tyr Gly340 345 350Asp Thr Leu Val Thr Gly Phe Ala Arg Ile Phe Gly Tyr Pro Val Gly355 360 365Ile Val Gly Asn Asn Gly Val Leu Phe Ser Glu Ser Ala Lys Lys Gly370 375 380Thr His Phe Val Gln Leu Cys Cys Gln Arg Asn Ile Pro Leu Leu Phe385 390 395 400Leu Gln Asn Ile Thr Gly Phe Met Val Gly Arg Glu Tyr Glu Ala Glu405 410 415
Gly Ile Ala Lys Asp Gly Ala Lys Met Val Ala Ala Val Ala Cys Ala420 425 430Gln Val Pro Lys Ile Thr Leu Ile Ile Gly Gly Ser Tyr Gly Ala Gly435 440 445Asn Tyr Gly Met Cys Gly Arg Ala Tyr Ser Pro Arg Phe Leu Tyr Ile450 455 460Trp Pro Asn Ala Arg Ile Ser Val Met Gly Gly Glu Gln Ala Ala Asn465 470 475 480Val Leu Ala Thr Ile Thr Lys Asp Gln Arg Ala Arg Glu Gly Lys Gln485 490 495Phe Ser Ser Ala Asp Glu Ala Ala Leu Lys Glu Pro Ile Ile Lys Lys500 505 510Phe Glu Glu Glu Gly Asn Pro Tyr Tyr Ser Ser Ala Arg Val Trp Asp515 520 525Asp Gly Ile Ile Asp Pro Ala Asp Thr Arg Leu Val Leu Gly Leu Ser530 535 540Phe Ser Ala Ala Leu Asn Ala Pro Ile Glu Lys Thr Asp Phe Gly Ile545 550 555 560Phe Arg Met<210>136<211>1410<212>PRT<213>人<300>
<308>sw_hum/rrb1_human<309>2003-02-28<400>136Met Asp Ile Tyr Asp Thr Gln Thr Leu Gly Val Val Val Phe Gly Gly1 5 10 15Phe Met Val Val Ser Ala Ile Gly Ile Phe Leu Val Ser Thr Phe Ser20 25 30Met Lys Glu Thr Ser Tyr Glu Glu Ala Leu Ala Asn Gln Arg Lys Glu
35 40 45Met Ala Lys Thr His His Gln Lys Val Glu Lys Lys Lys Lys Glu Lys50 55 60Thr Val Glu Lys Lys Gly Lys Thr Lys Lys Lys Glu Glu Lys Pro Asn65 70 75 80Gly Lys Ile Pro Asp His Asp Pro Ala Pro Asn Val Thr Val Leu Leu85 90 95Arg Glu Pro Val Arg Ala Pro Ala Val Ala Val Ala Pro Thr Pro Val100 105 110Gln Pro Pro Ile Ile Val Ala Pro Val Ala Thr Val Pro Ala Met Pro115 120 125Gln Glu Lys Leu Ala Ser Ser Pro Lys Asp Lys Lys Lys Lys Glu Lys130 135 140Lys Val Ala Lys Val Glu Pro Ala Val Ser Ser Val Val Asn Ser Ile145 150 155 160Gln Val Leu Thr Ser Lys Ala Ala Ile Leu Glu Thr Ala Pro Lys Glu165 170 175Val Pro Met Val Val Val Pro Pro Val Gly Ala Lys Gly Asn Thr Pro180 185 190Ala Thr Gly Thr Thr Gln Gly Lys Lys Ala Glu Gly Thr Gln Asn Gln195 200 205Ser Lys Lys Ala Glu Gly Ala Pro Asn Gln Gly Arg Lys Ala Glu Gly210 215 220Thr Pro Asn Gln Gly Lys Lys Thr Glu Gly Thr Pro Asn Gln Gly Lys225 230 235 240Lys Ala Glu Gly Thr Pro Asn Gln Gly Lys Lys Ala Glu Gly Thr Pro245 250 255Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Val260 265 270Asp Thr Thr Pro Asn Gln Gly Lys Lys Val Glu Gly Ala Pro Thr Gln275 280 285
Gly Arg Lys Ala Glu Gly Ala Gln Asn Gln Ala Lys Lys Val Glu Gly290 295 300Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys305 310 315 320Lys Gly Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln325 330 335Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala340 345 350Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln355 360 365Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ser Glu Gly370 375 380Ala Gln Asn Gln Gly Lys Lys Val Glu Gly Ala Gln Asn Gln Gly Lys385 390 395 400Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln405 410 415Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala420 425 430Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln435 440 445Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly450 455 460Ala Gln Asn Gln Gly Lys Lys Val Glu Gly Ala Gln Asn Gln Gly Lys465 470 475 480Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln485 490 495Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Gln Lys Gly500 505 510Glu Gly Ala Gln Asn Gln Gly Lys Lys Thr Glu Gly Ala Gln Gly Lys515 520 525Lys Ala Glu Arg Ser Pro Asn Gln Gly Lys Lys Gly Glu Gly Ala Pro
530 535 540Ile Gln Gly Lys Lys Ala Asp Ser Val Ala Asn Gln Gly Thr Lys Val545 550 555 560Glu Gly Ile Thr Asn Gln Gly Lys Lys Ala Glu Gly Ser Pro Ser Glu565 570 575Gly Lys Lys Ala Glu Gly Ser Pro Asn Gln Gly Lys Lys Ala Asp Ala580 585 590Ala Ala Asn Gln Gly Lys Lys Thr Glu Ser Ala Ser Val Gln Gly Arg595 600 605Asn Thr Asp Val Ala Gln Ser Pro Glu Ala Pro Lys Gln Glu Ala Pro610 615 620Ala Lys Lys Lys Ser Gly Ser Lys Lys Lys Gly Glu Pro Gly Pro Pro625 630 635 640Asp Ala Asp Gly Pro Leu Tyr Leu Pro Tyr Lys Thr Leu Val Ser Thr645 650 655Val Gly Ser Met Val Phe Asn Glu Gly Glu Ala Gln Arg Leu Ile Glu660 665 670Ile Leu Ser Glu Lys Ala Gly Ile Ile Gln Asp Thr Trp His Lys Ala675 680 685Thr Gln Lys Gly Asp Pro Val Ala Ile Leu Lys Arg Gln Leu Glu Glu690 695 700Lys Glu Lys Leu Leu Ala Thr Glu Gln Glu Asp Ala Ala Val Ala Lys705 710 715 720Ser Lys Leu Arg Glu Leu Asn Lys Glu Met Ala Ala Glu Lys Ala Lys725 730 735Ala Ala Ala Gly Glu Ala Lys Val Lys Lys Gln Leu Val Ala Arg Glu740 745 750Gln Glu Ile Thr Ala Val Gln Ala Arg Met Gln Ala Ser Tyr Arg Glu755 760 765His Val Lys Glu Val Gln Gln Leu Gln Gly Lys Ile Arg Thr Leu Gln770 775 780
Glu Gln Leu Glu Asn Gly Pro Asn Thr Gln Leu Ala Arg Leu Gln Gln785 790 795 800Glu Asn Ser Ile Leu Arg Asp Ala Leu Asn Gln Ala Thr Ser Gln Val805 810 815Glu Ser Lys Gln Asn Ala Glu Leu Ala Lys Leu Arg Gln Glu Leu Ser820 825 830Lys Val Ser Lys Glu Leu Val Glu Lys Ser Glu Ala Val Arg Gln Asp835 840 845Glu Gln Gln Arg Lys Ala Leu Glu Ala Lys Ala Ala Ala Phe Glu Lys850 855 860Gln Val Leu Gln Leu Gln Ala Ser His Arg Glu Ser Glu Glu Ala Leu865 870 875 880Gln Lys Arg Leu Asp Glu Val Ser Arg Glu Leu Cys His Thr Gln Ser885 890 895Ser His Ala Ser Leu Arg Ala Asp Ala Glu Lys Ala Gln Glu Gln Gln900 905 910Gln Gln Met Ala Glu Leu His Ser Lys Leu Gln Ser Ser Glu Ala Glu915 920 925Val Arg Ser Lys Cys Glu Glu Leu Ser Gly Leu His Gly Gln Leu Gln930 935 940Glu Ala Arg Ala Glu Asn Ser Gln Leu Thr Glu Arg Ile Arg Ser Ile945 950 955 960Glu Ala Leu Leu Glu Ala Gly Gln Ala Arg Asp Ala Gln Asp Val Gln965 970 975Ala Ser Gln Ala Glu Ala Asp Gln Gln Gln Thr Arg Leu Lys Glu Leu980 985 990Glu Ser Gln Val Ser Gly Leu Glu Lys Glu Ala Ile Glu Leu Arg Glu995 1000 1005Ala Val Glu Gln Gln Lys Val Lys Asn Asn Asp Leu Arg Glu Lys1010 1015 1020Asn Trp Lys Ala Met Glu Ala Leu Ala Thr Ala Glu Gln Ala Cys
1025 1030 1035Lys Glu Lys Leu Leu Ser Leu Thr Gln Ala Lys Glu Glu Ser Glu1040 1045 1050Lys Gln Leu Cys Leu Ile Glu Ala Gln Thr Met Glu Ala Leu Leu1055 1060 1065Ala Leu Leu Pro Glu Leu Ser Val Leu Ala Gln Gln Asn Tyr Thr1070 1075 1080Glu Trp Leu Gln Asp Leu Lys Glu Lys Gly Pro Thr Leu Leu Lys1085 1090 1095His Pro Pro Ala Pro Ala Glu Pro Ser Ser Asp Leu Ala Ser Lys1100 1105 1110Leu Arg Glu Ala Glu Glu Thr Gln Ser Thr Leu Gln Ala Glu Cys1115 1120 1125Asp Gln Tyr Arg Ser Ile Leu Ala Glu Thr Glu Gly Met Leu Arg1130 1135 1140Asp Leu Gln Lys Ser Val Glu Glu Glu Glu Gln Val Trp Arg Ala1145 1150 1155Lys Val Gly Ala Ala Glu Glu Glu Leu Gln Lys Ser Arg Val Thr1160 1165 1170Val Lys His Leu Glu Glu Ile Val Glu Lys Leu Lys Gly Glu Leu1175 1180 1185Glu Ser Ser Asp Gln Val Arg Glu His Thr Ser His Leu Glu Ala1190 1195 1200Glu Leu Glu Lys His Met Ala Ala Ala Ser Ala Glu Cys Gln Asn1205 1210 1215Tyr Ala Lys Glu Val Ala Gly Leu Arg Gln Leu Leu Leu Glu Ser1220 1225 1230Gln Ser Gln Leu Asp Ala Ala Lys Ser Glu Ala Gln Lys Gln Ser1235 1240 1245Asp Glu Leu Ala Leu Val Arg Gln Gln Leu Ser Glu Met Lys Ser1250 1255 1260
His Val Glu Asp Gly Asp Ile Ala Gly Ala Pro Ala Ser Ser Pro1265 1270 1275Glu Ala Pro Pro Ala Glu Gln Asp Pro Val Gln Leu Lys Thr Gln1280 1285 1290Leu Glu Trp Thr Glu Ala Ile Leu Glu Asp Glu Gln Thr Gln Arg1295 1300 1305Gln Lys Leu Thr Ala Glu Phe Glu Glu Ala Gln Thr Ser Ala Cys1310 1315 1320Arg Leu Gln Glu Glu Leu Glu Lys Leu Arg Thr Ala Gly Pro Leu1325 1330 1335Glu Ser Ser Glu Thr Glu Glu Ala Ser Gln Leu Lys Glu Arg Leu1340 1345 1350Glu Lys Glu Lys Lys Leu Thr Ser Asp Leu Gly Arg Ala Ala Thr1355 1360 1365Arg Leu Gln Glu Leu Leu Lys Thr Thr Gln Glu Gln Leu Ala Arg1370 1375 1380Glu Lys Asp Thr Val Lys Lys Leu Gln Glu Gln Leu Glu Lys Ala1385 1390 1395Glu Asp Gly Ser Ser Ser Lys Glu Gly Thr Ser Val1400 1405 1410<210>137<211>360<212>PRT<213>人<300>
<308>tr_hum/q96e67<309>2001-12-01<400>137Met Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe1 5 10 15Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met20 25 30Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly35 40 45
Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp50 55 60Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg65 70 75 80Val Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn85 90 95Pro Lys Ala Asn Leu Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe100 105 110Asn Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr115 120 125Ala Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val130 135 140Thr His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile145 150 155 160Leu Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys165 170 175Ile Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu180 185 190Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe195 200 205Glu Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser210 215 220Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe225 230 235 240Arg Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser245 250 255Cys Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val260 265 270Asp Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr275 280 285
Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala290 295 300Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg305 310 315 320Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr325 330 335Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro340 345 350Ser Ile Val His Arg Lys Cys Phe355 360<210>138<211>445<212>PRT<213>人<300>
<308>sw_hum/hgd_human<309>1997-11-01<400>138Met Ala Glu Leu Lys Tyr Ile Ser Gly Phe Gly Asn Glu Cys Ser Ser1 5 10 15Glu Asp Pro Arg Cys Pro Gly Ser Leu Pro Glu Gly Gln Asn Asn Pro20 25 30Gln Val Cys Pro Tyr Asn Leu Tyr Ala Glu Gln Leu Ser Gly Ser Ala35 40 45Phe Thr Cys Pro Arg Ser Thr Asn Lys Arg Ser Trp Leu Tyr Arg Ile50 55 60Leu Pro Ser Val Ser His Lys Pro Phe Glu Ser Ile Asp Glu Gly His65 70 75 80Val Thr His Asn Trp Asp Glu Val Asp Pro Asp Pro Asn Gln Leu Arg85 90 95Trp Lys Pro Phe Glu Ile Pro Lys Ala Ser Gln Lys Lys Val Asp Phe100 105 110Val Ser Gly Leu His Thr Leu Cys Gly Ala Gly Asp Ile Lys Ser Asn115 120 125
Asn Gly Leu Ala Ile His Ile Phe Leu Cys Asn Thr Ser Met Glu Asn130 135 140Arg Cys Phe Tyr Asn Ser Asp Gly Asp Phe Leu Ile Val Pro Gln Lys145 150 155 160Gly Asn Leu Leu Ile Tyr Thr Glu Phe Gly Lys Met Leu Val Gln Pro165 170 175Asn Glu Ile Cys Val Ile Gln Arg Gly Met Arg Phe Ser Ile Asp Val180 185 190Phe Glu Glu Thr Arg Gly Tyr Ile Leu Glu Val Tyr Gly Val His Phe195 200 205Glu Leu Pro Asp Leu Gly Pro Ile Gly Ala Asn Gly Leu Ala Asn Pro210 215 220Arg Asp Phe Leu Ile Pro Ile Ala Trp Tyr Glu Asp Arg Gln Val Pro225 230 235 240Gly Gly Tyr Thr Val Ile Asn Lys Tyr Gln Gly Lys Leu Phe Ala Ala245 250 255Lys Gln Asp Val Ser Pro Phe Asn Val Val Ala Trp His Gly Asn Tyr260 265 270Thr Pro Tyr Lys Tyr Asn Leu Lys Asn Phe Met Val Ile Asn Ser Val275 280 285Ala Phe Asp His Ala Asp Pro Ser Ile Phe Thr Val Leu Thr Ala Lys290 295 300Ser Val Arg Pro Gly Val Ala Ile Ala Asp Phe Val Ile Phe Pro Pro305 310 315 320Arg Trp Gly Val Ala Asp Lys Thr Phe Arg Pro Pro Tyr Tyr His Arg325 330 335Asn Cys Met Ser Glu Phe Met Gly Leu Ile Arg Gly His Tyr Glu Ala340 345 350Lys Gln Gly Gly Phe Leu Pro Gly Gly Gly Ser Leu His Ser Thr Met355 360 365Thr Pro His Gly Pro Asp Ala Asp Cys Phe Glu Lys Ala Ser Lys Val
370 375 380Lys Leu Ala Pro Glu Arg Ile Ala Asp Gly Thr Met Ala Phe Met Phe385 390 395 400Glu Ser Ser Leu Ser Leu Ala Val Thr Lys Trp Gly Leu Lys Ala Ser405 410 415Arg Cys Leu Asp Glu Asn Tyr His Lys Cys Trp Glu Pro Leu Lys Ser420 425 430His Phe Thr Pro Asn Ser Arg Asn Pro Ala Glu Pro Asn435 440 445<210>139<211>482<212>PRT<213>人<300>
<308>sw_hum/6pgd_human<309>1996-10-01<400>139Ala Gln Ala Asp Ile Ala Leu Ile Gly Leu Ala Val Met Gly Gln Asn1 5 10 15Leu Ile Leu Asn Met Asn Asp His Gly Phe Val Val Cys Ala Phe Asn20 25 30Arg Thr Val Ser Lys Val Asp Asp Phe Leu Ala Asn Glu Ala Lys Gly35 40 45Thr Lys Val Val Gly Ala Gln Ser Leu Lys Glu Met Val Ser Lys Leu50 55 60Lys Lys Pro Arg Arg Ile Ile Leu Leu Val Lys Ala Gly Gln Ala Val65 70 75 80Asp Asp Phe Ile Glu Lys Leu Val Pro Leu Leu Asp Thr Gly Asp Ile85 90 95Ile Ile Asp Gly Gly Asn Ser Glu Tyr Arg Asp Thr Thr Arg Arg Cys100 105 110Arg Asp Leu Lys Ala Lys Gly Ile Leu Phe Val Gly Ser Gly Val Ser115 120 125
Gly Gly Glu Glu Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro Gly Gly130 135 140Asn Lys Glu Ala Trp Pro His Ile Lys Thr Ile Phe Gln Gly Ile Ala145 150 155 160Ala Lys Val Gly Thr Gly Glu Pro Cys Cys Asp Trp Val Gly Asp Glu165 170 175Gly Ala Gly His Phe Val Lys Met Val His Asn Gly Ile Glu Tyr Gly180 185 190Asp Met Gln Leu Ile Cys Glu Ala Tyr His Leu Met Lys Asp Val Leu195 200 205Gly Met Ala Gln Asp Glu Met Ala Gln Ala Phe Glu Asp Trp Asn Lys210 215 220Thr Glu Leu Asp Ser Phe Leu Ile Glu Ile Thr Ala Asn Ile Leu Lys225 230 235 240Phe Gln Asp Thr Asp Gly Lys His Leu Leu Pro Lys Ile Arg Asp Ser245 250 255Ala Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Ser Ala Leu Glu260 265 270Tyr Gly Val Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala Arg Cys275 280 285Leu Ser Ser Leu Lys Asp Glu Arg Ile Gln Ala Ser Lys Lys Leu Lys290 295 300Gly Pro Gln Lys Phe Gln Phe Asp Gly Asp Lys Lys Ser Phe Leu Glu305 310 315 320Asp Ile Arg Lys Ala Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Ala Gln325 330 335Gly Phe Met Leu Leu Arg Gln Ala Ala Thr Glu Phe Gly Trp Thr Leu340 345 350Asn Tyr Gly Gly Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile Arg355 360 365Ser Val Phe Leu Gly Lys Ile Lys Asp Ala Phe Asp Arg Asn Pro Glu370 375 380
Leu Gln Asn Leu Leu Leu Asp Asp Phe Phe Lys Ser Ala Val Glu Asn385 390 395 400Cys Gln Asp Ser Trp Arg Arg Ala Val Ser Thr Gly Val Gln Ala Gly405 410 415Ile Pro Met Pro Cys Phe Thr Thr Ala Leu Ser Phe Tyr Asp Gly Tyr420 425 430Arg His Glu Met Leu Pro Ala Ser Leu Ile Gln Ala Gln Arg Asp Tyr435 440 445Phe Gly Ala His Thr Tyr Glu Leu Leu Ala Lys Pro Gly Gln Phe Ile450 455 460His Thr Asn Trp Thr Gly His Gly Gly Thr Val Ser Ser Ser Ser Tyr465 470 475 480Asn Ala<210>140<211>411<212>PRT<213>人<300>
<308>sw_hum/if4n_human<309>1995-02-01<400>140Met Ala Thr Thr Ala Thr Met Ala Thr Ser Gly Ser Ala Arg Lys Arg1 5 10 15Leu Leu Lys Glu Glu Asp Met Thr Lys Val Glu Phe Glu Thr Ser Glu20 25 30Glu Val Asp Val Thr Pro Thr Phe Asp Thr Met Gly Leu Arg Glu Asp35 40 45Leu Leu Arg Gly Ile Tyr Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile50 55 60Gln Gln Arg Ala Ile Lys Gln Ile Ile Lys Gly Arg Asp Val Ile Ala65 70 75 80Gln Ser Gln Ser Gly Thr Gly Lys Thr Ala Thr Phe Ser Ile Ser Val
85 90 95Leu Gln Cys Leu Asp Ile Gln Val Arg Glu Thr Gln Ala Leu Ile Leu100 105 110Ala Pro Thr Arg Glu Leu Ala Val Gln Ile Gln Lys Gly Leu Leu Ala115 120 125Leu Gly Asp Tyr Met Asn Val Gln Cys His Ala Cys Ile Gly Gly Thr130 135 140Asn Val Gly Glu Asp Ile Arg Lys Leu Asp Tyr Gly Gln His Val Val145 150 155 160Ala Gly Thr Pro Gly Arg Val Phe Asp Met Ile Arg Arg Arg Ser Leu165 170 175Arg Thr Arg Ala Ile Lys Met Leu Val Leu Asp Glu Ala Asp Glu Met180 185 190Leu Asn Lys Gly Phe Lys Glu Gln Ile Tyr Asp Val Tyr Arg Tyr Leu195 200 205Pro Pro Ala Thr Gln Val Val Leu Ile Ser Ala Thr Leu Pro His Glu210 215 220Ile Leu Glu Met Thr Asn Lys Phe Met Thr Asp Pro Ile Arg Ile Leu225 230 235 240Val Lys Arg Asp Glu Leu Thr Leu Glu Gly Ile Lys Gln Phe Phe Val245 250 255Ala Val Glu Arg Glu Glu Trp Lys Phe Asp Thr Leu Cys Asp Leu Tyr260 265 270Asp Thr Leu Thr Ile Thr Gln Ala Val Ile Phe Cys Asn Thr Lys Arg275 280 285Lys Val Asp Trp Leu Thr Glu Lys Met Arg Glu Ala Asn Phe Thr Val290 295 300Ser Ser Met His Gly Asp Met Pro Gln Lys Glu Arg Glu Ser Ile Met305 310 315 320Lys Glu Phe Arg Ser Gly Ala Ser Arg Val Leu Ile Ser Thr Asp Val325 330 335
Trp Ala Arg Gly Leu Asp Val Pro Gln Val Ser Leu Ile Ile Asn Tyr340 345 350Asp Leu Pro Asn Asn Arg Glu Leu Tyr Ile His Arg Ile Gly Arg Ser355 360 365Gly Arg Tyr Gly Arg Lys Gly Val Ala Ile Asn Phe Val Lys Asn Asp370 375 380Asp Ile Arg Ile Leu Arg Asp Ile Glu Gln Tyr Tyr Ser Thr Gln Ile385 390 395 400Asp Glu Met Pro Met Asn Val Ala Asp Leu Ile405 410<210>141<211>453<212>PRT<213>人<300>
<308>sw_hum/ucr2_human<309>1991-08-01<400>141Met Lys Leu Leu Thr Arg Ala Gly Ser Phe Ser Arg Phe Tyr Ser Leu1 5 10 15Lys Val Ala Pro Lys Val Lys Ala Thr Ala Ala Pro Ala Gly Ala Pro20 25 30Pro Gln Pro Gln Asp Leu Glu Phe Thr Lys Leu Pro Asn Gly Leu Val35 40 45Ile Ala Ser Leu Glu Asn Tyr Ser Pro Val Ser Arg Ile Gly Leu Phe50 55 60Ile Lys Ala Gly Ser Arg Tyr Glu Asp Phe Ser Asn Leu Gly Thr Thr65 70 75 80His Leu Leu Arg Leu Thr Ser Ser Leu Thr Thr Lys Gly Ala Ser Ser85 90 95Phe Lys Ile Thr Arg Gly Ile Glu Ala Val Gly Gly Lys Leu Ser Val100 105 110Thr Ala Thr Arg Glu Asn Met Ala Tyr Thr Val Glu Cys Leu Arg Gly115 120 125
Asp Val Asp Ile Leu Met Glu Phe Leu Leu Asn Val Thr Thr Ala Pro130 135 140Glu Phe Arg Arg Trp Glu Val Ala Asp Leu Gln Pro Gln Leu Lys Ile145 150 155 160Asp Lys Ala Val Ala Phe Gln Asn Pro Gln Thr His Val Ile Glu Asn165 170 175Leu His Ala Ala Ala Tyr Arg Asn Ala Leu Ala Asn Pro Leu Tyr Cys180 185 190Pro Asp Tyr Arg Ile Gly Lys Val Thr Ser Glu Glu Leu His Tyr Phe195 200 205Val Gln Asn His Phe Thr Ser Ala Arg Met Ala Leu Ile Gly Leu Gly210 215 220Val Ser His Pro Val Leu Lys Gln Val Ala Glu Gln Phe Leu Asn Met225 230 235 240Arg Gly Gly Leu Gly Leu Ser Gly Ala Lys Ala Asn Tyr Arg Gly Gly245 250 255Glu Ile Arg Glu Gln Asn Gly Asp Ser Leu Val His Ala Ala Phe Val260 265 270Ala Glu Ser Ala Val Ala Gly Ser Ala Glu Ala Asn Ala Phe Ser Val275 280 285Leu Gln His Val Leu Gly Ala Gly Pro His Val Lys Arg Gly Ser Asn290 295 300Thr Thr Ser His Leu His Gln Ala Val Ala Lys Ala Thr Gln Gln Pro305 310 315 320Phe Asp Val Ser Ala Phe Asn Ala Ser Tyr Ser Asp Ser Gly Leu Phe325 330 335Gly Ile Tyr Thr Ile Ser Gln Ala Thr Ala Ala Gly Asp Val Ile Lys340 345 350Ala Ala Tyr Asn Gln Val Lys Thr Ile Ala Gln Gly Asn Leu Ser Asn355 360 365
Thr Asp Val Gln Ala Ala Lys Asn Lys Leu Lys Ala Gly Tyr Leu Met370 375 380Ser Val Glu Ser Ser Glu Cys Phe Leu Glu Glu Val Gly Ser Gln Ala385 390 395 400Leu Val Ala Gly Ser Tyr Met Pro Pro Ser Thr Val Leu Gln Gln Ile405 410 415Asp Ser Val Ala Asn Ala Asp Ile Ile Asn Ala Ala Lys Lys Phe Val420 425 430Ser Gly Gln Lys Ser Met Ala Ala Ser Gly Asn Leu Gly His Thr Pro435 440 445Phe Val Asp Glu Leu450<210>142<211>245<212>PRT<213>人<300>
<308>s_hum/143z_human<309>1992-12-01<400>142Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala1 5 10 15Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln20 25 30Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr35 40 45Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser50 55 60Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg65 70 75 80Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp85 90 95Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala100 105 110
Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr115 120 125Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln130 135 140Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met145 150 155 160Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val165 170 175Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala180 185 190Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu195 200 205Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn210 215 220Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly225 230 235 240Glu Gly Gly Glu Asn245<210>143<211>337<212>PRT<213>人<300>
<308>sw_hum/tal1_human<309>1994-10-01<400>143Met Ser Ser Ser Pro Val Lys Arg Gln Arg Met Glu Ser Ala Leu Asp1 5 10 15Gln Leu Lys Gln Phe Thr Thr Val Val Ala Asp Thr Gly Asp Phe His20 25 30Ala Ile Asp Glu Tyr Lys Pro Gln Asp Ala Thr Thr Asn Pro Ser Leu35 40 45Ile Leu Ala Ala Ala Gln Met Pro Ala Tyr Gln Glu Leu Val Glu Glu50 55 60
Ala Ile Ala Tyr Gly Arg Lys Leu Gly Gly Ser Gln Glu Asp Gln Ile65 70 75 80Lys Asn Ala Ile Asp Lys Leu Phe Val Leu Phe Gly Ala Glu Ile Leu85 90 95Lys Lys Ile Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg Leu Ser100 105 110Phe Asp Lys Asp Ala Met Val Ala Arg Ala Arg Arg Leu Ile Glu Leu115 120 125Tyr Lys Glu Ala Gly Ile Ser Lys Asp Arg Ile Leu Ile Lys Leu Ser130 135 140Ser Thr Trp Glu Gly Ile Gln Ala Gly Lys Glu Leu Glu Glu Gln His145 150 155 160Gly Ile His Cys Asn Met Thr Leu Leu Phe Ser Phe Ala Gln Ala Val165 170 175Ala Cys Ala Glu Ala Gly Val Thr Leu Ile Ser Pro Phe Val Gly Arg180 185 190Ile Leu Asp Trp His Val Ala Asn Thr Asp Lys Lys Ser Tyr Glu Pro195 200 205Leu Glu Asp Pro Gly Val Lys Ser Val Thr Lys Ile Tyr Asn Tyr Tyr210 215 220Lys Lys Phe Ser Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg Asn225 230 235 240Thr Gly Glu Ile Lys Ala Leu Ala Gly Cys Asp Phe Leu Thr Ile Ser245 250 255Pro Lys Leu Leu Gly Glu Leu Leu Gln Asp Asn Ala Lys Leu Val Pro260 265 270Val Leu Ser Ala Lys Ala Ala Gln Ala Ser Asp Leu Glu Lys Ile His275 280 285Leu Asp Glu Lys Ser Phe Arg Trp Leu His Asn Glu Asp Gln Met Ala290 295 300
Val Glu Lys Leu Ser Asp Gly Ile Arg Lys Phe Ala Ala Asp Ala Val305 310 315 320Lys Leu Glu Arg Met Leu Thr Glu Arg Met Phe Asn Ala Glu Asn Gly325 330 335Lys<210>144<211>284<212>PRT<213>人<300>
<308>sw_hum/nps1_human<309>2001-10-16<400>144Met Ala Pro Arg Leu Cys Ser Ile Ser Val Thr Ala Arg Arg Leu Leu1 5 10 15Gly Gly Pro Gly Pro Arg Ala Gly Asp Val Ala Ser Ala Ala Ala Ala20 25 30Arg Phe Tyr Ser Lys Asp Asn Glu Gly Ser Trp Phe Arg Ser Leu Phe35 40 45Val His Lys Val Asp Pro Arg Lys Asp Ala His Ser Thr Leu Leu Ser50 55 60Lys Lys Glu Thr Ser Asn Leu Tyr Lys Ile Gln Phe His Asn Val Lys65 70 75 80Pro Glu Tyr Leu Asp Ala Tyr Asn Ser Leu Thr Glu Ala Val Leu Pro85 90 95Lys Leu His Leu Asp Glu Asp Tyr Pro Cys Ser Leu Val Gly Asn Trp100 105 110Asn Thr Trp Tyr Gly Glu Gln Asp Gln Ala Val His Leu Trp Arg Phe115 120 125Ser Gly Gly Tyr Pro Ala Leu Met Asp Cys Met Asn Lys Leu Lys Asn130 135 140Asn Lys Glu Tyr Leu Glu Phe Arg Arg Glu Arg Ser Gln Met Leu Leu145 150 155 160
Ser Arg Arg Asn Gln Leu Leu Leu Glu Phe Ser Phe Trp Asn Glu Pro165 170 175Gln Pro Arg Met Gly Pro Asn Ile Tyr Glu Leu Arg Thr Tyr Lys Leu180 185 190Lys Pro Gly Thr Met Ile Glu Trp Gly Asn Asn Trp Ala Arg Ala Ile195 200 205Lys Tyr Arg Gln Glu Asn Gln Glu Ala Val Gly Gly Phe Phe Ser Gln210 215 220Ile Gly Glu Leu Tyr Val Val His His Leu Trp Ala Tyr Lys Asp Leu225 230 235 240Gln Ser Arg Glu Glu Thr Arg Asn Ala Ala Trp Arg Lys Arg Gly Trp245 250 255Asp Glu Asn Val Tyr Tyr Thr Val Pro Leu Val Arg His Met Glu Ser260 265 270Arg Ile Met Ile Pro Leu Lys Ile Ser Pro Leu Gln275 280<210>145<211>367<212>PRT<213>人<300>
<308>sw_hum/dcup_human<309>1988-01-01<400>145Met Glu Ala Asn Gly Leu Gly Pro Gln Gly Phe Pro Glu Leu Lys Asn1 5 10 15Asp Thr Phe Leu Arg Ala Ala Trp Gly Glu Glu Thr Asp Tyr Thr Pro20 25 30Val Trp Cys Met Arg Gln Ala Gly Arg Tyr Leu Pro Glu Phe Arg Glu35 40 45Thr Arg Ala Ala Gln Asp Phe Phe Ser Thr Cys Arg Ser Pro Glu Ala50 55 60Cys Cys Glu Leu Thr Leu Gln Pro Leu Arg Arg Phe Pro Leu Asp Ala65 70 75 80
Ala Ile Ile Phe Ser Asp Ile Leu Val Val Pro Gln Ala Leu Gly Met85 90 95Glu Val Thr Met Val Pro Gly Lys Gly Pro Ser Phe Pro Glu Pro Leu100 105 110Arg Glu Glu Gln Asp Leu Glu Arg Leu Arg Asp Pro Glu Val Val Ala115 120 125Ser Glu Leu Gly Tyr Val Phe Gln Ala Ile Thr Leu Thr Arg Gln Arg130 135 140Leu Ala Gly Arg Val Pro Leu Ile Gly Phe Ala Gly Ala Pro Trp Thr145 150 155 160Leu Met Thr Tyr Met Val Glu Gly Gly Gly Ser Ser Thr Met Ala Gln165 170 175Ala Lys Arg Trp Leu Tyr Gln Arg Pro Gln Ala Ser His Gln Leu Leu180 185 190Arg Ile Leu Thr Asp Ala Leu Val Pro Tyr Leu Val Gly Gln Val Val195 200 205Ala Gly Ala Gln Ala Leu Gln Leu Phe Glu Ser His Ala Gly His Leu210 215 220Gly Pro Gln Leu Phe Asn Lys Phe Ala Leu Pro Tyr Ile Arg Asp Val225 230 235 240Ala Lys Gln Val Lys Ala Arg Leu Arg Glu Ala Gly Leu Ala Pro Val245 250 255Pro Met Ile Ile Phe Ala Lys Asp Gly His Phe Ala Leu Glu Glu Leu260 265 270Ala Gln Ala Gly Tyr Glu Val Val Gly Leu Asp Trp Thr Val Ala Pro275 280 285Lys Lys Ala Arg Glu Cys Val Gly Lys Thr Val Thr Leu Gln Gly Asn290 295 300Leu Asp Pro Cys Ala Leu Tyr Ala Ser Glu Glu Glu Ile Gly Gln Leu305 310 315 320
Val Lys Gln Met Leu Asp Asp Phe Gly Pro His Arg Tyr Ile Ala Asn325 330 335Leu Gly His Gly Leu Tyr Pro Asp Met Asp Pro Glu His Val Gly Ala340 345 350Phe Val Asp Ala Val His Lys His Ser Arg Leu Leu Arg Gln Asn355 360 365<210>146<211>430<212>PRT<213>人<300>
<308>sw_hum/aatm_human<309>1986-07-21<400>146Met Ala Leu Leu His Ser Gly Arg Val Leu Pro Gly Ile Ala Ala Ala1 5 10 15Phe His Pro Gly Leu Ala Ala Ala Ala Ser Ala Arg Ala Ser Ser Trp20 25 30Trp Thr His Val Glu Met Gly Pro Pro Asp Pro Ile Leu Gly Val Thr35 40 45Glu Ala Phe Lys Arg Asp Thr Asn Ser Lys Lys Met Asn Leu Gly Val50 55 60Gly Ala Tyr Arg Asp Asp Asn Gly Lys Pro Tyr Val Leu Pro Ser Val65 70 75 80Arg Lys Ala Glu Ala Gln Ile Ala Ala Lys Asn Leu Asp Lys Glu Tyr85 90 95Leu Pro Ile Gly Gly Leu Ala Glu Phe Cys Lys Ala Ser Ala Glu Leu100 105 110Ala Leu Gly Glu Asn Ser Glu Val Leu Lys Ser Gly Arg Phe Val Thr115 120 125Val Gln Thr Ile Ser Gly Thr Gly Ala Leu Arg Ile Gly Ala Ser Phe130 135 140Leu Gln Arg Phe Phe Lys Phe Ser Arg Asp Val Phe Leu Pro Lys Pro145 150 155 160
Thr Trp Gly Asn His Thr Pro Ile Phe Arg Asp Ala Gly Met Gln Leu165 170 175Gln Gly Tyr Arg Tyr Tyr Asp Pro Lys Thr Cys Gly Phe Asp Phe Thr180 185 190Gly Ala Val Glu Asp Ile Ser Lys Ile Pro Glu Gln Ser Val Leu Leu195 200 205Leu His Ala Cys Ala His Asn Pro Thr Gly Val Asp Pro Arg Pro Glu210 215 220Gln Trp Lys Glu Ile Ala Thr Val Val Lys Lys Arg Asn Leu Phe Ala225 230 235 240Phe Phe Asp Met Ala Tyr Gln Gly Phe Ala Ser Gly Asp Gly Asp Lys245 250 255Asp Ala Trp Ala Val Arg His Phe Ile Glu Gln Gly Ile Asn Val Cys260 265 270Leu Cys Gln Ser Tyr Ala Lys Asn Met Gly Leu Tyr Gly Glu Arg Val275 280 285Gly Ala Phe Thr Met Val Cys Lys Asp Ala Asp Glu Ala Lys Arg Val290 295 300Glu Ser Gln Leu Lys Ile Leu Ile Arg Pro Met Tyr Ser Asn Pro Pro305 310 315 320Leu Asn Gly Ala Arg Ile Ala Ala Ala Ile Leu Asn Thr Pro Asp Leu325 330 335Arg Lys Gln Trp Leu Gln Glu Val Lys Gly Met Ala Asp Arg Ile Ile340 345 350Gly Met Arg Thr Gln Leu Val Ser Asn Leu Lys Lys Glu Gly Ser Thr355 360 365His Asn Trp Gln His Ile Thr Asp Gln Ile Gly Met Phe Cys Phe Thr370 375 380Gly Leu Lys Pro Glu Gln Val Glu Arg Leu Ile Lys Glu Phe Ser Ile385 390 395 400Tyr Met Thr Lys Asp Gly Arg Ile Ser Val Ala Gly Val Thr Ser Ser
405 410 415Asn Val Gly Tyr Leu Ala His Ala Ile His Gln Val Thr Lys420 425 430<210>147<211>233<212>PRT<213>人<300>
<308>sw_hum/psa2_human<309>1992-05-01<400>147Ala Glu Arg Gly Tyr Ser Phe Ser Leu Thr Thr Phe Ser Pro Ser Gly1 5 10 15Lys Leu Val Gln Ile Glu Tyr Ala Leu Ala Ala Val Ala Gly Gly Ala20 25 30Pro Ser Val Gly Ile Lys Ala Ala Asn Gly Val Val Leu Ala Thr Glu35 40 45Lys Lys Gln Lys Ser Ile Leu Tyr Asp Glu Arg Ser Val His Lys Val50 55 60Glu Pro Ile Thr Lys His Ile Gly Leu Val Tyr Ser Gly Met Gly Pro65 70 75 80Asp Tyr Arg Val Leu Val His Arg Ala Arg Lys Leu Ala Gln Gln Tyr85 90 95Tyr Leu Val Tyr Gln Glu Pro Ile Pro Thr Ala Gln Leu Val Gln Arg100 105 110Val Ala Ser Val Met Gln Glu Tyr Thr Gln Ser Gly Gly Val Arg Pro115 120 125Phe Gly Val Ser Leu Leu Ile Cys Gly Trp Asn Glu Gly Arg Pro Tyr130 135 140Leu Phe Gln Ser Asp Pro Ser Gly Ala Tyr Phe Ala Trp Lys Ala Thr145 150 155 160Ala Met Gly Lys Asn Tyr Val Asn Gly Lys Thr Phe Leu Glu Lys Arg165 170 175
Tyr Asn Glu Asp Leu Glu Leu Glu Asp Ala Ile His Thr Ala Ile Leu180 185 190Thr Leu Lys Glu Ser Phe Glu Gly Gln Met Thr Glu Asp Asn Ile Glu195 200 205Val Gly Ile Cys Asn Glu Ala Gly Phe Arg Arg Leu Thr Pro Thr Glu210 215 220Val Lys Asp Tyr Leu Ala Ala Ile Ala225 230<210>148<211>530<212>PRT<213>人<300>
<308>sw_hum/kpy1_human<309>1990-04-01<400>148Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln Gln1 5 10 15Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg Leu20 25 30Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile Cys35 40 45Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met Ile50 55 60Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr His65 70 75 80Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu Ser85 90 95Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu Asp100 105 110Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly Thr115 120 125Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu Asp130 135 140
Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp Tyr145 150 155 160Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val Asp165 170 175Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe Leu180 185 190Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly Val195 200 205Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys Asp210 215 220Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val Phe225 230 235 240Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys Val245 250 255Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu Asn260 265 270His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp Gly275 280 285Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu Lys290 295 300Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala Gly305 3l0 315 320Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys Lys325 330 335Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val Leu340 345 350Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly Asp355 360 365Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu Ala370 375 380Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg Leu
385 390 395 400Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala Val405 410 415Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr Lys420 425 430Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala Pro435 440 445Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His Leu450 455 460Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu Ala465 470 475 480Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val Gly485 490 495Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu Thr500 505 510Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val Pro515 520 525Val Pro530<210>149<211>412<212>PRT<213>人<300>
<308>sw_hum/aatc_human<309>1990-08-01<400>149Ala Pro Pro Ser Val Phe Ala Glu Val Pro Gln Ala Gln Pro Val Leu1 5 10 15Val Phe Lys Leu Thr Ala Asp Phe Arg Glu Asp Pro Asp Pro Arg Lys20 25 30Val Asn Leu Gly Val Gly Ala Tyr Arg Thr Asp Asp Cys His Pro Trp35 40 45
Val Leu Pro Val Val Lys Lys Val Glu Gln Lys Ile Ala Asn Asp Asn50 55 60Ser Leu Asn His Glu Tyr Leu Pro Ile Leu Gly Leu Ala Glu Phe Arg65 70 75 80Ser Cys Ala Ser Arg Leu Ala Leu Gly Asp Asp Ser Pro Ala Leu Lys85 90 95Glu Lys Arg Val Gly Gly Val Gln Ser Leu Gly Gly Thr Gly Ala Leu100 105 110Arg Ile Gly Ala Asp Phe Leu Ala Arg Trp Tyr Asn Gly Thr Asn Asn115 120 125Lys Asn Thr Pro Val Tyr Val Ser Ser Pro Thr Trp Glu Asn His Asn130 135 140Ala Val Phe Ser Ala Ala Gly Phe Lys Asp Ile Arg Ser Tyr Arg Tyr145 150 155 160Trp Asp Ala Glu Lys Arg Gly Leu Asp Leu Gln Gly Phe Leu Asn Asp165 170 175Leu Glu Asn Ala Pro Glu Phe Ser Ile Val Val Leu His Ala Cys Ala180 185 190His Asn Pro Thr Gly Ile Asp Pro Thr Pro Glu Gln Trp Lys Gln Ile195 200 205Ala Ser Val Met Lys His Arg Phe Leu Phe Pro Phe Phe Asp Ser Ala210 215 220Tyr Gln Gly Phe Ala Ser Gly Asn Leu Glu Arg Asp Ala Trp Ala Ile225 230 235 240Arg Tyr Phe Val Ser Glu Gly Phe Glu Phe Phe Cys Ala Gln Ser Phe245 250 255Ser Lys Asn Phe Gly Leu Tyr Asn Glu Arg Val Gly Asn Leu Thr Val260 265 270Val Gly Lys Glu Pro Glu Ser Ile Leu Gln Val Leu Ser Gln Met Glu275 280 285Lys Ile Val Arg Ile Thr Trp Ser Asn Pro Pro Ala Gln Gly Ala Arg290 295 300
Ile Val Ala Ser Thr Leu Ser Asn Pro Glu Leu Phe Glu Glu Trp Thr305 310 315 320Gly Asn Val Lys Thr Met Ala Asp Arg Ile Leu Thr Met Arg Ser Glu325 330 335Leu Arg Ala Arg Leu Glu Ala Leu Lys Thr Pro Gly Thr Trp Asn His340 345 350Ile Thr Asp Gln Ile Gly Met Phe Ser Phe Thr Gly Leu Asn Pro Lys355 360 365Gln Val Glu Tyr Leu Val Asn Glu Lys His Ile Tyr Leu Leu Pro Ser370 375 380Gly Arg Ile Asn Val Ser Gly Leu Thr Thr Lys Asn Leu Asp Tyr Val385 390 395 400Ala Thr Ser Ile His Glu Ala Val Thr Lys Ile Gln405 410<210>150<211>553<212>PRT<213>人<300>
<308>sw_hum/atpa_human<309>1992-05-01<400>150Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg1 5 10 15Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala20 25 30Ala Arg Asn Phe His Ala Ser Asn Thr His Leu Gln Lys Thr Gly Thr35 40 45Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr50 55 60Ser Val Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly65 70 75 80Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val
85 90 95Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp100 105 110Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly115 120 125Asp Ile Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu130 135 140Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly145 150 155 160Lys Gly Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala165 170 175Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly180 185 190Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu195 200 205Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp210 215 220Thr Ile Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys225 230 235 240Lys Leu Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val245 250 255Ala Gln Leu Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr260 265 270Ile Val Val Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu275 280 285Ala Pro Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly290 295 300Lys His Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala305 310 315 320Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala325 330 335
Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala340 345 350Ala Lys Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro355 360 365Val Ile Glu Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn370 375 380Val Ile Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe385 390 395 400Tyr Lys Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg405 410 415Val Gly Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr420 425 430Met Lys Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln435 440 445Phe Gly Ser Asp Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly450 455 460Val Arg Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala465 470 475 480Ile Glu Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu485 490 495Asp Lys Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu500 505 510Ser His Val Val Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala515 520 525Asp Gly Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val530 535 540Thr Asn Phe Leu Ala Gly Phe Glu Ala545 550<210>151<211>452<212>PRT<213>人
<300>
<308>sw_hum/e2bg_human<309>2001-10-16<400>151Met Glu Phe Gln Ala Val Val Met Ala Val Gly Gly Gly Ser Arg Met1 5 10 15Thr Asp Leu Thr Ser Ser Ile Pro Lys Pro Leu Leu Pro Val Gly Asn20 25 30Lys Pro Leu Ile Trp Tyr Pro Leu Asn Leu Leu Glu Arg Val Gly Phe35 40 45Glu Glu Val Ile Val Val Thr Thr Arg Asp Val Gln Lys Ala Leu Cys50 55 60Ala Glu Phe Lys Met Lys Met Lys Pro Asp Ile Val Cys Ile Pro Asp65 70 75 80Asp Ala Asp Met Gly Thr Ala Asp Ser Leu Arg Tyr Ile Tyr Pro Lys85 90 95Leu Lys Thr Asp Val Leu Val Leu Ser Cys Asp Leu Ile Thr Asp Val100 105 110Ala Leu His Glu Val Val Asp Leu Phe Arg Ala Tyr Asp Ala Ser Leu115 120 125Ala Met Leu Met Arg Lys Gly Gln Asp Ser Ile Glu Pro Val Pro Gly130 135 140Gln Lys Gly Lys Lys Lys Ala Val Glu Gln Arg Asp Phe Ile Gly Val145 150 155 160Asp Ser Thr Gly Lys Arg Leu Leu Phe Met Ala Asn Glu Ala Asp Leu165 170 175Asp Glu Glu Leu Val Ile Lys Gly Ser Ile Leu Gln Lys His Pro Arg180 185 190Ile Arg Phe His Thr Gly Leu Val Asp Ala His Leu Tyr Cys Leu Lys195 200 205Lys Tyr Ile Val Asp Phe Leu Met Glu Asn Gly Ser Ile Thr Ser Ile210 215 220
Arg Ser Glu Leu Ile Pro Tyr Leu Val Arg Lys Gln Phe Ser Ser Ala225 230 235 240Ser Ser Gln Gln Gly Gln Glu Glu Lys Glu Glu Asp Leu Lys Lys Lys245 250 255Glu Leu Lys Ser Leu Asp Ile Tyr Ser Phe Ile Lys Glu Ala Asn Thr260 265 270Leu Asn Leu Ala Pro Tyr Asp Ala Cys Trp Asn Ala Cys Arg Gly Asp275 280 285Arg Trp Glu Asp Leu Ser Arg Ser Gln Val Arg Cys Tyr Val His Ile290 295 300Met Lys Glu Gly Leu Cys Ser Arg Val Ser Thr Leu Gly Leu Tyr Met305 310 315 320Glu Ala Asn Arg Gln Val Pro Lys Leu Leu Ser Ala Leu Cys Pro Glu325 330 335Glu Pro Pro Val His Ser Ser Ala Gln Ile Val Ser Lys His Leu Val340 345 350Gly Val Asp Ser Leu Ile Gly Pro Glu Thr Gln Ile Gly Glu Lys Ser355 360 365Ser Ile Lys Arg Ser Val Ile Gly Ser Ser Cys Leu Ile Lys Asp Arg370 375 380Val Thr Ile Thr Asn Cys Leu Leu Met Asn Ser Val Thr Val Glu Glu385 390 395 400Gly Ser Asn Ile Gln Gly Ser Val Ile Cys Asn Asn Ala Val Ile Glu405 410 415Lys Gly Ala Asp Ile Lys Asp Cys Leu Ile Gly Ser Gly Gln Arg Ile420 425 430Glu Ala Lys Ala Lys Arg Val Asn Glu Val Ile Val Gly Asn Asp Gln435 440 445Leu Met Glu Ile450<210>152<211>524
<212>PRT<213>人<300>
<308>sw_hum/glpk_human<309>1993-10-01<400>152Met Ala Ala Ser Lys Lys Ala Val Leu Gly Pro Leu Val Gly Ala Val1 5 10 15Asp Gln Gly Thr Ser Ser Thr Arg Phe Leu Val Phe Asn Ser Lys Thr20 25 30Ala Glu Leu Leu Ser His His Gln Val Glu Ile Lys Gln Glu Phe Pro35 40 45Arg Glu Gly Trp Val Glu Gln Asp Pro Lys Glu Ile Leu His Ser Val50 55 60Tyr Glu Cys Ile Glu Lys Thr Cys Glu Lys Leu Gly Gln Leu Asn Ile65 70 75 80Asp Ile Ser Asn Ile Lys Ala Ile Gly Val Ser Asn Gln Arg Glu Thr85 90 95Thr Val Val Trp Asp Lys Ile Thr Gly Glu Pro Leu Tyr Asn Ala Val100 105 110Val Trp Leu Asp Leu Arg Thr Gln Ser Thr Val Glu Ser Leu Ser Lys115 120 125Arg Ile Pro Gly Asn Asn Asn Phe Val Lys Ser Lys Thr Gly Leu Pro130 135 140Leu Ser Thr Tyr Phe Ser Ala Val Lys Leu Arg Trp Leu Leu Asp Asn145 150 155 160Val Arg Lys Val Gln Lys Ala Val Glu Glu Lys Arg Ala Leu Phe Gly165 170 175Thr Ile Asp Ser Trp Leu Ile Trp Ser Leu Thr Gly Gly Val Asn Gly180 185 190Gly Val His Cys Thr Asp Val Thr Asn Ala Ser Arg Thr Met Leu Phe195 200 205Asn Ile His Ser Leu Glu Trp Asp Lys Gln Leu Cys Glu Phe Phe Gly
210 215 220Ile Pro Met Glu Ile Leu Pro Asn Val Arg Ser Ser Ser Glu Ile Tyr225 230 235 240Gly Leu Met Lys Ala Gly Ala Leu Glu Gly Val Pro Ile Ser Gly Cys245 250 255Leu Gly Asp Gln Ser Ala Ala Leu Val Gly Gln Met Cys Phe Gln Ile260 265 270Gly Gln Ala Lys Asn Thr Tyr Gly Thr Gly Cys Phe Leu Leu Cys Asn275 280 285Thr Gly His Lys Cys Val Phe Ser Asp His Gly Leu Leu Thr Thr Val290 295 300Ala Tyr Lys Leu Gly Arg Asp Lys Pro Val Tyr Tyr Ala Leu Glu Gly305 310 315 320Ser Val Ala Ile Ala Gly Ala Val Ile Arg Trp Leu Arg Asp Asn Leu325 330 335Gly Ile Ile Lys Thr Ser Glu Glu Ile Glu Lys Leu Ala Lys Glu Val340 345 350Gly Thr Ser Tyr Gly Cys Tyr Phe Val Pro Ala Phe Ser Gly Leu Tyr355 360 365Ala Pro Tyr Trp Glu Pro Ser Ala Arg Gly Ile Ile Cys Gly Leu Thr370 375 380Gln Phe Thr Asn Lys Cys His Ile Ala Phe Ala Ala Leu Glu Ala Val385 390 395 400Cys Phe Gln Thr Arg Glu Ile Leu Asp Ala Met Asn Arg Asp Cys Gly405 410 415Ile Pro Leu Ser His Leu Gln Val Asp Gly Gly Met Thr Ser Asn Lys420 425 430Ile Leu Met Gln Leu Gln Ala Asp Ile Leu Tyr Ile Pro Val Val Lys435 440 445Pro Ser Met Pro Glu Thr Thr Ala Leu Gly Ala Ala Met Ala Ala Gly450 455 460
Ala Ala Glu Gly Val Gly Val Trp Ser Leu Glu Pro Glu Asp Leu Ser465 470 475 480Ala Val Thr Met Glu Arg Phe Glu Pro Gln Ile Asn Ala Glu Glu Ser485 490 495Glu Ile Arg Tyr Ser Thr Trp Lys Lys Ala Val Met Lys Ser Met Gly500 505 510Trp Val Thr Thr Gln Ser Pro Glu Ser Gly Ile Pro515 520<210>153<211>293<212>PRT<213>人<300>
<308>sw_hum/rs2_human<309>1990-04-0l<400>153Met Ala Asp Asp Ala Gly Ala Ala Gly Gly Pro Gly Gly Pro Gly Gly1 5 10 15Pro Gly Met Gly Asn Arg Gly Gly Phe Arg Gly Gly Phe Gly Ser Gly20 25 30Ile Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg35 40 45Gly Ala Arg Gly Gly Lys Ala Glu Asp Lys Glu Trp Met Pro Val Thr50 55 60Lys Leu Gly Arg Leu Val Lys Asp Met Lys Ile Lys Ser Leu Glu Glu65 70 75 80Ile Tyr Leu Phe Ser Leu Pro Ile Lys Glu Ser Glu Ile Ile Asp Phe85 90 95Phe Leu Gly Ala Ser Leu Lys Asp Glu Val Leu Lys Ile Met Pro Val100 105 110Gln Lys Gln Thr Arg Ala Gly Gln Arg Thr Arg Phe Lys Ala Phe Val115 120 125Ala Ile Gly Asp Tyr Asn Gly His Val Gly Leu Gly Val Lys Cys Ser130 135 140
Lys Glu Val Ala Thr Ala Ile Arg Gly Ala Ile Ile Leu Ala Lys Leu145 150 155 160Ser Ile Val Pro Val Arg Arg Gly Tyr Trp Gly Asn Lys Ile Gly Lys165 170 175Pro His Thr Val Pro Cys Lys Val Thr Gly Arg Cys Gly Ser Val Leu180 185 190Val Arg Leu Ile Pro Ala Pro Arg Gly Thr Gly Ile Val Ser Ala Pro195 200 205Val Pro Lys Lys Leu Leu Met Met Ala Gly Ile Asp Asp Cys Tyr Thr210 215 220Ser Ala Arg Gly Cys Thr Ala Thr Leu Gly Asn Phe Ala Lys Ala Thr225 230 235 240Phe Asp Ala Ile Ser Lys Thr Tyr Ser Tyr Leu Thr Pro Asp Leu Trp245 250 255Lys Glu Thr Val Phe Thr Lys Ser Pro Tyr Gln Glu Phe Thr Asp His260 265 270Leu Val Lys Thr His Thr Arg Val Ser Val Gln Arg Thr Gln Ala Pro275 280 285Ala Val Ala Thr Thr290<210>154<211>508<212>PRT<213>人<300>
<308>sw_hum/syfa_human<309>2001-10-16<400>154Met Ala Asp Gly Gln Val Ala Glu Leu Leu Leu Arg Arg Leu Glu Ala1 5 10 15Ser Asp Gly Gly Leu Asp Ser Ala Glu Leu Ala Ala Glu Leu Gly Met20 25 30Glu His Gln Ala Val Val Gly Ala Val Lys Ser Leu Gln Ala Leu Gly
35 40 45Glu Val Ile Glu Ala Glu Leu Arg Ser Thr Lys His Trp Glu Leu Thr50 55 60Ala Glu Gly Glu Glu Ile Ala Arg Glu Gly Ser His Glu Ala Arg Val65 70 75 80Phe Arg Ser Ile Pro Pro Glu Gly Leu Ala Gln Ser Glu Leu Met Arg85 90 95Leu Pro Ser Gly Lys Val Gly Phe Ser Lys Ala Met Ser Asn Lys Trp100 105 110Ile Arg Val Asp Lys Ser Ala Ala Asp Gly Pro Arg Val Phe Arg Val115 120 125Val Asp Ser Met Glu Asp Glu Val Gln Arg Arg Leu Gln Leu Val Arg130 135 140Gly Gly Gln Ala Glu Lys Leu Gly Glu Lys Glu Arg Ser Glu Leu Arg145 150 155 160Lys Arg Lys Leu Leu Ala Glu Val Thr Leu Lys Thr Tyr Trp Val Ser165 170 175Lys Gly Ser Ala Phe Ser Thr Ser Ile Ser Lys Gln Glu Thr Glu Leu180 185 190Ser Pro Glu Met Ile Ser Ser Gly Ser Trp Arg Asp Arg Pro Phe Lys195 200 205Pro Tyr Asn Phe Leu Ala His Gly Val Leu Pro Asp Ser Gly His Leu210 215 220His Pro Leu Leu Lys Val Arg Ser Gln Phe Arg Gln Ile Phe Leu Glu225 230 235 240Met Gly Phe Thr Glu Met Pro Thr Asp Asn Phe Ile Glu Ser Ser Phe245 250 255Trp Asn Phe Asp Ala Leu Phe Gln Pro Gln Gln His Pro Ala Arg Asp260 265 270Gln His Asp Thr Phe Phe Leu Arg Asp Pro Ala Glu Ala Leu Gln Leu275 280 285
Pro Met Asp Tyr Val Gln Arg Val Lys Arg Thr His Ser Gln Gly Gly290 295 300Tyr Gly Ser Gln Gly Tyr Lys Tyr Asn Trp Lys Leu Asp Glu Ala Arg305 310 315 320Lys Asn Leu Leu Arg Thr His Thr Thr Ser Ala Ser Ala Arg Ala Leu325 330 335Tyr Arg Leu Ala Gln Lys Lys Pro Phe Thr Pro Val Lys Tyr Phe Ser340 345 350Ile Asp Arg Val Phe Arg Asn Glu Thr Leu Asp Ala Thr His Leu Ala355 360 365Glu Phe His Gln Ile Glu Gly Val Val Ala Asp His Gly Leu Thr Leu370 375 380Gly His Leu Met Gly Val Leu Arg Glu Phe Phe Thr Lys Leu Gly Ile385 390 395 400Thr Gln Leu Arg Phe Lys Pro Ala Tyr Asn Pro Tyr Thr Glu Pro Ser405 410 415Met Glu Val Phe Ser Tyr His Gln Gly Leu Lys Lys Trp Val Glu Val420 425 430Gly Asn Ser Gly Val Phe Arg Pro Glu Met Leu Leu Pro Met Gly Leu435 440 445Pro Glu Asn Val Ser Val Ile Ala Trp Gly Leu Ser Leu Glu Arg Pro450 455 460Thr Met Ile Lys Tyr Gly Ile Asn Asn Ile Arg Glu Leu Val Gly His465 470 475 480Lys Val Asn Leu Gln Met Val Tyr Asp Ser Pro Leu Cys Arg Leu Asp485 490 495Ala Glu Pro Arg Pro Pro Pro Thr Gln Glu Ala Ala500 505<210>155<211>397<212>PRT<213>人
<300>
<308>sw_hum/dja1_human<309>1993-07-01<400>155Met Val Lys Glu Thr Thr Tyr Tyr Asp Val Leu Gly Val Lys Pro Asn1 5 10 15Ala Thr Gln Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys20 25 30Tyr His Pro Asp Lys Asn Pro Asn Glu Gly Glu Lys Phe Lys Gln Ile35 40 45Ser Gln Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Glu Leu Tyr50 55 60Asp Lys Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ala Gly Gly Gly65 70 75 80Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly85 90 95Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser100 105 110Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr Arg Lys Leu Ala Leu115 120 125Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly Arg Gly Gly Lys Lys130 135 140Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly Thr Gly Met Gln Ile145 150 155 160Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Ser Val165 170 175Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro Lys Asp Arg180 185 190Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys Lys Ile Leu195 200 205Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys Ile Thr Phe210 215 220
His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly Asp Ile Ile225 230 235 240Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg Arg Gly Glu245 250 255Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala Leu Cys Gly260 265 270Phe Gln Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile Val Ile Thr275 280 285Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys Cys Val Leu290 295 300Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys Gly Arg Leu305 310 315 320Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro325 330 335Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg Lys Glu Val340 345 350Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp Phe Asp Pro355 360 365Asn Gln Glu Arg Arg Arg His Tyr Asn Gly Glu Ala Tyr Glu Asp Asp370 375 380Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser385 390 395<210>156<211>518<212>PRT<213>人<300>
<308>sw_hum/sysm_human<309>2003-02-28<400>156Met Ala Ala Ser Met Ala Arg Arg Leu Trp Pro Leu Leu Thr Arg Arg1 5 10 15Gly Phe Arg Pro Arg Gly Gly Cys Ile Ser Asn Asp Ser Pro Arg Arg20 25 30
Ser Phe Thr Thr Glu Lys Arg Asn Arg Asn Leu Leu Tyr Glu Tyr Ala35 40 45Arg Glu Gly Tyr Ser Ala Leu Pro Gln Leu Asp Ile Glu Arg Phe Cys50 55 60Ala Cys Pro Glu Glu Ala Ala His Ala Leu Glu Leu Arg Lys Gly Glu65 70 75 80Leu Arg Ser Ala Asp Leu Pro Ala Ile Ile Ser Thr Trp Gln Glu Leu85 90 95Arg Gln Leu Gln Glu Gln Ile Arg Ser Leu Glu Glu Glu Lys Ala Ala100 105 110Val Thr Glu Ala Val Arg Ala Leu Leu Ala Asn Gln Asp Ser Gly Glu115 120 125Val Gln Gln Asp Pro Lys Tyr Gln Gly Leu Arg Ala Arg Gly Arg Glu130 135 140Ile Arg Lys Glu Leu Val His Leu Tyr Pro Arg Glu Ala Gln Leu Glu145 150 155 160Glu Gln Phe Tyr Leu Gln Ala Leu Lys Leu Pro Asn Gln Thr His Pro165 170 175Asp Val Pro Val Gly Asp Glu Ser Gln Ala Arg Val Leu His Met Val180 185 190Gly Asp Lys Pro Val Phe Ser Phe Gln Pro Arg Gly His Leu Glu Ile195 200 205Gly Glu Lys Leu Asp Ile Ile Arg Gln Lys Arg Leu Ser His Val Ser210 215 220Gly His Arg Ser Tyr Tyr Leu Arg Gly Ala Gly Ala Leu Leu Gln His225 230 235 240Gly Leu Val Asn Phe Thr Phe Asn Lys Leu Leu Arg Arg Gly Phe Thr245 250 255Pro Met Thr Val Pro Asp Leu Leu Arg Gly Ala Val Phe Glu Gly Cys260 265 270Gly Met Thr Pro Asn Ala Asn Pro Ser Gln Ile Tyr Asn Ile Asp Pro
275 280 285Ala Arg Phe Lys Asp Leu Asn Leu Ala Gly Thr Ala Glu Val Gly Leu290 295 300Ala Gly Tyr Phe Met Asp His Thr Val Ala Phe Arg Asp Leu Pro Val305 310 315 320Arg Met Val Cys Ser Ser Thr Cys Tyr Arg Ala Glu Thr Asn Thr Gly325 330 335Gln Glu Pro Arg Gly Leu Tyr Arg Val His His Phe Thr Lys Val Glu340 345 350Met Phe Gly Val Thr Gly Pro Gly Leu Glu Gln Ser Ser Gln Leu Leu355 360 365Glu Glu Phe Leu Ser Leu Gln Met Glu Ile Leu Thr Glu Leu Gly Leu370 375 380His Phe Arg Val Leu Asp Met Pro Thr Gln Glu Leu Gly Leu Pro Ala385 390 395 400Tyr Arg Lys Phe Asp Ile Glu Ala Trp Met Pro Gly Arg Gly Arg Phe405 410 415Gly Glu Val Thr Ser Ala Ser Asn Cys Thr Asp Phe Gln Ser Arg Arg420 425 430Leu His Ile Met Phe Gln Thr Glu Ala Gly Glu Leu Gln Phe Ala His435 440 445Thr Val Asn Ala Thr Ala Cys Ala Val Pro Arg Leu Leu Ile Ala Leu450 455 460Leu Glu Ser Asn Gln Gln Lys Asp Gly Ser Val Leu Val Pro Pro Ala465 470 475 480Leu Gln Ser Tyr Leu Gly Thr Asp Arg Ile Thr Ala Pro Thr His Val485 490 495Pro Leu Gln Tyr Ile Gly Pro Asn Gln Pro Arg Lys Pro Gly Leu Pro500 505 510Gly Gln Pro Ala Val Ser515
<210>157<211>279<212>PRT<213>人<300>
<308>sw_hum/hax1_human<309>1998-07-15<400>157Met Ser Leu Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro1 5 10 15Arg Ser His Arg Asp Pro Phe Phe Gly Gly Met Thr Arg Asp Glu Asp20 25 30Asp Asp Glu Glu Glu Glu Glu Glu Gly Gly Ser Trp Gly Arg Gly Asn35 40 45Pro Arg Phe His Ser Pro Gln His Pro Pro Glu Glu Phe Gly Phe Gly50 55 60Phe Ser Phe Ser Pro Gly Gly Gly Ile Arg Phe His Asp Asn Phe Gly65 70 75 80Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Asp Met Gly85 90 95Ala Trp Thr Leu Pro Ser His Pro Pro Glu Leu Pro Gly Pro Glu Ser100 105 110Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly Gln Thr Leu Arg Asp Ser115 120 125Met Leu Lys Tyr Pro Asp Ser His Gln Pro Arg Ile Phe Gly Gly Val130 135 140Leu Glu Ser Asp Ala Arg Ser Glu Ser Pro Gln Pro Ala Pro Asp Trp145 150 155 160Gly Ser Gln Arg Pro Phe His Arg Phe Asp Asp Val Trp Pro Met Asp165 170 175Pro His Pro Arg Thr Arg Glu Asp Asn Asp Leu Asp Ser Gln Val Ser180 185 190Gln Glu Gly Leu Gly Pro Val Leu Gln Pro Gln Pro Lys Ser Tyr Phe195 200 205
Lys Ser Ile Ser Val Thr Lys Ile Thr Lys Pro Asp Gly Ile Val Glu210 215 220Glu Arg Arg Thr Val Val Asp Ser Glu Gly Arg Thr Glu Thr Thr Val225 230 235 240Thr Arg His Glu Ala Asp Ser Ser Pro Arg Gly Asp Pro Glu Ser Pro245 250 255Arg Pro Pro Ala Leu Asp Asp Ala Phe Ser Ile Leu Asp Leu Phe Leu260 265 270Gly Arg Trp Phe Arg Ser Arg275<210>158<211>476<212>PRT<213>人<300>
<308>humangp/chr19-q96g16<309>2003-04-22<400>158Met Val Ser Lys Arg Ile Ala Gln Glu Thr Phe Asp Ala Ala Val Arg1 5 10 15Glu Asn Ile Glu Glu Phe Ala Met Gly Pro Glu Glu Ala Val Lys Glu20 25 30Ala Val Glu Gln Phe Glu Ser Gln Gly Val Asp Leu Ser Asn Ile Val35 40 45Lys Thr Ala Pro Lys Val Ser Ala Asp Gly Ser Gln Glu Pro Thr His50 55 60Asp Ile Leu Gln Met Leu Ser Asp Leu Gln Glu Ser Val Ala Ser Ser65 70 75 80Arg Pro Gln Glu Val Ser Ala Tyr Leu Thr Arg Phe Cys Asp Gln Cys85 90 95Lys Gln Asp Lys Ala Cys Arg Phe Leu Ala Ala Gln Lys Gly Ala Tyr100 105 110Pro Ile Ile Phe Thr Ala Trp Lys Leu Ala Thr Ala Gly Asp Gln Gly
115 120 125Leu Leu Leu Gln Ser Leu Asn Ala Leu Ser Val Leu Thr Asp Gly Gln130 135 140Pro Asp Leu Leu Asp Ala Gln Gly Leu Gln Leu Leu Val Ala Thr Leu145 l50 155 160Thr Gln Asn Ala Asp Glu Ala Asp Leu Thr Cys Ser Gly Ile Arg Cys165 170 175Val Arg His Ala Cys Leu Lys His Glu Gln Asn Arg Gln Asp Leu Val180 185 190Lys Ala Gly Val Leu Pro Leu Leu Thr Gly Ala Ile Thr His His Gly195 200 205His His Thr Asp Val Val Arg Glu Ala Cys Trp Ala Leu Arg Val Met210 215 220Thr Phe Asp Asp Asp Ile Arg Val Pro Phe Gly His Ala His Asn His225 230 235 240Ala Lys Met Ile Val Gln Glu Asn Lys Gly Leu Lys Val Leu Ile Glu245 250 255Ala Thr Lys Ala Phe Leu Asp Asn Pro Gly Ile Leu Ser Glu Leu Cys260 265 270Gly Thr Leu Ser Arg Leu Ala Ile Arg Asn Glu Phe Cys Gln Glu Val275 280 285Val Asp Leu Gly Gly Leu Ser Ile Leu Val Ser Leu Leu Ala Asp Cys290 295 300Asn Asp His Gln Met Arg Asp Gln Ser Gly Val Gln Glu Leu Val Lys305 310 315 320Gln Val Leu Ser Thr Leu Arg Ala Ile Ala Gly Asn Asp Asp Val Lys325 330 335Asp Ala Ile Val Arg Ala Gly Gly Thr Glu Ser Ile Val Ala Ala Met340 345 350Thr Gln His Leu Thr Ser Pro Gln Val Cys Glu Gln Ser Cys Ala Ala355 360 365
Leu Cys Phe Leu Ala Leu Arg Lys Pro Asp Asn Ser Arg Ile Ile Val370 375 380Glu Gly Gly Gly Ala Val Ala Ala Leu Gln Ala Met Lys Ala His Pro385 390 395 400Gln Lys Ala Gly Val Gln Lys Gln Ala Cys Met Leu Ile Arg Asn Leu405 410 415Val Ala His Gly Gln Ala Phe Ser Lys Pro Ile Leu Asp Leu Gly Ala420 425 430Glu Ala Leu Ile Met Gln Ala Arg Ser Ala His Arg Asp Cys Glu Asp435 440 445Val Ala Lys Ala Ala Leu Arg Asp Leu Gly Cys His Val Glu Leu Arg450 455 460Glu Leu Trp Thr Gly Gln Arg Gly Asn Leu Ala Pro465 470 475<210>159<211>319<212>PRT<213>人<300>
<308>human/chr10-q9hbk9<309>2003-04-22<400>159Gln Thr Tyr Tyr Gly Gln Val Leu Lys Arg Ser Ala Asp Leu Gln Thr1 5 10 15Asn Gly Cys Val Thr Thr Ala Arg Pro Val Pro Lys His Ile Arg Glu20 25 30Ala Leu Gln Asn Val His Glu Glu Val Ala Leu Arg Tyr Tyr Gly Cys35 40 45Gly Leu Val Ile Pro Glu His Leu Glu Asn Cys Trp Ile Leu Asp Leu50 55 60Gly Ser Gly Ser Gly Arg Asp Cys Tyr Val Leu Ser Gln Leu Val Gly65 70 75 80Glu Lys Gly His Val Thr Gly Ile Asp Met Thr Lys Gly Gln Val Glu85 90 95
Val Ala Glu Lys Tyr Leu Asp Tyr His Met Glu Lys Tyr Gly Phe Gln100 105 1l0Ala Ser Asn Val Thr Phe Ile His Gly Tyr Ile Glu Lys Leu Gly Glu115 120 125Ala Gly Ile Lys Asn Glu Ser His Asp Ile Val Val Ser Asn Cys Val130 135 140Ile Asn Leu Val Pro Asp Lys Gln Gln Val Leu Gln Glu Ala Tyr Arg145 150 155 160Val Leu Lys His Gly Gly Glu Leu Tyr Phe Ser Asp Val Tyr Thr Ser165 170 175Leu Glu Leu Pro Glu Glu Ile Arg Thr His Lys Val Leu Trp Gly Glu180 185 190Cys Leu Gly Gly Ala Leu Tyr Trp Lys Glu Leu Ala Val Leu Ala Gln195 200 205Lys Ile Gly Phe Cys Pro Pro Arg Leu Val Thr Ala Asn Leu Ile Thr210 215 220Ile Gln Asn Lys Glu Leu Glu Arg Val Ile Gly Asp Cys Arg Phe Val225 230 235 240Ser Ala Thr Phe Arg Leu Phe Lys His Ser Lys Thr Gly Pro Thr Lys245 250 255Arg Cys Gln Val Ile Tyr Asn Gly Gly Ile Thr Gly His Glu Lys Glu260 265 270Leu Met Phe Asp Ala Asn Phe Thr Phe Lys Glu Gly Glu Ile Val Glu275 280 285Val Asp Glu Glu Thr Ala Ala Ile Leu Lys Asn Ser Arg Phe Ala Gln290 295 300Asp Phe Leu Ile Arg Pro Ile Gly Glu Lys Leu Pro Thr Ser Gly305 310 315<210>160<211>392<212>PRT<213>人
<300>
<308>sw_hum/sps1_human<309>1996-10-01<400>160Met Ser Thr Arg Glu Ser Phe Asn Pro Glu Ser Tyr Glu Leu Asp Lys1 5 10 15Ser Phe Arg Leu Thr Arg Phe Thr Glu Leu Lys Gly Thr Gly Cys Lys20 25 30Val Pro Gln Asp Val Leu Gln Lys Leu Leu Glu Ser Leu Gln Glu Asn35 40 45His Phe Gln Glu Asp Glu Gln Phe Leu Gly Ala Val Met Pro Arg Leu50 55 60Gly Ile Gly Met Asp Thr Cys Val Ile Pro Leu Arg His Gly Gly Leu65 70 75 80Ser Leu Val Gln Thr Thr Asp Tyr Ile Tyr Pro Ile Val Asp Asp Pro85 90 95Tyr Met Met Gly Arg Ile Ala Cys Ala Asn Val Leu Ser Asp Leu Tyr100 105 110Ala Met Gly Val Thr Glu Cys Asp Asn Met Leu MetLeu Leu Gly Val115 120 125Ser Asn Lys Met Thr Asp Arg Glu Arg Asp Lys Val Met Pro Leu Ile130 135 140Ile Gln Gly Phe Lys Asp Ala Ala Glu Glu Ala Gly Thr Ser Val Thr145 150 155 160Gly Gly Gln Thr Val Leu Asn Pro Trp Ile Val Leu Gly Gly Val Ala165 170 175Thr Thr Val Cys Gln Pro Asn Glu Phe Ile Met Pro Asp Asn Ala Val180 185 190Pro Gly Asp Val Leu Val Leu Thr Lys Pro Leu Gly Thr Gln Val Ala195 200 205Val Ala Val His Gln Trp Leu Asp Ile Pro Glu Lys Trp Asn Lys Ile210 215 220
Lys Leu Val Val Thr Gln Glu Asp Val Glu Leu Ala Tyr Gln Glu Ala225 230 235 240Met Met Asn Met Ala Arg Leu Asn Arg Thr Ala Ala Gly Leu Met His245 250 255Thr Phe Asn Ala His Ala Ala Thr Asp Ile Thr Gly Phe Gly Ile Leu260 265 270Gly His Ala Gln Asn Leu Ala Lys Gln Gln Arg Asn Glu Val Ser Phe275 280 285Val Ile His Asn Leu Pro Val Leu Ala Lys Met Ala Ala Val Ser Lys290 295 300Ala Cys Gly Asn Met Phe Gly Leu Met His Gly Thr Cys Pro Glu Thr305 310 315 320Ser Gly Gly Leu Leu Ile Cys Leu Pro Arg Glu Gln Ala Ala Arg Phe325 330 335Cys Ala Glu Ile Lys Ser Pro Lys Tyr Gly Glu Gly His Gln Ala Trp340 345 350Ile Ile Gly Ile Val Glu Lys Gly Asn Arg Thr Ala Arg Ile Ile Asp355 360 365Lys Pro Arg Ile Ile Glu Val Ala Pro Gln Val Ala Thr Gln Asn Val370 375 380Asn Pro Thr Pro Gly Ala Thr Ser385 390<210>161<211>814<212>PRT<213>人<300>
<308>sw_hum/if39_human<309>1997-11-01<400>161Met Gln Asp Ala Glu Asn Val Ala Val Pro Glu Ala Ala Glu Glu Arg1 5 10 15Ala Glu Pro Gly Gln Gln Gln Pro Ala Ala Glu Pro Pro Pro Ala Glu20 25 30
Gly Leu Leu Arg Pro Ala Gly Pro Gly Ala Pro Glu Ala Ala Gly Thr35 40 45Glu Ala Ser Ser Glu Glu Val Gly Ile Ala Glu Ala Gly Pro Glu Pro50 55 60Glu Val Arg Thr Glu Pro Ala Ala Glu Ala Glu Ala Ala Ser Gly Pro65 70 75 80Ser Glu Ser Pro Ser Pro Pro Ala Ala Glu Glu Leu Pro Gly Ser His85 90 95Ala Glu Pro Pro Val Pro Ala Gln Gly Glu Ala Pro Gly Glu Gln Ala100 105 110Arg Asp Glu Arg Ser Asp Ser Arg Ala Gln Ala Val Ser Glu Asp Ala115 120 125Gly Gly Asn Glu Gly Arg Ala Ala Glu Ala Glu Pro Arg Ala Leu Glu130 135 140Asn Gly Asp Ala Asp Glu Pro Ser Phe Ser Asp Pro Glu Asp Phe Val145 150 155 160Asp Asp Val Ser Glu Glu Glu Leu Leu Gly Asp Val Leu Lys Asp Arg165 170 175Pro Gln Glu Ala Asp Gly Ile Asp Ser Val Ile Val Val Asp Asn Val180 185 190Pro Gln Val Gly Pro Asp Arg Leu Glu Lys Leu Lys Asn Val Ile His195 200 205Lys Ile Phe Ser Lys Phe Gly Lys Ile Thr Asn Asp Phe Tyr Pro Glu210 215 220Glu Asp Gly Lys Thr Lys Gly Tyr Ile Phe Leu Glu Tyr Ala Ser Pro225 230 235 240Ala His Ala Val Asp Ala Val Lys Asn Ala Asp Gly Tyr Lys Leu Asp245 250 255Lys Gln His Thr Phe Arg Val Asn Leu Phe Thr Asp Phe Asp Lys Tyr260 265 270
Met Thr Ile Ser Asp Glu Trp Asp Ile Pro Glu Lys Gln Pro Phe Lys275 280 285Asp Leu Gly Asn Leu Arg Tyr Trp Leu Glu Glu Ala Glu Cys Arg Asp290 295 300Gln Tyr Ser Val Ile Phe Glu Ser Gly Asp Arg Thr Ser Ile Phe Trp305 310 315 320Asn Asp Val Lys Asp Pro Val Ser Ile Glu Glu Arg Ala Arg Trp Thr325 330 335Glu Thr Tyr Val Arg Trp Ser Pro Lys Gly Thr Tyr Leu Ala Thr Phe340 345 350His Gln Arg Gly Ile Ala Leu Trp Gly Gly Glu Lys Phe Lys Gln Ile355 360 365Gln Arg Phe Ser His Gln Gly Val Gln Leu Ile Asp Phe Ser Pro Cys370 375 380Glu Arg Tyr Leu Val Thr Phe Ser Pro Leu Met Asp Thr Gln Asp Asp385 390 395 400Pro Gln Ala Ile Ile Ile Trp Asp Ile Leu Thr Gly His Lys Lys Arg405 410 415Gly Phe His Cys Glu Ser Ser Ala His Trp Pro Ile Phe Lys Trp Ser420 425 430His Asp Gly Lys Phe Phe Ala Arg Met Thr Leu Asp Thr Leu Ser Ile435 440 445Tyr Glu Thr Pro Ser Met Gly Leu Leu Asp Lys Lys Ser Leu Lys Ile450 455 460Ser Gly Ile Lys Asp Phe Ser Trp Ser Pro Gly Gly Asn Ile Ile Ala465 470 475 480Phe Trp Val Pro Glu Asp Lys Asp Ile Pro Ala Arg Val Thr Leu Met485 490 495Gln Leu Pro Thr Arg Gln Glu Ile Arg Val Arg Asn Leu Phe Asn Val500 505 510Val Asp Cys Lys Leu His Trp Gln Lys Asn Gly Asp Tyr Leu Cys Val515 520 525
Lys Val Asp Arg Thr Pro Lys Gly Thr Gln Gly Val Val Thr Asn Phe530 535 540Glu Ile Phe Arg Met Arg Glu Lys Gln Val Pro Val Asp Val Val Glu545 550 555 560Met Lys Glu Thr Ile Ile Ala Phe Ala Trp Glu Pro Asn Gly Ser Lys565 570 575Phe Ala Val Leu His Gly Glu Ala Pro Arg Ile Ser Val Ser Phe Tyr580 585 590His Val Lys Asn Asn Gly Lys Ile Glu Leu Ile Lys Met Phe Asp Lys595 600 605Gln Gln Ala Asn Thr Ile Phe Trp Ser Pro Gln Gly Gln Phe Val Val610 615 620Leu Ala Gly Leu Arg Ser Met Asn Gly Ala Leu Ala Phe Val Asp Thr625 630 635 640Ser Asp Cys Thr Val Met Asn Ile Ala Glu His Tyr Met Ala Ser Asp645 650 655Val Glu Trp Asp Pro Thr Gly Arg Tyr Val Val Thr Ser Val Ser Trp660 665 670Trp Ser His Lys Val Asp Asn Ala Tyr Trp Leu Trp Thr Phe Gln Gly675 680 685Arg Leu Leu Gln Lys Asn Asn Lys Asp Arg Phe Cys Gln Leu Leu Trp690 695 700Arg Pro Arg Pro Pro Thr Leu Leu Ser Gln Glu Gln Ile Lys Gln Ile705 710 715 720Lys Lys Asp Leu Lys Lys Tyr Ser Lys Ile Phe Glu Gln Lys Asp Arg725 730 735Leu Ser Gln Ser Lys Ala Ser Lys Glu Leu Val Glu Arg Arg Arg Thr740 745 750Met Met Glu Asp Phe Arg Lys Tyr Arg Lys Met Ala Gln Glu Leu Tyr755 760 765
Met Glu Gln Lys Asn Glu Arg Leu Glu Leu Arg Gly Gly Val Asp Thr770 775 780Asp Glu Leu Asp Ser Asn Val Asp Asp Trp Glu Glu Glu Thr Ile Glu785 790 795 800Phe Phe Val Thr Glu Glu Ile Ile Pro Leu Gly Asn Gln Glu805 810<210>162<211>461<212>PRT<213>人<300>
<308>sw_hum/ncb1_human<309>1993-07-01<400>162Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu1 5 10 15Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly20 25 30Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly35 40 45Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr50 55 60Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile65 70 75 80Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val85 90 95Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg100 105 110Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln115 120 125Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln130 135 140Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr145 150 155 160
Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe165 170 175Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu180 185 190Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu195 200 205Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser210 215 220Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro225 230 235 240Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser245 250 255Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu260 265 270Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu275 280 285Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val290 295 300Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser305 310 315 320Thr Gln Arg Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val325 330 335Glu Met His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu340 345 350Glu Leu Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu355 360 365Ser Gln Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala370 375 380Lys Lys Arg Glu Leu Leu Leu Ala Val Leu His Met Glu Gln Gln Lys385 390 395 400Gln Gln Gln Gln Gln Gln Gln Gly His Lys Ala Pro Ala Ala His Pro
405 410 415Glu Gly Gln Leu Lys Phe His Pro Asp Thr Asp Asp Val Pro Val Pro420 425 430Ala Pro Ala Gly Asp Gln Lys Glu Val Asp Thr Ser Glu Lys Lys Leu435 440 445Leu Glu Arg Leu Pro Glu Val Glu Val Pro Gln His Leu450 455 460<210>163<211>297<212>PRT<213>人<300>
<308>sw_hum/y33k_human<309>1996-10-01<400>163Met Ala Glu Leu Thr Ala Leu Glu Ser Leu Ile Glu Met Gly Phe Pro15 10 15Arg Gly Arg Ala Glu Lys Ala Leu Ala Leu Thr Gly Asn Gln Gly Ile20 25 30Glu Ala Ala Met Asp Trp Leu Met Glu His Glu Asp Asp Pro Asp Val35 40 45Asp Glu Pro Leu Glu Thr Pro Leu Gly His Ile Leu Gly Arg Glu Pro50 55 60Thr Ser Ser Glu Gln Gly Gly Leu Glu Gly Ser Gly Ser Ala Ala Gly65 70 75 80Glu Gly Lys Pro Ala Leu Ser Glu Glu Glu Arg Gln Glu Gln Thr Lys85 90 95Arg Met Leu Glu Leu Val Ala Gln Lys Gln Arg Glu Arg Glu Glu Arg100 105 110Glu Glu Arg Glu Ala Leu Glu Arg Glu Arg Gln Arg Arg Arg Gln Gly115 120 125Gln Glu Leu Ser Ala Ala Arg Gln Arg Leu Gln Glu Asp Glu Met Arg130 135 140
Arg Ala Ala Glu Glu Arg Arg Arg Glu Lys Ala Glu Glu Leu Ala Ala145 150 155 160Arg Gln Arg Val Arg Glu Lys Ile Glu Arg Asp Lys Ala Glu Arg Ala165 170 175Lys Lys Tyr Gly Gly Ser Val Gly Ser Gln Pro Pro Pro Val Ala Pro180 185 190Glu Pro Gly Pro Val Pro Ser Ser Pro Ser Gln Glu Pro Pro Thr Lys195 200 205Arg Glu Tyr Asp Gln Cys Arg Ile Gln Val Arg Leu Pro Asp Gly Thr210 215 220Ser Leu Thr Gln Thr Phe Arg Ala Arg Glu Gln Leu Ala Ala Val Arg225 230 235 240Leu Tyr Val Glu Leu His Arg Gly Glu Glu Leu Gly Gly Gly Gln Asp245 250 255Pro Val Gln Leu Leu Ser Gly Phe Pro Arg Arg Ala Phe Ser Glu Ala260 265 270Asp Met Glu Arg Pro Leu Gln Glu Leu Gly Leu Val Pro Ser Ala Val275 280 285Leu Ile Val Ala Lys Lys Cys Pro Ser290 295<210>164<211>354<212>PRT<213>人<300>
<308>sw_hum/hem6_human<309>1994-06-01<400>164Met Leu Pro Lys Thr Ser Gly Thr Arg Ala Thr Ser Leu Gly Arg Pro1 5 10 15Glu Glu Glu Glu Asp Glu Leu Ala His Arg Cys Ser Ser Phe Met Ala20 25 30Pro Pro Val Thr Asp Leu Gly Glu Leu Arg Arg Arg Pro Gly Asp Met35 40 45
Lys Thr Lys Met Glu Leu Leu Ile Leu Glu Thr Gln Ala Gln Val Cys50 55 60Gln Ala Leu Ala Gln Val Asp Gly Gly Ala Asn Phe Ser Val Asp Arg65 70 75 80Trp Glu Arg Lys Glu Gly Gly Gly Gly Ile Ser Cys Val Leu Gln Asp85 90 95Gly Cys Val Phe Glu Lys Ala Gly Val Ser Ile Ser Val Val His Gly100 105 110Asn Leu Ser Glu Glu Ala Ala Lys Gln Met Arg Ser Arg Gly Lys Val115 120 125Leu Lys Thr Lys Asp Gly Lys Leu Pro Phe Cys Ala Met Gly Val Ser130 135 140Ser Val Thr His Pro Lys Asn Pro His Ala Pro Thr Ile His Phe Asn145 150 155 160Tyr Arg Tyr Phe Glu Val Glu Glu Ala Asp Gly His Lys Gln Trp Trp165 170 175Phe Gly Gly Gly Cys Asp Leu Thr Pro Thr Tyr Leu Asn Gln Glu Asp180 185 190Ala Val His Phe His Arg Thr Leu Lys Glu Ala Cys Asp Gln His Gly195 200 205Pro Asp Leu Tyr Pro Lys Phe Lys Lys Trp Cys Asp Asp Tyr Phe Phe210 215 220Ile Ala His Arg Gly Glu Arg Arg Gly Ile Gly Gly Ile Phe Phe Asp225 230 235 240Asp Leu Asp Ser Pro Ser Lys Glu Glu Val Phe Arg Phe Val Gln Ser245 250 255Cys Ala Arg Ala Val Val Pro Ser Tyr Ile Pro Leu Val Lys Lys His260 265 270Cys Asp Asp Ser Phe Thr Pro Gln Glu Lys Leu Trp Gln Gln Leu Arg275 280 285Arg Gly Arg Tyr Val Glu Phe Asn Leu Leu Tyr Asp Arg Gly Thr Lys
290 295 300Phe Gly Leu Phe Thr Pro Gly Ser Arg Ile Glu Ser Ile Leu Met Ser305 310 315 320Leu Pro Leu Thr Ala Arg Trp Glu Tyr Met His Ser Pro Ser Glu Asn325 330 335Ser Lys Glu Ala Glu Ile Leu Glu Val Leu Arg His Pro Arg Asp Trp340 345 350Val Arg<210>165<211>397<212>PRT<213>人<300>
<308>sw_hum/thim_human<309>1995-11-01<400>165Met Arg Leu Leu Arg Gly Val Phe Val Val Ala Ala Lys Arg Thr Pro1 5 10 15Phe Gly Ala Tyr Gly Gly Leu Leu Lys Asp Phe Thr Ala Thr Asp Leu20 25 30Ser Glu Phe Ala Ala Lys Ala Ala Leu Ser Ala Gly Lys Val Ser Pro35 40 45Glu Thr Val Asp Ser Val Ile Met Gly Asn Val Leu Gln Ser Ser Ser50 55 60Asp Ala Ile Tyr Leu Ala Arg His Val Gly Leu Arg Val Gly Ile Pro65 70 75 80Lys Glu Thr Pro Ala Leu Thr Ile Asn Arg Leu Cys Gly Ser Gly Phe85 90 95Gln Ser Ile Val Asn Gly Cys Gln Glu Ile Cys Val Lys Glu Ala Glu100 105 110Val Val Leu Cys Gly Gly Thr Glu Ser Met Ser Gln Ala Pro Tyr Cys115 120 125
Val Arg Asn Val Arg Phe Gly Thr Lys Leu Gly Ser Asp Ile Lys Leu130 135 140Glu Asp Ser Leu Trp Val Ser Leu Thr Asp Gln His Val Gln Leu Pro145 150 155 160Met Ala Met Thr Ala Glu Asn Leu Thr Val Lys His Lys Ile Ser Arg165 170 175Glu Glu Cys Asp Lys Tyr Ala Leu Gln Ser Gln Gln Arg Trp Lys Ala180 185 190Ala Asn Asp Ala Gly Tyr Phe Asn Asp Glu Met Ala Pro Ile Glu Val195 200 205Lys Thr Lys Lys Gly Lys Gln Thr Met Gln Val Asp Glu His Ala Arg210 215 220Pro Gln Thr Thr Leu Glu Gln Leu Gln Lys Leu Pro Pro Val Phe Lys225 230 235 240Lys Asp Gly Thr Val Thr Ala Gly Asn Ala Ser Gly Val Ala Asp Gly245 250 255Ala Gly Ala Val Ile Ile Ala Ser Glu Asp Ala Val Lys Lys His Asn260 265 270Phe Thr Pro Leu Ala Arg Ile Val Gly Tyr Phe Val Ser Gly Cys Asp275 280 285Pro Ser Ile Met Gly Ile Gly Pro Val Pro Ala Ile Ser Gly Ala Leu290 295 300Lys Lys Ala Gly Leu Ser Leu Lys Asp Met Asp Leu Val Glu Val Asn305 310 315 320Glu Ala Phe Ala Pro Gln Tyr Leu Ala Val Glu Arg Ser Leu Asp Leu325 330 335Asp Ile Ser Lys Thr Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His340 345 350Pro Leu Gly Gly Ser Gly Ser Arg Ile Thr Ala His Leu Val His Glu355 360 365Leu Arg Arg Arg Gly Gly Lys Tyr Ala Val Gly Ser Ala Cys Ile Gly370 375 380
Gly Gly Gln Gly Ile Ala Val Ile Ile Gln Ser Thr Ala385 390 395<210>166<211>550<212>PRT<213>人<300>
<308>sw_hum/src8_human<309>1997-11-01<400>166Met Trp Lys Ala Ser Ala Gly His Ala Val Ser Ile Ala Gln Asp Asp1 5 10 15Ala Gly Ala Asp Asp Trp Glu Thr Asp Pro Asp Phe Val Asn Asp Val20 25 30Ser Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Val Gln Gly Ser Gly35 40 45His Gln Glu His Ile Asn Ile His Lys Leu Arg Glu Asn Val Phe Gln50 55 60Glu His Gln Thr Leu Lys Glu Lys Glu Leu Glu Thr Gly Pro Lys Ala65 70 75 80Ser His Gly Tyr Gly Gly Lys Phe Gly Val Glu Gln Asp Arg Met Asp85 90 95Lys Ser Ala Val Gly His Glu Tyr Gln Ser Lys Leu Ser Lys His Cys100 105 110Ser Gln Val Asp Ser Val Arg Gly Phe Gly Gly Lys Phe Gly Val Gln115 120 125Met Asp Arg Val Asp Gln Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys130 135 140Thr Glu Lys His Ala Ser Gln Lys Asp Tyr Ser Ser Gly Phe Gly Gly145 150 155 160Lys Tyr Gly Val Gln Ala Asp Arg Val Asp Lys Ser Ala Val Gly Phe165 170 175Asp Tyr Gln Gly Lys Thr Glu Lys His Glu Ser Gln Arg Asp Tyr Ser
180 185 190Lys Gly Phe Gly Gly Lys Tyr Gly Ile Asp Lys Asp Lys Val Asp Lys195 200 205Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys Thr Glu Lys His Glu Ser210 215 220Gln Lys Asp Tyr Val Lys Gly Phe Gly Gly Lys Phe Gly Val Gln Thr225 230 235 240Asp Arg Gln Asp Lys Cys Ala Leu Gly Trp Asp His Gln Glu Lys Leu245 250 255Gln Leu His Glu Ser Gln Lys Asp Tyr Lys Thr Gly Phe Gly Gly Lys260 265 270Phe Gly Val Gln Ser Glu Arg Gln Asp Ser Ala Ala Val Gly Phe Asp275 280 285Tyr Lys Glu Lys Leu Ala Lys His Glu Ser Gln Gln Asp Tyr Ser Lys290 295 300Gly Phe Gly Gly Lys Tyr Gly Val Gln Lys Asp Arg Met Asp Lys Asn305 310 315 320Ala Ser Thr Phe Glu Asp Val Thr Gln Val Ser Ser Ala Tyr Gln Lys325 330 335Thr Val Pro Val Glu Ala Val Thr Ser Lys Thr Ser Asn Ile Arg Ala340 345 350Asn Phe Glu Asn Leu Ala Lys Glu Lys Glu Gln Glu Asp Arg Arg Lys355 360 365Ala Glu Ala Glu Arg Ala Gln Arg Met Ala Lys Glu Arg Gln Glu Gln370 375 380Glu Glu Ala Arg Arg Lys Leu Glu Glu Gln Ala Arg Ala Lys Thr Gln385 390 395 400Thr Pro Pro Val Ser Pro Ala Pro Gln Pro Thr Glu Glu Arg Leu Pro405 410 415Ser Ser Pro Val Tyr Glu Asp Ala Ala Ser Phe Lys Ala Glu Leu Ser420 425 430
Tyr Arg Gly Pro Val Ser Gly Thr Glu pro Glu Pro Val Tyr Ser Met435 440 445Glu Ala Ala Asp Tyr Arg Glu Ala Ser Ser Gln Gln Gly Leu Ala Tyr450 455 460Ala Thr Glu Ala Val Tyr Glu Ser Ala Glu Ala Pro Gly His Tyr Pro465 470 475 480Ala Glu Asp Ser Thr Tyr Asp Glu Tyr Glu Asn Asp Leu Gly Tyr Thr485 490 495Ala Val Ala Leu Tyr Asp Tyr Gln Ala Ala Gly Asp Asp Glu Ile Ser500 505 510Phe Asp Pro Asp Asp Ile Ile Thr Asn Ile Glu Met Ile Asp Asp Gly515 520 525Trp Trp Arg Gly Val Cys Lys Gly Arg Tyr Gly Leu Phe Pro Ala Asn530 535 540Tyr Val Glu Leu Arg Gln545 550<210>167<211>223<212>PRT<213>人<300>
<308>sw_hum/kad4_human<309>1992-08-01<400>167Met Ala Ser Lys Leu Leu Arg Ala Val Ile Leu Gly Pro Pro Gly Ser1 5 10 15Gly Lys Gly Thr Val Cys Gln Arg Ile Ala Gln Asn Phe Gly Leu Gln20 25 30His Leu Ser Ser Gly His Phe Leu Arg Glu Asn Ile Lys Ala Ser Thr35 40 45Glu Val Gly Glu Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val50 55 60Pro Asp His Val Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg65 70 75 80
Arg Gly Gln His Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln85 90 95Ala Glu Ala Leu Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu100 105 110Asn Ile Pro Phe Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile115 120 125His Pro Pro Ser Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His130 135 140Val His Gly Ile Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu145 150 155 160Asp Asp Lys Pro Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp165 170 175Val Ala Lys Pro Val Ile Glu Leu Tyr Lys Ser Arg Gly Val Leu His180 185 190Gln Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val Tyr Thr195 200 205Leu Phe Ser Asn Lys Ile Thr Pro Ile Gln Ser Lys Glu Ala Tyr210 215 220<210>168<211>189<212>PRT<213>人<300>
<308>humangp/chr12-q9nrv9<309>2003-04-22<400>168Met Leu Gly Met Ile Lys Asn Ser Leu Phe Gly Ser Val Glu Thr Trp1 5 10 15Pro Trp Gln Val Leu Ser Lys Gly Asp Lys Glu Glu Val Ala Tyr Glu20 25 30Glu Arg Ala Cys Glu Gly Gly Lys Phe Ala Thr Val Glu Val Thr Asp35 40 45Lys Pro Val Asp Glu Ala Leu Arg Glu Ala Met Pro Lys Val Ala Lys
50 55 60Tyr Ala Gly Gly Thr Asn Asp Lys Gly Ile Gly Met Gly Met Thr Val65 70 75 80Pro Ile Ser Phe Ala Val Phe Pro Asn Glu Asp Gly Ser Leu Gln Lys85 90 95Lys Leu Lys Val Trp Phe Arg Ile Pro Asn Gln Phe Gln Ser Asp Pro100 105 110Pro Ala Pro Ser Asp Lys Ser Val Lys Ile Glu Glu Arg Glu Gly Ile115 120 125Thr Val Tyr Ser Met Gln Phe Gly Gly Tyr Ala Lys Glu Ala Asp Tyr130 135 140Val Ala Gln Ala Thr Arg Leu Arg Ala Ala Leu Glu Gly Thr Ala Thr145 150 155 160Tyr Arg Gly Asp Ile Tyr Phe Cys Thr Gly Tyr Asp Pro Pro Met Lys165 170 175Pro Tyr Gly Arg Arg Asn Glu Ile Trp Leu Leu Lys Thr180 185<210>169<211>1404<212>PRT<213>人<300>
<308>humangp/chr12-q14221<309>2003-04-22<400>169Gln Thr Pro Gly Arg Val Gly Ser Gln Gly Ser Asp Leu Asp Ser Ser1 5 10 15Ala Thr Pro Ile Asn Thr Val Asp Val Asn Asn Glu Ser Ser Ser Glu20 25 30Gly Phe Ile Cys Pro Gln Cys Met Lys Ser Leu Gly Ser Ala Asp Glu35 40 45Leu Phe Lys His Tyr Glu Ala Val His Asp Ala Gly Asn Asp Ser Gly50 55 60
His Gly Gly Glu Ser Asn Leu Ala Leu Lys Arg Asp Asp Val Thr Leu65 70 75 80Leu Arg Gln Glu Val Gln Asp Leu Gln Ala Ser Leu Lys Glu Glu Lys85 90 95Trp Tyr Ser Glu Glu Leu Lys Lys Glu Leu Glu Lys Tyr Gln Gly Leu100 105 110Gln Gln Gln Glu Ala Lys Pro Asp Gly Leu Val Thr Asp Ser Ser Ala115 120 125Glu Leu Gln Ser Leu Glu Gln Gln Leu Glu Glu Ala Gln Thr Glu Asn130 135 140Phe Asn Ile Lys Gln Met Lys Asp Leu Phe Glu Gln Lys Ala Ala Gln145 150 155 160Leu Ala Thr Glu Ile Ala Asp Ile Lys Ser Lys Tyr Asp Glu Glu Arg165 170 175Ser Leu Arg Glu Ala Ala Glu Gln Lys Val Thr Arg Leu Thr Glu Glu180 185 190Leu Asn Lys Glu Ala Thr Val Ile Gln Asp Leu Lys Thr Glu Leu Leu195 200 205Gln Arg Pro Gly Ile Glu Asp Val Ala Val Leu Lys Lys Glu Leu Val210 215 220Gln Val Gln Thr Leu Met Asp Asn Met Thr Leu Glu Arg Glu Arg Glu225 230 235 240Ser Glu Lys Leu Lys Asp Glu Cys Lys Lys Leu Gln Ser Gln Tyr Ala245 250 255Ser Ser Glu Ala Thr Ile Ser Gln Leu Arg Ser Glu Leu Ala Lys Gly260 265 270Pro Gln Glu Val Ala Val Tyr Val Gln Glu Leu Gln Lys Leu Lys Ser275 280 285Ser Val Asn Glu Leu Thr Gln Lys Asn Gln Thr Leu Thr Glu Asn Leu290 295 300Leu Lys Lys Glu Gln Asp Tyr Thr Lys Leu Glu Glu Lys His Asn Glu305 310 315 320
Glu Ser Val Ser Lys Lys Asn Ile Gln Ala Thr Leu His Gln Lys Asp325 330 335Leu Asp Cys Gln Gln Leu Gln Ser Arg Leu Ser Ala Ser Glu Thr Ser340 345 350Leu His Arg Ile His Val Glu Leu Ser Glu Lys Gly Glu Ala Thr Gln355 360 365Lys Leu Lys Glu Glu Leu Ser Glu Val Glu Thr Lys Tyr Gln His Leu370 375 380Lys Ala Glu Phe Lys Gln Leu Gln Gln Gln Arg Glu Glu Lys Glu Gln385 390 395 400His Gly Leu Gln Leu Gln Ser Glu Ile Asn Gln Leu His Ser Lys Leu405 410 415Leu Glu Thr Glu Arg Gln Leu Gly Glu Ala His Gly Arg Leu Lys Glu420 425 430Gln Arg Gln Leu Ser Ser Glu Lys Leu Met Asp Lys Glu Gln Gln Val435 440 445Ala Asp Leu Gln Leu Lys Leu Ser Arg Leu Glu Glu Gln Leu Lys Glu450 455 460Lys Val Thr Asn Ser Thr Glu Leu Gln His Gln Leu Asp Lys Thr Lys465 470 475 480Gln Gln His Gln Glu Gln Gln Ala Leu Gln Gln Ser Thr Thr Ala Lys485 490 495Leu Arg Glu Ala Gln Asn Asp Leu Glu Gln Val Leu Arg Gln Ile Gly500 505 510Asp Lys Asp Gln Lys Ile Gln Asn Leu Glu Ala Leu Leu Gln Lys Ser515 520 525Lys Glu Asn Ile Ser Leu Leu Glu Lys Glu Arg Glu Asp Leu Tyr Ala530 535 540Lys Ile Gln Ala Gly Glu Gly Glu Thr Ala Val Leu Asn Gln Leu Gln545 550 555 560
Glu Lys Asn His Thr Leu Gln Glu Gln Val Thr Gln Leu Thr Glu Lys565 570 575Leu Lys Asn Gln Ser Glu Ser His Lys Gln Ala Gln Glu Asn Leu His580 585 590Asp Gln Val Gln Glu Gln Lys Ala His Leu Arg Ala Ala Gln Asp Arg595 600 605Val Leu Ser Leu Glu Thr Ser Val Asn Glu Leu Asn Ser Gln Leu Asn610 615 620Glu Ser Lys Glu Lys Val Ser Gln Leu Asp Ile Gln Ile Lys Ala Lys625 630 635 640Thr Glu Leu Leu Leu Ser Ala Glu Ala Ala Lys Thr Ala Gln Arg Ala645 650 655Asp Leu Gln Asn His Leu Asp Thr Ala Gln Asn Ala Leu Gln Asp Lys660 665 670Gln Gln Glu Leu Asn Lys Ile Thr Thr Gln Leu Asp Gln Val Thr Ala675 680 685Lys Leu Gln Asp Lys Gln Glu His Cys Ser Gln Leu Glu Ser His Leu690 695 700Lys Glu Tyr Lys Glu Lys Tyr Leu Ser Leu Glu Gln Lys Thr Glu Glu705 710 715 720Leu Glu Gly Gln Ile Lys Lys Leu Glu Ala Asp Ser Leu Glu Val Lys725 730 735Ala Ser Lys Glu Gln Ala Leu Gln Asp Leu Gln Gln Gln Arg Gln Leu740 745 750Asn Thr Asp Leu Glu Leu Arg Ala Thr Glu Leu Ser Lys Gln Leu Glu755 760 765Met Glu Lys Glu Ile Val Ser Ser Thr Arg Leu Asp Leu Gln Lys Lys770 775 780Ser Glu Ala Leu Glu Ser Ile Lys Gln Lys Leu Thr Lys Gln Glu Glu785 790 795 800Glu Lys Lys Ile Leu Lys Gln Asp Phe Glu Thr Leu Ser Gln Glu Thr805 810 815
Lys Ile Gln His Glu Glu Leu Asn Asn Arg Ile Gln Thr Thr Val Thr820 825 830Glu Leu Gln Lys Val Lys Met Glu Lys Glu Ala Leu Met Thr Glu Leu835 840 845Ser Thr Val Lys Asp Lys Leu Ser Lys Val Ser Asp Ser Leu Lys Asn850 855 860Ser Lys Ser Glu Phe Glu Lys Glu Asn Gln Lys Gly Lys Ala Ala Ile865 870 875 880Leu Asp Leu Glu Lys Thr Cys Lys Glu Leu Lys His Gln Leu Gln Val885 890 895Gln Met Glu Asn Thr Leu Lys Glu Gln Lys Glu Leu Lys Lys Ser Leu900 905 910Glu Lys Glu Lys Glu Ala Ser His Gln Leu Lys Leu Glu Leu Asn Ser915 920 925Met Gln Glu Gln Leu Ile Gln Ala Gln Asn Thr Leu Lys Gln Asn Glu930 935 940Lys Glu Glu Gln Gln Leu Gln Gly Asn Ile Asn Glu Leu Lys Gln Ser945 950 955 960Ser Glu Gln Lys Lys Lys Gln Ile Glu Ala Leu Gln Gly Glu Leu Lys965 970 975Ile Ala Val Leu Gln Lys Thr Glu Leu Glu Asn Lys Leu Gln Gln Gln980 985 990Leu Thr Gln Ala Ala Gln Glu Leu Ala Ala Glu Lys Glu Lys Ile Ser995 1000 1005Val Leu Gln Asn Asn Tyr Glu Lys Ser Gln Glu Thr Phe Lys Gln1010 1015 1020Leu Gln Ser Asp Phe Tyr Gly Arg Glu Ser Glu Leu Leu Ala Thr1025 1030 1035Arg Gln Asp Leu Lys Ser Val Glu Glu Lys Leu Ser Leu Ala Gln1040 1045 1050
Glu Asp Leu Ile Ser Asn Arg Asn Gln Ile Gly Asn Gln Asn Lys1055 1060 1065Leu Ile Gln Glu Leu Lys Thr Ala Lys Ala Thr Leu Glu Gln Asp1070 1075 1080Ser Ala Lys Lys Glu Gln Gln Leu Gln Glu Arg Cys Lys Ala Leu1085 1090 1095Gln Asp Ile Gln Lys Glu Lys Ser Leu Lys Glu Lys Glu Leu Val1100 1105 1110Asn Glu Lys Ser Lys Leu Ala Glu Ile Glu Glu Ile Lys Cys Arg1115 1120 1125Gln Glu Lys Glu Ile Thr Lys Leu Asn Glu Glu Leu Lys Ser His1130 1135 1140Lys Leu Glu Ser Ile Lys Glu Ile Thr Asn Leu Lys Asp Ala Lys1145 1150 1155Gln Leu Leu Ile Gln Gln Lys Leu Glu Leu Gln Gly Lys Ala Asp1160 1165 1170Ser Leu Lys Ala Ala Val Glu Gln Glu Lys Arg Asn Gln Gln Ile1175 1180 1185Leu Lys Asp Gln Val Lys Lys Glu Glu Glu Glu Leu Lys Lys Glu1190 1195 1200Phe Ile Glu Lys Glu Ala Lys Leu His Ser Glu Ile Lys Glu Lys1205 1210 1215Glu Val Gly Met Lys Lys His Glu Glu Asn Glu Ala Lys Leu Thr1220 1225 1230Met Gln Ile Thr Ala Leu Asn Glu Asn Leu Gly Thr Val Lys Lys1235 1240 1245Glu Trp Gln Ser Ser Gln Arg Arg Val Ser Glu Leu Glu Lys Gln1250 1255 1260Thr Asp Asp Leu Arg Gly Glu Ile Ala Val Leu Glu Ala Thr Val1265 1270 1275Gln Asn Asn Gln Asp Glu Arg Arg Ala Leu Leu Glu Arg Cys Leu1280 1285 1290
Lys Gly Glu Gly Glu Ile Glu Lys Leu Gln Thr Lys Val Leu Glu1295 1300 1305Leu Gln Arg Lys Leu Asp Asn Thr Thr Ala Ala Val Gln Glu Leu1310 1315 1320Gly Arg Glu Asn Gln Ser Leu Gln Ile Lys His Thr Gln Ala Leu1325 1330 1335Asn Arg Lys Trp Ala Glu Asp Asn Glu Val Gln Asn Cys Met Ala1340 1345 1350Cys Gly Lys Gly Phe Ser Val Thr Val Arg Arg His His Cys Arg1355 1360 1365Gln Cys Gly Asn Ile Phe Cys Ala Glu Cys Ser Ala Lys Asn Ala1370 1375 1380Leu Thr Pro Ser Ser Lys Lys Pro Val Arg Val Cys Asp Ala Cys1385 1390 1395Phe Asn Asp Leu Gln Gly1400<210>170<211>376<212>PRT<213>人<300>
<308>sw_hum/myg1_human<309>2001-10-16<400>170Met Gly His Arg Phe Leu Arg Gly Leu Leu Thr Leu Leu Leu Pro Pro1 5 10 15Pro Pro Leu Tyr Thr Arg His Arg Met Leu Gly Pro Glu Ser Val Pro20 25 30Pro Pro Lys Arg Ser Arg Ser Lys Leu Met Ala Pro Pro Arg Ile Gly35 40 45Thr His Asn Gly Thr Phe His Cys Asp Glu Ala Leu Ala Cys Ala Leu50 55 60Leu Arg Leu Leu Pro Glu Tyr Arg Asp Ala Glu Ile Val Arg Thr Arg
65 70 75 80Asp Pro Glu Lys Leu Ala Ser Cys Asp Ile Val Val Asp Val Gly Gly85 90 95Glu Tyr Asp Pro Arg Arg His Arg Tyr Asp His His Gln Arg Ser Phe100 105 110Thr Glu Thr Met Ser Ser Leu Ser Pro Gly Lys Pro Trp Gln Thr Lys115 120 125Leu Ser Ser Ala Gly Leu Ile Tyr Leu His Phe Gly His Lys Leu Leu130 135 140Ala Gln Leu Leu Gly Pro Ser Glu Glu Asp Ser Met Val Gly Thr Leu145 150 155 160Tyr Asp Lys Met Tyr Glu Asn Phe Val Glu Glu Val Asp Ala Val Asp165 170 175Asn Gly Ile Ser Gln Trp Ala Glu Gly Glu Pro Arg Tyr Ala Leu Thr180 185 190Thr Thr Leu Ser Ala Arg Val Ala Arg Leu Asn Pro Thr Trp Asn His195 200 205Pro Asp Gln Asp Thr Glu Ala Gly Phe Lys Arg Ala Met Asp Leu Val210 215 220Gln Glu Glu Phe Leu Gln Arg Leu Asp Phe Tyr Gln His Ser Trp Leu225 230 235 240Pro Ala Arg Ala Leu Val Glu Glu Ala Leu Ala Gln Arg Phe Gln Val245 250 255Asp Pro Ser Gly Glu Ile Val Glu Leu Ala Lys Gly Ala Cys Pro Trp260 265 270Lys Glu His Leu Tyr His Leu Glu Ser Gly Leu Ser Pro Pro Val Ala275 280 285Ile Phe Phe Val Ile Tyr Thr Asp Gln Ala Gly Gln Trp Arg Ile Gln290 295 300Cys Val Pro Lys Glu Pro His Ser Phe Gln Ser Arg Leu Pro Leu Pro305 310 315 320
Glu Pro Trp Arg Gly Leu Arg Asp Glu Ala Leu Asp Gln Val Ser Gly325 330 335Ile Pro Gly Cys Ile Phe Val His Ala Ser Gly Phe Ile Gly Gly His340 345 350Pro Thr Arg Glu Gly Ala Leu Ser Met Ala Arg Ala Thr Leu Ala Gln355 360 365Arg Ser Tyr Leu Pro Gln Ile Ser370 375<210>171<211>525<212>PRT<213>人<300>
<308>sw_hum/mppa_human<309>1996-10-01<400>171Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly1 5 10 15Ser Trp Gly Cys Ser Arg Leu Arg Phe Gly Pro Pro Ala Tyr Arg Arg20 25 30Phe Ser Ser Gly Gly Ala Tyr Pro Asn Ile Pro Leu Ser Ser Pro Leu35 40 45Pro Gly Val Pro Lys Pro Val Phe Ala Thr Val Asp Gly Gln Glu Lys50 55 60Phe Glu Thr Lys Val Thr Thr Leu Asp Asn Gly Leu Arg Val Ala Ser65 70 75 80Gln Asn Lys Phe Gly Gln Phe Cys Thr Val Gly Ile Leu Ile Asn Ser85 90 95Gly Ser Arg Tyr Glu Ala Lys Tyr Leu Ser Gly Ile Ala His Phe Leu100 105 110Glu Lys Leu Ala Phe Ser Ser Thr Ala Arg Phe Asp Ser Lys Asp Glu115 120 125Ile Leu Leu Thr Leu Glu Lys His Gly Gly Ile Cys Asp Cys Gln Thr130 135 140
Ser Arg Asp Thr Thr Met Tyr Ala Val Ser Ala Asp Ser Lys Gly Leu145 150 155 160Asp Thr Val Val Ala Leu Leu Ala Asp Val Val Leu Gln Pro Arg Leu165 170 175Thr Asp Glu Glu Val Glu Met Thr Arg Met Ala Val Gln Phe Glu Leu180 185 190Glu Asp Leu Asn Leu Arg Pro Asp Pro Glu Pro Leu Leu Thr Glu Met195 200 205Ile His Glu Ala Ala Tyr Arg Glu Asn Thr Val Gly Leu His Arg Phe210 215 220Cys Pro Thr Glu Asn Val Ala Lys Ile Asn Arg Glu Val Leu His Ser225 230 235 240Tyr Leu Arg Asn Tyr Tyr Thr Pro Asp Arg Met Val Leu Ala Gly Val245 250 255Gly Val Glu His Glu His Leu Val Asp Cys Ala Arg Lys Tyr Leu Leu260 265 270Gly Val Gln Pro Ala Trp Gly Ser Ala Glu Ala Val Asp Ile Asp Arg275 280 285Ser Val Ala Gln Tyr Thr Gly Gly Ile Ala Lys Leu Glu Arg Asp Met290 295 300Ser Asn Val Ser Leu Gly Pro Thr Pro Ile Pro Glu Leu Thr His Ile305 310 315 320Met Val Gly Leu Glu Ser Cys Ser Phe Leu Glu Glu Asp Phe Ile Pro325 330 335Phe Ala Val Leu Asn Met Met Met Gly Gly Gly Gly Ser Phe Ser Ala340 345 350Gly Gly Pro Gly Lys Gly Met Phe Ser Arg Leu Tyr Leu Asn Val Leu355 360 365Asn Arg His His Trp Met Tyr Asn Ala Thr Ser Tyr His His Ser Tyr370 375 380
Glu Asp Thr Gly Leu Leu Cys Ile His Ala Ser Ala Asp Pro Arg Gln385 390 395 400Val Arg Glu Met Val Glu Ile Ile Thr Lys Glu Phe Ile Leu Met Gly405 410 415Gly Thr Val Asp Thr Val Glu Leu Glu Arg Ala Lys Thr Gln Leu Thr420 425 430Ser Met Leu Met Met Asn Leu Glu Ser Arg Pro Val Ile Phe Glu Asp435 440 445Val Gly Arg Gln Val Leu Ala Thr Arg Ser Arg Lys Leu Pro His Glu450 455 460Leu Cys Thr Leu Ile Arg Asn Val Lys Pro Glu Asp Val Lys Arg Val465 470 475 480Ala Ser Lys Met Leu Arg Gly Lys Pro Ala Val Ala Ala Leu Gly Asp485 490 495Leu Thr Asp Leu Pro Thr Tyr Glu His Ile Gln Thr Ala Leu Ser Ser500 505 510Lys Asp Gly Arg Leu Pro Arg Thr Tyr Arg Leu Phe Arg515 520 525<210>172<211>422<212>PRT<213>人<300>
<308>sw_hum/psdb_human<309>2003-02-28<400>172Met Ala Ala Ala Ala Val Val Glu Phe Gln Arg Ala Gln Ser Leu Leu1 5 10 15Ser Thr Asp Arg Glu Ala Ser Ile Asp Ile Leu His Ser Ile Val Lys20 25 30Arg Asp Ile Gln Glu Asn Asp Glu Glu Ala Val Gln Val Lys Glu Gln35 40 45Ser Ile Leu Glu Leu Gly Ser Leu Leu Ala Lys Thr Gly Gln Ala Ala50 55 60
Glu Leu Gly Gly Leu Leu Lys Tyr Val Arg Pro Phe Leu Asn Ser Ile65 70 75 80Ser Lys Ala Lys Ala Ala Arg Leu Val Arg Ser Leu Leu Asp Leu Phe85 90 95Leu Asp Met Glu Ala Ala Thr Gly Gln Glu Val Glu Leu Cys Leu Glu100 105 110Cys Ile Glu Trp Ala Lys Ser Glu Lys Arg Thr Phe Leu Arg Gln Ala115 120 125Leu Glu Ala Arg Leu Val Ser Leu Tyr Phe Asp Thr Lys Arg Tyr Gln130 135 140Glu Ala Leu His Leu Gly Ser Gln Leu Leu Arg Glu Leu Lys Lys Met145 150 155 160Asp Asp Lys Ala Leu Leu Val Glu Val Gln Leu Leu Glu Ser Lys Thr165 170 175Tyr His Ala Leu Ser Asn Leu Pro Lys Ala Arg Ala Ala Leu Thr Ser180 185 190Ala Arg Thr Thr Ala Asn Ala Ile Tyr Cys Pro Pro Lys Leu Gln Ala195 200 205Thr Leu Asp Met Gln Ser Gly Ile Ile His Ala Ala Glu Glu Lys Asp210 215 220Trp Lys Thr Ala Tyr Ser Tyr Phe Tyr Glu Ala Phe Glu Gly Tyr Asp225 230 235 240Ser Ile Asp Ser Pro Lys Ala Ile Thr Ser Leu Lys Tyr Met Leu Leu245 250 255Cys Lys Ile Met Leu Asn Thr Pro Glu Asp Val Gln Ala Leu Val Ser260 265 270Gly Lys Leu Ala Leu Arg Tyr Ala Gly Arg Gln Thr Glu Ala Leu Lys275 280 285Cys Val Ala Gln Ala Ser Lys Asn Arg Ser Leu Ala Asp Phe Glu Lys290 295 300Ala Leu Thr Asp Tyr Arg Ala Glu Leu Arg Asp Asp Pro Ile Ile Ser
305 310 315 320Thr His Leu Ala Lys Leu Tyr Asp Asn Leu Leu Glu Gln Asn Leu Ile325 330 335Arg Val Ile Glu Pro Phe Ser Arg Val Gln Ile Glu His Ile Ser Ser340 345 350Leu Ile Lys Leu Ser Lys Ala Asp Val Glu Arg Lys Leu Ser Gln Met355 360 365Ile Leu Asp Lys Lys Phe His Gly Ile Leu Asp Gln Gly Glu Gly Val370 375 380Leu Ile Ile Phe Asp Glu Pro Pro Val Asp Lys Thr Tyr Glu Ala Ala385 390 395 400Leu Glu Thr Ile Gln Asn Met Ser Lys Val Val Asp Ser Leu Tyr Asn405 410 415Lys Ala Lys Lys Leu Thr420<210>173<211>421<212>PRT<213>人<300>
<308>sw_hum/acdm_human<309>1989-07-01<400>173Met Ala Ala Gly Phe Gly Arg Cys Cys Arg Val Leu Arg Ser Ile Ser1 5 10 15Arg Phe His Trp Arg Ser Gln His Thr Lys Ala Asn Arg Gln Arg Glu20 25 30Pro Gly Leu Gly Phe Ser Phe Glu Phe Thr Glu Gln Gln Lys Glu Phe35 40 45Gln Ala Thr Ala Arg Lys Phe Ala Arg Glu Glu Ile Ile Pro Val Ala50 55 60Ala Glu Tyr Asp Lys Thr Gly Glu Tyr Pro Val Pro Leu Ile Arg Arg65 70 75 80
Ala Trp Glu Leu Gly Leu Met Asn Thr His Ile Pro Glu Asn Cys Gly85 90 95Gly Leu Gly Leu Gly Thr Phe Asp Ala Cys Leu Ile Ser Glu Glu Leu100 105 110Ala Tyr Gly Cys Thr Gly Val Gln Thr Ala Ile Glu Gly Asn Ser Leu115 120 125Gly Gln Met Pro Ile Ile Ile Ala Gly Asn Asp Gln Gln Lys Lys Lys130 135 140Tyr Leu Gly Arg Met Thr Glu Glu Pro Leu Met Cys Ala Tyr Cys Val145 150 155 160Thr Glu Pro Gly Ala Gly Ser Asp Val Ala Gly Ile Lys Thr Lys Ala165 170 175Glu Lys Lys Gly Asp Glu Tyr Ile Ile Asn Gly Gln Lys Met Trp Ile180 185 190Thr Asn Gly Gly Lys Ala Asn Trp Tyr Phe Leu Leu Ala Arg Ser Asp195 200 205Pro Asp Pro Lys Ala Pro Ala Asn Lys Ala Phe Thr Gly Phe Ile Val210 215 220Glu Ala Asp Thr Pro Gly Ile Gln Ile Gly Arg Lys Glu Leu Asn Met225 230 235 240Gly Gln Arg Cys Ser Asp Thr Arg Gly Ile Val Phe Glu Asp Val Lys245 250 255Val Pro Lys Glu Asn Val Leu Ile Gly Asp Gly Ala Gly Phe Lys Val260 265 270Ala Met Gly Ala Phe Asp Lys Thr Arg Pro Val Val Ala Ala Gly Ala275 280 285Val Gly Leu Ala Gln Arg Ala Leu Asp Glu Ala Thr Lys Tyr Ala Leu290 295 300Glu Arg Lys Thr Phe Gly Lys Leu Leu Val Glu His Gln Ala Ile Ser305 310 315 320Phe Met Leu Ala Glu Met Ala Met Lys Val Glu Leu Ala Arg Met Ser325 330 335
Tyr Gln Arg Ala Ala Trp Glu Val Asp Ser Gly Arg Arg Asn Thr Tyr340 345 350Tyr Ala Ser Ile Ala Lys Ala Phe Ala Gly Asp Ile Ala Asn Gln Leu355 360 365Ala Thr Asp Ala Val Gln Ile Leu Gly Gly Asn Gly Phe Asn Thr Glu370 375 380Tyr Pro Val Glu Lys Leu Met Arg Asp Ala Lys Ile Tyr Gln Ile Tyr385 390 395 400Glu Gly Thr Ser Gln Ile Gln Arg Leu Ile Val Ala Arg Glu His Ile405 410 415Asp Lys Tyr Lys Asn420<210>174<211>333<212>PRT<213>人<300>
<308>sw_hum/gipc_human<309>2001-10-16<400>174Met Pro Leu Gly Leu Gly Arg Arg Lys Lys Ala Pro Pro Leu Val Glu1 5 10 15Asn Glu Glu Ala Glu Pro Gly Arg Gly Gly Leu Gly Val Gly Glu Pro20 25 30Gly Pro Leu Gly Gly Gly Gly Ser Gly Gly Pro Gln Met Gly Leu Pro35 40 45Pro Pro Pro Pro Ala Leu Arg Pro Arg Leu Val Phe His Thr Gln Leu50 55 60Ala His Gly Ser Pro Thr Gly Arg Ile Glu Gly Phe Thr Asn Val Lys65 70 75 80Glu Leu Tyr Gly Lys Ile Ala Glu Ala Phe Arg Leu Pro Thr Ala Glu85 90 95Val Met Phe Cys Thr Leu Asn Thr His Lys Val Asp Met Asp Lys Leu
100 105 110Leu Gly Gly Gln Ile Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys115 120 125Gly Gln Arg Lys Glu Val Glu Val Phe Lys Ser Glu Asp Ala Leu Gly130 135 140Leu Thr Ile Thr Asp Asn Gly Ala Gly Tyr Ala Phe Ile Lys Arg Ile145 150 155 160Lys Glu Gly Ser Val Ile Asp His Ile His Leu Ile Ser Val Gly Asp165 170 175Met Ile Glu Ala Ile Asn Gly Gln Ser Leu Leu Gly Cys Arg His Tyr180 185 190Glu Val Ala Arg Leu Leu Lys Glu Leu Pro Arg Gly Arg Thr Phe Thr195 200 205Leu Lys Leu Thr Glu Pro Arg Lys Ala Phe Asp Met Ile Ser Gln Arg210 215 220Ser Ala Gly Gly Arg Pro Gly Ser Gly Pro Gln Leu Gly Thr Gly Arg225 230 235 240Gly Thr Leu Arg Leu Arg Ser Arg Gly Pro Ala Thr Val Glu Asp Leu245 250 255Pro Ser Ala Phe Glu Glu Lys Ala Ile Glu Lys Val Asp Asp Leu Leu260 265 270Glu Ser Tyr Met Gly Ile Arg Asp Thr Glu Leu Ala Ala Thr Met Val275 280 285Glu Leu Gly Lys Asp Lys Arg Asn Pro Asp Glu Leu Ala Glu Ala Leu290 295 300Asp Glu Arg Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp305 310 315 320Val Trp Gly Ala Ile Gly Asp Ala Lys Val Gly Arg Tyr325 330<210>175<211>248<212>PRT
<213>人<300>
<308>humangp/chr1-aah15403<309>2003-04-22<400>175Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val1 5 10 15Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln20 25 30Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu35 40 45Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp50 55 60Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala65 70 75 80Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn85 90 95Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu100 105 110Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu115 120 125Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu130 135 140Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln145 150 155 160Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu165 170 175Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu180 185 190Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg195 200 205Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys Leu210 215 220
Lys Cys Thr Lys Glu Glu His Leu Cys Thr Gln Arg Met Leu Asp Gln225 230 235 240Thr Leu Leu Asp Leu Asn Glu Met245<210>176<211>423<212>PRT<213>人<300>
<308>sw_gatm_human<309>1996-10-01<400>176Met Leu Arg Val Arg Cys Leu Arg Gly Gly Ser Arg Gly Ala Glu Ala1 5 10 15Val His Tyr Ile Gly Ser Arg Leu Gly Arg Thr Leu Thr Gly Trp Val20 25 30Gln Arg Thr Phe Gln Ser Thr Gln Ala Ala Thr Ala Ser Ser Arg Asn35 40 45Ser Cys Ala Ala Asp Asp Lys Ala Thr Glu Pro Leu Pro Lys Asp Cys50 55 60Pro Val Ser Ser Tyr Asn Glu Trp Asp Pro Leu Glu Glu Val Ile Val65 70 75 80Gly Arg Ala Glu Asn Ala Cys Val Pro Pro Phe Thr Ile Glu Val Lys85 90 95Ala Asn Thr Tyr Glu Lys Tyr Trp Pro Phe Tyr Gln Lys Gln Gly Gly100 105 110His Tyr Phe Pro Lys Asp His Leu Lys Lys Ala Val Ala Glu Ile Glu115 120 125Glu Met Cys Asn Ile Leu Lys Thr Glu Gly Val Thr Val Arg Arg Pro130 135 140Asp Pro Ile Asp Trp Ser Leu Lys Tyr Lys Thr Pro Asp Phe Glu Ser145 150 155 160Thr Gly Leu Tyr Ser Ala Met Pro Arg Asp Ile Leu Ile Val Val Gly
165 170 175Asn Glu Ile Ile Glu Ala Pro Met Ala Trp Arg Ser Arg Phe Phe Glu180 185 190Tyr Arg Ala Tyr Arg Ser Ile Ile Lys Asp Tyr Phe His Arg Gly Ala195 200 205Lys Trp Thr Thr Ala Pro Lys Pro Thr Met Ala Asp Glu Leu Tyr Asn210 215 220Gln Asp Tyr Pro Ile His Ser Val Glu Asp Arg His Lys Leu Ala Ala225 230 235 240Gln Gly Lys Phe Val Thr Thr Glu Phe Glu Pro Cys Phe Asp Ala Ala245 250 255Asp Phe Ile Arg Ala Gly Arg Asp Ile Phe Ala Gln Arg Ser Gln Val260 265 270Thr Asn Tyr Leu Gly Ile Glu Trp Met Arg Arg His Leu Ala Pro Asp275 280 285Tyr Arg Val His Ile Ile Ser Phe Lys Asp Pro Asn Pro Met His Ile290 295 300Asp Ala Thr Phe Asn Ile Ile Gly Pro Gly Ile Val Leu Ser Asn Pro305 310 315 320Asp Arg Pro Cys His Gln Ile Asp Leu Phe Lys Lys Ala Gly Trp Thr325 330 335Ile Ile Thr Pro Pro Thr Pro Ile Ile Pro Asp Asp His Pro Leu Trp340 345 350Met Ser Ser Lys Trp Leu Ser Met Asn Val Leu Met Leu Asp Glu Lys355 360 365Arg Val Met Val Asp Ala Asn Glu Val Pro Ile Gln Lys Met Phe Glu370 375 380Lys Leu Gly Ile Thr Thr Ile Lys Val Asn Ile Arg Asn Ala Asn Ser385 390 395 400Leu Gly Gly Gly Phe His Cys Trp Thr Cys Asp Val Arg Arg Arg Gly405 410 415
Thr Leu Gln Ser Tyr Leu Asp420<210>177<211>254<212>PRT<213>人<300>
<308>sw_hum/pse3_human<309>2001-10-16<400>177Met Ala Ser Leu Leu Lys Val Asp Gln Glu Val Lys Leu Lys Val Asp1 5 10 15Ser Phe Arg Glu Arg Ile Thr Ser Glu Ala Glu Asp Leu Val Ala Asn20 25 30Phe Phe Pro Lys Lys Leu Leu Glu Leu Asp Ser Phe Leu Lys Glu Pro35 40 45Ile Leu Asn Ile His Asp Leu Thr Gln Ile His Ser Asp Met Asn Leu50 55 60Pro Val Pro Asp Pro Ile Leu Leu Thr Asn Ser His Asp Gly Leu Asp65 70 75 80Gly Pro Thr Tyr Lys Lys Arg Arg Leu Asp Glu Cys Glu Glu Ala Phe85 90 95Gln Gly Thr Lys Val Phe Val Met Pro Asn Gly Met Leu Lys Ser Asn100 105 110Gln Gln Leu Val Asp Ile Ile Glu Lys Val Lys Pro Glu Ile Arg Leu115 120 125Leu Ile Glu Lys Cys Asn Thr Val Lys Met Trp Val Gln Leu Leu Ile130 135 140Pro Arg Ile Glu Asp Gly Asn Asn Phe Gly Val Ser Ile Gln Glu Glu145 150 155 160Thr Val Ala Glu Leu Arg Thr Val Glu Ser Glu Ala Ala Ser Tyr Leu165 170 175Asp Gln Ile Ser Arg Tyr Tyr Ile Thr Arg Ala Lys Leu Val Ser Lys180 185 190
Ile Ala Lys Tyr Pro His Val Glu Asp Tyr Arg Arg Thr Val Thr Glu195 200 205Ile Asp Glu Lys Glu Tyr Ile Ser Leu Arg Leu Ile Ile Ser Glu Leu210 215 220Arg Asn Gln Tyr Val Thr Leu His Asp Met Ile Leu Lys Asn Ile Glu225 230 235 240Lys Ile Lys Arg Pro Arg Ser Ser Asn Ala Glu Thr Leu Tyr245 250<210>178<211>315<212>PRT<213>人<300>
<308>sw_hum/calu_human<309>1999-07-15<400>178Met Asp Leu Arg Gln Phe Leu Met Cys Leu Ser Leu Cys Thr Ala Phe1 5 10 15Ala Leu Ser Lys Pro Thr Glu Lys Lys Asp Arg Val His His Glu Pro20 25 30Gln Leu Ser Asp Lys Val His Asn Asp Ala Gln Ser Phe Asp Tyr Asp35 40 45His Asp Ala Phe Leu Gly Ala Glu Glu Ala Lys Thr Phe Asp Gln Leu50 55 60Thr Pro Glu Glu Ser Lys Glu Arg Leu Gly Lys Ile Val Ser Lys Ile65 70 75 80Asp Gly Asp Lys Asp Gly Phe Val Thr Val Asp Glu Leu Lys Asp Trp85 90 95Ile Lys Phe Ala Gln Lys Arg Trp Ile Tyr Glu Asp Val Glu Arg Gln100 105 110Trp Lys Gly His Asp Leu Asn Glu Asp Gly Leu Val Ser Trp Glu Glu115 120 125Tyr Lys Asn Ala Thr Tyr Gly Tyr Val Leu Asp Asp Pro Asp Pro Asp
130 135 140Asp Gly Phe Asn Tyr Lys Gln Met Met Val Arg Asp Glu Arg Arg Phe145 150 155 160Lys Met Ala Asp Lys Asp Gly Asp Leu Ile Ala Thr Lys Glu Glu Phe165 170 175Thr Ala Phe Leu His Pro Glu Glu Tyr Asp Tyr Met Lys Asp Ile Val180 185 190Val Gln Glu Thr Met Glu Asp Ile Asp Lys Asn Ala Asp Gly Phe Ile195 200 205Asp Leu Glu Glu Tyr Ile Gly Asp Met Tyr Ser His Asp Gly Asn Thr210 215 220Asp Glu Pro Glu Trp Val Lys Thr Glu Arg Glu Gln Phe Val Glu Phe225 230 235 240Arg Asp Lys Asn Arg Asp Gly Lys Met Asp Lys Glu Glu Thr Lys Asp245 250 255Trp Ile Leu Pro Ser Asp Tyr Asp His Ala Glu Ala Glu Ala Arg His260 265 270Leu Val Tyr Glu Ser Asp Gln Asn Lys Asp Gly Lys Leu Thr Lys Glu275 280 285Glu Ile Val Asp Lys Tyr Asp Leu Phe Val Gly Ser Gln Ala Thr Asp290 295 300Phe Gly Glu Ala Leu Val Arg His Asp Glu Phe305 310 315<210>179<211>401<212>PRT<213>人<300>
<308>sw_hum/dct2_human<309>1997-11-01<400>179Met Ala Asp Pro Lys Tyr Ala Asp Leu Pro Gly Ile Ala Arg Asn Glu1 5 10 15
Pro Asp Val Tyr Glu Thr Ser Asp Leu Pro Glu Asp Asp Gln Ala Glu20 25 30Phe Asp Ala Glu Glu Leu Thr Ser Thr Ser Val Glu His Ile Ile Val35 40 45Asn Pro Asn Ala Ala Tyr Asp Lys Phe Lys Asp Lys Arg Val Gly Thr50 55 60Lys Gly Leu Asp Phe Ser Asp Arg Ile Gly Lys Thr Lys Arg Thr Gly65 70 75 80Tyr Glu Ser Gly Glu Tyr Glu Met Leu Gly Glu Gly Leu Gly Val Lys85 90 95Glu Thr Pro Gln Gln Lys Tyr Gln Arg Leu Leu His Glu Val Gln Glu100 105 110Leu Thr Thr Glu Val Glu Lys Ile Lys Thr Thr Val Lys Glu Ser Ala115 120 125Thr Glu Glu Lys Leu Thr Pro Val Leu Leu Ala Lys Gln Leu Ala Ala130 135 140Leu Lys Gln Gln Leu Val Ala Ser His Leu Glu Lys Leu Leu Gly Pro145 150 155 160Asp Ala Ala Ile Asn Leu Thr Asp Pro Asp Gly Ala Leu Ala Lys Arg165 170 175Leu Leu Leu Gln Leu Glu Ala Thr Lys Asn Ser Lys Gly Gly Ser Gly180 185 190Gly Lys Thr Thr Gly Thr Pro Pro Asp Ser Ser Leu Val Thr Tyr Glu195 200 205Leu His Ser Arg Pro Glu Gln Asp Lys Phe Ser Gln Ala Ala Lys Val210 215 220Ala Glu Leu Glu Lys Arg Leu Thr Glu Leu Glu Thr Ala Val Arg Cys225 230 235 240Asp Gln Asp Ala Gln Asn Pro Leu Ser Ala Gly Leu Gln Gly Ala Cys245 250 255Leu Met Glu Thr Val Glu Leu Leu Gln Ala Lys Val Ser Ala Leu Asp260 265 270
Leu Ala Val Leu Asp Gln Val Glu Ala Arg Leu Gln Ser Val Leu Gly275 280 285Lys Val Asn Glu Ile Ala Lys His Lys Ala Ser Val Glu Asp Ala Asp290 295 300Thr Gln Ser Lys Val His Gln Leu Tyr Glu Thr Ile Gln Arg Trp Ser305 310 315 320Pro Ile Ala Ser Thr Leu Pro Glu Leu Val Gln Arg Leu Val Thr Ile325 330 335Lys Gln Leu His Glu Gln Ala Met Gln Phe Gly Gln Leu Leu Thr His340 345 350Leu Asp Thr Thr Gln Gln Met Ile Ala Asn Ser Leu Lys Asp Asn Thr355 360 365Thr Leu Leu Thr Gln Val Gln Thr Thr Met Arg Glu Asn Leu Ala Thr370 375 380Val Glu Gly Asn Phe Ala Ser Ile Asp Glu Arg Met Lys Lys Leu Gly385 390 395 400Lys<2l0>180<211>261<212>PRT<213>人<300>
<308>sw_hum/hcd2_human<309>1997-11-01<400>180Met Ala Ala Ala Cys Arg Ser Val Lys Gly Leu Val Ala Val Ile Thr1 5 10 15Gly Gly Ala Ser Gly Leu Gly Leu Ala Thr Ala Glu Arg Leu Val Gly20 25 30Gln Gly Ala Ser Ala Val Leu Leu Asp Leu Pro Asn Ser Gly Gly Glu35 40 45Ala Gln Ala Lys Lys Leu Gly Asn Asn Cys Val Phe Ala Pro Ala Asp
50 55 60Val Thr Ser Glu Lys Asp Val Gln Thr Ala Leu Ala Leu Ala Lys Gly65 70 75 80Lys Phe Gly Arg Val Asp Val Ala Val Asn Cys Ala Gly Ile Ala Val85 90 95Ala Ser Lys Thr Tyr Asn Leu Lys Lys Gly Gln Thr His Thr Leu Glu100 105 110Asp Phe Gln Arg Val Leu Asp Val Asn Leu Met Gly Thr Phe Asn Val115 120 125Ile Arg Leu Val Ala Gly Glu Met Gly Gln Asn Glu Pro Asp Gln Gly130 135 140Gly Gln Arg Gly Val Ile Ile Asn Thr Ala Ser Val Ala Ala Phe Glu145 150 155 160Gly Gln Val Gly Gln Ala Ala Tyr Ser Ala Ser Lys Gly Gly Ile Val165 170 175Gly Met Thr Leu Pro Ile Ala Arg Asp Leu Ala Pro Ile Gly Ile Arg180 185 190Val Met Thr Ile Ala Pro Gly Leu Phe Gly Thr Pro Leu Leu Thr Ser195 200 205Leu Pro Glu Lys Val Cys Asn Phe Leu Ala Ser Gln Val Pro Phe Pro210 215 220Ser Arg Leu Gly Asp Pro Ala Glu Tyr Ala His Leu Val Gln Ala Ile225 230 235 240Ile Glu Asn Pro Phe Leu Asn Gly Glu Val Ile Arg Leu Asp Gly Ala245 250 255Ile Arg Met Gln Pro260<210>18l<211>312<212>PRT<213>人<300>
<308>sw_hum/pdxk_human
<309>1997-11-01<400>181Met Glu Glu Glu Cys Arg Val Leu Ser Ile Gln Ser His Val Ile Arg1 5 10 15Gly Tyr Val Gly Asn Arg Ala Ala Thr Phe Pro Leu Gln Val Leu Gly20 25 30Phe Glu Ile Asp Ala Val Asn Ser Val Gln Phe Ser Asn His Thr Gly35 40 45Tyr Ala His Trp Lys Gly Gln Val Leu Asn Ser Asp Glu Leu Gln Glu50 55 60Leu Tyr Glu Gly Leu Arg Leu Asn Asn Met Asn Lys Tyr Asp Tyr Val65 70 75 80Leu Thr Gly Tyr Thr Arg Asp Lys Ser Phe Leu Ala Met Val Val Asp85 90 95Ile Val Gln Glu Leu Lys Gln Gln Asn Pro Arg Leu Val Tyr Val Cys100 105 110Asp Pro Val Leu Gly Asp Lys Trp Asp Gly Glu Gly Ser Met Tyr Val115 120 125Pro Glu Asp Leu Leu Pro Val Tyr Lys Glu Lys Val Val Pro Leu Ala130 135 140Asp Ile Ile Thr Pro Asn Gln Phe Glu Ala Glu Leu Leu Ser Gly Arg145 150 155 160Lys Ile His Ser Gln Glu Glu Ala Leu Arg Val Met Asp Met Leu His165 170 175Ser Met Gly Pro Asp Thr Val Val Ile Thr Ser Ser Asp Leu Pro Ser180 185 190Pro Gln Gly Ser Asn Tyr Leu Ile Val Leu Gly Ser Gln Arg Arg Arg195 200 205Asn Pro Ala Gly Ser Val Val Met Glu Arg Ile Arg Met Asp Ile Arg210 215 220Lys Val Asp Ala Val Phe Val Gly Thr Gly Asp Leu Phe Ala Ala Met225 230 235 240
Leu Leu Ala Trp Thr His Lys His Pro Asn Asn Leu Lys Val Ala Cys245 250 255Glu Lys Thr Val Ser Thr Leu His His Val Leu Gln Arg Thr Ile Gln260 265 270Cys Ala Lys Ala Gln Ala Gly Glu Gly Val Arg Pro Ser Pro Met Gln275 280 285Leu Glu Leu Arg Met Val Gln Ser Lys Arg Asp Ile Glu Asp Pro Glu290 295 300Ile Val Val Gln Ala Thr Val Leu305 310<210>182<211>245<212>PRT<213>人<300>
<308>sw_hum/if6_human<309>1998-07-15<400>182Met Ala Val Arg Ala Ser Phe Glu Asn Asn Cys Glu Ile Gly Cys Phe1 5 10 15Ala Lys Leu Thr Asn Thr Tyr Cys Leu Val Ala Ile Gly Gly Ser Glu20 25 30Asn Phe Tyr Ser Val Phe Glu Gly Glu Leu Ser Asp Thr Ile Pro Val35 40 45Val His Ala Ser Ile Ala Gly Cys Arg Ile Ile Gly Arg Met Cys Val50 55 60Gly Asn Arg His Gly Leu Leu Val Pro Asn Asn Thr Thr Asp Gln Glu65 70 75 80Leu Gln His Ile Arg Asn Ser Leu Pro Asp Thr Val Gln Ile Arg Arg85 90 95Val Glu Glu Arg Leu Ser Ala Leu Gly Asn Val Thr Thr Cys Asn Asp100 105 110Tyr Val Ala Leu Val His Pro Asp Leu Asp Arg Glu Thr Glu Glu Ile
115 120 125Leu Ala Asp Val Leu Lys Val Glu Val Phe Arg Gln Thr Val Ala Asp130 135 140Gln Val Leu Val Gly Ser Tyr Cys Val Phe Ser Asn Gln Gly Gly Leu145 150 155 160Val His Pro Lys Thr Ser Ile Glu Asp Gln Asp Glu Leu Ser Ser Leu165 170 175Leu Gln Val Pro Leu Val Ala Gly Thr Val Asn Arg Gly Ser Glu Val180 185 190Ile Ala Ala Gly Met Val Val Asn Asp Trp Cys Ala Phe Cys Gly Leu195 200 205Asp Thr Thr Ser Thr Glu Leu Ser Val Val Glu Ser Val Phe Lys Leu2l0 215 220Asn Glu Ala Gln Pro Ser Thr Ile Ala Thr Ser Met Arg Asp Ser Leu225 230 235 240Ile Asp Ser Leu Thr245<210>183<211>214<212>PRT<213>人<300>
<308>sw_hum/pdx5_human<309>1993-04-01<400>183Met Gly Leu Ala Gly Val Cys Ala Leu Arg Arg Ser Ala Gly Tyr Ile1 5 10 15Leu Val Gly Gly Ala Gly Gly Gln Ser Ala Ala Ala Ala Ala Arg Arg20 25 30Cys Ser Glu Gly Glu Trp Ala Ser Gly Gly Val Arg Ser Phe Ser Arg35 40 45Ala Ala Ala Ala Met Ala Pro Ile Lys Val Gly Asp Ala Ile Pro Ala50 55 60
Val Glu Val Phe Glu Gly Glu Pro Gly Asn Lys Val Asn Leu Ala Glu65 70 75 80Leu Phe Lys Gly Lys Lys Gly Val Leu Phe Gly Val Pro Gly Ala Phe85 90 95Thr Pro Gly Cys Ser Lys Thr His Leu Pro Gly Phe Val Glu Gln Ala100 105 110Glu Ala Leu Lys Ala Lys Gly Val Gln Val Val Ala Cys Leu Ser Val115 120 125Asn Asp Ala Phe Val Thr Gly Glu Trp Gly Arg Ala His Lys Ala Glu130 135 140Gly Lys Val Arg Leu Leu Ala Asp Pro Thr Gly Ala Phe Gly Lys Glu145 150 155 160Thr Asp Leu Leu Leu Asp Asp Ser Leu Val Ser Ile Phe Gly Asn Arg165 170 175Arg Leu Lys Arg Phe Ser Met Val Val Gln Asp Gly Ile Val Lys Ala180 185 190Leu Asn Val Glu Pro Asp Gly Thr Gly Leu Thr Cys Ser Leu Ala Pro195 200 205Asn Ile Ile Ser Gln Leu210<210>184<211>323<212>PRT<213>人<300>
<308>sw_hum/pp1g_human<309>1994-06-01<400>184Met Ala Asp Leu Asp Lys Leu Asn Ile Asp Ser Ile Ile Gln Arg Leu1 5 10 15Leu Glu Val Arg Gly Ser Lys Pro Gly Lys Asn Val Gln Leu Gln Glu20 25 30Asn Glu Ile Arg Gly Leu Cys Leu Lys Ser Arg Glu Ile Phe Leu Ser35 40 45
Gln Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp50 55 60Ile His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly65 70 75 80Phe Pro Pro Glu Ser Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg85 90 95Gly Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile100 105 110Lys Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala115 120 125Ser Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Tyr130 135 140Asn Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro145 150 155 160Ile Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu165 170 175Ser Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro180 185 190Thr Asp Val Pro Asp Gln Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp195 200 205Pro Asp Lys Asp Val Leu Gly Trp Gly Glu Asn Asp Arg Gly Val Ser210 215 220Phe Thr Phe Gly Ala Glu Val Val Ala Lys Phe Leu His Lys His Asp225 230 235 240Leu Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu245 250 255Phe Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr260 265 270Cys Gly Glu Phe Asp Asn Ala Gly Ala Met Met Ser Val Asp Glu Thr275 280 285Leu Met Cys Ser Phe Gln Ile Leu Lys Pro Ala Glu Lys Lys Lys Pro
290 295 300Asn Ala Thr Arg Pro Val Thr Pro Pro Arg Gly Met Ile Thr Lys Gln305 310 315 320Ala Lys Lys<210>185<211>226<212>PRT<213>人<300>
<308>sw_hum/pimt_human<309>1991-08-01<400>185Ala Trp Lys Ser Gly Gly Ala Ser His Ser Glu Leu Ile His Asn Leu1 5 10 15Arg Lys Asn Gly Ile Ile Lys Thr Asp Lys Val Phe Glu Val Met Leu20 25 30Ala Thr Asp Arg Ser His Tyr Ala Lys Cys Asn Pro Tyr Met Asp Ser35 40 45Pro Gln Ser Ile Gly Phe Gln Ala Thr Ile Ser Ala Pro His Met His50 55 60Ala Tyr Ala Leu Glu Leu Leu Phe Asp Gln Leu His Glu Gly Ala Lys65 70 75 80Ala Leu Asp Val Gly Ser Gly Ser Gly Ile Leu Thr Ala Cys Phe Ala85 90 95Arg Met Val Gly Cys Thr Gly Lys Val Ile Gly Ile Asp His Ile Lys100 105 110Glu Leu Val Asp Asp Ser Ile Asn Asn Val Arg Lys Asp Asp Pro Thr115 120 125Leu Leu Ser Ser Gly Arg Val Gln Leu Val Val Gly Asp Gly Arg Met130 135 140Gly Tyr Ala Glu Glu Ala Pro Tyr Asp Ala Ile His Val Gly Ala Ala145 150 155 160
Ala Pro Val Val Pro Gln Ala Leu Ile Asp Gln Leu Lys Pro Gly Gly165 170 175Arg Leu Ile Leu Pro Val Gly Pro Ala Gly Gly Asn Gln Met Leu Glu180 185 190Gln Tyr Asp Lys Leu Gln Asp Gly Ser Ile Lys Met Lys Pro Leu Met195 200 205Gly Val Ile Tyr Val Pro Leu Thr Asp Lys Glu Lys Gln Trp Ser Arg210 215 220Trp Lys225<210>186<211>548<212>PRT<213>人<300>
<308>sw_hum/tcpq_human<309>1996-10-01<400>186Met Ala Leu His Val Pro Lys Ala Pro Gly Phe Ala Gln Met Leu Lys1 5 10 15Glu Gly Ala Lys His Phe Ser Gly Leu Glu Glu Ala Val Tyr Arg Asn20 25 30Ile Gln Ala Cys Lys Glu Leu Ala Gln Thr Thr Arg Thr Ala Tyr Gly35 40 45Pro Asn Gly Met Asn Lys Met Val Ile Asn His Leu Glu Lys Leu Phe50 55 60Val Thr Asn Asp Ala Ala Thr Ile Leu Arg Glu Leu Glu Val Gln His65 70 75 80Pro Ala Ala Lys Met Ile Val Met Ala Ser His Met Gln Glu Gln Glu85 90 95Val Gly Asp Gly Thr Asn Phe Val Leu Val Phe Ala Gly Ala Leu Leu100 105 110Glu Leu Ala Glu Glu Leu Leu Arg Ile Gly Leu Ser Val Ser Glu Val115 120 125
Ile Glu Gly Tyr Glu Ile Ala Cys Arg Lys Ala His Glu Ile Leu Pro130 135 140Asn Leu Val Cys Cys Ser Ala Lys Asn Leu Arg Asp Ile Asp Glu Val145 150 155 160Ser Ser Leu Leu Arg Thr Ser Ile Met Ser Lys Gln Tyr Gly Asn Glu165 170 175Val Phe Leu Ala Lys Leu Ile Ala Gln Ala Cys Val Ser Ile Phe Pro180 185 190Asp Ser Gly His Phe Asn Val Asp Asn Ile Arg Val Cys Lys Ile Leu195 200 205Gly Ser Gly Ile Ser Ser Ser Ser Val Leu His Gly Met Val Phe Lys210 215 220Lys Glu Thr Glu Gly Asp Val Thr Ser Val Lys Asp Ala Lys Ile Ala225 230 235 240Val Tyr Ser Cys Pro Phe Asp Gly Met Ile Thr Glu Thr Lys Gly Thr245 250 255Val Leu Ile Lys Thr Ala Glu Glu Leu Met Asn Phe Ser Lys Gly Glu260 265 270Glu Asn Leu Met Asp Ala Gln Val Lys Ala Ile Ala Asp Thr Gly Ala275 280 285Asn Val Val Val Thr Gly Gly Lys Val Ala Asp Met Ala Leu His Tyr290 295 300Ala Asn Lys Tyr Asn Ile Met Leu Val Arg Leu Asn Ser Lys Trp Asp305 310 315 320Leu Arg Arg Leu Cys Lys Thr Val Gly Ala Thr Ala Leu Pro Arg Leu325 330 335Thr Pro Pro Val Leu Glu Glu Met Gly His Cys Asp Ser Val Tyr Leu340 345 350Ser Glu Val Gly Asp Thr Gln Val Val Val Phe Lys His Glu Lys Glu355 360 365Asp Gly Ala Ile Ser Thr Ile Val Leu Arg Gly Ser Thr Asp Asn Leu
370 375 380Met Asp Asp Ile Glu Arg Ala Val Asp Asp Gly Val Asn Thr Phe Lys385 390 395 400Val Leu Thr Arg Asp Lys Arg Leu Val Pro Gly Gly Gly Ala Thr Glu405 410 415Ile Glu Leu Ala Lys Gln Ile Thr Ser Tyr Gly Glu Thr Cys Pro Gly420 425 430Leu Glu Gln Tyr Ala Ile Lys Lys Phe Ala Glu Ala Phe Glu Ala Ile435 440 445Pro Arg Ala Leu Ala Glu Asn Ser Gly Val Lys Ala Asn Glu Val Ile450 455 460Ser Lys Leu Tyr Ala Val His Gln Glu Gly Asn Lys Asn Val Gly Leu465 470 475 480Asp Ile Glu Ala Glu Val Pro Ala Val Lys Asp Met Leu Glu Ala Gly485 490 495Ile Leu Asp Thr Tyr Leu Gly Lys Tyr Trp Ala Ile Lys Leu Ala Thr500 505 510Asn Ala Ala Val Thr Val Leu Arg Val Asp Gln Ile Ile Met Ala Lys515 520 525Pro Ala Gly Gly Pro Lys Pro Pro Ser Gly Lys Lys Asp Trp Asp Asp530 535 540Asp Gln Asn Asp545<210>187<211>51<212>PRT<213>人<300>
<308>hsugp/333417-11-0<309>2002-02-16<400>187Ser Arg Phe Lys Ile Val Met Val Val Leu Tyr Gly Asn Thr Ala Val1 5 10 15
Ile His Pro Met Cys Ala Ile Asp Glu Tyr Ala Met Ile Phe Arg Ser20 25 30Trp Val Trp Phe Ser Pro Pro His Pro Pro Ile Lys Ile Asp Asn Met35 40 45Ala Ile Val50<210>188<211>205<212>PRT<213>人<300>
<308>sw_hum/psb3_human<309>1993-07-01<400>188Met Ser Ile Met Ser Tyr Asn Gly Gly Ala Val Met Ala Met Lys Gly1 5 10 15Lys Asn Cys Val Ala Ile Ala Ala Asp Arg Arg Phe Gly Ile Gln Ala20 25 30Gln Met Val Thr Thr Asp Phe Gln Lys Ile Phe Pro Met Gly Asp Arg35 40 45Leu Tyr Ile Gly Leu Ala Gly Leu Ala Thr Asp Val Gln Thr Val Ala50 55 60Gln Arg Leu Lys Phe Arg Leu Asn Leu Tyr Glu Leu Lys Glu Gly Arg65 70 75 80Gln Ile Lys Pro Tyr Thr Leu Met Ser Met Val Ala Asn Leu Leu Tyr85 90 95Glu Lys Arg Phe Gly Pro Tyr Tyr Thr Glu Pro Val Ile Ala Gly Leu100 105 110Asp Pro Lys Thr Phe Lys Pro Phe Ile Cys Ser Leu Asp Leu Ile Gly115 120 125Cys Pro Met Val Thr Asp Asp Phe Val Val Ser Gly Thr Cys Ala Glu130 135 140Gln Met Tyr Gly Met Cys Glu Ser Leu Trp Glu Pro Asn Met Asp Pro145 150 155 160
Asp His Leu Phe Glu Thr Ile Ser Gln Ala Met Leu Asn Ala Val Asp165 170 175Arg Asp Ala Val Ser Gly Met Gly Val Ile Val His Ile Ile Glu Lys180 185 190Asp Lys Ile Thr Thr Arg Thr Leu Lys Ala Arg Met Asp195 200 205<210>189<211>397<212>PRT<213>人<300>
<308>humangp/chr6-q8tdm4<309>2003-04-22<400>189Met Asn Ala Gly Ser Asp Pro Val Val Ile Val Ser Ala Ala Arg Thr1 5 10 15Ile Ile Gly Ser Phe Asn Gly Ala Leu Ala Ala Val Pro Val Gln Asp20 25 30Leu Gly Ser Thr Val Ile Lys Glu Val Leu Lys Arg Ala Thr Val Ala35 40 45Pro Glu Asp Val Ser Glu Val Ile Phe Gly His Val Leu Ala Ala Gly50 55 60Cys Gly Gln Asn Pro Val Arg Gln Ala Ser Val Gly Ala Gly Ile Pro65 70 75 80Tyr Ser Val Pro Ala Trp Ser Cys Gln Met Ile Cys Gly Ser Gly Leu85 90 95Lys Ala Val Cys Leu Ala Val Gln Ser Ile Gly Ile Gly Asp Ser Ser100 105 110Ile Val Val Ala Gly Gly Met Glu Asn Met Ser Lys Ala Pro His Leu115 120 125Ala Tyr Leu Arg Thr Gly Val Lys Ile Gly Glu Met Pro Leu Thr Asp130 135 140Ser Ile Leu Cys Asp Gly Leu Thr Asp Ala Phe His Asn Cys His Met145 150 155 160
Gly Ile Thr Ala Glu Asn Val Ala Lys Lys Trp Gln Val Ser Arg Glu165 170 175Asp Gln Asp Lys Val Ala Val Leu Ser Gln Asn Arg Thr Glu Asn Ala180 185 190Gln Lys Ala Gly His Phe Asp Lys Glu Ile Val Pro Val Leu Val Ser195 200 205Thr Arg Lys Gly Leu Ile Glu Val Lys Thr Asp Glu Phe Pro Arg His210 215 220Gly Ser Asn Ile Glu Ala Met Ser Lys Leu Lys Pro Tyr Phe Leu Thr225 230 235 240Asp Gly Thr Gly Thr Val Thr Pro Ala Asn Ala Ser Gly Ile Asn Asp245 250 255Gly Ala Ala Ala Val Val Leu Met Lys Lys Ser Glu Ala Asp Lys Arg260 265 270Gly Leu Thr Pro Leu Ala Arg Ile Val Ser Trp Ser Gln Val Gly Val275 280 285Glu Pro Ser Ile Met Gly Ile Gly Pro Ile Pro Ala Ile Lys Gln Ala290 295 300Val Thr Lys Ala Gly Trp Ser Leu Glu Asp Val Asp Ile Phe Glu Ile305 310 315 320Asn Glu Ala Phe Ala Ala Val Ser Ala Ala Ile Val Lys Glu Leu Gly325 330 335Leu Asn Pro Glu Lys Val Asn Ile Glu Gly Gly Ala Ile Ala Leu Gly340 345 350His Pro Leu Gly Ala Ser Gly Cys Arg Ile Leu Val Thr Leu Leu His355 360 365Thr Leu Glu Arg Met Gly Arg Ser Arg Gly Val Ala Ala Leu Cys Ile370 375 380Gly Gly Gly Met Gly Ile Ala Met Cys Val Gln Arg Glu385 390 395
<210>190<211>296<212>PRT<213>人<300>
<308>sw_hum/biea_human<309>1996-10-01<400>190Met Asn Ala Glu Pro Glu Arg Lys Phe Gly Val Val Val Val Gly Val1 5 10 15Gly Arg Ala Gly Ser Val Arg Met Arg Asp Leu Arg Asn Pro His Pro20 25 30Ser Ser Ala Phe Leu Asn Leu Ile Gly Phe Val Ser Arg Arg Glu Leu35 40 45Gly Ser Ile Asp Gly Val Gln Gln Ile Ser Leu Glu Asp Ala Leu Ser50 55 60Ser Gln Glu Val Glu Val Ala Tyr Ile Cys Ser Glu Ser Ser Ser His65 70 75 80Glu Asp Tyr Ile Arg Gln Phe Leu Asn Ala Gly Lys His Val Leu Val85 90 95Glu Tyr Pro Met Thr Leu Ser Leu Ala Ala Ala Gln Glu Leu Trp Glu100 105 110Leu Ala Glu Gln Lys Gly Lys Val Leu His Glu Glu His Val Glu Leu115 120 125Leu Met Glu Glu Phe Ala Phe Leu Lys Lys Glu Val Val Gly Lys Asp130 135 140Leu Leu Lys Gly Ser Leu Leu Phe Thr Ala Gly Pro Leu Glu Glu Glu145 150 155 160Arg Phe Gly Phe Pro Ala Phe Ser Gly Ile Ser Arg Leu Thr Trp Leu165 170 175Val Ser Leu Phe Gly Glu Leu Ser Leu Val Ser Ala Thr Leu Glu Glu180 185 190Arg Lys Glu Asp Gln Tyr Met Lys Met Thr Val Cys Leu Glu Thr Glu195 200 205
Lys Lys Ser Pro Leu Ser Trp Ile Glu Glu Lys Gly Pro Gly Leu Lys210 215 220Arg Asn Arg Tyr Leu Ser Phe His Phe Lys Ser Gly Ser Leu Glu Asn225 230 235 240Val Pro Asn Val Gly Val Asn Lys Asn Ile Phe Leu Lys Asp Gln Asn245 250 255Ile Phe Val Gln Lys Leu Leu Gly Gln Phe Ser Glu Lys Glu Leu Ala260 265 270Ala Glu Lys Lys Arg Ile Leu His Cys Leu Gly Leu Ala Glu Glu Ile275 280 285Gln Lys Tyr Cys Cys Ser Arg Lys290 295<210>191<211>216<212>PRT<213>人<300>
<308>sw_hum/ran_human<309>1990-08-01<400>191Met Ala Ala Gln Gly Glu Pro Gln Val Gln Phe Lys Leu Val Leu Val1 5 10 15Gly Asp Gly Gly Thr Gly Lys Thr Thr Phe Val Lys Arg His Leu Thr20 25 30Gly Glu Phe Glu Lys Lys Tyr Val Ala Thr Leu Gly Val Glu Val His35 40 45Pro Leu Val Phe His Thr Asn Arg Gly Pro Ile Lys Phe Asn Val Trp50 55 60Asp Thr Ala Gly Gln Glu Lys Phe Gly Gly Leu Arg Asp Gly Tyr Tyr65 70 75 80Ile Gln Ala Gln Cys Ala Ile Ile Met Phe Asp Val Thr Ser Arg Val85 90 95Thr Tyr Lys Asn Val Pro Asn Trp His Arg Asp Leu Val Arg Val Cys100 105 110
Glu Asn Ile Pro Ile Val Leu Cys Gly Asn Lys Val Asp Ile Lys Asp115 120 125Arg Lys Val Lys Ala Lys Ser Ile Val Phe His Arg Lys Lys Asn Leu130 135 140Gln Tyr Tyr Asp Ile Ser Ala Lys Ser Asn Tyr Asn Phe Glu Lys Pro145 150 155 160Phe Leu Trp Leu Ala Arg Lys Leu Ile Gly Asp Pro Asn Leu Glu Phe165 170 175Val Ala Met Pro Ala Leu Ala Pro Pro Glu Val Val Met Asp Pro Ala180 185 190Leu Ala Ala Gln Tyr Glu His Asp Leu Glu Val Ala Gln Thr Thr Ala195 200 205Leu Pro Asp Glu Asp Asp Asp Leu210 215<210>192<211>406<212>PRT<213>人<300>
<308>sw_hum/prs8_human<309>1996-02-01<400>192Met Ala Leu Asp Gly Pro Glu Gln Met Glu Leu Glu Glu Gly Lys Ala1 5 10 15Gly Ser Gly Leu Arg Gln Tyr Tyr Leu Ser Lys Ile Glu Glu Leu Gln20 25 30Leu Ile Val Asn Asp Lys Ser Gln Asn Leu Arg Arg Leu Gln Ala Gln35 40 45Arg Asn Glu Leu Asn Ala Lys Val Arg Leu Leu Arg Glu Glu Leu Gln50 55 60Leu Leu Gln Glu Gln Gly Ser Tyr Val Gly Glu Val Val Arg Ala Met65 70 75 80Asp Lys Lys Lys Val Leu Val Lys Val His Pro Glu Gly Lys Phe Val
85 90 95Val Asp Val Asp Lys Asn Ile Asp Ile Asn Asp Val Thr Pro Asn Cys100 105 110Arg Val Ala Leu Arg Asn Asp Ser Tyr Thr Leu His Lys Ile Leu Pro115 120 125Asn Lys Val Asp Pro Leu Val Ser Leu Met Met Val Glu Lys Val Pro130 135 140Asp Ser Thr Tyr Glu Met Ile Gly Gly Leu Asp Lys Gln Ile Lys Glu145 150 155 160Ile Lys Glu Val Ile Glu Leu Pro Val Lys His Pro Glu Leu Phe Glu165 170 175Ala Leu Gly Ile Ala Gln Pro Lys Gly Val Leu Leu Tyr Gly Pro Pro180 185 190Gly Thr Gly Lys Thr Leu Leu Ala Arg Ala Val Ala His His Thr Asp195 200 205Cys Thr Phe Ile Arg Val Ser Gly Ser Glu Leu Val Gln Lys Phe Ile210 215 220Gly Glu Gly Ala Arg Met Val Arg Glu Leu Phe Val Met Ala Arg Glu225 230 235 240His Ala Pro Ser Ile Ile Phe Met Asp Glu Ile Asp Ser Ile Gly Ser245 250 255Ser Arg Leu Glu Gly Gly Ser Gly Gly Asp Ser Glu Val Gln Arg Thr260 265 270Met Leu Glu Leu Leu Asn Gln Leu Asp Gly Phe Glu Ala Thr Lys Asn275 280 285Ile Lys Val Ile Met Ala Thr Asn Arg Ile Asp Ile Leu Asp Ser Ala290 295 300Leu Leu Arg Pro Gly Arg Ile Asp Arg Lys Ile Glu Phe Pro Pro Pro305 310 315 320Asn Glu Glu Ala Arg Leu Asp Ile Leu Lys Ile His Ser Arg Lys Met325 330 335
Asn Leu Thr Arg Gly Ile Asn Leu Arg Lys Ile Ala Glu Leu Met Pro340 345 350Gly Ala Ser Gly Ala Glu Val Lys Gly Val Cys Thr Glu Ala Gly Met355 360 365Tyr Ala Leu Arg Glu Arg Arg Val His Val Thr Gln Glu Asp Phe Glu370 375 380Met Ala Val Ala Lys Val Met Gln Lys Asp Ser Glu Lys Asn Met Ser385 390 395 400Ile Lys Lys Leu Trp Lys405<210>193<211>189<212>PRT<213>人<300>
<308>humangp/chr1-014805<309>2003-04-22<400>193Met Ala Ser Lys Arg Ala Leu Val Ile Leu Ala Lys Gly Ala Glu Glu1 5 10 15Met Glu Thr Val Ile Pro Val Asp Val Met Arg Arg Ala Gly Ile Lys20 25 30Val Thr Val Ala Gly Leu Ala Gly Lys Asp Pro Val Gln Cys Ser Arg35 40 45Asp Val Val Ile Cys Pro Asp Ala Ser Leu Glu Asp Ala Lys Lys Glu50 55 60Gly Pro Tyr Asp Val Val Val Leu Pro Gly Gly Asn Leu Gly Ala Gln65 70 75 80Asn Leu Ser Glu Ser Ala Ala Val Lys Glu Ile Leu Lys Glu Gln Glu85 90 95Asn Arg Lys Gly Leu Ile Ala Ala Ile Cys Ala Gly Pro Thr Ala Leu100 105 110Leu Ala His Glu Ile Gly Phe Gly Ser Lys Val Thr Thr His Pro Leu115 120 125
Ala Lys Asp Lys Met Met Asn Gly Gly His Tyr Thr Tyr Ser Glu Asn130 135 140Arg Val Glu Lys Asp Gly Leu Ile Leu Thr Ser Arg Gly Pro Gly Thr145 150 155 160Ser Phe Glu Phe Ala Leu Ala Ile Val Glu Ala Leu Asn Gly Lys Glu165 170 175Val Ala Ala Gln Val Lys Ala Pro Leu Val Leu Lys Asp180 185<210>194<211>246<212>PRT<213>人<300>
<308>sw_hum/psa6_human<309>1994-02-01<400>194Met Ser Arg Gly Ser Ser Ala Gly Phe Asp Arg His Ile Thr Ile Phe1 5 10 15Ser Pro Glu Gly Arg Leu Tyr Gln Val Glu Tyr Ala Phe Lys Ala Ile20 25 30Asn Gln Gly Gly Leu Thr Ser Val Ala Val Arg Gly Lys Asp Cys Ala35 40 45Val Ile Val Thr Gln Lys Lys Val Pro Asp Lys Leu Leu Asp Ser Ser50 55 60Thr Val Thr His Leu Phe Lys Ile Thr Glu Asn Ile Gly Cys Val Met65 70 75 80Thr Gly Met Thr Ala Asp Ser Arg Ser Gln Val Gln Arg Ala Arg Tyr85 90 95Glu Ala Ala Asn Trp Lys Tyr Lys Tyr Gly Tyr Glu Ile Pro Val Asp100 105 110Met Leu Cys Lys Arg Ile Ala Asp Ile Ser Gln Val Tyr Thr Gln Asn115 120 125Ala Glu Met Arg Pro Leu Gly Cys Cys Met Ile Leu Ile Gly Ile Asp
130 135 140Glu Glu Gln Gly Pro Gln Val Tyr Lys Cys Asp Pro Ala Gly Tyr Tyr145 150 155 160Cys Gly Phe Lys Ala Thr Ala Ala Gly Val Lys Gln Thr Glu Ser Thr165 170 175Ser Phe Leu Glu Lys Lys Val Lys Lys Lys Phe Asp Trp Thr Phe Glu180 185 190Gln Thr Val Glu Thr Ala Ile Thr Cys Leu Ser Thr Val Leu Ser Ile195 200 205Asp Phe Lys Pro Ser Glu Ile Glu Val Gly Val Val Thr Val Glu Asn210 215 220Pro Lys Phe Arg Ile Leu Thr Glu Ala Glu Ile Asp Ala His Leu Val225 230 235 240Ala Leu Ala Glu Arg Asp245<210>195<211>258<212>PRT<213>人<300>
<308>sw_hum/6pgl_human<309>2000-05-30<400>195Met Ala Ala Pro Ala Pro Gly Leu Ile Ser Val Phe Ser Ser Ser Gln1 5 10 15Glu Leu Gly Ala Ala Leu Ala Gln Leu Val Ala Gln Arg Ala Ala Cys20 25 30Cys Leu Ala Gly Ala Arg Ala Arg Phe Ala Leu Gly Leu Ser Gly Gly35 40 45Ser Leu Val Ser Met Leu Ala Arg Glu Leu Pro Ala Ala Val Ala Pro50 55 60Ala Gly Pro Ala Ser Leu Ala Arg Trp Thr Leu Gly Phe Cys Asp Glu65 70 75 80
Arg Leu Val Pro Phe Asp His Ala Glu Ser Thr Tyr Gly Leu Tyr Arg85 90 95Thr His Leu Leu Ser Arg Leu Pro Ile Pro Glu Ser Gln Val Ile Thr100 105 110Ile Asn Pro Glu Leu Pro Val Glu Glu Ala Ala Glu Asp Tyr Ala Lys115 120 125Lys Leu Arg Gln Ala Phe Gln Gly Asp Ser Ile Pro Val Phe Asp Leu130 135 140Leu Ile Leu Gly Val Gly Pro Asp Gly His Thr Cys Ser Leu Phe Pro145 150 155 160Asp His Pro Leu Leu Gln Glu Arg Glu Lys Ile Val Ala Pro Ile Ser165 170 175Asp Ser Pro Lys Pro Pro Pro Gln Arg Val Thr Leu Thr Leu Pro Val180 185 190Leu Asn Ala Ala Arg Thr Val Ile Phe Val Ala Thr Gly Glu Gly Lys195 200 205Ala Ala Val Leu Lys Arg Ile Leu Glu Asp Gln Glu Glu Asn Pro Leu210 215 220Pro Ala Ala Leu Val Gln Pro His Thr Gly Lys Leu Cys Trp Phe Leu225 230 235 240Asp Glu Ala Ala Ala Arg Leu Leu Thr Val Pro Phe Glu Lys His Ser245 250 255Thr Leu<210>196<211>310<212>PRT<213>人<300>
<308>humangp/chr19-q8wvx0<309>2003-04-22<400>196Leu Thr Gly Ser Asn Tyr Pro Gly Leu Ser Ile Ser Leu Arg Leu Thr1 5 10 15
Gly Ser Ser Ala Gln Glu Glu Ala Ser Gly Val Ala Leu Gly Glu Ala20 25 30Pro Asp His Ser Tyr Glu Ser Leu Arg Val Thr Ser Ala Gln Lys His35 40 45Val Leu His Val Gln Leu Asn Arg Pro Asn Lys Arg Asn Ala Met Asn50 55 60Lys Val Phe Trp Arg Glu Met Val Glu Cys Phe Asn Lys Ile Ser Arg65 70 75 80Asp Ala Asp Cys Arg Ala Val Val Ile Ser Gly Ala Gly Lys Met Phe85 90 95Thr Ala Gly Ile Asp Leu Met Asp Met Ala Ser Asp Ile Leu Gln Pro100 105 110Lys Gly Asp Asp Val Ala Arg Ile Ser Trp Tyr Leu Arg Asp Ile Ile115 120 125Thr Arg Tyr Gln Glu Thr Phe Asn Val Ile Glu Arg Cys Pro Lys Pro130 135 140Val Ile Ala Ala Val His Gly Gly Cys Ile Gly Gly Gly Val Asp Leu145 150 155 160Val Thr Ala Cys Asp Ile Arg Tyr Cys Ala Gln Asp Ala Phe Phe Gln165 170 175Val Lys Glu Val Asp Val Gly Leu Ala Ala Asp Val Gly Thr Leu Gln180 185 190Arg Leu Pro Lys Val Ile Gly Asn Gln Ser Leu Val Asn Glu Leu Ala195 200 205Phe Thr Ala Arg Lys Met Met Ala Asp Glu Ala Leu Gly Ser Gly Leu210 215 220Val Ser Arg Val Phe Pro Asp Lys Glu Val Met Leu Asp Ala Ala Leu225 230 235 240Ala Leu Ala Ala Glu Ile Ser Ser Lys Ser Pro Val Ala Val Gln Ser245 250 255Thr Lys Val Asn Leu Leu Tyr Ser Arg Asp His Ser Val Ala Glu Ser
260 265 270Leu Asn Tyr Val Ala Ser Trp Asn Met Ser Met Leu Gln Thr Gln Asp275 280 285Leu Val Lys Ser Val Gln Ala Thr Thr Glu Asn Lys Glu Leu Lys Thr290 295 300Val Thr Phe Ser Lys Leu305 310<210>197<211>780<212>PRT<213>人<300>
<308>sw_hum/acon_human<309>1997-11-01<400>197Met Ala Pro Tyr Ser Leu Leu Val Thr Arg Leu Gln Lys Ala Leu Gly1 5 10 15Val Arg Gln Tyr His Val Ala Ser Val Leu Cys Gln Arg Ala Lys Val20 25 30Ala Met Ser His Phe Glu Pro Asn Glu Tyr Ile His Tyr Asp Leu Leu35 40 45Glu Lys Asn Ile Asn Ile Val Arg Lys Arg Leu Asn Arg Pro Leu Thr50 55 60Leu Ser Glu Lys Ile Val Tyr Gly His Leu Asp Asp Pro Ala Ser Gln65 70 75 80Glu Ile Glu Arg Gly Lys Ser Tyr Leu Arg Leu Arg Pro Asp Arg Val85 90 95Ala Met Gln Asp Ala Thr Ala Gln Met Ala Met Leu Gln Phe Ile Ser100 105 110Ser Gly Leu Ser Lys Val Ala Val Pro Ser Thr Ile His Cys Asp His115 120 125Leu Ile Glu Ala Gln Val Gly Gly Glu Lys Asp Leu Arg Arg Ala Lys130 135 140
Asp Ile Asn Gln Glu Val Tyr Asn Phe Leu Ala Thr Ala Gly Ala Lys145 150 155 160Tyr Gly Val Gly Phe Trp Lys Pro Gly Ser Gly Ile Ile His Gln Ile165 170 175Ile Leu Glu Asn Tyr Ala Tyr Pro Gly Val Leu Leu Ile Gly Thr Asp180 185 190Ser His Thr Pro Asn Gly Gly Gly Leu Gly Gly Ile Cys Ile Gly Val195 200 205Gly Gly Ala Asp Ala Val Asp Val Met Ala Gly Ile Pro Trp Glu Leu210 215 220Lys Cys Pro Lys Val Ile Gly Val Lys Leu Thr Gly Ser Leu Ser Gly225 230 235 240Trp Ser Ser Pro Lys Asp Val Ile Leu Lys Val Ala Gly Ile Leu Thr245 250 255Val Lys Gly Gly Thr Gly Ala Ile Val Glu Tyr His Gly Pro Gly Val260 265 270Asp Ser Ile Ser Cys Thr Gly Met Ala Thr Ile Cys Asn Met Gly Ala275 280 285Glu Ile Gly Ala Thr Thr Ser Val Phe Pro Tyr Asn His Arg Met Lys290 295 300Lys Tyr Leu Ser Lys Thr Gly Arg Glu Asp Ile Ala Asn Leu Ala Asp305 310 315 320Glu Phe Lys Asp His Leu Val Pro Asp Pro Gly Cys His Tyr Asp Gln325 330 335Leu Ile Glu Ile Asn Leu Ser Glu Leu Lys Pro His Ile Asn Gly Pro340 345 350Phe Thr Pro Asp Leu Ala His Pro Val Ala Glu Val Gly Lys Val Ala355 360 365Glu Lys Glu Gly Trp Pro Leu Asp Ile Arg Val Gly Leu Ile Gly Ser370 375 380Cys Thr Asn Ser Ser Tyr Glu Asp Met Gly Arg Ser Ala Ala Val Ala385 390 395 400
Lys Gln Ala Leu Ala His Gly Leu Lys Cys Lys Ser Gln Phe Thr Ile405 410 415Thr Pro Gly Ser Glu Gln Ile Arg Ala Thr Ile Glu Arg Asp Gly Tyr420 425 430Ala Gln Ile Leu Arg Asp Leu Gly Gly Ile Val Leu Ala Asn Ala Cys435 440 445Gly Pro Cys Ile Gly Gln Trp Asp Arg Lys Asp Ile Lys Lys Gly Glu450 455 460Lys Asn Thr Ile Val Thr Ser Tyr Asn Arg Asn Phe Thr Gly Arg Asn465 470 475 480Asp Ala Asn Pro Glu Thr His Ala Phe Val Thr Ser Pro Glu Ile Val485 490 495Thr Ala Leu Ala Ile Ala Gly Thr Leu Lys Phe Asn Pro Glu Thr Asp500 505 510Tyr Leu Thr Gly Thr Asp Gly Lys Lys Phe Arg Leu Glu Ala Pro Asp515 520 525Ala Asp Glu Leu Pro Lys Gly Glu Phe Asp Pro Gly Gln Asp Thr Tyr530 535 540Gln His Pro Pro Lys Asp Ser Ser Gly Gln His Val Asp Val Ser Pro545 550 555 560Thr Ser Gln Arg Leu Gln Leu Leu Glu Pro Phe Asp Lys Trp Asp Gly565 570 575Lys Asp Leu Glu Asp Leu Gln Ile Leu Ile Lys Val Lys Gly Lys Cys580 585 590Thr Thr Asp His Ile Ser Ala Ala Gly Pro Trp Leu Lys Phe Arg Gly595 600 605His Leu Asp Asn Ile Ser Asn Asn Leu Leu Ile Gly Ala Ile Asn Ile610 615 620Glu Asn Gly Lys Ala Asn Ser Val Arg Asn Ala Val Thr Gln Glu Phe625 630 635 640
Gly Pro Val Pro Asp Thr Ala Arg Tyr Tyr Lys Lys His Gly Ile Arg645 650 655Trp Val Val Ile Gly Asp Glu Asn Tyr Gly Glu Gly Ser Ser Arg Glu660 665 670His Ala Ala Leu Glu Pro Arg His Leu Gly Gly Arg Ala Ile Ile Thr675 680 685Lys Ser Phe Ala Arg Ile His Glu Thr Asn Leu Lys Lys Gln Gly Leu690 695 700Leu Pro Leu Thr Phe Ala Asp Pro Ala Asp Tyr Asn Lys Ile His Pro705 710 715 720Val Asp Lys Leu Thr Ile Gln Gly Leu Lys Asp Phe Thr Pro Gly Lys725 730 735Pro Leu Lys Cys Ile Ile Lys His Pro Asn Gly Thr Gln Glu Thr Ile740 745 750Leu Leu Asn His Thr Phe Asn Glu Thr Gln Ile Glu Trp Phe Arg Ala755 760 765Gly Ser Ala Leu Asn Arg Met Lys Glu Leu Gln Gln770 775 780<210>198<211>480<212>PRT<213>人<300>
<308>sw_hum/ucr1_human<309>1993-07-01<400>198Met Ala Ala Ser Val Val Cys Arg Ala Ala Thr Ala Gly Ala Gln Val1 5 10 15Leu Leu Arg Ala Arg Arg Ser Pro Ala Leu Leu Arg Thr Pro Ala Leu20 25 30Arg Ser Thr Ala Thr Phe Ala Gln Ala Leu Gln Phe Val Pro Glu Thr35 40 45Gln Val Ser Leu Leu Asp Asn Gly Leu Arg Val Ala Ser Glu Gln Ser50 55 60
Ser Gln Pro Thr Cys Thr Val Gly Val Trp Ile Asp Val Gly Ser Arg65 70 75 80Phe Glu Thr Glu Lys Asn Asn Gly Ala Gly Tyr Phe Leu Glu His Leu85 90 95Ala Phe Lys Gly Thr Lys Asn Arg Pro Gly Ser Ala Leu Glu Lys Glu100 105 110Val Glu Ser Met Gly Ala His Leu Asn Ala Tyr Ser Thr Arg Glu His115 120 125Thr Ala Tyr Tyr Ile Lys Ala Leu Ser Lys Asp Leu Pro Lys Ala Val130 135 140Glu Leu Leu Gly Asp Ile Val Gln Asn Cys Ser Leu Glu Asp Ser Gln145 150 155 160Ile Glu Lys Glu Arg Asp Val Ile Leu Arg Glu Met Gln Glu Asn Asp165 170 175Ala Ser Met Arg Asp Val Val Phe Asn Tyr Leu His Ala Thr Ala Phe180 185 190Gln Gly Thr Pro Leu Ala Gln Ala Val Glu Gly Pro Ser Glu Asn Val195 200 205Arg Lys Leu Ser Arg Ala Asp Leu Thr Glu Tyr Leu Ser Thr His Tyr210 215 220Lys Ala Pro Arg Met Val Leu Ala Ala Ala Gly Gly Val Glu His Gln225 230 235 240Gln Leu Leu Asp Leu Ala Gln Lys His Leu Gly Gly Ile Pro Trp Thr245 250 255Tyr Ala Glu Asp Ala Val Pro Thr Leu Thr Pro Cys Arg Phe Thr Gly260 265 270Ser Glu Ile Arg His Arg Asp Asp Ala Leu Pro Phe Ala His Val Ala275 280 285Ile Ala Val Glu Gly Pro Gly Trp Ala Ser Pro Asp Ser Val Ala Leu290 295 300Gln Val Ala Asn Ala Ile Ile Gly His Tyr Asp Cys Thr Tyr Gly Gly
305 310 315 320Gly Val His Leu Ser Ser Pro Leu Ala Ser Gly Ala Val Ala Asn Lys325 330 335Leu Cys Gln Ser Phe Gln Thr Phe Ser Ile Cys Tyr Ala Glu Thr Gly340 345 350Leu Leu Gly Ala His Phe Val Cys Asp Arg Met Lys Ile Asp Asp Met355 360 365Met Phe Val Leu Gln Gly Gln Trp Met Arg Leu Cys Thr Ser Ala Thr370 375 380Glu Ser Glu Val Ala Arg Gly Lys Asn Ile Leu Arg Asn Ala Leu Val385 390 395 400Ser His Leu Asp Gly Thr Thr Pro Val Cys Glu Asp Ile Gly Arg Ser405 410 415Leu Leu Thr Tyr Gly Arg Arg Ile Pro Leu Ala Glu Trp Glu Ser Arg420 425 430Ile Ala Glu Val Asp Ala Ser Val Val Arg Glu Ile Cys Ser Lys Tyr435 440 445Ile Tyr Asp Gln Cys Pro Ala Val Ala Gly Tyr Gly Pro Ile Glu Gln450 455 460Leu Pro Asp Tyr Asn Arg Ile Arg Ser Gly Met Phe Trp Leu Arg Phe465 470 475 480<210>199<211>205<212>PRT<213>人<300>
<308>sw_hum/hs27_human<309>1987-08-13<400>199Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp1 5 10 15Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala20 25 30
Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly35 40 45Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu50 55 60Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln65 70 75 80Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg85 90 95Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys100 105 110Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln115 120 125Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu130 135 140Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu145 150 155 160Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser165 170 175Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly180 185 190Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys195 200 20權(quán)利要求
1.抗病毒化合物的靶標(biāo)，其包括至少一種選自表1和表2中所列多肽的多肽。
2.抗病毒化合物的靶標(biāo)，其包括至少一種選自表3中所列多肽的多肽。
3.抗病毒化合物的靶標(biāo)，其包括至少一種選自表4中所列多肽的多肽。
4.抗病毒化合物的靶標(biāo)，其包括至少一種選自表5中所列多肽的多肽。
5.抗病毒化合物的靶標(biāo)，其包括至少一種選自表6中所列多肽的多肽。
6.根據(jù)權(quán)利要求1到6任一項(xiàng)的靶標(biāo)，其中抗病毒化合物為抗HCV化合物。
7.預(yù)測病毒感染后果的標(biāo)記，其包括至少一種選自表1和表2中所列多肽的多肽。
8.預(yù)測病毒感染后果的標(biāo)記，其包括至少一種選自表3到表6中所列多肽的多肽。
9.根據(jù)權(quán)利要求7和8任一項(xiàng)的標(biāo)記，其中病毒感染為HCV感染。
10.預(yù)測個(gè)體中HCV感染后果的體外方法，其包括從HCV感染的個(gè)體得到生物學(xué)樣品并測定至少一種選自表1和表2中所列多肽的多肽的表達(dá)水平。
11.預(yù)測個(gè)體中HCV感染后果的體外方法，其包括測定至少一種選自表3到表6中所列多肽的多肽的表達(dá)水平。
12.根據(jù)權(quán)利要求10和11任一項(xiàng)的方法，其還包括將該至少一種多肽的表達(dá)水平與HCV感染過程中另一個(gè)時(shí)間點(diǎn)測定的該多肽的表達(dá)水平或健康個(gè)體中該多肽的表達(dá)水平相比較。
13.用于鑒定和/或得到與選自表1到表6中所列多肽的多肽相互作用的化合物的篩選方法，其中，所述多肽的表達(dá)在HCV感染的組織中被上調(diào)或下調(diào)，所述篩選方法包括步驟a)將所述多肽與一種或多種化合物在允許所述化合物與所述多肽相互作用的條件下接觸；和b)檢測所述化合物或多種化合物與所述多肽的相互作用。
14.用于鑒定和/或得到作為表2到6所列多肽之抑制劑或拮抗劑的化合物的篩選方法，其中，所述多肽的表達(dá)在HCV感染的組織中被上調(diào)，所述篩選方法包括步驟a)將所述多肽與一種或多種化合物在允許所述化合物與所述多肽相互作用的條件下接觸；b)測定所述多肽的活性；c)將存在該化合物或多種化合物時(shí)所述多肽的活性與沒有該化合物或多種化合物時(shí)測定的活性相比較；和d)鑒定和/或得到抑制劑或拮抗劑，其中(c)中測定的降低的活性指示抑制劑或拮抗劑。
15.用于鑒定和/或得到作為表1，3到6中所列多肽之激活劑或興奮劑的化合物的篩選方法，其中，所述多肽在HCV感染的組織中的表達(dá)被下調(diào)，所述篩選方法包括步驟a)將所述多肽與一種或多種化合物在允許所述化合物與所述多肽接觸的條件下接觸；b)測定所述多肽的活性；c)將存在該化合物或多種化合物時(shí)所述多肽的活性與沒有該化合物或多種化合物時(shí)測定的活性相比較；和d)鑒定和/或得到激活劑或興奮劑，其中(c)中測定的升高的活性指示激活劑或興奮劑。
16.用于鑒定和/或得到作為多肽的表達(dá)抑制劑的化合物的篩選方法，其中，所述多肽選自在HCV感染的組織中表達(dá)被上調(diào)的表2到6所列的多肽，所述篩選方法包括步驟a)將表達(dá)所述多肽的宿主與一種或多種化合物接觸；b)測定所述多肽的表達(dá)水平；c)將存在該化合物或多種化合物時(shí)測定的表達(dá)水平與沒有該化合物或多種化合物時(shí)測定的表達(dá)水平相比較；和d)鑒定和/或得到多肽表達(dá)的抑制劑，其中(c)中測定的降低的表達(dá)水平指示所述多肽表達(dá)的抑制劑。
17.用于鑒定和/或得到作為多肽的表達(dá)激活劑的化合物的篩選方法，其中，所述多肽選自在HCV感染的組織中表達(dá)被下調(diào)的表1，3到6所列多肽，所述篩選方法包括步驟a)將表達(dá)所述多肽的宿主與一種或多種化合物接觸；b)測定所述多肽的表達(dá)水平；c)將存在該化合物或多種化合物時(shí)測定的表達(dá)水平與沒有該化合物或多種化合物時(shí)測定的表達(dá)水平相比較；和d)鑒定和/或得到多肽表達(dá)的激活劑，其中(c)中測定的升高的表達(dá)水平指示所述多肽表達(dá)的激活劑。
18.通過權(quán)利要求13到17任一項(xiàng)的篩選方法鑒定和/或得到的化合物。
19.含有權(quán)利要求18的化合物和藥學(xué)上可接受的載體或稀釋劑的藥物組合物。
20.制備權(quán)利要求19的藥物組合物的方法，其包括將權(quán)利要求18的化合物配制在藥學(xué)上可接受的載體或稀釋劑中。
21.權(quán)利要求18的化合物的用途，用于制備治療或預(yù)防HCV感染的藥物。
22.權(quán)利要求21的用途，其中所述化合物選自抗體、抗體衍生物、抗體片段、肽或反義構(gòu)建體。
23.表1和表2中所列多肽的抗體或其抗原結(jié)合片段，其用于預(yù)測個(gè)體的HCV感染后果的體外方法。
24.用于預(yù)測個(gè)體的HCV感染后果的試劑盒，其含有一種或多種權(quán)利要求23的抗體或其抗原結(jié)合片段。
25.用于篩選激活或抑制表1和表2中所列多肽中任一種多肽的活性或表達(dá)的化合物的試劑盒。
全文摘要
本發(fā)明涉及通過分析HCV復(fù)制子調(diào)節(jié)的多肽表達(dá)鑒定的抗病毒、優(yōu)選抗丙型肝炎病毒(HCV)的化合物的新宿主細(xì)胞靶標(biāo)，涉及預(yù)測病毒感染后果的預(yù)后標(biāo)記，涉及預(yù)測個(gè)體中HCV感染后果的體外方法，還涉及用于鑒定與此新的宿主細(xì)胞靶標(biāo)相互作用和/或調(diào)節(jié)其活性或者調(diào)節(jié)所述新的宿主細(xì)胞靶標(biāo)的表達(dá)的化合物的篩選方法。
文檔編號(hào)C07K16/10GK1673368SQ20041005945
公開日2005年9月28日 申請(qǐng)日期2004年6月28日 優(yōu)先權(quán)日2003年6月30日
發(fā)明者P·伯恩特, P·M·基爾比, P·魯格曼 申請(qǐng)人:弗·哈夫曼-拉羅切有限公司